Abstract
Magnetic resonance imaging (MRI) and ultrasound (US) are two prominent medical imaging modalities. They are extensively and routinely used in various medical fields, such as cardiology, embryology, neurology, and oncology. In this chapter we describe the application of nanoparticles for MRI and US image enhancement. Moreover, the utilization of nano-scaled compounds for multimodal MRI-US imaging, allowing further increase of diagnosis certainty, is depicted.
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References
Wolbarst AB, Hendee WR (2006) Evolving and experimental technologies in medical imaging. Radiology 238(1):16–39
Smith-Bindman R, Miglioretti DL, Johnson E, Lee C et al (2012) Use of diagnostic imaging studies and associated radiation exposure for patients enrolled in large integrated health care systems, 1996–2010. JAMA 307(22):2400–2409
Beckett KR, Moriarity AK, Langer JM (2015) Safe use of contrast media: what the radiologist needs to know. Radiographics 35(6):1738–1750
Vandsburger MH, Epstein FH (2011) Emerging MRI methods in translational cardiovascular research. J Cardiovasc Transl Res 4(4):477–492
Fidler JL, Guimaraes L, Einstein DM (2009) MR imaging of the small bowel 1. Radiographics 29(6):1811–1825
Sun MR, Ngo L, Genega EM, Atkins MB et al (2009) Renal cell carcinoma: dynamic contrast-enhanced MR imaging for differentiation of tumor subtypes – correlation with pathologic findings 1. Radiology 250(3):793–802
Farkas J, Christian P, Urrea JAG, Roos N et al (2010) Effects of silver and gold nanoparticles on rainbow trout (Oncorhynchus mykiss) hepatocytes. Aquat Toxicol 96(1):44–52
Bihari P, Vippola M, Schultes S, Praetner M et al (2008) Optimized dispersion of nanoparticles for biological in vitro and in vivo studies. Part Fibre Toxicol 5(1):14
Mohanraj V, Chen Y (2006) Nanoparticles-a review. Trop J Pharm Res 5(1):561–573
Moreno-Manas M, Pleixats R (2003) Formation of carbon– carbon bonds under catalysis by transition-metal nanoparticles. Acc Chem Res 36(8):638–643
Kayser O, Lemke A, Hernandez-Trejo N (2005) The impact of nanobiotechnology on the development of new drug delivery systems. Curr Pharm Biotechnol 6(1):3–5
Wang AZ, Langer R, Farokhzad OC (2012) Nanoparticle delivery of cancer drugs. Annu Rev Med 63:185–198
Hobbs SK, Monsky WL, Yuan F, Roberts WG et al (1998) Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment. Proc Natl Acad Sci 95(8):4607–4612
Fang J, Nakamura H, Maeda H (2011) The EPR effect: unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect. Adv Drug Deliv Rev 63(3):136–151
Li S-D, Huang L (2010) Stealth nanoparticles: high density but sheddable PEG is a key for tumor targeting. J Control Release 145(3):178
Moore A, Marecos E, Bogdanov A Jr, Weissleder R (2000) Tumoral distribution of long-circulating dextran-coated iron oxide nanoparticles in a rodent model 1. Radiology 214(2):568–574
Nune SK, Gunda P, Thallapally PK, Lin Y-Y et al (2009) Nanoparticles for biomedical imaging. Expert Opin Drug Deliv 6(11):1175–1194
Li L, Gao F, Jiang W, Wu X et al (2016) Folic acid-conjugated superparamagnetic iron oxide nanoparticles for tumor-targeting MR imaging. Drug Deliv 23(5):1726–1733
Grenha A, Gomes ME, Rodrigues M, Santo VE et al (2010) Development of new chitosan/carrageenan nanoparticles for drug delivery applications. J Biomed Mater Res A 92(4):1265–1272
Alivisatos P (2004) The use of nanocrystals in biological detection. Nat Biotechnol 22(1):47–52
Zhou L, Gu Z, Liu X, Yin W et al (2012) Size-tunable synthesis of lanthanide-doped Gd2O3 nanoparticles and their applications for optical and magnetic resonance imaging. J Mater Chem 22(3):966–974
Zhao Z, Zhou Z, Bao J, Wang Z et al (2013) Octapod iron oxide nanoparticles as high-performance T2 contrast agents for magnetic resonance imaging. Nat Commun 4:2266
Baetke SC, Lammers T, Kiessling F (2015) Applications of nanoparticles for diagnosis and therapy of cancer. Br J Radiol 88(1054):20150207
Popovtzer R, Agrawal A, Kotov NA, Popovtzer A et al (2008) Targeted gold nanoparticles enable molecular CT imaging of cancer. Nano Lett 8(12):4593–4596
Yin T, Wang P, Zheng R, Zheng B et al (2012) Nanobubbles for enhanced ultrasound imaging of tumors. Int J Nanomedicine 7(2):895–904
Liu Y, Welch MJ (2012) Nanoparticles labeled with positron emitting nuclides: advantages, methods, and applications. Bioconjug Chem 23(4):671–682
Polyák A, Hajdu I, Bodnár M, Trencsényi G et al (2013) 99m Tc-labelled nanosystem as tumour imaging agent for SPECT and SPECT/CT modalities. Int J Pharm 449(1):10–17
Morana G, Salviato E, Guarise A (2007) Contrast agents for hepatic MRI. Cancer Imaging 7(Spec No A):S24–S27
Louie A (2010) Multimodality imaging probes: design and challenges. Chem Rev (Washington, DC, United States) 110(5):3146–3195
Deshpande N, Needles A, Willmann JK (2010) Molecular ultrasound imaging: current status and future directions. Clin Radiol 65(7):567–581
Gao Z, Ma T, Zhao E, Docter D et al (2016) Small is smarter: nano MRI contrast agents–advantages and recent achievements. Small 12(5):556–576
Lee D-E, Koo H, Sun I-C, Ryu JH et al (2012) Multifunctional nanoparticles for multimodal imaging and theragnosis. Chem Soc Rev 41(7):2656–2672
Albrecht T, Blomley M, Bolondi L, Claudon M et al (2004) Guidelines for the use of contrast agents in ultrasound. January 2004. Ultraschall Med 25(04):249–256
Chang PH, Shun K, Wu S-J, Levene HB (1995) Second harmonic imaging and harmonic Doppler measurements with Albunex. IEEE Trans Ultrason Ferroelectr Freq Control 42(6):1020–1027
Calliada F, Campani R, Bottinelli O, Bozzini A et al (1998) Ultrasound contrast agents: basic principles. Eur J Radiol 27:S157–S160
Blomley MJ, Cooke JC, Unger EC, Monaghan MJ et al (2001) Microbubble contrast agents: a new era in ultrasound. Br Med J 322(7296):1222
Potdevin T, Fowlkes J, Moskalik A, Carson P (2004) Analysis of refill curve shape in ultrasound contrast agent studies. Med Phys 31(3):623–632
Claudon M, Dietrich CF, Choi BI, Cosgrove DO et al (2013) Guidelines and good clinical practice recommendations for contrast enhanced ultrasound (CEUS) in the liver–update 2012. Ultraschall Med 34(01):11–29
Wang C-H, Huang Y-F, Yeh C-K (2011) Aptamer-conjugated nanobubbles for targeted ultrasound molecular imaging. Langmuir 27(11):6971–6976
Fan X, Wang L, Guo Y, Tong H et al (2013) Experimental investigation of the penetration of ultrasound nanobubbles in a gastric cancer xenograft. Nanotechnology 24(32):325102
Cai WB, Yang HL, Zhang J, Yin JK et al (2015) The optimized fabrication of nanobubbles as ultrasound contrast agents for tumor imaging. Sci Rep 5:13725
Yang H, Cai W, Xu L, Lv X et al (2015) Nanobubble–affibody: novel ultrasound contrast agents for targeted molecular ultrasound imaging of tumor. Biomaterials 37:279–288
Tong H-P, Wang L-F, Guo Y-L, Li L et al (2013) Preparation of protamine cationic nanobubbles and experimental study of their physical properties and in vivo contrast enhancement. Ultrasound Med Biol 39(11):2147–2157
Makadia HK, Siegel SJ (2011) Poly lactic-co-glycolic acid (PLGA) as biodegradable controlled drug delivery carrier. Polymers 3(3):1377–1397
Néstor M-M, Kei N-PE, Guadalupe N-AM, Elisa M-ES et al (2011) Preparation and in vitro evaluation of poly (D, L-lactide-co-glycolide) air-filled nanocapsules as a contrast agent for ultrasound imaging. Ultrasonics 51(7):839–845
Zhang X, Zheng Y, Wang Z, Huang S et al (2014) Methotrexate-loaded PLGA nanobubbles for ultrasound imaging and synergistic targeted therapy of residual tumor during HIFU ablation. Biomaterials 35(19):5148–5161
Krupka TM, Solorio L, Wilson RE, Wu H et al (2009) Formulation and characterization of echogenic lipid– pluronic nanobubbles. Mol Pharm 7(1):49–59
Wu H, Rognin NG, Krupka TM, Solorio L et al (2013) Acoustic characterization and pharmacokinetic analyses of new nanobubble ultrasound contrast agents. Ultrasound Med Biol 39(11):2137–2146
Shapiro MG, Goodwill PW, Neogy A, Yin M et al (2014) Biogenic gas nanostructures as ultrasonic molecular reporters. Nat Nanotechnol 9(4):311–316
Sheeran PS, Wong VP, Luois S, McFarland RJ et al (2011) Decafluorobutane as a phase-change contrast agent for low-energy extravascular ultrasonic imaging. Ultrasound Med Biol 37(9):1518–1530
Díaz-López R, Tsapis N, Santin M, Bridal SL et al (2010) The performance of PEGylated nanocapsules of perfluorooctyl bromide as an ultrasound contrast agent. Biomaterials 31(7):1723–1731
Peyman SA, McLaughlan JR, Abou-Saleh RH, Marston G et al (2016) On-chip preparation of nanoscale contrast agents towards high-resolution ultrasound imaging. Lab Chip 16(4):679–687
Liu J, Shang T, Wang F, Cao Y et al (2017) Low-intensity focused ultrasound (LIFU)-induced acoustic droplet vaporization in phase-transition perfluoropentane nanodroplets modified by folate for ultrasound molecular imaging. Int J Nanomedicine 12:911
Nguyen AT, Wrenn SP (2014) Acoustically active liposome-nanobubble complexes for enhanced ultrasonic imaging and ultrasound-triggered drug delivery. Wiley Interdiscip Rev Nanomed Nanobiotechnol 6(3):316–325
Raymond JL, Luan Y, Peng T, Huang S-L et al (2016) Loss of gas from echogenic liposomes exposed to pulsed ultrasound. Phys Med Biol 61(23):8321
Liang H, Blomley M (2003) The role of ultrasound in molecular imaging. Br J Radiol 76:S140
Kopechek JA, Haworth KJ, Raymond JL, Douglas Mast T et al (2011) Acoustic characterization of echogenic liposomes: frequency-dependent attenuation and backscatter. J Acoust Soc Am 130(5):3472–3481
Radhakrishnan K, Haworth KJ, Huang S-L, Klegerman ME et al (2012) Stability of echogenic liposomes as a blood pool ultrasound contrast agent in a physiologic flow phantom. Ultrasound Med Biol 38(11):1970–1981
Kim H, Moody MR, Laing ST, Kee PH et al (2010) In vivo volumetric intravascular ultrasound visualization of early/inflammatory arterial atheroma using targeted echogenic immunoliposomes. Investig Radiol 45(10):685
Laing ST, Moody M, Smulevitz B, Kim H et al (2011) Ultrasound-enhanced thrombolytic effect of tissue plasminogen activator–loaded echogenic liposomes in an in vivo rabbit aorta thrombus model – brief report. Arterioscler Thromb Vasc Biol 31(6):1357–1359
Kang E, Min HS, Lee J, Han MH et al (2010) Nanobubbles from gas-generating polymeric nanoparticles: ultrasound imaging of living subjects. Angew Chem Int Ed 49(3):524–528
Olson ES, Orozco J, Wu Z, Malone CD et al (2013) Toward in vivo detection of hydrogen peroxide with ultrasound molecular imaging. Biomaterials 34(35):8918–8924
Kang C, Cho W, Park M, Kim J et al (2016) H2O2-triggered bubble generating antioxidant polymeric nanoparticles as ischemia/reperfusion targeted nanotheranostics. Biomaterials 85:195–203
Kim M, Lee JH, Kim SE, Kang SS et al (2016) Nanosized ultrasound enhanced-contrast agent for in vivo tumor imaging via intravenous injection. ACS Appl Mater Interfaces 8(13):8409–8418
Liu J, Levine AL, Mattoon JS, Yamaguchi M et al (2006) Nanoparticles as image enhancing agents for ultrasonography. Phys Med Biol 51(9):2179
Liu J, Li J, Rosol TJ, Pan X et al (2007) Biodegradable nanoparticles for targeted ultrasound imaging of breast cancer cells in vitro. Phys Med Biol 52(16):4739
Ji Y, Li X-T, Chen G-Q (2008) Interactions between a poly (3-hydroxybutyrate-co-3-hydroxyvalerate-co-3-hydroxyhexanoate) terpolyester and human keratinocytes. Biomaterials 29(28):3807–3814
Liberman A, Martinez HP, Ta CN, Barback CV et al (2012) Hollow silica and silica-boron nano/microparticles for contrast-enhanced ultrasound to detect small tumors. Biomaterials 33(20):5124–5129
Liberman A, Wu Z, Barback CV, Viveros R et al (2013) Color doppler ultrasound and gamma imaging of intratumorally injected 500 nm iron–silica nanoshells. ACS Nano 7(7):6367–6377
Foroutan F, Jokerst JV, Gambhir SS, Vermesh O et al (2015) Sol–gel synthesis and electrospraying of biodegradable (P2O5) 55–(CaO) 30–(Na2O) 15 glass nanospheres as a transient contrast agent for ultrasound stem cell imaging. ACS Nano 9(2):1868–1877
Delogu LG, Vidili G, Venturelli E, Ménard-Moyon C et al (2012) Functionalized multiwalled carbon nanotubes as ultrasound contrast agents. Proc Natl Acad Sci 109(41):16612–16617
Lee GH, Chang Y (2015) Magnetic properties, water proton relaxivities, and in-vivo MR images of paramagnetic nanoparticles. J Korean Phys Soc 67(1):44–51
Weissleder R (1994) Liver MR imaging with iron oxides: toward consensus and clinical practice. Radiology 193(3):593–595
Raymond KN, Pierre VC (2005) Next generation, high relaxivity gadolinium MRI agents. Bioconjug Chem 16(1):3–8
Kuo PH, Kanal E, Abu-Alfa AK, Cowper SE (2007) Gadolinium-based MR contrast agents and nephrogenic systemic fibrosis 1. Radiology 242(3):647–649
Pan D, Caruthers SD, Senpan A, Schmieder AH et al (2011) Revisiting an old friend: manganese-based MRI contrast agents. Wiley Interdiscip Rev Nanomed Nanobiotechnol 3(2):162–173
Amsalem Y, Mardor Y, Feinberg MS, Landa N et al (2007) Iron-oxide labeling and outcome of transplanted mesenchymal stem cells in the infarcted myocardium. Circulation 116(Suppl 11):I-38–I-45
Bar-Shir A, Avram L, Yariv-Shoushan S, Anaby D et al (2014) Alginate-coated magnetic nanoparticles for noninvasive MRI of extracellular calcium. NMR Biomed 27(7):774–783
Temme S, Grapentin C, Quast C, Jacoby C et al (2015) Non-invasive imaging of early venous thrombosis by 19F MRI using targeted perfluorocarbon nanoemulsions. Circulation. https://doi.org/10.1161/CIRCULATIONAHA.114.010962
Lesniak WG, Oskolkov N, Song X, Lal B et al (2016) Salicylic acid conjugated dendrimers are a tunable, high performance CEST MRI NanoPlatform. Nano Lett 16(4):2248–2253
Faucher L, Tremblay Ml, Lagueux J, Gossuin Y et al (2012) Rapid synthesis of PEGylated ultrasmall gadolinium oxide nanoparticles for cell labeling and tracking with MRI. ACS Appl Mater Interfaces 4(9):4506–4515
Fang J, Chandrasekharan P, Liu X-L, Yang Y et al (2014) Manipulating the surface coating of ultra-small Gd2O3 nanoparticles for improved T 1-weighted MR imaging. Biomaterials 35(5):1636–1642
Bertini I, Bianchini F, Calorini L, Colagrande S et al (2004) Persistent contrast enhancement by sterically stabilized paramagnetic liposomes in murine melanoma. Magn Reson Med 52(3):669–672
Chen H, Wang GD, Tang W, Todd T et al (2014) Gd-encapsulated carbonaceous dots with efficient renal clearance for magnetic resonance imaging. Adv Mater (Weinheim, Germany) 26(39):6761–6766
Perera VS, Chen G, Cai Q, Huang SD (2016) Nanoparticles of gadolinium-incorporated Prussian blue with PEG coating as an effective oral MRI contrast agent for gastrointestinal tract imaging. Analyst 141(6):2016
Na HB, Lee JH, An K, Park YI et al (2007) Development of a T1 contrast agent for magnetic resonance imaging using MnO nanoparticles. Angew Chem 119(28):5493–5497
Kim T, Momin E, Choi J, Yuan K et al (2011) Mesoporous silica-coated hollow manganese oxide nanoparticles as positive T 1 contrast agents for labeling and MRI tracking of adipose-derived mesenchymal stem cells. J Am Chem Soc 133(9):2955–2961
An K, Na HB, Park YI, Choi SH et al (2015) Hollow MnOxPy and Pt/MnOxPy yolk/shell nanoparticles as a T 1 MRI contrast agent. J Colloid Interface Sci 439:134–138
Kanakia S, Toussaint J, Hoang DM, Lee S et al (2014) Towards an advanced graphene-based magnetic resonance imaging contrast agent: sub-acute toxicity and efficacy studies in small animals. Sci Rep 5:17182–17182
Bao G, Mitragotri S, Tong S (2013) Multifunctional nanoparticles for drug delivery and molecular imaging. Annu Rev Biomed Eng 15:253–282
Wu Y, Briley K, Tao X (2015) Nanoparticle-based imaging of inflammatory bowel disease. Wiley Interdiscip Rev Nanomed Nanobiotechnol 8:300–315
Raynal I, Prigent P, Peyramaure S, Najid A et al (2004) Macrophage endocytosis of superparamagnetic iron oxide nanoparticles: mechanisms and comparison of ferumoxides and ferumoxtran-10. Investig Radiol 39(1):56–63
Van Beers B, Gallez B, Pringot J (1997) Contrast-enhanced MR imaging of the liver. Radiology 203(2):297–306
Frericks BB, Wacker F, Loddenkemper C, Valdeig S et al (2009) Magnetic resonance imaging of experimental inflammatory bowel disease: quantitative and qualitative analyses with histopathologic correlation in a rat model using the ultrasmall iron oxide SHU 555 C. Investig Radiol 44(1):23–30
Wu Y, Briley-Saebo K, Xie J, Zhang R et al (2014) Inflammatory bowel disease: MR-and SPECT/CT-based macrophage imaging for monitoring and evaluating disease activity in experimental mouse model – pilot study. Radiology 271(2):400–407
Neuwelt A, Sidhu N, Hu C-AA, Mlady G et al (2015) Iron-based superparamagnetic nanoparticle contrast agents for MRI of infection and inflammation. Am J Roentgenol 204(3):W302–W313
Aryal S, Key J, Stigliano C, Ananta JS et al (2013) Engineered magnetic hybrid nanoparticles with enhanced relaxivity for tumor imaging. Biomaterials 34(31):7725–7732
Aghighi M, Golovko D, Ansari C, Marina NM et al (2015) Imaging tumor necrosis with ferumoxytol. PLoS One 10(11):e0142665
Bashir MR, Bhatti L, Marin D, Nelson RC (2015) Emerging applications for ferumoxytol as a contrast agent in MRI. J Magn Reson Imaging 41(4):884–898
Klenk C, Gawande R, Uslu L, Khurana A et al (2014) Ionising radiation-free whole-body MRI versus 18 F-fluorodeoxyglucose PET/CT scans for children and young adults with cancer: a prospective, non-randomised, single-centre study. Lancet Oncol 15(3):275–285
Cunningham CH, Arai T, Yang PC, McConnell MV et al (2005) Positive contrast magnetic resonance imaging of cells labeled with magnetic nanoparticles. Magn Reson Med 53(5):999–1005
Zhao Q, Langley J, Lee S, Liu W (2011) Positive contrast technique for the detection and quantification of superparamagnetic iron oxide nanoparticles in MRI. NMR Biomed 24(5):464–472
Wang L, Zhong X, Qian W, Huang J et al (2014) Ultrashort echo time (UTE) imaging of receptor targeted magnetic iron oxide nanoparticles in mouse tumor models. J Magn Reson Imaging 40(5):1071–1081
Zhu B, Witzel T, Jiang S, Huang SY et al (2016) Selective magnetic resonance imaging of magnetic nanoparticles by acoustically induced rotary saturation. Magn Reson Med 75(1):97–106
Yang H-W, Huang C-Y, Lin C-W, Liu H-L et al (2014) Gadolinium-functionalized nanographene oxide for combined drug and microRNA delivery and magnetic resonance imaging. Biomaterials 35(24):6534–6542
Cui Y, Zhang C, Luo R, Liu H et al (2016) Noninvasive monitoring of early antiangiogenic therapy response in human nasopharyngeal carcinoma xenograft model using MrI with rgD-conjugated ultrasmall superparamagnetic iron oxide nanoparticles. Int J Nanomedicine 11:5671
Yuan Y, Ding Z, Qian J, Zhang J et al (2016) Casp3/7-instructed intracellular aggregation of Fe3O4 nanoparticles enhances T2 MR imaging of tumor apoptosis. Nano Lett 16(4):2686–2691
Zhang H, Li J, Hu Y, Shen M et al (2016) Folic acid-targeted iron oxide nanoparticles as contrast agents for magnetic resonance imaging of human ovarian cancer. J Ovarian Res 9(1):19
Chaudhary R, Roy K, Kanwar RK, Walder K et al (2016) Engineered atherosclerosis-specific zinc ferrite nanocomplex-based MRI contrast agents. J Nanobiotechnol 14(1):6
Dósa E, Guillaume DJ, Haluska M, Lacy CA et al (2010) Magnetic resonance imaging of intracranial tumors: intra-patient comparison of gadoteridol and ferumoxytol. Neuro Oncol 13:251. https://doi.org/10.1093/neuonc/noq172
Cheng KK, Chan PS, Fan S, Kwan SM et al (2015) Curcumin-conjugated magnetic nanoparticles for detecting amyloid plaques in Alzheimer’s disease mice using magnetic resonance imaging (MRI). Biomaterials 44:155–172
Pouw JJ, Grootendorst MR, Bezooijen R, Klazen CA et al (2015) Pre-operative sentinel lymph node localization in breast cancer with superparamagnetic iron oxide MRI: the SentiMAG multicentre trial imaging subprotocol. Br J Radiol 88(1056):20150634
Cowger TA, Tang W, Zhen Z, Hu K et al (2015) Casein-coated Fe5C2 nanoparticles with superior r2 relaxivity for liver-specific magnetic resonance imaging. Theranostics 5(11):1225
Liu F, Le W, Mei T, Wang T et al (2016) In vitro and in vivo targeting imaging of pancreatic cancer using a Fe3O4@ SiO2 nanoprobe modified with anti-mesothelin antibody. Int J Nanomedicine 11:2195
Huang J, Qian W, Wang L, Wu H et al (2016) Functionalized milk-protein-coated magnetic nanoparticles for MRI-monitored targeted therapy of pancreatic cancer. Int J Nanomedicine 11:3087
Jeon TY, Kim JH, Im GH, Kim J-H et al (2016) Hollow manganese oxide nanoparticle-enhanced MRI of hypoxic-ischaemic brain injury in the neonatal rat. Br J Radiol 89(1067):20150806
Luo Y, Yang J, Li J, Yu Z et al (2015) Facile synthesis and functionalization of manganese oxide nanoparticles for targeted T1-weighted tumor MR imaging. Colloids Surf B: Biointerfaces 136:506–513
Huang H, Yue T, Xu K, Golzarian J et al (2015) Fabrication and evaluation of tumor-targeted positive MRI contrast agent based on ultrasmall MnO nanoparticles. Colloids Surf B: Biointerfaces 131:148–154
Kuo Y-T, Chen C-Y, Liu G-C, Wang Y-M (2016) Development of bifunctional gadolinium-labeled superparamagnetic nanoparticles (Gd-MnMEIO) for in vivo MR imaging of the liver in an animal model. PLoS One 11(2):e0148695
Vu-Quang H, Vinding MS, Xia D, Nielsen T et al (2016) Chitosan-coated poly (lactic-co-glycolic acid) perfluorooctyl bromide nanoparticles for cell labeling in 19 F magnetic resonance imaging. Carbohydr Polym 136:936–944
Duan L, Yang F, Song L, Fang K et al (2015) Controlled assembly of magnetic nanoparticles on microbubbles for multimodal imaging. Soft Matter 11(27):5492–5500
Xu S, Yang F, Zhou X, Zhuang Y et al (2015) Uniform PEGylated PLGA microcapsules with embedded Fe3O4 nanoparticles for US/MR dual-modality imaging. ACS Appl Mater Interfaces 7(36):20460–20468
Song S, Guo H, Jiang Z, Jin Y et al (2015) Self-assembled microbubbles as contrast agents for ultrasound/magnetic resonance dual-modality imaging. Acta Biomater 24:266–278
Niu C, Wang Z, Lu G, Krupka TM et al (2013) Doxorubicin loaded superparamagnetic PLGA-iron oxide multifunctional microbubbles for dual-mode US/MR imaging and therapy of metastasis in lymph nodes. Biomaterials 34(9):2307–2317
Huang H-Y, Hu S-H, Hung S-Y, Chiang C-S et al (2013) SPIO nanoparticle-stabilized PAA-F127 thermosensitive nanobubbles with MR/US dual-modality imaging and HIFU-triggered drug release for magnetically guided in vivo tumor therapy. J Control Release 172(1):118–127
Xu B, Dou H, Tao K, Sun K et al (2011) “Two-in-one” fabrication of Fe3O4/MePEG-PLA composite nanocapsules as a potential ultrasonic/MRI dual contrast agent. Langmuir 27(19):12134–12142
Zhao Y, Song W, Wang D, Ran H et al (2015) Phase-shifted PFH@ PLGA/Fe3O4 nanocapsules for MRI/US imaging and photothermal therapy with near-infrared irradiation. ACS Appl Mater Interfaces 7(26):14231–14242
Cheng X, Li H, Chen Y, Luo B et al (2013) Ultrasound-triggered phase transition sensitive magnetic fluorescent nanodroplets as a multimodal imaging contrast agent in rat and mouse model. PLoS One 8(12):e85003
Kempen PJ, Greasley S, Parker KA, Campbell JL et al (2015) Theranostic mesoporous silica nanoparticles biodegrade after pro-survival drug delivery and ultrasound/magnetic resonance imaging of stem cells. Theranostics 5(6):631
Nolte I, Vince GH, Maurer M, Herbold C et al (2005) Iron particles enhance visualization of experimental gliomas with high-resolution sonography. Am J Neuroradiol 26(6):1469–1474
Linker R, Kroner A, Horn T, Gold R et al (2006) Iron particle–enhanced visualization of inflammatory central nervous system lesions by high resolution: preliminary data in an animal model. Am J Neuroradiol 27(6):1225–1229
Oh J, Feldman MD, Kim J, Condit C et al (2006) Detection of magnetic nanoparticles in tissue using magneto-motive ultrasound. Nanotechnology 17(16):4183
Mehrmohammadi M, Oh J, Mallidi S, Emelianov SY (2011) Pulsed magneto-motive ultrasound imaging using ultrasmall magnetic nanoprobes. Mol Imaging 10(2):102. https://doi.org/10.2310/7290.2010.00037
Evertsson M, Kjellman P, Cinthio M, Fredriksson S et al (2014) Multimodal detection of iron oxide nanoparticles in rat lymph nodes using magnetomotive ultrasound imaging and magnetic resonance imaging. IEEE Trans Ultrason Ferroelectr Freq Control 61(8):1276–1283
Perlman O, Azhari H (2017) Ultrasonic computed tomography imaging of iron oxide nanoparticles. Phys Med Biol 62(3):825
Perlman O, Weitz IS, Azhari H (2015) Copper oxide nanoparticles as contrast agents for MRI and ultrasound dual-modality imaging. Phys Med Biol 60(15):5767
An L, Hu H, Du J, Wei J et al (2014) Paramagnetic hollow silica nanospheres for in vivo targeted ultrasound and magnetic resonance imaging. Biomaterials 35(20):5381–5392
Barnett BP, Ruiz-Cabello J, Hota P, Ouwerkerk R et al (2011) Use of perfluorocarbon nanoparticles for non-invasive multimodal cell tracking of human pancreatic islets. Contrast Media Mol Imaging 6(4):251–259
Thakor AS, Jokerst JV, Ghanouni P, Campbell JL et al (2016) Clinically approved nanoparticle imaging agents. J Nucl Med 57(12):1833–1837
Scheinberg DA, Grimm J, Heller DA, Stater EP et al (2017) Advances in the clinical translation of nanotechnology. Curr Opin Biotechnol 46:66–73
Kiessling F, Mertens ME, Grimm J, Lammers T (2014) Nanoparticles for imaging: top or flop? Radiology 273(1):10–28
Gu FX, Karnik R, Wang AZ, Alexis F et al (2007) Targeted nanoparticles for cancer therapy. Nano Today 2(3):14–21
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Perlman, O., Azhari, H. (2018). MRI and Ultrasound Imaging of Nanoparticles for Medical Diagnosis. In: Kumar, C. (eds) Nanotechnology Characterization Tools for Biosensing and Medical Diagnosis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-56333-5_8
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