Skip to main content
SpringerLink
Log in

Adenomyose

  • Chapter
  • First Online:
Reproduktionsmedizin

Part of the book series: Springer Reference Medizin ((SRM))

  • 4383 Accesses

Zusammenfassung

Die Adenomyose ist nach heutigem Kenntnisstand offensichtlich für viele der klinischen Symptome verantwortlich, die ursprünglich der Endometriose zugesprochen wurden. Das Kapitel stellt die aktuellen Aspekte der Diagnostik sowie den Kenntnisstand zu unterschiedlichen therapeutischen Optionen der Adenomyose dar. Eine ursächliche Therapie vor allem bei bestehendem Kinderwunsch ist insbesondere bei der diffusen Form nicht möglich. Es bestehen noch offene Fragen zur Effektivität und klinischen Relevanz einzelner Verfahren.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 289.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 299.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Literatur

  • Abou-Setta AM, Houston B, Al-Inany HG, Farquhar C (2013) Levonorgestrel-releasing intrauterine device (LNG-IUD) for symptomatic endometriosis following surgery. Cochrane Database Syst Rev (1):CD005072

    Google Scholar 

  • Andres MP, Borrelli GM, Ribeiro J, Baracat EC, Abrão MS, Kho RM (2018) Transvaginal ultrasound for the diagnosis of adenomyosis: systematic review and meta-analysis. J Minim Invasive Gynecol 25:257–264

    Article  PubMed  Google Scholar 

  • Badawy AM, Elnashar AM, Mosbah AA (2012) Aromatase inhibitors or gonadotropin-releasing hormone agonists for the management of uterine adenomyosis: a randomized controlled trial. Acta Obstet Gynecol Scand 91:489–495

    Article  CAS  PubMed  Google Scholar 

  • Bazot M, Cortez A, Darai E, Rouger J, Chopier J, Antoine JM, Uzan S (2001) Ultrasonography compared with magnetic resonance imaging for the diagnosis of adenomyosis: correlation with histopathology. Hum Reprod 16:2427–2433

    Article  CAS  PubMed  Google Scholar 

  • Bazot M, Daraï E, Rouger J, Detchev R, Cortez A, Uzan S (2002) Limitations of transvaginal sonography for the diagnosis of adenomyosis, with histopathological correlation. Ultrasound Obstet Gynecol 20:605–611

    Article  CAS  PubMed  Google Scholar 

  • Bragheto AM, Caserta N, Bahamondes L, Petta CA (2007) Effectiveness of the levonorgestrel-releasing intrauterine system in the treatment of adenomyosis diagnosed and monitored by magnetic resonance imaging. Contraception 76:195–199

    Article  CAS  PubMed  Google Scholar 

  • Bratby MJ, Walker WJ (2009) Uterine artery embolisation for symptomatic adenomyosis-mid-term results. Eur J Radiol 70:128–132

    Article  CAS  PubMed  Google Scholar 

  • Brown J, Pan A, Hart RJ (2010) Gonadotrophin-releasing hormone analogues for pain associated with endometriosis. Cochrane Database Syst Rev (8):CD008475

    Google Scholar 

  • Brown J, Kives S, Akhtar M (2012) Progestagens and anti-progestagens for pain associated with endometriosis. Cochrane Database Syst Rev (3):CD002122

    Google Scholar 

  • Brown J, Crawford TJ, Allen C, Hopewell S, Prentice A (2017) Nonsteroidal anti-inflammatory drugs for pain in women with endometriosis. Cochrane Database Syst Rev (1):CD004753

    Google Scholar 

  • Champaneria R, Abedin P, Daniels J, Balogun M, Khan KS (2010) Ultrasound scan and magnetic resonance imaging for the diagnosis of adenomyosis: systematic review comparing test accuracy. Acta Obstet Gynecol Scand 89:1374–1384

    Article  PubMed  Google Scholar 

  • Cheung VY (2017) Current status of high-intensity focused ultrasound for the management of uterine adenomyosis. Ultrasonography 36:95–102

    Article  PubMed  Google Scholar 

  • Cho S, Nam A, Kim H, Chay D, Park K, Cho DJ, Park Y, Lee B (2008) Clinical effects of the levonorgestrel-releasing intrauterine device in patients with adenomyosis. Am J Obstet Gynecol 198:373.e1–373.e7

    Article  CAS  Google Scholar 

  • Cirpan T, Yeniel O, Ulukus M, Ozbal A, Gundem G, Ozsener S, Mete Itil I, Zekioglu O (2008) Clinical symptoms and histopathological findings in subjects with adenomyosis uteri. Clin Exp Obstet Gynecol 35:48–53

    CAS  PubMed  Google Scholar 

  • Dartmouth K (2014) A systematic review with meta-analysis: the common sonographic characteristics of adenomyosis. Ultrasound 22:148–157

    Article  PubMed  PubMed Central  Google Scholar 

  • Davis L, Kennedy SS, Moore J, Prentice A (2007) Modern combined oral contraceptives for pain associated with endometriosis. Cochrane Database Syst Rev (18):CD001019

    Google Scholar 

  • Di Spiezio Sardo A, Calagna G, Santangelo F, Zizolfi B, Tanos V, Perino A, De Wilde RL (2017) The role of hysteroscopy in the diagnosis and treatment of adenomyosis. Biomed Res Int 2017, Art. 2518396.

    Google Scholar 

  • Dueholm M (2006) Transvaginal ultrasound for diagnosis of adenomyosis: a review. Best Pract Res Clin Obstet Gynaecol 20:569–582

    Article  PubMed  Google Scholar 

  • Dueholm M (2017) Uterine adenomyosis and infertility, review of reproductive outcome after in vitro fertilization and surgery. Acta Obstet Gynecol Scand 96:715–726

    Article  PubMed  Google Scholar 

  • Dueholm M, Lundorf E (2007) Transvaginal ultrasound or MRI for diagnosis of adenomyosis. Curr Opin Obstet Gynecol 19:505–512

    Article  PubMed  Google Scholar 

  • Dunselman GA, Vermeulen N, Becker C, Calhaz-Jorge C, D’Hooghe T, De Bie B, Heikinheimo O, Horne AW, Kiesel L, Nap A, Prentice A, Saridogan E, Soriano D, Nelen W, European Society of Human Reproduction and Embryology (2014) ESHRE guideline: management of women with endometriosis. Hum Reprod 29:400–412

    Article  CAS  PubMed  Google Scholar 

  • Gordts S, Brosens JJ, Fusi L, Benagiano G, Brosens I (2008) Uterine adenomyosis: a need for uniform terminology and consensus classification. Reprod Biomed Online 17:244–248

    Article  PubMed  Google Scholar 

  • Harada T, Momoeda M, Taketani Y, Aso T, Fukunaga M, Hagino H, Terakawa N (2009) Dienogest is as effective as intranasal buserelin acetate for the relief of pain symptoms associated with endometriosis – a randomized, double-blind, multicenter, controlled trial. Fertil Steril 91:675–681

    Article  CAS  PubMed  Google Scholar 

  • Jeng CJ, Huang SH, Shen J, Chou CS, Tzeng CR (2007) Laparoscopy-guided myometrial biopsy in the definite diagnosis of diffuse adenomyosis. Hum Reprod 22:2016–2019

    Article  PubMed  Google Scholar 

  • Juang CM, Chou P, Yen MS, Twu NF, Horng HC, Hsu WL (2007a) Primary dysmenorrhea and risk of preterm delivery. Am J Perinatol 24:11–16

    Article  PubMed  Google Scholar 

  • Juang CM, Chou P, Yen MS, Twu NF, Horng HC, Hsu WL (2007b) Adenomyosis and risk of preterm delivery. BJOG 114:165–169

    Article  PubMed  Google Scholar 

  • Kim MD, Kim S, Kim NK, Lee MH, Ahn EH, Kim HJ, Cho JH, Cha SH (2007) Long-term results of uterine artery embolization for symptomatic adenomyosis. Am J Roentgenol 188:176–181

    Article  Google Scholar 

  • Kissler S, Zangos S, Wiegratz I, Kohl J, Rody A, Gaetje R, Doebert N, Wildt L, Kunz G, Leyendecker G, Kaufmann M (2007) Utero-tubal sperm transport and its impairment in endometriosis and adenomyosis. Ann N Y Acad Sci 1101:38–48

    Article  PubMed  Google Scholar 

  • Kissler S, Zangos S, Kohl J, Wiegratz I, Rody A, Gätje R, Vogl TJ, Kunz G, Leyendecker G, Kaufmann M (2008) Duration of dysmenorrhea and extent of adenomyosis visualised by magnetic resonance imaging. Eur J Obstet Gynecol Reprod Biol 137:204–209

    Article  CAS  PubMed  Google Scholar 

  • Kunz G, Beil D, Huppert P, Noe M, Kissler S, Leyendecker G (2005) Adenomyosis in endometriosis – prevalence and impact on fertility. Evidence from magnetic resonance imaging. Hum Reprod 20:2309–2316

    Article  CAS  PubMed  Google Scholar 

  • Kunz G, Herbertz M, Beil D, Huppert P, Leyendecker G (2007) Adenomyosis as a disorder of the early and late human reproductive period. Reprod Biomed Online 15:681–685

    Article  CAS  PubMed  Google Scholar 

  • Leyendecker G, Herbertz M, Kunz G, Mall G (2002) Endometriosis results from the dislocation of basal endometrium. Hum Reprod 17:2725–2736

    Article  CAS  PubMed  Google Scholar 

  • Mochimaru A, Aoki S, Oba MS, Kurasawa K, Takahashi T, Hirahara F (2015) Adverse pregnancy outcomes associated with adenomyosis with uterine enlargement. J Obstet Gynaecol Res 41:529–533

    Article  PubMed  Google Scholar 

  • Molinas CR, Campo R (2006) Office hysteroscopy and adenomyosis. Best Pract Res Clin Obstet Gynaecol 20:557–567

    Article  PubMed  Google Scholar 

  • Osada H, Silber S, Kakinuma T, Nagaishi M, Kato K, Kato O (2011) Surgical procedure to conserve the uterus for future pregnancy in patients suffering from massive adenomyosis. Reprod Biomed Online 22:94–99

    Article  PubMed  Google Scholar 

  • Osuga Y, Fujimoto-Okabe H, Hagino A (2017) Evaluation of the efficacy and safety of dienogest in the treatment of painful symptoms in patients with adenomyosis: a randomized, double-blind, multicenter, placebo-controlled study. Fertil Steril 108:673–678

    Article  CAS  PubMed  Google Scholar 

  • Parazzini F, Vercellini P, Panazza S, Chatenoud L, Oldani S, Crosignani PG (1997) Risk factors for adenomyosis. Hum Reprod 12:1275–1279

    Article  CAS  PubMed  Google Scholar 

  • Parazzini F, Mais V, Cipriani S, Busacca M, Venturini P, GISE (2009) Determinants of adenomyosis in women who underwent hysterectomy for benign gynecological conditions: results from a prospective multicentric study in Italy. Eur J Obstet Gynecol Reprod Biol 143:103–106

    Article  CAS  PubMed  Google Scholar 

  • Parker JD, Leondires M, Sinaii N, Premkumar A, Nieman LK, Stratton P (2006) Persistence of dysmenorrhea and nonmenstrual pain after optimal endometriosis surgery may indicate adenomyosis. Fertil Steril 86:711–715

    Article  PubMed  Google Scholar 

  • Peric H, Fraser IS (2006) The symptomatology of adenomyosis. Best Pract Res Clin Obstet Gynaecol 20:547–555

    Article  CAS  PubMed  Google Scholar 

  • Pontis A, D’Alterio MN, Pirarba S, de Angelis C, Tinelli R, Angioni S (2016) Adenomyosis: a systematic review of medical treatment. Gynecol Endocrinol 32:696–700

    Article  CAS  PubMed  Google Scholar 

  • Popovic M, Puchner S, Berzaczy D, Lammer J, Bucek RA (2011) Uterine artery embolization for the treatment of adenomyosis: a review. J Vasc Interv Radiol 22:901–909

    Article  PubMed  Google Scholar 

  • Rabinovici J, Inbar Y, Eylon SC, Schiff E, Hananel A, Freundlich D (2006) Pregnancy and live birth after focused ultrasound surgery for symptomatic focal adenomyosis: a case report. Hum Reprod 21:1255–1259

    Article  CAS  PubMed  Google Scholar 

  • Sammour A, Pirwany I, Usubutun A, Arseneau J, Tulandi T (2002) Correlations between extent and spread of adenomyosis and clinical symptoms. Gynecol Obstet Invest 54:213–216

    Article  PubMed  Google Scholar 

  • Selak V, Farquhar C, Prentice A, Singla A (2007) Danazol for pelvic pain associated with endometriosis. Cochrane Database Syst Rev (4):CD000068

    Google Scholar 

  • Sheng J, Zhang WY, Zhang JP, Lu D (2009) The LNG-IUS study on adenomyosis: a 3-year follow-up study on the efficacy and side effects of the use of levonorgestrel intrauterine system for the treatment of dysmenorrhea associated with adenomyosis. Contraception 79:189–193

    Article  CAS  PubMed  Google Scholar 

  • Strowitzki T, Faustmann T, Gerlinger C, Seitz C (2010a) Dienogest in the treatment of endometriosis-associated pelvic pain: a 12-week, randomized, double-blind, placebo-controlled study. Eur J Obstet Gynecol Reprod Biol 151:193–198

    Article  CAS  PubMed  Google Scholar 

  • Strowitzki T, Marr J, Gerlinger C, Faustmann T, Seitz C (2010b) Dienogest is as effective as leuprolide acetate in treating the painful symptoms of endometriosis: a 24-week, randomized, multicentre, open-label trial. Hum Reprod 25:633–641

    Article  CAS  PubMed  Google Scholar 

  • Templeman C, Marshall SF, Ursin G, Horn-Ross PL, Clarke CA, Allen M, Deapen D, Ziogas A, Reynolds P, Cress R, Anton-Culver H, West D, Ross RK, Bernstein L (2008) Adenomyosis and endometriosis in the California Teachers Study. Fertil Steril 90:415–424

    Article  PubMed  Google Scholar 

  • Tocci A, Greco E, Ubaldi FM (2008) Adenomyosis and ‚endometrial-subendometrial myometrium unit disruption disease‘ are two different entities. Reprod Biomed Online 17:281–291

    Article  PubMed  Google Scholar 

  • Vercellini P, Vigano P, Somigliana E, Fedele L (2013) Endometriosis: pathogenesis and treatment. Nat Rev Endocrinol 10:261–275

    Article  PubMed  CAS  Google Scholar 

  • Wada S, Kudo M, Minakami H (2006) Spontaneous uterine rupture of a twin pregnancy after a laparoscopic adenomyomectomy: a case report. J Minim Invasiv Gynecol 13:166–168

    Article  Google Scholar 

  • Weiss G, Maseelall P, Schott LL, Brockwell SE, Schocken M, Johnston JM (2009) Adenomyosis a variant, not a disease? Evidence from hysterectomized menopausal women in the Study of Women’s Health Across the Nation (SWAN). Fertil Steril 91:201–206

    Article  PubMed  Google Scholar 

  • Yeniel O, Cirpan T, Ulukus M, Ozbal A, Gundem G, Ozsener S, Zekioglu O, Yilmaz H (2007) Adenomyosis: prevalence, risk factors, symptoms and clinical findings. Clin Exp Obstet Gynecol 34:163–167

    CAS  PubMed  Google Scholar 

  • Younes G, Tulandi T (2018) Conservative surgery for adenomyosis and results: a systematic review. J Minim Invasive Gynecol 25:265–276

    Article  PubMed  Google Scholar 

  • Zacharia TT, O’Neill MJ (2006) Prevalence and distribution of adnexal findings suggesting endometriosis in patients with MR diagnosis of adenomyosis. Br J Radiol 79:303–307

    Article  CAS  PubMed  Google Scholar 

  • Zaloudek C, Norris HJ (1987) Mesenchymal tumors of the uterus. In: Kurmann RJ (Hrsg) Blaunstein’s pathology of the female genital tract, 3. Aufl. Springer, New York, S 374

    Google Scholar 

  • Zhang L, Rao F, Setzen R (2017) High intensity focused ultrasound for the treatment of adenomyosis: selection criteria, efficacy, safety and fertility. Acta Obstet Gynecol Scand 96:707–714

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Facharzt-Zentrum für Kinderwunsch, Pränatale Medizin, Endokrinologie und Osteologie, amedes MVZ Hamburg, Hamburg, Deutschland

    Frank Nawroth

Authors
  1. Frank Nawroth
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Frank Nawroth .

Editor information

Editors and Affiliations

  1. Facharzt-Zentrum für Kinderwunsch Pränatale Medizin, Endokrinologie und Osteologie Hamburg GmbH, amedes experts, Hamburg, Germany

    Klaus Diedrich

  2. SYNLAB Holding Deutschland GmbH, Augsburg, Germany

    Michael Ludwig

  3. Sektion für gynäkologische Endokrinologie und Reproduktionsmedizin, Universitätsklinikum Schleswig-Holstein – Campus Lübeck, Lübeck, Germany

    Georg Griesinger

Rights and permissions

Reprints and permissions

Copyright information

© 2020 Springer-Verlag GmbH Deutschland, ein Teil von Springer Nature

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Nawroth, F. (2020). Adenomyose. In: Diedrich, K., Ludwig, M., Griesinger, G. (eds) Reproduktionsmedizin. Springer Reference Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-57636-6_36

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-57636-6_36

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-57635-9

  • Online ISBN: 978-3-662-57636-6

  • eBook Packages: Medicine (German Language)

Publish with us

Policies and ethics

Search

Navigation