Skip to main content

Psychopharmaka in Schwangerschaft und Stillzeit

  • Chapter

Zusammenfassung

Es wird eine praxisrelevante Übersicht zu den Risiken von Psychopharmaka in Schwangerschaft und Stillzeit gegeben. Sehr ausführlich wird das Risiko von Antidepressiva besprochen.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   49.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   64.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Literatur

  • Bérard A, Sheehy O, Zhao JP et al (2017) SSRI and SNRI use during pregnancy and the risk of persistent pulmonary hypertension of the newborn. Br J Clin Pharmacol 83(5): 1126–1133

    Article  Google Scholar 

  • Boukhris T, Sheehy O, Mottron L et al (2016) Antidepressant use during pregnancy and the risk of autism spectrum disorder in children. JAMA Pediatr 170: 117–124

    Article  Google Scholar 

  • Bromley RL, Weston J, Marson AG (2017) Maternal use of antiepileptic agents during pregnancy and major congenital malformations in children. JAMA 318(17): 1700–1701

    Article  Google Scholar 

  • Cohen LS, Viguera AC, McInerney KA et al (2016) Reproductive safety of second-generation antipsychotics: current data from the Massachusetts General Hospital National Pregnancy Registry for Atypical Antipsychotics. Am J Psychiatry 173(3): 263–270

    Article  Google Scholar 

  • Cuomo A, Goracci A, Fagiolini A (2018) Aripiprazole use during pregnancy, peripartum and lactation. A systematic literature search and review to inform clinical practice. J Affect Disord 228: 229–237

    Article  CAS  Google Scholar 

  • Damkier P, Videbech P (2018) The safety of second-generation antipsychotics during pregnancy: a clinically focused review. CNS Drugs 32(4): 351–366

    Article  CAS  Google Scholar 

  • DGPPN, BÄK, KBV, AWMF, AkdÄ, BPtK, BApK, DAGSHG, DEGAM, DGPM, DGPs, DGRW (Hrsg) für die Leitliniengruppe Unipolare Depression (2015) S3-Leitlinie/Nationale VersorgungsLeitlinie Unipolare Depression – Langfassung, 2. Aufl. Version 2. http://www.depression.versorgungsleitlinien.de (Online-Zugriff: 13.05.2018)

  • Forsberg L, Adler M, Römer EI et al (2018) Maternal mood disorders and lithium exposure in utero were not associated with poor cognitive development during childhood. Acta Paediatr 107(8): 1379–1388

    Article  Google Scholar 

  • Hernandez-Diaz S, Huybrechts KF, Desai RJ et al (2018) Topiramate use early in pregnancy and the risk of oral clefts: a pregnancy cohort study. Neurology 90(4): e342–e351

    Article  Google Scholar 

  • Huybrechts KF, Bateman BT, Palmsten K et al (2015) Antidepressant use late in pregnancy and risk of persistent pulmonary hypertension of the newborn. JAMA 313(21): 2142–2151

    Article  CAS  Google Scholar 

  • Huybrechts KF, Hernández-Díaz S, Patorno E et al (2016) Antipsychotic use in pregnancy and the rRisk for congenital malformations. JAMA Psychiatry 73(9): 938–946

    Article  Google Scholar 

  • Huybrechts KF, Bröms G, Christensen LB et al (2018) Association between methylphenidate and amphetamine use in pregnancy and risk of congenital malformations: a cohort study from the International Pregnancy Safety Study Consortium. JAMA Psychiatry 75(2): 167–175

    Article  Google Scholar 

  • Kaltenbach K, O’Grady KE, Heil SH (2018) Prenatal exposure to methadone or buprenorphine: Early childhood developmental outcomes. Drug Alcohol Depend 185: 40–49

    Article  CAS  Google Scholar 

  • Leiknes KA, Cooke MJ, Jarosch-von Schweder L et al (2015) Electroconvulsive therapy during pregnancy: a systematic review of case studies. Arch Womens Ment Health 18(1): 1–39

    Article  Google Scholar 

  • Liu X, Agerbo E, Ingstrup KG (2017) Antidepressant use during pregnancy and psychiatric disorders in offspring: Danish nationwide register based cohort study. BMJ 358: j3668

    Google Scholar 

  • Lugo-Candelas C, Cha J, Hong S (2018) Associations between brain structure and connectivity in infants and exposure to selective serotonin reuptake inhibitors during pregnancy. JAMA Pediatr 172(6): 525–533

    Article  Google Scholar 

  • Lupattelli A, Wood M, Ystrom E et al (2018) Effect of time-dependent selective serotonin reuptake inhibitor antidepressants during pregnancy on behavioral, emotional, and social development in preschool-aged children. J Am Acad Child Adolesc Psychiatry 57(3): 200–208

    Article  Google Scholar 

  • Malm H, Brown AS, Gissler M et al (2016) Gestational exposure to selective serotonin reuptake inhibitors and offspring psychiatric disorders: a national register-based study. J Am Acad Child Adolesc Psychiatry. 55(5): 359–66

    Article  Google Scholar 

  • Meador KJ, Baker GA, Browning N et al (2014) Breastfeeding in children of women taking antiepileptic drugs: cognitive outcomes at age 6 years. JAMA Pediatr 168(8): 729–736

    Article  Google Scholar 

  • Mehta TM, Van Lieshout RJ (2017) A review of the safety of clozapine during pregnancy and lactation. Arch Womens Ment Health 20(1): 1–9

    Article  Google Scholar 

  • Nechanská B, Mravčík V, Skurtveit S (2018) Neonatal outcomes after fetal exposure to methadone and buprenorphine: national registry studies from the Czech Republic and Norway. Addiction 113(7): 1286–1294

    Article  Google Scholar 

  • Onken M, Mick I, Schaefer C (2018) Paliperidone and pregnancy-an evaluation of the German Embryotox database. Arch Womens Ment Health [Epub ahead of print]

    Google Scholar 

  • Patorno E, Bateman BT, Huybrechts KF et al (2017a) Pregabalin use early in pregnancy and the risk of major congenital malformations. Neurology 88(21): 2020–2025

    Article  CAS  Google Scholar 

  • Patorno E, Huybrechts KF, Bateman BT et al (2017b) Lithium use in pregnancy and the risk of cardiac malformations. N Engl J Med 376(23): 2245–2254

    Article  CAS  Google Scholar 

  • Paulzen M, Goecke TW, Stingl J et al (2017a) Pregnancy exposure to citalopram – therapeutic drug monitoring in maternal blood, amniotic fluid and cord blood. Prog Neuropsychopharmacol Biol Psychiatry 79(Pt B): 213–219

    Article  CAS  Google Scholar 

  • Paulzen M, Goecke TW, Stickeler E et al (2017b) Sertraline in pregnancy – therapeutic drug monitoring in maternal blood, amniotic fluid and cord blood. J Affect Disord 212: 1–6

    Article  CAS  Google Scholar 

  • Paulzen M, Goecke TW, Kuzin M et al (2017c) Pregnancy exposure to quetiapine – therapeutic drug monitoring in maternal blood, amniotic fluid and cord blood and obstetrical outcomes. Schizophr Res 195: 252–257

    Article  Google Scholar 

  • Pinheiro EA, Wisner KL, Clark CT (2018) Quetiapine Dose Adjustments in Pregnant and Postpartum Women With Bipolar Disorder. J Clin Psychopharmacol. 38(1): 89–91

    Google Scholar 

  • Schaffir J (2018) Consequences of antepartum depression. Clin Obstet Gynecol 61(3): 533–543

    Google Scholar 

  • Sinha P, Goyal P, Andrade C (2017) A meta-review of the safety of electroconvulsive therapy in pregnancy. J ECT 33(2): 81–88

    Article  Google Scholar 

  • Sujan AC, Rickert ME, Öberg AS et al (2017) Associations of maternal antidepressant use during the first trimester of pregnancy with preterm birth, small for gestational age, autism spectrum disorder, and attention-deficit/hyperactivity disorder in offspring. JAMA 317(15): 1553–1562

    Article  Google Scholar 

  • Tomson T, Battino D, Perucca E (2015) Valproic acid after five decades of use in epilepsy: time to reconsider the indications of a time-honoured drug. Lancet Neurol pii: S1474-4422(15)00314-2

    Google Scholar 

  • Wemakor A, Casson K, Garne E et al (2015) Selective serotonin reuptake inhibitor antidepressant use in first trimester pregnancy and risk of specific congenital anomalies: a European register-based study. Eur J Epidemiol 30(11): 1187–1198

    Article  CAS  Google Scholar 

  • Westin AA, Brekke M, Molden E et al (2017) Changes in drug disposition of lithium during pregnancy: a retrospective observational study of patient data from two routine therapeutic drug monitoring services in Norway. BMJ Open 7(3): e015738

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding authors

Correspondence to M. Paulzen or O. Benkert .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer-Verlag GmbH Deutschland

About this chapter

Cite this chapter

Paulzen, M., Benkert, O. (2019). Psychopharmaka in Schwangerschaft und Stillzeit. In: Benkert, O., Hippius, H. (eds) Kompendium der Psychiatrischen Pharmakotherapie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-57334-1_14

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-57334-1_14

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-57333-4

  • Online ISBN: 978-3-662-57334-1

  • eBook Packages: Medicine (German Language)

Publish with us

Policies and ethics