Skip to main content
SpringerLink
Log in

Lymphödem

  • Chapter
  • First Online:
Praxisbuch Gynäkologische Onkologie

  • 2727 Accesses

Zusammenfassung

Die häufigste Ursache eines Lymphödems der oberen Extremität ist die Behandlung eines Mammakarzinoms durch axillare Operation oder Bestrahlung. Die Inzidenz des Lymphödems korreliert dabei mit der Anzahl entfernter Lymphknoten, ist aber auch abhängig von patienten- und tumorassoziierten Eigenschaften. Durch die Sentinel-Lymphknoten-Entfernung, die heute bei klinisch nodal-negativen Patientinnen standardmäßig durchgeführt wird, ist es bereits zu einer deutlichen Reduktion von Lymphödemen des Armes gekommen. Anhand von klinischen Studien wird weiter untersucht, bei welchen Patientinnen auch bei Lymphknotenbefall schonender vorgegangen werden kann und wo auf eine Axilladissektion verzichtet werden kann. Bei bestehendem Lymphödem ist die frühzeitige Diagnose und Therapie entscheidend für die Lebensqualität der Patientin.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 99.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 129.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Literatur

  • Abu-Rustum NR, Gemignani ML, Moore K et al (2003) Total laparoscopic radical hysterectomy with pelvic lymphadenectomy using the argon-beam coagulator: pilot-data and comparison to laparotomy. Gynecol Oncol 91:402–409

    Article  Google Scholar 

  • ASTEC study group, Kitchener H, Swart AM, Qian Q et al (2009) Efficacy of systemic pelvic lymphadenectomy in endometrial cancer (MRC ASTEC trial): a randomized study. The Lancet 373(9658): 125–136

    Google Scholar 

  • Biglia N, Zanfagnini V, Daniele A et al (2017) Lower body lymphedema in patients with gynecologic cancer. Anticancer Res 37(8):4005–4015

    PubMed  Google Scholar 

  • Boileau JF, Poirier B, Basik M et al (2015) Sentinel node biopsy after eboadjuvant chemotherapy in biopsy-proven node-positive breast cancer: The SN FNAC Study. J Clin Oncol 33(3):258–264

    Article  Google Scholar 

  • Boughey JC, Suman VJ, Mittendorf EA et al (2013) Sentinel lymph node surgery after neoadjuvant chemotherapy in patients with node-positive breast cancer: the ACOSOG Z1071 (Alliance) clinical trial. JAMA 310:1455–1461

    Article  CAS  Google Scholar 

  • Caudle A, Yang W, Krishnamurthy S et al (2016) Improved axillary evaluation following neoadjuvant therapy for patients with node-positive breast cancer using selective evaluation of clipped nodes: implementation of targeted axillary dissection. J Clin Oncol 34(10):1072–1078

    Article  CAS  Google Scholar 

  • Cibula D, Oonk MH, Abu-Rustum NR et al (2015) Sentinel lymph node biopsy in the management of gynecologic cancer. Curr Opin Obstet Gynecol 27(1):66–72

    Article  Google Scholar 

  • Classe JM, Campion L, Alran S et al (2014) Sentinel node surgery after neoadjuvant chemotherapy in patient with axillary node involvment: the French GANEA 2 prospective multi-institutional trial. San Antonio 2014 P2-01-01

    Google Scholar 

  • Donker M, van Tienhoven G, Straver ME et al (2014) Radiotherapy or surgery of the axilla after a positive sentinel in breast cancer (EORTC 10981-22023 AMAROS): a randomized, mulicentre, open-label, phase 3 non-inferiority trial. Lancet Oncol 15(12):1303–1310

    Article  Google Scholar 

  • Frost JA, Webster KE, Bryant A et al (2015) Lymphadenectomy for the management of endometrial cancer. Cochrane Database Syst Rev, September 21(9): CD007585

    Google Scholar 

  • Galimberti V, Kahler Ribeiro Fontana S, Maisonneuve P et al (2016) Sentinel node biopsy after neoadjuvant treatment in breast cancer: five-year follow-up of patients with clinically node-negative or node-positive disease before treatment. Eur J Surg Oncol 42(3):361–368

    Article  CAS  Google Scholar 

  • Gartner R, Jensen MB, Kronborg L et al (2010) Self-reported arm-lymphedema and functional impairment after breast cancer treatment–a nationwide study of prevalence and associated factors. Breast 19:506–515

    Article  Google Scholar 

  • Garza III R, Skoracki R, Hock K (2017) A comprehensive overview of the surgical management od secondary lymphedema of the upper and lower extremeties related to prior oncologic therapies. BMC Cancer 17(1):468

    Google Scholar 

  • Giuliano AE, Hunt KK, Ballman KV et al (2011) Axillary dissection vs no axillary dissection in women with invasive breast cancer and sentinel node metastasis: a randomized clinical trial. JAMA 305:569–575

    Article  CAS  Google Scholar 

  • Hayes S, Cornish B, Newman B (2005) Comparison of methods to diagnose lymphoedema among breast cancer survivors: 6-month follow-up. Breast Cancer Res Treat 89:221–226

    Article  Google Scholar 

  • Holloway RW, Abu-Rustum NR, Bakces FJ (2017) Sentinel lymph node mapping and staging in endometrial cancer: a society of gynecologic oncology literature review with consensus recommendations. Gynecol Oncol 146(2):405–415

    Article  Google Scholar 

  • Kuehn T, Bauerfeind I, Fehm T et al (2013) Sentinel-lymph-node biopsy in patients with breast cancer before and after neoadjuvant chemotherapy (SENTINA): a prospective, multicentre cohort study. Lancet 14:609–618

    Article  Google Scholar 

  • Lécuru F, Mathevet P, Querleu D et al (2011) Bilateral negative sentinel nodes accurately predict absence of lymph node metastasis in early cervical cancer: results of the SENTICOL study. J Clin Oncol May1, 29(13): 1686–1691

    Article  Google Scholar 

  • Panici PB, Baile S, Maneschi F (2008) Systematic pelvic lymphadenectomy vs. no lymphadenectomy in early-stage endometrial carcinoma: randomized clinical trial. J Natl Cancer Inst 100:1707–1716

    Article  Google Scholar 

  • Panici PB, Maggioni A, Hacker N (2005) Systemic aortic and pelvic lymphadenectomy versus resection of bulky nodes only in optimally debulked advanced ovarian cancer: a randomized clinical trial. J Natl Cancer Inst 97(8):560–566

    Article  Google Scholar 

  • Reimer T, Stachs A, Nekljudiva V (2017) Restricted axillary staging in clinically and sonographically node-negative early invasive breast cancer (c/iT1-2) in the context of breast conserving therapy: first results following commencement of the Intergroup-Sentinel-Mamma (INSEMA) trial. Geburtshilfe und Frauenheilkunde77(2): 149

    Article  CAS  Google Scholar 

  • Soliman PT et al (2017) A prospective validation study of sentinel lymph node mapping for high-risk endometrium cancer. Gynecol Oncol 146(2):234–239

    Article  Google Scholar 

  • Tanaka T, Terai Y, Fujiwara S et al (2017) Detection of sentinel lymph nodes in laaroscopic surgery can eliminate lymphadenectomy for patients with early stage endometrial cancer. Int J of Clin Oncol Nov. 2 https://doi.org/10.1007/s10147-017-1196-9

    Article  Google Scholar 

  • Wojcinski S, Nuengsri S, Hillemanns P et al (2012) Axillary dissection in primary breast cancer: variations of the surgical technique and influence on morbidity. Cancer Manag Res 4:121–127

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Klinik für Frauenheilkunde und Geburtshilfe, Universitätsklinikum Schleswig-Holstein, Lübeck, Deutschland

    Sarah L. Fründt

  2. Klinik für Gynäkologie mit Zentrum für onkologische Chirurgie und Klinik für Gynäkologie, Charité-Universitätsmedizin Berlin, Berlin, Deutschland

    Cornelia Liedtke

  3. Klinik für Frauenheilkunde und Geburtshilfe, Klinikum Esslingen, Esslingen, Deutschland

    Thorsten Kühn

  4. Frauenklinik und Brustzentrum, Helios Klinikum Berlin-Buch, Berlin, Deutschland

    Michael Untch

Authors
  1. Sarah L. Fründt
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Cornelia Liedtke
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Thorsten Kühn
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Michael Untch
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Sarah L. Fründt .

Editor information

Editors and Affiliations

  1. Universitätsklinik für Frauenheilkunde und Geburtshilfe, Medizinische Universität Graz, Graz, Austria

    Edgar Petru

  2. Klinik für Gynäkologie, UniversitätsSpital Zürich, Zürich, Switzerland

    Daniel Fink

  3. Gynäkologisch-onkologische Praxis, BrustCentrum, Privatklinik Zürich-Bethanien, Zürich, Switzerland

    Ossi R. Köchli

  4. German Breast Group Forschungs GmbH, Neu-Isenburg, Germany

    Sibylle Loibl

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer-Verlag GmbH Deutschland, ein Teil von Springer Nature

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Fründt, S.L., Liedtke, C., Kühn, T., Untch, M. (2019). Lymphödem. In: Petru, E., Fink, D., Köchli, O., Loibl, S. (eds) Praxisbuch Gynäkologische Onkologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-57430-0_17

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-57430-0_17

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-57429-4

  • Online ISBN: 978-3-662-57430-0

  • eBook Packages: Medicine (German Language)

Publish with us

Policies and ethics

Search

Navigation