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Evidenzbasierte Viszeralchirurgie maligner Erkrankungen pp 189–202Cite as

Neuroendokrine Tumoren des Pankreas

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Part of the book series: Evidenzbasierte Chirurgie ((EC))

Zusammenfassung

Neuroendokrine Tumoren sind seltene Tumoren, jedoch steigt ihre Inzidenz und Prävalenz in den letzten Jahrzehnten kontinuierlich. Pankreatische neuroendokrine Tumoren (p-NET) machen ca. 30 % aller gastroenteropankreatischen neuroendokrinen Tumoren aus. Abhängig von ihrer hormonellen Aktivität werden p-NETs als funktionelle und nicht funktionelle p-NETs klassifiziert. Die verschiedenen Fachgesellschaften (ENETS, NANETS, ESMO) haben Leitlinien zur Behandlung von p-NETs veröffentlicht. p-NETs metastasieren häufig, weshalb hierzu ebenfalls Leitlinien herausgegeben wurden. Ob die gegebenen Empfehlungen die jeweils beste Therapie von p-NETs darstellen ist jedoch oft unklar, da nur wenige prospektiv randomisierte Studien vorliegen und die Therapieempfehlungen im Wesentlichen auf systematischen Reviews und Metaanalysen retrospektiver Fallserien beruhen.

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Literatur

  • Akerstrom G, Falconi M, Kianmanesh R, Ruszniewski P, Plockinger U; Mallorca Consensus Conference and European; Neuroendocrine Tumor Society (2009) ENETS Consensus Guidelines for the Standards of Care in Neuroendocrine Tumors: pre- and perioperative therapy in patients with neuroendocrine tumors. Neuroendocrinology 90(2): 203–208

    Google Scholar 

  • Caplin ME, Pavel M, Cwikla JB, Phan AT, Raderer M, Sedlackova E, Cadiot G, Wolin EM, Capdevila J, Wall L, Rindi G, Langley A, Martinez S, Blumberg J, Ruszniewski P, Investigators C (2014) Lanreotide in metastatic enteropancreatic neuroendocrine tumors. N Engl J Med 371(3): 224–233

    Google Scholar 

  • Cienfuegos JA, Salguero J, Nunez Cordoba J-M, Ruiz-Canela M, Benito A, Ocana S, Zozaya G, Marti-Cruchaga P, Pardo F, Hernandez Lizoain JL, Rotellar F (2017) Short- and long-term outcomes of laparoscopic organ-sparing resection in pancreatic neuroendocrine tumors: a single-center experience. Surg Endosc 31(10): 3847–3857

    Google Scholar 

  • Daouadi M, Zureikat AH, Zenati MS, Choudry H, Tsung A, Bartlett DL, Hughes SJ, Lee KK, Moser AJ, Zeh HJ (2013) Robot-assisted minimally invasive distal pancreatectomy is superior to the laparoscopic technique. Ann Surg 257(1): 128–132

    Google Scholar 

  • Drymousis P, Raptis DA, Spalding D, Fernandez-Cruz L, Menon D, Breitenstein S, Davidson B, Frilling A (2014) Laparoscopic versus open pancreas resection for pancreatic neuroendocrine tumours: a systematic review and meta-analysis. HPB (Oxford) 16(5): 397–406

    Google Scholar 

  • Falconi M, Bartsch DK, Eriksson B, Kloppel G, Lopes JM, O’Connor JM, Salazar R, Taal BG, Vullierme MP, O’Toole D; Barcelona Consensus Conference (2012) ENETS Consensus Guidelines for the management of patients with digestive neuroendocrine neoplasms of the digestive system: well-differentiated pancreatic non-functioning tumors. Neuroendocrinology 95(2): 120–134

    Google Scholar 

  • Falconi M, Eriksson B, Kaltsas G, Bartsch DK, Capdevila J, Caplin M, Kos-Kudla B, Kwekkeboom D, Rindi G, Kloppel G, Reed N, Kianmanesh R, Jensen RT; Vienna Consensus Conference (2016) ENETS Consensus Guidelines Update for the Management of Patients with Functional Pancreatic Neuroendocrine Tumors and Non-Functional Pancreatic Neuroendocrine Tumors. Neuroendocrinology 103(2): 153–171

    Google Scholar 

  • Garcia-Carbonero R, Sorbye H, Baudin E, Raymond E, Wiedenmann B, Niederle B, Sedlackova E, Toumpanakis C, Anlauf M, Cwikla JB, Caplin M, O’Toole D, Perren A; Vienna Consensus Conference (2016) ENETS Consensus Guidelines for High-Grade Gastroenteropancreatic Neuroendocrine Tumors and Neuroendocrine Carcinomas. Neuroendocrinology 103(2): 186–194

    Google Scholar 

  • Hörsch D, Ezziddin S, Haug A, Gratz KF, Dunkelmann S, Miederer M, Schreckenberger M, Krause BJ, Bengel FM, Bartenstein P, Biersack HJ, Popperl G, Baum RP (2016) Effectiveness and side-effects of peptide receptor radionuclide therapy for neuroendocrine neoplasms in Germany: A multi-institutional registry study with prospective follow-up. Eur J Cancer 58: 41–51

    Google Scholar 

  • Jilesen P, van A. Eijck CH, in’t Hof KH, van Dieren S, Gouma DJ, van Dijkum EJ (2016) Postoperative Complications, In-Hospital Mortality and 5-Year Survival After Surgical Resection for Patients with a Pancreatic Neuroendocrine Tumor: A Systematic Review. World J Surg 40(3): 729–748

    Google Scholar 

  • Jin T, Altaf K, Xiong JJ, Huang W, Javed MA, Mai G, Liu XB, Hu WM, Xia Q (2012) A systematic review and meta-analysis of studies comparing laparoscopic and open distal pancreatectomy. HPB (Oxford) 14(11): 711–724

    Google Scholar 

  • Jusoh AC, Ammori BJ (2012) Laparoscopic versus open distal pancreatectomy: a systematic review of comparative studies. Surg Endosc 26(4): 904–913

    Google Scholar 

  • Kulke MH, Anthony LB, Bushnell DL, de Herder WW, Goldsmith SJ, Klimstra DS, Marx S, Pasieka JL, Pommier RF, Yao JC, Jensen RT; North American Neuroendocrine Tumor (2010) NANETS treatment guidelines: well-differentiated neuroendocrine tumors of the stomach and pancreas. Pancreas 39(6): 735–752

    Google Scholar 

  • Kunz PL, Reidy-Lagunes D, Anthony LB, Bertino EM, Brendtro K, Chan JA, Chen H, Jensen RT, Kim MK, Klimstra DS, Kulke MH, Liu EH, Metz DC, Phan AT, Sippel RS, Strosberg JR, Yao JC; North American Neuroendocrine Tumor (2013) Consensus guidelines for the management and treatment of neuroendocrine tumors. Pancreas 42(4): 557–577

    Google Scholar 

  • Laliotis A, Martin J, Worthington TR, Marshall M, Isla AM (2015) A novel technique of needle-guided laparoscopic enucleation of insulinomas. Surg Laparosc Endosc Percutan Tech 25(1): e24–26

    Google Scholar 

  • Langer, P, Fendrich V, K. Bartsch D (2009) [Minimally invasive resection of neuroendocrine pancreatic tumors]. Chirurg 80(2): 105–112

    Google Scholar 

  • Libutti SK, Choyke PL, Alexander HR, Glenn G, Bartlett DL, Zbar B, Lubensky I, McKee SA, Maher ER, Linehan WM, Walther MM. (2000) Clinical and genetic analysis of patients with pancreatic neuroendocrine tumors associated with von Hippel-Lindau disease. Surgery 128(6): 1022–1027;discussion 1027–1028

    Google Scholar 

  • Lopez L, Falconi CM, Waldmann J, Boninsegna L, Fendrich V, Goretzki PK, Langer P, Kann PH, Partelli S, Bartsch DK. (2013) Partial pancreaticoduodenectomy can provide cure for duodenal gastrinoma associated with multiple endocrine neoplasia type 1. Ann Surg 257(2): 308–314

    Google Scholar 

  • Mehrabi A, Fischer L, Hafezi M, Dirlewanger A, Grenacher L, Diener MK, Fonouni H, Golriz M, Garoussi C, Fard N, Rahbari NN, Werner J, Buchler MW (2014) A systematic review of localization, surgical treatment options, and outcome of insulinoma. Pancreas 43(5): 675–686

    Google Scholar 

  • Mehrabi A, Hafezi M, Arvin J, Esmaeilzadeh M, Garoussi C, Emami G, Kossler-Ebs J, Muller-Stich BP, W. Buchler M, Hackert T, Diener MK (2015) A systematic review and meta-analysis of laparoscopic versus open distal pancreatectomy for benign and malignant lesions of the pancreas: it’s time to randomize. Surgery 157(1): 45–55

    Google Scholar 

  • Merola E, Panzuto F, Delle Fave G (2017) Antiproliferative effect of somatostatin analogs in advanced gastro-entero-pancreatic neuroendocrine tumors: a systematic review and meta-analysis. Oncotarget 8(28): 46624–46634

    Google Scholar 

  • Nakamura M, Wakabayashi G, Miyasaka Y, Tanaka M, Morikawa T, Unno M, Tajima H, Kumamoto Y, Satoi S, Kwon M, Toyama H, Ku Y, Yoshitomi H, Nara S, Shimada K, Yokoyama T, Miyagawa S, Toyama Y, Yanaga K, Fujii T, Kodera Y, Study J. Group of, Jseps, Tomiyama Y, Miyata H, Takahara T, Beppu T, Yamaue H, Miyazaki M, Takada T (2015) Multicenter comparative study of laparoscopic and open distal pancreatectomy using propensity score-matching. J Hepatobiliary Pancreat Sci 22(10): 731–736

    Google Scholar 

  • Oberg K, Knigge U, Kwekkeboom D, Perren A, Group EGW (2012) Neuroendocrine gastro-entero-pancreatic tumors: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 23 Suppl 7: vii124–130

    Google Scholar 

  • Paiella S, De Pastena M, Landoni L, Esposito A, Casetti L, Miotto M, Ramera M, Salvia R, Secchettin E, Bonamini D, Manzini G, D’Onofrio M, Marchegiani G, Bassi C (2017) Is there a role for near-infrared technology in laparoscopic resection of pancreatic neuroendocrine tumors? Results of the COLPAN colour-and-resect the pancreas study. Surg Endosc 31(11): 4478–4484

    Google Scholar 

  • Pavel M, O’Toole D, Costa F, Capdevila J, Gross D, Kianmanesh R, Krenning E, Knigge U, Salazar R, Pape UF, Oberg K; Vienna Consensus Conference (2016) ENETS Consensus Guidelines Update for the Management of Distant Metastatic Disease of Intestinal, Pancreatic, Bronchial Neuroendocrine Neoplasms (NEN) and NEN of Unknown Primary Site. Neuroendocrinology 103(2): 172–185

    Google Scholar 

  • Pericleous S, Middleton N, C. McKay S, A. Bowers K, R. Hutchins R (2012) Systematic review and meta-analysis of case-matched studies comparing open and laparoscopic distal pancreatectomy: is it a safe procedure? Pancreas 41(7): 993–1000

    Google Scholar 

  • Raymond E, Dahan L, Raoul JL, Bang YJ, Borbath I, Lombard C-Bohas, Valle J, Metrakos P, Smith D, Vinik A, Chen JS, Horsch D, Hammel P, Wiedenmann B, Van Cutsem E, Patyna S, Lu DR, Blanckmeister C, Chao R, Ruszniewski P (2011) Sunitinib malate for the treatment of pancreatic neuroendocrine tumors. N Engl J Med 364(6): 501–513

    Google Scholar 

  • Rinke A, Muller HH, Schade-Brittinger C, Klose KJ, Barth P, Wied M, Mayer C, Aminossadati B, Pape UF, Blaker M, Harder J, Arnold C, Gress T, Arnold R; Promid Study Group (2009) Placebo-controlled, double-blind, prospective, randomized study on the effect of octreotide LAR in the control of tumor growth in patients with metastatic neuroendocrine midgut tumors: a report from the PROMID Study Group. J Clin Oncol 27(28): 4656–4663

    Google Scholar 

  • Venkat R, Edil BH, Schulick RD, Lidor AO, Makary MA, Wolfgang CL. (2012) Laparoscopic distal pancreatectomy is associated with significantly less overall morbidity compared to the open technique: a systematic review and meta-analysis. Ann Surg 255(6): 1048–1059

    Google Scholar 

  • Vinik A, Bottomley A, Korytowsky B, Bang YJ, Raoul JL, Valle JW, Metrakos P, Horsch D, Mundayat R, Reisman A, Wang Z, Chao RC, Raymond E (2016) Patient-Reported Outcomes and Quality of Life with Sunitinib Versus Placebo for Pancreatic Neuroendocrine Tumors: Results From an International Phase III Trial. Target Oncol 11(6): 815–824

    Google Scholar 

  • von Ducker L, Walz MK, Voss C, Arnold G, Eng C, Neumann HP (2011) Laparoscopic organ-sparing resection of von Hippel-Lindu disease-associated pancreatic neuroendocrine tumors. World J Surg 35(3): 563–567

    Google Scholar 

  • Wittel UA, Hopt UT (2015) [Complications of minimally invasive pancreas resection for pancreatic neuroendocrine tumors]. Chirurg 86(1): 33–37

    Google Scholar 

  • Xourafas D, Tavakkoli A, Clancy TE, Ashley SW (2015) Distal pancreatic resection for neuroendocrine tumors: is laparoscopic really better than open? J Gastrointest Surg 19(5): 831–840

    Google Scholar 

  • Yao C, MH Shah J, Ito T, Bohas CL, Wolin EM, Van Cutsem E, J. Hobday T, Okusaka T, Capdevila J, de Vries EG, Tomassetti P, Pavel ME, Hoosen S, Haas T, Lincy J, Lebwohl D, Oberg K; for the RAD001 in Advanced Neuroendocrine Tumors, Third Trial (RADIANT-3) Study Group (2011) Everolimus for advanced pancreatic neuroendocrine tumors. N Engl J Med 364(6): 514–523

    Google Scholar 

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Authors and Affiliations

  1. UKSH Schleswig-Holstein, Klinik für Chirurgie am Universitätsklinikum Schleswig-Holstein, Lübeck, Deutschland

    Dr. med. K. C. Honselmann & PD Dr. med. D. Bausch

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  1. Dr. med. K. C. Honselmann
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  2. PD Dr. med. D. Bausch
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Editors and Affiliations

  1. Universitätsklinikum Würzburg, Würzburg, Deutschland

    Christoph-Thomas Germer

  2. Universitätsklinikum Schleswig-Holstein, Lübeck, Deutschland

    Tobias Keck

  3. ehem. Wissenschaftlich Medizinischer Direktor Kreiskliniken Altötting-Burghausen, Burghausen, Deutschland

    Reinhart T. Grundmann

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© 2018 Springer-Verlag GmbH Deutschland, ein Teil von Springer Nature

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Honselmann, K.C., Bausch, D. (2018). Neuroendokrine Tumoren des Pankreas. In: Germer, CT., Keck, T., Grundmann, R.T. (eds) Evidenzbasierte Viszeralchirurgie maligner Erkrankungen. Evidenzbasierte Chirurgie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-56533-9_9

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  • DOI: https://doi.org/10.1007/978-3-662-56533-9_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-56532-2

  • Online ISBN: 978-3-662-56533-9

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