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Cellular Dedifferentiation and Regenerative Medicine pp 195–245Cite as

Dedifferentiation and Organ Regeneration

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Abstract

Regenerative medicine is an emerging research trend in current biology and medicine. The envious ability of regeneration in lower animals has attracted generations of scientists to explore and investigate the underlying mechanisms. The organogenesis, or organ regeneration, which is composed of parenchyma, functioning cell populations, and vasculature, is indispensable for terrestrial life. In recent years, extensive progress was done in defining organ development’s temporal progression, and exciting findings have been led to by this, including the derivation of assorted epithelium from pluripotent stem cells and the discovery of developmental pathways that are objectives for novel therapeutics. Fresh insights have been also provided by these discoveries into different organs’ regenerative capability. In this review, the author highlights several important and productive research areas in current regenerative medicine. Different animal models are studied with emphasis on specific organs in these animals, ranging from the regeneration of salamander limb, Xenopus tadpole tail, to zebrafish heart and fin. Molecular mechanism is the core content of relevant research, which could be modified and manipulated in the translation to human-based researches and clinical practice. In addition to the common research direction of growth factor, signaling pathway, transcription factors, and epigenetic modulation, this review has also included progenitor cells and potentials of dedifferentiation and transdifferentiation.

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Authors and Affiliations

  1. Key Laboratory of Wound Repair and Regeneration of PLA, The First Hospital Affiliated to the PLA General Hospital, Beijing, China

    Xiaobing Fu

  2. Tianjin Medical University, Tianjin, China

    Andong Zhao

  3. School of Medicine, Nankai University, Tianjin, China

    Tian Hu

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Fu, X., Zhao, A., Hu, T. (2018). Dedifferentiation and Organ Regeneration. In: Cellular Dedifferentiation and Regenerative Medicine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-56179-9_10

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