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Bewertung der Qualität menschlicher Oozyten und Embryonen

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Reproduktionsmedizin

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Zusammenfassung

Die Erkennung der Viabilität der menschlichen Metaphase-II-Oozyten ist in der Literatur des letzten Jahrzehnts ein kontrovers diskutiertes Thema. Die Entwicklung der Oozyten während der follikulären Maturation ist entscheidend für ihre Fähigkeit, eine normale Fertilisation sowie die folgenden embryonalen Entwicklungsschritte zu durchlaufen. Die komplette physiologische Reifung der Eizelle erfordert konzertiert ablaufende nukleäre und zytoplasmatische Prozesse, um optimale zelluläre Bedingungen herzustellen. Abweichungen von diesen optimalen Prozessen führen zu Eizellen, deren Qualitätseinschränkungen sich in verschiedenen Dysmorphien ausdrücken und im weiteren Verlauf dann unter Umständen nicht zu der gewünschten Implantation führen.

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Literatur

  • Alikani M, Palermo G, Adler A et al (1995) Intracytoplasmic sperm injection in dysmorphic human oocytes. Zygote 3:283–288

    Article  CAS  PubMed  Google Scholar 

  • Alpha Scientists in Reproductive Medicine, ESHRE Special Interest Group Embryology (2011) Istanbul consensus workshops on embryo assessment: proceedings of an expert meeting. Reprod Biomed Online 22:632–646

    Article  Google Scholar 

  • Baart EB, Martini E, Eijkemans MJ et al (2007) Milder ovarian stimulation for in vitro fertilization reduces aneuploidy in the human preimplantation embryo: a randomized controlled trial. Hum Reprod 22:980–988

    Article  PubMed  Google Scholar 

  • Balaban B, Urman B (2006) Effect of oocyte morphology on embryo development and implantation. Reprod Biomed Online 12:608–615

    Article  PubMed  Google Scholar 

  • Balaban B, Urman B, Setac A et al (1998) Oocyte morphology does not affect fertilization rate, embryo quality and implantation rate after intracytoplasmic sperm injection. Hum Reprod 13:3431–3433

    Article  CAS  PubMed  Google Scholar 

  • Balaban B, Urman B, Isiklar A, Alatas C, Aksoy S, Mervan R, Mumcu A, Nuhoglu A (2001a) The effect of pronuclear morphology on embryo quality parameters and blastocyst transfer outcome. Hum Reprod 16:2357–2361

    Article  CAS  PubMed  Google Scholar 

  • Balaban B, Urman B, Isiklar A et al (2001b) The effect of polar body (PB) morphology on embryo quality, implantation and pregnancy rates. Fertil Steril 76:S11

    Google Scholar 

  • Balakier H, Bouman D, Sojecki et al (2002) Morphological and cytoplasmic analysis of human giant ooctes and giant embryos. Hum Reprod 17:2394–2401

    Article  PubMed  Google Scholar 

  • Borini A, Lagalla C, Cattoli M et al (2005) Predictive factors for embryo implantation potential. Reprod Biomed Online 10:653–658

    Article  PubMed  Google Scholar 

  • Brewis IA (1999) Proteomics in reproductive research: The potential importance of proteomics to research in reproduction. Hum Reprod 14:2927–2929

    Article  CAS  PubMed  Google Scholar 

  • Choi T, Fukasawa K, Zhou R et al (1996) The Mos/mitogen-activated protein kinase (MAPK) pathway regulates the size and degradation of the first polar body in maturing mouse oocytes. Proc Natl Acad Sci U S A 93:7032–7035

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ciotti PM, Notarangelo L, Morselli-Labate AM et al (2004) First polar body morphology before ICSI is not related to embryo quality or pregnancy rate. Hum Reprod 19:2334–2339

    Article  CAS  PubMed  Google Scholar 

  • Ciray HN, Karagenc L, Ulug U et al (2005) Use of both early cleavage and day 2 mononucleation to predict embryos with high implantation potential in intracytoplasmic sperm injection cycles. Fertil Steril 84:1411–1416

    Article  PubMed  Google Scholar 

  • De Cassia R, Figueira MS, Braga DPAF et al (2010) Metaphase II human oocyte morphology: contributing factors and effects on fertilization potential and embryo developmental ability in ICSI cycles. Fertil Steril 94:1115–1117

    Google Scholar 

  • De Santis L, Cino I, Rabelloti E et al (2005) Polar body morphology and spindle imaging as predictors of oocyte quality. Reprod Biomed Online 11:36–42

    Article  PubMed  Google Scholar 

  • De Sutter P, Dozortsev D, Qian C et al (1996) Oocytes morphology does not correlate with fertilization rate and embryo quality after intracytoplasmic sperm injection. Hum Reprod 11:595–597

    Article  CAS  PubMed  Google Scholar 

  • Devreker F (2005) Uptake and release of glucose, pyruvate and lactate, non-invasive embryo quality assessment. Eshre Campus:77–91

    Google Scholar 

  • Ebner T, Moser M, Yaman C et al (1999) Elective transfer of embryos selected on the basis of first polar body morphology is associated with increased rates of implantation and pregnancy. Fertil Steril 72:599–603

    Article  CAS  PubMed  Google Scholar 

  • Gardner DK, Lane M, Stevens J et al (2000) Blastocysts score affects implantation and pregnancy outcome: towards a single blastocyst transfer. Fertil Steril 73:1155–1158

    Article  CAS  PubMed  Google Scholar 

  • Giovanni C, Elena S, Lucia S et al (2004) What criteria for the definition of oocyte quality? Ann N Y Acad Sci 1034:132–144

    Article  Google Scholar 

  • Hamamah S (2005) Oocyte and embryo quality: is their morphology a good criterion? J Gynecol Obstet Biol Reprod 34:5S38–5S41

    Article  CAS  Google Scholar 

  • Hassan-Ali H, Hisham-Saleh A, El-Gezeriry D et al (1998) Perivitelline space granularity: a sign of human menopausal gonadotrophin overdose in intracytoplasmic sperm injection. Hum Reprod 13:3425–3430

    Article  CAS  PubMed  Google Scholar 

  • Kere J, Hofmann B (2011) Comprehensive molecular analysis of oocytes and embryos. Hum Reprod 26(Suppl 1):i56

    Article  Google Scholar 

  • Kirkegaard K, Agerholm IE, Ingerslev HJ (2012) Time-lapse monitoring as a tool for clinical embryo assessment. Hum Reprod 27(5):1277–1285. https://doi.org/10.1093/humrep/des079

    Article  PubMed  Google Scholar 

  • Klein NA, Battaglia DE, Fujimoto VY, Davis GS, Bremner WJ, Soules MR (1996) Reproductive aging: accelerated ovarian follicular development associated with a monotropic follicle-stimulating hormone rise in normal older women. J Clin Endocrinol Metabol 81:1038–1045

    CAS  Google Scholar 

  • Ludwig M, Schopper B, Al-Hasani S, Diedrich K (2000) Clincial use of pronuclear stage score following intracytoplasmatic sperm injection: impact on pregnancy rates under the condition of the German embryo protection law. Hum Reprod 15:325–329

    Article  CAS  PubMed  Google Scholar 

  • Mikkelsen A, Lindenberg S (2001) Morphology of in vitro matured oocytes: impact on fertility potential and embryo quality. Hum Reprod 16:1714–1718

    Article  CAS  PubMed  Google Scholar 

  • Montag M, Van der Ven H (2001) Evaluation of pronuclear morphology as the only selection criterion for further embryo culture and transfer: results of a prospective multicentre study. Hum Repaired 16:2384–2389

    Article  CAS  Google Scholar 

  • Montag M, Köster K, van der Ven K, Van der Ven H (2009) Qualität der Eizelle. J Reproduktionsmed Endokrinol 6(Sonderheft 1):26–28

    Google Scholar 

  • Ng EH, Lau EY, Yeung WS et al (2001) hMG is as good as recombinant human FSH in terms of oocyte and embryo quality: a prospective randomized trial. Hum Reprod 16:319–325

    Article  CAS  PubMed  Google Scholar 

  • Niakan KK, Han J, Pedersen RA, Simon C, Reijo Pera RA (2012) Human pre-implantation embryo development. Development 139:829–841

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Palermo G, Alikani M, Bertoli M et al (1996) Oolemma characteristics in relation to survival and fertilization patterns of oocyte treated by intracytoplasmic sperm injection. Hum Reprod 11:172–176

    Article  CAS  PubMed  Google Scholar 

  • Papanikolaou EG, Kolbianakis EM, Tournaye H, Venedig CA, Fatemi H, Tarlatzis B, Devroey P (2008) Live birth rates after transfer of equal number of blastocysts or cleavage-stage embryos in IVF. A systematic review and meta-analysis. Hum Reprod 23:91–99

    Article  PubMed  Google Scholar 

  • Pena JE, Chang PL, Chan LK et al (2002) Supraphsiological estradiol levels do not effect oocyte and embryo quality in oocyte donation cycles. Hum Reprod 17:83–87

    Article  CAS  PubMed  Google Scholar 

  • Rashidi BH, Sarvi F, Tehrani ES et al (2005) The effect of hMG and recombinant human FSH on oocyte quality: a randomized single-blind clinical trial. Eur J Obstet Gynecol Reprod Biol 120:190–194

    Article  CAS  PubMed  Google Scholar 

  • Rienzi L, Ubaldi FM, Lacbelli M et al (2008) Significance of metaphase II human oocyte morphology on ICSI outcome. Fertil Steril 90:1692–1700

    Article  PubMed  Google Scholar 

  • Ritter-Eichenlaub U, Schmiady H, Kentenich H et al (1995) Recurrent failure in polar body formation and premature chromosome condensation in oocytes from human patient: indicatore ofasynchrony in nuclear and cytoplasmic maturation. Hum Reprod 10:2343–2349

    Article  Google Scholar 

  • Scott LA, Smith S (1998) The successful use of pronuclear embryo transfers the day following oocyte retrieval. Hum Report 13:1000–1013

    Article  CAS  PubMed  Google Scholar 

  • Shen Y, Stalf T, Mehnert C et al (2006) Light retardnace by human oocyte spindle is positively related to pronuclear score after ICSI. Reprod Biomed Online 12:737–751

    Article  CAS  PubMed  Google Scholar 

  • Steer CV, Mills CL, Tan SL, Campbell S, Edwards RG (1992) The cumulative embryo score: a predictive embryo scoring tecnique to select optimal number of embryos to transfer in an in-vitro fertilization and embryo transfer programme. Hum Reprod 7:117–119

    Article  CAS  PubMed  Google Scholar 

  • Tesarik J, Greco E (1999) The probability of abnormal preimplantation development can be predicted by single static observation on pronuclear stage morphology. Hum Reprod 14:1318–1323

    Article  CAS  PubMed  Google Scholar 

  • Trotnow S, Kniewald T, Al-Hasani S, Becker H (1981) Follikelpunktion, In vitro Fertilisation, Embryotransfer und eingetretene Schwangerschaften in Dyneric/HMG-stimulierten Zyklen. Geburtsh Frauenheilk 41:829–898

    Article  Google Scholar 

  • Verlinsky Y, Lerner S, Illkevitch N et al (2003) Is there any predictive value of first polar body morphology for embryo genotype or developmental potential. Reprod Biomed Online 7:336–341

    Article  PubMed  Google Scholar 

  • Xia P (1997) Intracytoplasmic sperm injection: correlation of oocyte grade based on polar body, perivitelline space and cytoplasmic inclusions with fertilization rate and embryo quality. Hum Reprod 12:1750–1755

    Article  CAS  PubMed  Google Scholar 

  • Yakin K, Balaban B, Isiklar A (2007) Oocyte dysmorphism is not associated with aneuploidy in the developing embryo. Fertil Steril 88:811–816

    Article  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Al-Hasani IVF-Consulting, Lübeck, Deutschland

    Safaa Al-Hasani

  2. Facharzt-Zentrum für Kinderwunsch, Pränatale Medizin, Endokrinologie und Osteologie Hamburg GmbH, amedes experts, Hamburg, Deutschland

    Klaus Diedrich

  3. Universitäts-Frauenklinik Lübeck, Lübeck, Deutschland

    Klaus Diedrich

Authors
  1. Safaa Al-Hasani
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  2. Klaus Diedrich
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Corresponding author

Correspondence to Safaa Al-Hasani .

Editor information

Editors and Affiliations

  1. Facharzt-Zentrum für Kinderwunsch Pränatale Medizin, Endokrinologie und Osteologie Hamburg GmbH, amedes experts, Hamburg, Germany

    Klaus Diedrich

  2. SYNLAB Holding Deutschland GmbH, Augsburg, Germany

    Michael Ludwig

  3. Sektion für gynäkologische Endokrinologie und Reproduktionsmedizin, Universitätsklinikum Schleswig-Holstein – Campus Lübeck, Lübeck, Germany

    Georg Griesinger

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Al-Hasani, S., Diedrich, K. (2020). Bewertung der Qualität menschlicher Oozyten und Embryonen. In: Diedrich, K., Ludwig, M., Griesinger, G. (eds) Reproduktionsmedizin. Springer Reference Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-57636-6_23

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  • DOI: https://doi.org/10.1007/978-3-662-57636-6_23

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  • Online ISBN: 978-3-662-57636-6

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