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Invasives Karzinom der Vagina

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Tumorerkrankungen der Vulva und Vagina

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Zusammenfassung

Vaginalkarzinome gehören zu den seltenen Tumoren (etwa 500 Fälle pro Jahr in Deutschland). Risikofaktoren sind die HPV-Infektion, Immundepression, Nikotinabusus und HPV-assoziierte Vorerkrankungen der Cervix uteri und der Vulva. Als teilweise Primärprävention kann die HPV-Impfung gelten. Eine systematische Früherkennung existiert angesichts der Seltenheit der Erkrankung nicht. Auffällige zytologische Befunde bei fehlender oder unauffälliger Zervix sollten zu einer intensivierten Untersuchung mit Inspektion und Kolposkopie veranlassen. Es handelt sich überwiegend um Plattenepithelkarzinome. Die definitive Diagnostik erfolgt durch histologische Sicherung. Zum Staging werden erst in fortgeschritteneren Stadien bildgebende Verfahren eingesetzt. Im Stadium I kann eine operative Resektion durchgeführt werden, die übrigen Stadien werden einer Radio(chemo)therapie zugeführt. Als Lymphabflussgebiete der Vaginalkarzinome müssen sowohl inguinofemoralen als auch die pelvinen Lymphknoten gelten. Das Sentinel-Verfahren kann zur Beschränkung der Therapieausdehnung eingesetzt werden.

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Authors and Affiliations

  1. Frauenklinik, Klinikum Darmstadt, Darmstadt, Deutschland

    Sven Ackermann

  2. Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe, Klinikum der Universität München, München, Deutschland

    Christian Dannecker

  3. Arbeitsgruppe Mamma-, Gynäko- & Perinatalpathologie Institut für Pathologie, Universitätsklinikum Leipzig, Leipzig, Deutschland

    Lars-Christian Horn

  4. Ehem Lukaskrankenhaus Neuss, Kaarst, Deutschland

    Hans-Georg Schnürch

  5. Klinik für Frauenheilkunde und Geburtshilfe, Kreiskliniken Altötting-Burghausen, Altötting, Deutschland

    Peer Hantschmann

  6. Klinik und Poliklinik für Geburtshilfe und Frauengesundheit, Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Mainz, Deutschland

    Wolfgang Weikel

  7. Klinik und Poliklinik für Gynäkologie, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Deutschland

    Linn Wölber

  8. Klinik und Poliklinik für Strahlentherapie, Universitätsklinikum Köln, Köln, Deutschland

    Simone Marnitz-Schulze

  9. Klinik für Gynäkologie, Charité Berlin, Berlin, Deutschland

    Jana Barinoff

  10. Erlangen, Deutschland

    Grit Mehlhorn

  11. Frauenklinik, Luzerner Kantonsspital, Luzern, Schweiz

    Andreas Günthert

  12. Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe, Universitätsklinikum Köln, Köln, Deutschland

    Peter Mallmann

  13. Institut für Diagnostische und Interventionelle Radiologie, Universitätsklinikum Düsseldorf, Düsseldorf, Deutschland

    Celine Alt-Radtke

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  1. Sven Ackermann
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  2. Christian Dannecker
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  5. Hans-Georg Schnürch
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Corresponding author

Correspondence to Sven Ackermann .

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Editors and Affiliations

  1. Kaarst, Germany

    Hans-Georg Schnürch

  2. Frauenklinik, Universitätsklinikum Düsseldorf, Düsseldorf, Germany

    Monika Hampl

  3. Klinik für Gynäkologie, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany

    Linn Wölber

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Ackermann, S. et al. (2018). Invasives Karzinom der Vagina. In: Schnürch, HG., Hampl, M., Wölber, L. (eds) Tumorerkrankungen der Vulva und Vagina. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-56636-7_9

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