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Integrated Multilayer Microfluidic Platforms with Silicon Architectures for Next-Generation Health Diagnostic Systems

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Abstract

Majority of research on lab-on-chip devices was on single layer devices. Stacking a combination of microfluidic layers to silicon architecture gives substantial advantage to integrate precise sensors, actuators, and control systems. Advantages of multilayer stack are: (i) multiple functions can be incorporated into single chip and (ii) simultaneous analysis of both macroscopic and microscopic properties, for example, characterizing blood as a bulk fluid and at the individual component level at the same time. Such integrated systems enable the applications that lead to development of comprehensive diagnostics system. Challenges for developing such devices are integrating multiple layers – a combination of biocompatible microfluidics and silicon architectures; individual automated systems that incorporate sensors, actuators, and control systems; development of rapid data analysis and management; and development of diagnostic metrics to manipulate the actuators based on the responses (feedback control). This chapter reviews existing literature and techniques to address the above challenges through the prospect of a state-of-the-art silicon integrated lab-on-chip device with advanced automation coupled with novel data analysis tools to address critical applications in healthcare.

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Acknowledgments

This work was supported by West Virginia University startup funds awarded to J. Maddala.

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Authors and Affiliations

  1. Intel Corp, Portland, OR, USA

    Aditya Kasukurti

  2. OHSU, Portland, OR, USA

    Hari Hara Sudhan Lakshmanan

  3. WVU, Morgantown, WV, USA

    Sarojini Tiwari & Jeevan Maddala

Authors
  1. Aditya Kasukurti
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  2. Hari Hara Sudhan Lakshmanan
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  3. Sarojini Tiwari
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  4. Jeevan Maddala
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Corresponding authors

Correspondence to Aditya Kasukurti or Jeevan Maddala .

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Editors and Affiliations

  1. Integrated Mesoscale Architectures for Sustainable Catalysis (IMASC), Rowland Institute of Science, Harvard University, Cambridge, MA, USA

    Challa S.S.R. Kumar

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Kasukurti, A., Lakshmanan, H.H.S., Tiwari, S., Maddala, J. (2019). Integrated Multilayer Microfluidic Platforms with Silicon Architectures for Next-Generation Health Diagnostic Systems. In: Kumar, C. (eds) Nanotechnology Characterization Tools for Tissue Engineering and Medical Therapy. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-59596-1_9

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