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Mobile Properties of Supramolecular Polyrotaxane Surfaces on Modulation of Cellular Functions

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Functional Hydrogels as Biomaterials

Part of the book series: Springer Series in Biomaterials Science and Engineering ((SSBSE,volume 12))

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Abstract

The concept of dynamic supramolecular surfaces and its performance as the functional biomaterials surfaces are introduced in this chapter. In order to provide the dynamic nature on substrate surfaces, supramolecular architecture of polyrotaxanes (PRXs) is introduced into designing block copolymers. In the PRX segment, many cyclodextrins are threaded onto a linear poly(ethylene glycol) chain capped both terminals with bulky endo-groups. The molecular mobility at surfaces in aqueous media could be controlled via changing the number of threaded CDs. By adopting the mobile supramolecular PRX platform, conformational change of adsorbed fibrinogen molecules is greatly suppressed, and the subsequent platelet adhesion is reduced. Further, introducing RGD sequence into the PRX platform can induce fast cellular response but reduce the later cellular metabolic response. These novel concepts of dynamic cell-adhesive surfaces are expected to provide a promising way to develop functional biomaterials that is able to induce selective cell adhesion, rapid cellular recognition, or suppression of differentiation.

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Author information

Authors and Affiliations

  1. Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Chiyoda, Tokyo, Japan

    Ji-Hun Seo & Nobuhiko Yui

Authors
  1. Ji-Hun Seo
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  2. Nobuhiko Yui
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Corresponding author

Correspondence to Nobuhiko Yui .

Editor information

Editors and Affiliations

  1. Department of Biomedical Engineering Faculty of Engineering, National University of Singapore, Singapore, Singapore

    Jun Li

  2. RIKEN Advanced Science Institute, Saitama, Japan

    Yoshihito Osada

  3. Tissue Engineering and Microfluidics Laboratory Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, St. Lucia, Australia

    Justin Cooper-White

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Seo, JH., Yui, N. (2018). Mobile Properties of Supramolecular Polyrotaxane Surfaces on Modulation of Cellular Functions. In: Li, J., Osada, Y., Cooper-White, J. (eds) Functional Hydrogels as Biomaterials. Springer Series in Biomaterials Science and Engineering, vol 12. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-57511-6_6

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