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Vaginale intraepitheliale Neoplasie (VaIN)

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Tumorerkrankungen der Vulva und Vagina

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Zusammenfassung

Die Häufigkeit der VaIN ist nicht genau bekannt: Für Deutschland werden 100–200 Fälle pro Jahr geschätzt. Als Risikofaktoren werden HPV-Infektion, Immuninsuffizienz und Nikotinabusus genannt. Als Primärprävention ist ein Effekt von der HPV-Impfung zu erwarten. Früherkennung ist nur möglich durch positive Zytologien bei unauffälliger oder fehlender Zervix. Therapiegrundlage ist die histologische Sicherung und die Ausbreitungsdiagnostik durch Differenzialkolposkopie. Therapiebedürftig sind die VaIN 2/3. Bei der Therapie kommen sowohl lokal medikamentöse Applikationen zum Einsatz als auch operative Verfahren. Die Brachytherapie ist in Deutschland wegen der ausgeprägten Nebenwirkungen nicht verbreitet. Als operative Verfahren werden die Laservaporisation und die Exzision mittels Skalpell oder Laserskalpell eingesetzt. Wegen der fehlenden Einsehbarkeit im oberen Scheidendrittel, insbesondere nach Hysterektomie, wird dort die Scheidenkuppelresektion als Vollhautexision oder Skinning-Verfahren empfohlen. Die klinische/zytologische Nachsorge sollte lebenslang erfolgen.

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Authors and Affiliations

  1. Frauenklinik, Klinikum Darmstadt, Darmstadt, Deutschland

    Sven Ackermann

  2. Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe, Klinikum der Universität München, München, Deutschland

    Christian Dannecker

  3. Arbeitsgruppe Mamma-, Gynäko- & Perinatalpathologie Institut für Pathologie, Universitätsklinikum Leipzig, Leipzig, Deutschland

    Lars-Christian Horn

  4. Ehem Lukaskrankenhaus Neuss, Kaarst, Deutschland

    Hans-Georg Schnürch

  5. Klinik für Frauenheilkunde und Geburtshilfe, Kreiskliniken Altötting-Burghausen, Altötting, Deutschland

    Peer Hantschmann

  6. Frauenklinik, Klinikum Wolfsburg, Wolfsburg, Deutschland

    Agnieszka Denecke & Karl Ulrich Petry

  7. Erlangen, Deutschland

    Grit Mehlhorn

Authors
  1. Sven Ackermann
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  2. Christian Dannecker
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  3. Lars-Christian Horn
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  4. Hans-Georg Schnürch
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  5. Peer Hantschmann
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  6. Agnieszka Denecke
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  7. Karl Ulrich Petry
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  8. Grit Mehlhorn
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Corresponding author

Correspondence to Sven Ackermann .

Editor information

Editors and Affiliations

  1. Kaarst, Germany

    Hans-Georg Schnürch

  2. Frauenklinik, Universitätsklinikum Düsseldorf, Düsseldorf, Germany

    Monika Hampl

  3. Klinik für Gynäkologie, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany

    Linn Wölber

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© 2018 Springer-Verlag GmbH Deutschland, ein Teil von Springer Nature

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Ackermann, S. et al. (2018). Vaginale intraepitheliale Neoplasie (VaIN). In: Schnürch, HG., Hampl, M., Wölber, L. (eds) Tumorerkrankungen der Vulva und Vagina. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-56636-7_8

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  • DOI: https://doi.org/10.1007/978-3-662-56636-7_8

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  • Online ISBN: 978-3-662-56636-7

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