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Peritonektomie und HIPEC

  • Chapter
Book cover Evidenzbasierte Viszeralchirurgie maligner Erkrankungen

Part of the book series: Evidenzbasierte Chirurgie ((EC))

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Zusammenfassung

Die peritoneale Metastasierung gastrointestinaler Tumoren wurde früher grundsätzlich palliativ behandelt. Die kombinierte Behandlungsstrategie der „zytoreduktiven Chirurgie“ und „hyperthermen intraperitonealen Chemotherapie“ (HIPEC) nutzt Verfahren der Peritonektomie und viszeralen Organresektionen, um Tumorformationen vollständig zu entfernen oder zu reduzieren. Im Anschluss wird die HIPEC durchgeführt, um potenziell verbliebene minimale Tumormasse zu beseitigen. Für das Pseudomyxoma peritonei und das maligne peritoneale Mesotheliom hat sich die Kombinationstherapie inzwischen als Therapiestandard etabliert. Viele Autoren plädieren auch dafür, diese Therapieform bei Peritonealkarzinose kolorektaler Tumoren und Tumoren der Appendix als Therapiestandard zu sehen. Für aggressivere Tumoren wie z. B. das peritoneal metastasierte Magenkarzinom ist die Studienlage weniger deutlich. Zur Behandlung peritoneal metastasierter Pankreas- oder Dünndarmkarzinome liegen kaum Studien vor.

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Literatur

  • Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften. S3-Leitlinie: Diagnostik und Therapie der Adenokarzinome des Magen und des ösophagogastralen Übergangs. Februar 2012 [zitiert am 03.04.2018]. URL: http://www.awmf.org/uploads/tx_szleitlinien/032–009l_S3_Magenkarzinom_Diagnostik_Therapie_Adenokarzinome_oesophagogastraler_Uebergang_2012-abgelaufen.pdf

  • Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften. S3-Leitlinie: Kolorektales Karzinom. November 2017 [zitiert am 03.04.2018]. URL: http://www.awmf.org/uploads/tx_szleitlinien/ 021–007OLl_S3_KRK_2017–12_1.pdf

  • Alexander HR, Bartlett DL Jr, Pingpank JF, Libutti SK, Royal R, Hughes MS, Holtzman M, Hanna N, Turner K, Beresneva T, Zhu Y (2013) Treatment factors associated with long-term survival after cytoreductive surgery and regional chemotherapy for patients with malignant peritoneal mesothelioma. Surgery 153: 779–86

    Google Scholar 

  • Baratti D, Kusamura S, Cabras AD, Bertulli R, Hutanu I, Deraco M (2013) Diffuse malignant peritoneal mesothelioma: long-term survival with complete cytoreductive surgery followed by hyperthermic intraperitoneal chemotherapy (HIPEC). Eur J Cancer 49: 3140–8

    Google Scholar 

  • Baratti D, Kusamura S, Iusco D, Bonomi S, Grassi A, Virzi S, Leo E, Deraco M (2014) Postoperative complications after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy affect long-term outcome of patients with peritoneal metastases from colorectal cancer: a two-center study of 101 patients. Dis Colon Rectum 57: 858–68

    Google Scholar 

  • Baratti D, Kusamura S, Nonaka D, Langer M, Andreola S, Favaro M, Gavazzi C, Laterza B, Deraco M (2008) Pseudomyxoma peritonei: clinical pathological and biological prognostic factors in patients treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC). Ann Surg Oncol 15: 526–34

    Google Scholar 

  • Baratti D, Kusamura S, Pietrantonio F, Guaglio M, Niger M, Deraco M (2016) Progress in treatments for colorectal cancer peritoneal metastases during the years 2010–2015. A systematic review. Crit Rev Oncol Hematol 100: 209–22

    Google Scholar 

  • Benizri EI, Bernard JL, Rahili A, Benchimol D, Bereder JM (2012) Small bowel involvement is a prognostic factor in colorectal carcinomatosis treated with complete cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy. World J Surg Oncol 10: 56

    Google Scholar 

  • Blackham AU, Russell GB, Stewart JH, Votanopoulos K, Levine EA, Shen P (2014) Metastatic colorectal cancer: survival comparison of hepatic resection versus cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. Ann Surg Oncol 21: 2667–74

    Google Scholar 

  • Blackham AU, Shen P, Stewart JH, Russell GB, Levine EA (2010) Cytoreductive surgery with intraperitoneal hyperthermic chemotherapy for malignant peritoneal mesothelioma: mitomycin versus cisplatin. Ann Surg Oncol 17: 2720–7

    Google Scholar 

  • Braam HJ, Boerma D, Wiezer MJ, van Ramshorst B (2013) Hyperthermic intraperitoneal chemotherapy during primary tumour resection limits extent of bowel resection compared to two-stage treatment. Eur J Surg Oncol 39: 988–93

    Google Scholar 

  • Brigand C, Monneuse O, Mohamed F, Sayag-Beaujard AC, Isaac S, Gilly FN, Glehen O (2006) Peritoneal mesothelioma treated by cytoreductive surgery and intraperitoneal hyperthermic chemotherapy: results of a prospective study. Ann Surg Oncol 13: 405–12

    Google Scholar 

  • Cao C, Yan TD, Black D, Morris DL (2009) A systematic review and meta-analysis of cytoreductive surgery with perioperative intraperitoneal chemotherapy for peritoneal carcinomatosis of colorectal origin. Ann Surg Oncol 16: 2152–65

    Google Scholar 

  • Cashin H, Dranichnikov PF, Mahteme H (2014) Cytoreductive surgery and hyperthermic intra-peritoneal chemotherapy treatment of colorectal peritoneal metastases: cohort analysis of high volume disease and cure rate. J Surg Oncol 110: 203–6

    Google Scholar 

  • Cashin PH, Graf W, Nygren P, Mahteme H (2012a) Cytoreductive surgery and intraperitoneal chemotherapy for colorectal peritoneal carcinomatosis: prognosis and treatment of recurrences in a cohort study. Eur J Surg Oncol 38: 509–15

    Google Scholar 

  • Cashin PH, Graf W, Nygren P, Mahteme H ( 2012b) Intraoperative hyperthermic versus postoperative normothermic intraperitoneal chemotherapy for colonic peritoneal carcinomatosis: a case-control study, Ann Oncol 23: 647–52

    Google Scholar 

  • Cashin PH, Mahteme H, Spang N, Syk I, Frodin JE, Torkzad M, Glimelius B, Graf W (2016) Cytoreductive surgery and intraperitoneal chemotherapy versus systemic chemotherapy for colorectal peritoneal metastases: A randomised trial. EurJ Cancer 53: 155–62

    Google Scholar 

  • Cavaliere F, De Simone M, Virzi S, Deraco M, Rossi CR, Garofalo A, Di Filippo F, Giannarelli D, Vaira M, Valle M, Pilati P, Perri P, La Pinta M, Monsellato I, Guadagni F (2011) Prognostic factors and oncologic outcome in 146 patients with colorectal peritoneal carcinomatosis treated with cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy: Italian multicenter study S.I.T.I.L.Eur O. J Surg Oncol 37: 148–54

    Google Scholar 

  • Ceelen W, Van Nieuwenhove Y, Putte DV, Pattyn P (2014) Neoadjuvant chemotherapy with bevacizumab may improve outcome after cytoreduction and hyperthermic intraperitoneal chemoperfusion (HIPEC) for colorectal carcinomatosis. Ann Surg Oncol 21: 3023–8

    Google Scholar 

  • Cheong JH, Shen JY, Song CS, Hyung WJ, Shen JG, Choi SH, Noh SH (2007) Early postoperative intraperitoneal chemotherapy following cytoreductive surgery in patients with very advanced gastric cancer. Ann Surg Oncol 14: 61–8

    Google Scholar 

  • Chia S, You CB, Decullier E, Vaudoyer D, Lorimier G, Abboud K, Bereder JM, Arvieux C, Boschetti G, Glehen O (2016) Patients with Peritoneal Carcinomatosis from Gastric Cancer Treated with Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy: Is Cure a Possibility? Ann Surg Oncol 23: 1971–9

    Google Scholar 

  • Chua TC, Esquivel J, Pelz JO, Morris DL (2013) Summary of current therapeutic options for peritoneal metastases from colorectal cancer. J Surg Oncol 107: 566–73

    Google Scholar 

  • Chua TC, Liauw W, Zhao J, Morris DL (2013) Comparative analysis of perioperative intraperitoneal chemotherapy regimen in appendiceal and colorectal peritoneal carcinomatosis. Int J Clin Oncol 18: 439–46

    Google Scholar 

  • Chua TC, Moran BJ, HSugarbaker PH, Levine EA, Glehen O, Gilly FN, Baratti D, Deraco M, Elias D, Sardi A, Liauw W, Yan TD, Barrios P, Gomez Portilla A, de IHingh IH, Ceelen WP, Pelz JO, Piso P, Gonzalez-Moreno S, Van Der Speeten K, Morris DL (2012) Early- and long-term outcome data of patients with pseudomyxoma peritonei from appendiceal origin treated by a strategy of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. J Clin Oncol 30: 2449–56

    Google Scholar 

  • Chua TC, Morris DL, Esquivel J (2010) Impact of the peritoneal surface disease severity score on survival in patients with colorectal cancer peritoneal carcinomatosis undergoing complete cytoreduction and hyperthermic intraperitoneal chemotherapy. Ann Surg Oncol 17: 1330–6

    Google Scholar 

  • Chua TC, Yan TD, Morris DL (2009) Outcomes of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for peritoneal mesothelioma: the Australian experience. J Surg Oncol 99: 109–13

    Google Scholar 

  • Chua TC, Yan TD, Smigielski ME, Zhu KJ, Ng KM, Zhao J, Morris LD (2009) Long-term survival in patients with pseudomyxoma peritonei treated with cytoreductive surgery and perioperative intraperitoneal chemotherapy: 10 years of experience from a single institution. Ann Surg Oncol 16: 1903–11

    Google Scholar 

  • Derac, M, Baratti D, Inglese MG, Allaria B, Andreola S, Gavazzi C, Kusamura S (2004) Peritonectomy and intraperitoneal hyperthermic perfusion (IPHP): a strategy that has confirmed its efficacy in patients with pseudomyxoma peritonei. Ann Surg Oncol 11: 393–8

    Google Scholar 

  • Elia D, Delperro JR, Sideris L, Benhamou E, Pocard M, Baton O, Giovannini M, Lasser P (2004) Treatment of peritoneal carcinomatosis from colorectal cancer: impact of complete cytoreductive surgery and difficulties in conducting randomized trials. Ann Surg Oncol 11: 518–21

    Google Scholar 

  • Elia D, Gilly F, Boutitie F, Quenet F, Bereder JM, Mansvelt B, Lorimier G, Dube P, Glehen O (2010) Peritoneal colorectal carcinomatosis treated with surgery and perioperative intraperitoneal chemotherapy: retrospective analysis of 523 patients from a multicentric French study. J Clin Oncol 28: 63–8

    Google Scholar 

  • Elia D, Gilly F, Quenet F, Bereder JM, Sideris L, Mansvelt B, Lorimier G, Glehen O (2010) Pseudomyxoma peritonei: a French multicentric study of 301 patients treated with cytoreductive surgery and intraperitoneal chemotherapy. Eur J Surg Oncol 36: 456–62

    Google Scholar 

  • Elia D, Lefevre JH, Chevalier J, Brouquet A, Marchal F, Classe JM, Ferron G, Guilloit JM, Meeus P, Goere D, Bonastre J (2009) Complete cytoreductive surgery plus intraperitoneal chemohyperthermia with oxaliplatin for peritoneal carcinomatosis of colorectal origin. J Clin Oncol 27: 681–5

    Google Scholar 

  • Elias D, Mariani A, Cloutier AS, Blot F, Goere D, Dumont F, Honore C, Billard V, Dartigues P, Ducreux M (2014) Modified selection criteria for complete cytoreductive surgery plus HIPEC based on peritoneal cancer index and small bowel involvement for peritoneal carcinomatosis of colorectal origin. Eur J Surg Oncol 40: 1467–73

    Google Scholar 

  • Esquivel J, Lowy AM, Markman M, Chua T, Pelz J, Baratti D, Baumgartner JM, Berri R, Bretcha P. -Boix, Deraco M, Flores-Ayala G, Glehen O, Gomez A. -Portilla, Gonzalez S. -Moreno, Goodman M, Halkia E, Kusamura S, Moller M, Passot G, Pocard M, Salti G, Sardi A, Senthil M, Spilioitis J, Torres-Melero J, Turaga K, Trout R (2014) The American Society of Peritoneal Surface Malignancies (ASPSM) Multiinstitution Evaluation of the Peritoneal Surface Disease Severity Score (PSDSS) in 1,013 Patients with Colorectal Cancer with Peritoneal Carcinomatosis. Ann Surg Oncol 21: 4195–201

    Google Scholar 

  • Feldman AL, Libutti SK, Pingpank JF, Bartlett DL, Beresnev TH, Mavroukakis SM, Steinberg SM, Liewehr DJ, Kleiner DE, Alexander HR (2003) Analysis of factors associated with outcome in patients with malignant peritoneal mesothelioma undergoing surgical debulking and intraperitoneal chemotherapy. J Clin Oncol 21: 4560–7

    Google Scholar 

  • Franko J, Ibrahim Z, Gusani NJ, Holtzman MP, Bartlett DL, Zeh HJ, 3rd (2010) Cytoreductive surgery and hyperthermic intraperitoneal chemoperfusion versus systemic chemotherapy alone for colorectal peritoneal carcinomatosis. Cancer 116: 3756–62

    Google Scholar 

  • Glehen O, Gilly FN, Arvieux C, Cotte E, Boutitie F, Mansvelt B, Bereder JM, Lorimier G, Quenet F, Elias D (2010) Peritoneal carcinomatosis from gastric cancer: a multi-institutional study of 159 patients treated by cytoreductive surgery combined with perioperative intraperitoneal chemotherapy. Ann Surg Oncol 17: 2370–7

    Google Scholar 

  • Glehen O, Mithieux F, Osinsky D, Beaujard AC, Freyer G, Guertsch P, Francois Y, Peyrat P, Panteix G, Vignal J, Gilly FN (2003) Surgery combined with peritonectomy procedures and intraperitoneal chemohyperthermia in abdominal cancers with peritoneal carcinomatosis: a phase II study. J Clin Oncol 21: 799–806

    Google Scholar 

  • Glehen O, Mohamed F, Sugarbaker PH (2004) Incomplete cytoreduction in 174 patients with peritoneal carcinomatosis from appendiceal malignancy. Ann Surg 240: 278–85

    Google Scholar 

  • Goere D, Souadka A, Faron M, Cloutier AS, Viana B, Honore C, Dumont F, Elias D (2015) Extent of colorectal peritoneal carcinomatosis: attempt to define a threshold above which HIPEC does not offer survival benefit: a comparative study. Ann Surg Oncol 22: 2958–64

    Google Scholar 

  • Guner Z, Schmidt U, Dahlke MH, Schlitt JH, Klempnauer J, Piso P (2005) Cytoreductive surgery and intraperitoneal chemotherapy for pseudomyxoma peritonei. Int J Colorectal Dis 20: 155–60

    Google Scholar 

  • Helm JH, Miura JT, Glenn JA, Marcus RK, Larrieux G, Jayakrishnan TT, Donahue AE, Gamblin TC, Turaga KK, Johnston FM (2015) Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for malignant peritoneal mesothelioma: a systematic review and meta-analysis. Ann Surg Oncol 22: 1686–93

    Google Scholar 

  • Hompes D, DHoore A, Van Cutsem E, Fieuws S, Ceelen W, Peeters M, Van der Speeten K, Bertrand C, Legendre H, Kerger J (2012) The treatment of peritoneal carcinomatosis of colorectal cancer with complete cytoreductive surgery and hyperthermic intraperitoneal peroperative chemotherapy (HIPEC) with oxaliplatin: a Belgian multicentre prospective phase II clinical study. Ann Surg Oncol 19: 2186–94

    Google Scholar 

  • Hompes D, D’Hoore A, Wolthuis A, Fieuws S, Mirck B, Bruin S, Verwaal V (2014) The use of Oxaliplatin or Mitomycin C in HIPEC treatment for peritoneal carcinomatosis from colorectal cancer: a comparative study. J Surg Oncol 109: 527–32

    Google Scholar 

  • Huang CQ, Yang XJ, Yu Y, Wu HT, Liu Y, Yonemura Y, Li Y (2014) Cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy improves survival for patients with peritoneal carcinomatosis from colorectal cancer: a phase II study from a Chinese center. PLoS One 9: e108509

    Google Scholar 

  • Hubert, J, Thiboutot E, Dube P, Cloutier AS, Drolet P, Sideris L (2015) Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy with oxaliplatin for peritoneal mesothelioma: preliminary results and survival analysis, Surg Oncol 24: 41–6

    Google Scholar 

  • Hultman B, Lundkvist J, Glimelius B, Nygren P, Mahteme H (2012) Costs and clinical outcome of neoadjuvant systemic chemotherapy followed by cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in peritoneal carcinomatosis from gastric cancer. Acta Oncol 51: 112–21

    Google Scholar 

  • Kuijpers AM, Mehta M, Boot H, van Leerdam ME, Hauptmann M, Aalbers AG, Verwaal VJ (2014) Perioperative systemic chemotherapy in peritoneal carcinomatosis of lymph node positive colorectal cancer treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. Ann Oncol 25: 864–9

    Google Scholar 

  • Kuijpers AM, Mirck B, Aalbers AG, Nienhuijs SW, de Hingh IA, Wiezer MJ, van Ramshorst B, van Ginkel RJ, Havenga K, Bremers AJ, de Wilt JH, Te EA. Velde, Verwaal VJ (2013) Cytoreduction and HIPEC in the Netherlands: nationwide long-term outcome following the Dutch protocol. Ann Surg Oncol 20: 4224–30

    Google Scholar 

  • Kuramoto M, Shimada S, Ikeshima S, Matsuo A, Yagi Y, Matsuda M, Yonemura Y, Baba H (2009) Extensive intraoperative peritoneal lavage as a standard prophylactic strategy for peritoneal recurrence in patients with gastric carcinoma. Ann Surg 250: 242–6

    Google Scholar 

  • Magge D, Zenati MS, Austin F, Mavanur A, Sathaiah M, Ramalingam L, Jones H, Zureikat AH, Holtzman M, Ahrendt S, Pingpank J, Zeh HJ, Bartlett DL, Choudry HA (2014) Malignant peritoneal mesothelioma: prognostic factors and oncologic outcome analysis. Ann Surg Oncol 21: 1159–65

    Google Scholar 

  • McBride K, McFadden D, Osler T (2013) Improved survival of patients with pseudomyxoma peritonei receiving intraperitoneal chemotherapy with cytoreductive surgery: a systematic review and meta-analysis. J Surg Res, 183: 246–52

    Google Scholar 

  • Morimoto (2018) Long-Term Outcome of a Randomized Phase III Trial Exploring the Significance of Extensive Intraoperative Peritoneal Lavage in Addition to Standard Treatment for ≥ T3 Resectable Gastric Cancer, ASCO 2018

    Google Scholar 

  • Passot G, Vaudoyer D, Cotte E, You B, Isaac S, Noel Gilly F, Mohamed F, Glehen O (2012) Progression following neoadjuvant systemic chemotherapy may not be a contraindication to a curative approach for colorectal carcinomatosis. Ann Surg 256: 125–9

    Google Scholar 

  • Passot G, You B, Boschetti G, Fontaine J, Isaac S, Decullier E, Maurice C, Vaudoyer D, Gilly FN, Cotte E, Glehen O (2014) Pathological response to neoadjuvant chemotherapy: a new prognosis tool for the curative management of peritoneal colorectal carcinomatosis. Ann Surg Oncol 21: 2608–14

    Google Scholar 

  • Prada-Villaverde A, Esquivel J, Lowy AM, Markman M, Chua T, Pelz J, Baratti D, Baumgartner JM, Berri R, Bretcha-Boix P, Deraco M, Flores-Ayala G, Glehen O, Gomez-Portilla A, Gonzalez-Moreno S, Goodman M, Halkia E, Kusamura S, Moller M, Passot G, Pocard M, Salti G, Sardi A, Senthil M, Spiliotis J, Torres-Melero J, Turaga K, Trout R (2014) The American Society of Peritoneal Surface Malignancies evaluation of HIPEC with Mitomycin C versus Oxaliplatin in 539 patients with colon cancer undergoing a complete cytoreductive surgery. J Surg Oncol 110: 779–85

    Google Scholar 

  • Rivard JD, McConnell YJ, Temple WJ, Mack LA (2014) Cytoreduction and heated intraperitoneal chemotherapy for colorectal cancer: are we excluding patients who may benefit? J Surg Oncol 109: 104–9

    Google Scholar 

  • Shetty J, Bathla SL, Govindarajan V, Thomas P, Loggie BW (2014) Comparison of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy with mitomycin or carboplatin for diffuse malignant peritoneal mesothelioma, Am Surg 80: 348–52

    Google Scholar 

  • Simkens GA, van Oudheusden TR, Braam HJ, Wiezer MJ, Nienhuijs SW, Rutten HJ, van Ramshorst B, Hingh IH (2016) Cytoreductive surgery and HIPEC offers similar outcomes in patients with rectal peritoneal metastases compared to colon cancer patients: a matched case control study. J Surg Oncol 113: 548–53

    Google Scholar 

  • Simkens GA, van Oudheusden TR, Luyer MD, Nienhuijs SW, Nieuwenhuijzen GA, Rutten HJ, de Hingh IH (2015) Serious Postoperative Complications Affect Early Recurrence After Cytoreductive Surgery and HIPEC for Colorectal Peritoneal Carcinomatosis. Ann Surg Oncol 22: 2656–62

    Google Scholar 

  • Smyth C, Verheij EM, Allum W, Cunningham D, Cervantes A, Arnold D (2016) Gastric cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up, Ann Oncol 27: v38-v49

    Google Scholar 

  • Stewart JH, Shen P, Russell GB, Bradley RF, Hundley JC, Loggie BL, Geisinger KR, Levine EA (2006) Appendiceal neoplasms with peritoneal dissemination: outcomes after cytoreductive surgery and intraperitoneal hyperthermic chemotherapy. Ann Surg Oncol 13: 624–34

    Google Scholar 

  • Van Cutsem E, Cervantes A, Adam R, Sobrero A, Van Krieken JH, Aderka D, Aranda Aguilar E, Bardelli A, Benson A, Bodoky G, Ciardiello F, D’Hoore A, Diaz Rubio E, Douillard JY, Ducreux M, Falcone A, Grothey A, Gruenberger T, Haustermans K, Heinemann V, Hoff P, Kohne CH, Labianca R, Laurent-Puig P, Ma B, Maughan T, Muro K, Normanno N, Osterlund P, Oyen WJ, Papamichael D, Pentheroudakis G, Pfeiffer P, Price TJ, Punt C, Ricke J, Roth A, Salazar R, Scheithauer W, Schmoll HJ, Tabernero J, Taieb J, Tejpar S, Wasan H, Yoshino T, Zaanan A, Arnold D (2016) ESMO consensus guidelines for the management of patients with metastatic colorectal cancer. Ann Oncol 27: 1386–422

    Google Scholar 

  • van Oudheusden TR, Lemmens VE, Braam HJ, van Ramshorst B, Meijerink J, te Velde EA, Mehta AM, Verwaal VJ, de Hingh IH (2015) Peritoneal metastases from small bowel cancer: Results of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in The Netherlands. Surgery 157: 1023–7

    Google Scholar 

  • Verwaal J, Bruin VS, Boot H, van Slooten G, van Tinteren H (2008( 8-year follow-up of randomized trial: cytoreduction and hyperthermic intraperitoneal chemotherapy versus systemic chemotherapy in patients with peritoneal carcinomatosis of colorectal cancer. Ann Surg Oncol 15: 2426–32

    Google Scholar 

  • Vogel D, Eskicioglu JC, Weiser MR, Feingold DL, Steele SR (2017) The American Society of Colon and Rectal Surgeons Clinical Practice Guidelines for the Treatment of Colon Cancer. Dis Colon Rectum 60: 999–1017

    Google Scholar 

  • Wong J, Koch AL, Deneve JL, Fulp W, Tanvetyanon T, Dessureault S (2014) Repeat cytoreductive surgery and heated intraperitoneal chemotherapy may offer survival benefit for intraperitoneal mesothelioma: a single institution experience. Ann Surg Oncol 21: 1480–6

    Google Scholar 

  • Yan TD, Black D, Sugarbaker PH, Zhu J, Yonemura Y, Petrou G, Morris DL (2007) A systematic review and meta-analysis of the randomized controlled trials on adjuvant intraperitoneal chemotherapy for resectable gastric cancer. Ann Surg Oncol 14: 2702–13

    Google Scholar 

  • Yan TD, Deraco M, Baratti D, Kusamura S, Elias D, Glehen O, Gilly FN, Levine EA, Shen P, Mohamed F, Moran BJ, Morris DL, Chua TC, Piso P, Sugarbaker PH (2009) Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for malignant peritoneal mesothelioma: multi-institutional experience. J Clin Oncol 27: 6237–42

    Google Scholar 

  • Yan TD, Welch L, Black D, Sugarbaker PH (2007) A systematic review on the efficacy of cytoreductive surgery combined with perioperative intraperitoneal chemotherapy for diffuse malignancy peritoneal mesothelioma, Ann Oncol 18: 827–34

    Google Scholar 

  • Yang XJ, Huang CQ, Suo T, Mei LJ, Yang GL, Cheng FL, Zhou YF, Xiong B, Yonemura Y, Li Y (2011) Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy improves survival of patients with peritoneal carcinomatosis from gastric cancer: final results of a phase III randomized clinical trial. Ann Surg Oncol 18: 1575–81

    Google Scholar 

  • Yang XJ, Li Y, Yonemura Y (2010) Cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy to treat gastric cancer with ascites and/or peritoneal carcinomatosis: Results from a Chinese center. J Surg Oncol 101: 457–64

    Google Scholar 

  • Yonemura Y, Canbay E, Ishibashi H (2013) Prognostic factors of peritoneal metastases from colorectal cancer following cytoreductive surgery and perioperative chemotherapy. Scientific World Journal 2013: 978394

    Google Scholar 

  • Yonemura Y, de Aretxabala X, Fujimura T, Fushida S, Katayama K, Bandou E, Sugiyama K, Kawamura T, Kinoshita K, Endou Y, Sasaki T (2001) Intraoperative chemohyperthermic peritoneal perfusion as an adjuvant to gastric cancer: final results of a randomized controlled study. Hepatogastroenterology 48: 1776–82

    Google Scholar 

  • Yonemura Y, Endou Y, Shinbo M, Sasaki T, Hirano M, Mizumoto A, Matsuda T, Takao N, Ichinose M, Mizuno M, Miura M, Ikeda M, Ikeda S, Nakajima G, Yonemura J, Yuuba T, Masuda S, Kimura H, Matsuki N (2009) Safety and efficacy of bidirectional chemotherapy for treatment of patients with peritoneal dissemination from gastric cancer: Selection for cytoreductive surgery. J Surg Oncol 100: 311–6

    Google Scholar 

  • Yonemura Y, Ishibashi H, Hirano M, Mizumoto A, Takeshita K, Noguchi K, Takao N, Ichinose M, Liu Y, Li Y (2017) Effects of Neoadjuvant Laparoscopic Hyperthermic Intraperitoneal Chemotherapy and Neoadjuvant Intraperitoneal/Systemic Chemotherapy on Peritoneal Metastases from Gastric Cancer. Ann Surg Oncol 24: 478–85

    Google Scholar 

  • Youssef H, Newman C, Chandrakumaran K, Mohamed F, Cecil TD, Moran BJ (2011) Operative findings, early complications, and long-term survival in 456 patients with pseudomyxoma peritonei syndrome of appendiceal origin. Dis Colon Rectum 54: 293–9

    Google Scholar 

  • Yu W, Whang I, Chung HY, Averbach A, Sugarbaker PH (2001) Indications for early postoperative intraperitoneal chemotherapy of advanced gastric cancer: results of a prospective randomized trial. World J Surg 25: 985–90

    Google Scholar 

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  1. Universitätskli, Klinik für Allgemeine, Vizeral- und ­Transplantationschirurgie, Deutschland

    Dr. med. C. Yurttas

  2. Universitätsklinikum Tübingen, Klinik für Allgemeine, Vizeral- und ­Transplantationschirurgie, Tübingen, Deutschland

    Dr. med. F. Struller & Dr. med. P. Horvath

  3. Universitätsklinikum Tübingen, Klinik für Allgemeine, Vizeral- und Transplantationschirurgie, Tübingen, Deutschland

    Prof. Dr. med. A. Königsrainer & Prof. Dr. med. S. Beckert

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    Reinhart T. Grundmann

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Yurttas, C., Struller, F., Horvath, P., Königsrainer, A., Beckert, S. (2018). Peritonektomie und HIPEC. In: Germer, CT., Keck, T., Grundmann, R.T. (eds) Evidenzbasierte Viszeralchirurgie maligner Erkrankungen. Evidenzbasierte Chirurgie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-56533-9_14

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  • DOI: https://doi.org/10.1007/978-3-662-56533-9_14

  • Publisher Name: Springer, Berlin, Heidelberg

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