Zusammenfassung
Polymere aus wasserlöslichen und wasserunlöslichen Blöcken bilden in wässriger Lösung Nanopartikel, die als Träger für medizinische Wirkstoffe dienen können. In diesem Kapitel wird ein System vorgestellt, das mit außergewöhnlich großen Mengen des häufig verwendeten Krebsmedikaments Paclitaxel beladen werden kann und somit für die Krebstherapie von großem Interesse ist. Mit Neutronen-Kleinwinkelstreuung konnten wir herausfinden, ob die Nanopartikel bei hoher Beladung mit Paclitaxel ihre Struktur ändern und wie dieses im Nanopartikel verteilt ist.
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Papadakis, C.M. (2019). Polymere Nanopartikel als Formulierung für die Krebstherapie. In: Duchardt, D., Bossmann, A., Denz, C. (eds) Vielfältige Physik. Springer Spektrum, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-58035-6_26
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DOI: https://doi.org/10.1007/978-3-662-58035-6_26
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