Skip to main content

Maligne Tumoren der Cervix uteri

  • Chapter
  • First Online:
Praxisbuch Gynäkologische Onkologie

Zusammenfassung

Eine persistierende HPV-Infektion mit Hochrisikosubtypen ist der wichtigste Risikofaktor für die Entstehung des Zervixkarzinoms. Die prophylaktische Impfung gegen HPV 16 und 18 kann die Rate an Zervixkarzinomen um ca. 70 % reduzieren. Im Frühstadium (IB1 und IIA) stellen die radikale Hysterektomie oder die Radiotherapie des Beckens den Therapiestandard dar. Die Kombination einer Strahlen- mit Chemotherapie ist die Standardbehandlung bei den fortgeschrittenen Stadien Ib2 und IIb–IV. Rezidive treten bevorzugt im Becken auf.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 99.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 129.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Literatur

  • Bader A, Winter R, Haas J, Tamussino K (2007) Where to look for the sentinel lymph-node in cervical cancer. Am J Obstet Gynecol 197: 678.e1–678.e7

    Article  Google Scholar 

  • Benedet J, Anderson G (1996) Stage IA carcinoma of the cervix revisited. Obstet Gynecol 87:1052–1059

    Article  CAS  Google Scholar 

  • Benedetti-Panici P, Greggi S, Colombo A et al (2001) Neoadjuvant chemotherapy and radical surgery versus exclusive radiotherapy in locally advanced squamous cell cervical cancer: results from the Italian multicenter randomized study. J Clin Oncol 20:179–188

    Article  Google Scholar 

  • Bornstein J, Bentely J, Bösze P, Giradi F, Haefner H, Menton M et al (2012) 2011 Colposcopic terminology of the International Federation of Cervical pathology and colposcopy. Obstet Gynecol 120: 166–72

    Article  Google Scholar 

  • Burghardt E (1984) Kolposkopie, spezielle Zervixpathologie. Thieme, Stuttgart

    Google Scholar 

  • Burghardt E, Baltzer J, Tulusan H, Haas J (1992) Results of surgical treatment of 1028 cervical cancers studied with volumetry. Cancer 70:648–655

    Article  CAS  Google Scholar 

  • Chou H, Chang T, Yen T et al (2006) Low value of 18-F-fluoro-2-deoxy-D-glucose-positron emission tomography in primary staging of early-stage cervical cancer before radical hysterectomy. J Clin Oncol 24:123–128

    Article  Google Scholar 

  • Diab Y (2017) Sentinel lymph nodes mapping in cervical cancer: a comprehensive review. Int J Gynecol Cancer 27:154–158

    Article  Google Scholar 

  • Eifel P, Winter K, Morris M et al (2004) Pelvic irradiation with concurrent chemotherapy versus pelvic and para-aortic irradiation for high-risk cervical cancer: an update of Radiation Therapy Oncology Group trial (RTOG) 90–01. J Clin Oncol 22:872–880

    Article  Google Scholar 

  • Frenel JS (2016) Pembrolizumab in patients with advanced cervical squamous cell cancer: Preliminary results from the phase Ib Keynote-028 study. J Clin Oncol 34 (Suppl 15) Abstr. 5515

    Article  Google Scholar 

  • Fyles AW, Milosevic M, Pintilie M et al (2000) Anemia, hypoxia and transfusion in patients with cervix cancer: a review. Radiother Oncol 57:13–19

    Article  CAS  Google Scholar 

  • Girardi F, Pickel H, Winter R (1993) Pelvic and parametrial lymph nodes in the quality control of the surgical treatment of cervical cancer. Gynecol Oncol 50:330–333

    Article  CAS  Google Scholar 

  • Girardi F, Reich O, Tamussino K (2014) Burghardt’s colposcopy and cervical pathology, 4. Aufl. Thieme, Stuttgart

    Google Scholar 

  • Gupta S et al (2017) Neoadjuvant chemotherapy followed by surgery versus concomitant cisplatin and radiation therapy in patients with stage IB2, IIA or IIB squamous carcinoma of the cervix. Eur J Cancer Suppl. 2 Suppl. Abstr. PR 5515

    Google Scholar 

  • Hacker N, Wain G, Nicklin J (1995) Resection of bulky positive lymph nodes in patients with cervical carcinoma. Int J Gynecol Cancer 5:250–256

    Article  Google Scholar 

  • Joura E, Giuliano A, Iversen OE et al (2015) A 9-valent HPV vaccine against infection and intraepithelial neropalasia in women. N Engl J Med 372:711–723

    Article  CAS  Google Scholar 

  • Kapp KS, Stuecklschweiger GF, Kapp DS et al (1997) Carcinoma of the cervix; analysis of complications after primary external beam radiation and Ir-192 HDR brachytherapy. Radiother Oncol 42:143–153

    Article  CAS  Google Scholar 

  • Kapp KS, Poschauko J, Geyer E et al (2002) Evaluation of the effect of routine packed red blood cell transfusion in anemic cervix cancer patients treated with radical radiotherapy. Int J Radiat Oncol Biol Phys 54:58–66

    Article  Google Scholar 

  • Kaufmann M, Costa SD, Scharl A (Hrsg) (2003) Die Gynäkologie. Springer, Berlin

    Google Scholar 

  • Landoni F, Maneo A, Colombo A et al (1997) Randomized study of radical surgery versus radiotherapy for stage Ib–IIa cervical cancer. Lancet 350:535–540

    Article  CAS  Google Scholar 

  • Lee J, Lee K, Nam J et al (2007) Prognostic factors in FIGO stage IB-IIA small cell neuroendocrine carcinoma of the uterine cervix treated surgically: Results of a multi-center retrospective Korean study. Ann Oncol 19:321–326

    Article  Google Scholar 

  • National Comprehensive Cancer Network (NCCN) NCCN guidelines version 1. 2017 cervical cancer

    Google Scholar 

  • Paavonen J, Jenkins D, Bosch FX et al (2007) Efficacy of a prophylactic adjuvant bivalent L1 virus-like vaccine against infection with human papillomavirus types 16 and 18 in young women: an interim analysis of a phase III double-blind, randomized controlled trial. Lancet 369:2161–2170

    Article  CAS  Google Scholar 

  • Peters WA, Liu P, Barrett R et al (2000) Concurrent chemotherapy and pelvic radiation therapy compared with pelvic radiation therapy alone as adjuvant therapy after radical surgery in high-risk early-stage cancer of the cervix. J Clin Oncol 18:1606–1613

    Article  CAS  Google Scholar 

  • Petru E, Tamussino K, Lahousen M et al (1989) Pelvic and paraaortic lymphocysts after radical surgery because of cervical and ovarian cancer. Am J Obstet Gynecol 161:937–941

    Article  CAS  Google Scholar 

  • Petru E, Pasterk C, Reich O et al (2005) Small cell carcinoma of the uterus and vagina. Experience with ten patients. Arch Gynecol Obstet 271:316–319

    Article  Google Scholar 

  • Podczaski E, Palombo C, Manetta A et al (1989) Assessment of pretreatment laparotomy in patients with cervical carcinoma prior to radiotherapy. Gynecol Oncol 33:71–75

    Article  CAS  Google Scholar 

  • Ramirez P, Frumovitz M, Pareja R, Lopez A, Viera M, Ribeiro R (2018) Phase III randomized trial of laparoscopic or robotic versus abdominal radical hysterectomy in patients with early stage cervical cancer: LACC trial. Society of Gynecologic Oncologists, March 26, LBA No. 1

    Google Scholar 

  • Reich O, Lahousen M, Pickel H et al (2002) Cervical intraepithelial neoplasia III: long-term follow-up after cold-knife conization with involved margins. Obstet Gynecol 99:193–196

    PubMed  Google Scholar 

  • Ronco G, Dillner J, Elfström M et al (2014) Efficacy of HPV-based screening for prevention of invasive cervical cancer: Follow-up of four European randomized controlled trials. Lancet 383:524–532

    Article  Google Scholar 

  • Rose P, Bundy B, Watkins E et al (1999) Concurrent cisplatin based radiotherapy and chemotherapy for locally advanced cervical cancer. N Engl J Med 340:1144–1153

    Article  CAS  Google Scholar 

  • Rotman M, Sedlis A, Piedmonte M et al (2006) A phase III randomized trial of postoperative pelvic irradiation in stage IB cervical carcinoma with poor prognostic features: Follow-up of a Gynecologic Oncology Group study. Int J Radiat Oncol Biol Phys 65:169–176

    Article  Google Scholar 

  • S3-Leitlinie Zervixkarzinom (2014) Leitlinienprogramm Onkologie

    Google Scholar 

  • S3-Leitlinie Prävention des Zervixkarzinoms (2017) Leitlinienprogramm Onkologie

    Google Scholar 

  • Sardi J, Sananes C, Giaroli A et al (1993) Results of a prospective randomized trial with neoadjuvant chemotherapy in stage IB, bulky, squamous carcinoma of the cervix. Gynecol Oncol 49:156–165

    Article  CAS  Google Scholar 

  • Sawaya G, McConnell J, Kulasingam S et al (2003) Risk of cervical cancer associated with extending the interval between cervical-cancer screenings. N Engl J Med 349:1501–1509

    Article  CAS  Google Scholar 

  • Selman TJ, Mann C, Zamora J, Applleyard TL, Khan K (2008) Diagnostic accuracy of tests for lymph node status in primary cervical cancer: A systematic review and meta-analysis. Canad Med Assoc J 178:855–862

    Article  Google Scholar 

  • Shimada M, Kigawa J, Nishimura et al (2006) Ovarian metastasis in carcinoma of the uterine cervix. Gynecol Oncol 101: 234–237

    Article  Google Scholar 

  • Shingleton H, Soong S, Gelder M et al (1989) Clinical and histopathological factors predicting recurrence and survival after pelvic exenteration for cancer of the cervix. Obstet Gynecol 73:1027–1034

    CAS  PubMed  Google Scholar 

  • Small W, Winter K, Levenback C et al (2007) Extended-field irradiation and intracavitary brachytherapy combined with cisplatin chemotherapy for cervical cancer with positive paraaortic or high common iliac lymph nodes: Results of arm 1 of RTOG 0116. Int J Radiat Oncol Biol Phys 68:1081–1087

    Article  CAS  Google Scholar 

  • Stehman FB, Bundy BN, DiSaia PJ et al (1991) Carcinoma of the cervix treated with radiation therapy I. A multi-variate analysis of prognostic variables in the Gynecologic Oncology Group. Cancer 67:2776–2785

    Article  CAS  Google Scholar 

  • Sutton G, Bundy B, Delgado G et al (1992) Ovarian metastases in stage Ib carcinoma of the cervix: a Gynecologic Oncology Group study. Am J Obstet Gynecol 166:50–53

    Article  CAS  Google Scholar 

  • Tewari K, Long HJ, Penson R et al (2014) Improved survival with bevacizumab in advanced cervical cancer. N Englö J Med 370:734–743

    Article  Google Scholar 

  • Vange V, Weverling G, Ketting B et al (1995) The prognosis of cervical cancer associated with pregnancy: a matched chort study. Obstet Gynecol 85:1022–1026

    Article  Google Scholar 

  • Webb M, Symmonds R (1980) Site of recurrence of cervical cancer after radical hysterectomy. Am J Obstet Gynecol 138:813–817

    Article  CAS  Google Scholar 

  • Winter R, Petru E, Haas J (1988) Pelvic and para-aortic lymphadenectomy in cervical cancer. Baillieres Clin Obstet Gynaecol 2:857–866

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Edgar Petru .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer-Verlag GmbH Deutschland, ein Teil von Springer Nature

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Petru, E., Winter, R., Bader, A., Kapp, K.K., Reich, O. (2019). Maligne Tumoren der Cervix uteri. In: Petru, E., Fink, D., Köchli, O., Loibl, S. (eds) Praxisbuch Gynäkologische Onkologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-57430-0_5

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-57430-0_5

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-57429-4

  • Online ISBN: 978-3-662-57430-0

  • eBook Packages: Medicine (German Language)

Publish with us

Policies and ethics