Skip to main content
SpringerLink
Log in

Fall 11: Spätschäden – 50 Jahre, ♂, DM Typ 1, Frakturheilungsstörung

  • Chapter
  • First Online:
Diabetes-Therapie – informiert entscheiden

  • 2274 Accesses

Zusammenfassung

Ein 50-jähriger Typ-1-Diabetiker mit einem nicht heilenden Knochenbruch und tauben Füßen. Kann eine strikte Zuckerkontrolle ihm bei der Heilung des Knochenbruches helfen?

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 29.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Literatur

  • Ali AA, Weinstein RS, van Stewart SA et al (2005) Rosiglitazone causes bone loss in mice by suppressing osteoblast differentiation and bone formation. Endocrinology 146:1126–1332

    Article  Google Scholar 

  • Beam HA, Parsons JR, Lin SS (2002) The effect of blood glucose control upon fracture healing in the BB Wistar rat with diabetes mellitus. J Orthoped Res 20:1210–1216

    Article  CAS  Google Scholar 

  • Bibbo C, Lin SS, Beam HA, Behrens FF (2001) Complications of ankle fractures in diabetic patients. Orthop Clin North Am 32:113–133

    Article  CAS  Google Scholar 

  • Botolin S, McCabe LR (2007) Bone loss and increased bone adiposity in spontaneous and pharmacologically induced diabetic mice. Endorcrinology 148:198–205

    Article  CAS  Google Scholar 

  • Chandran M (2017) Diabetes drug effects on the skeleton. Calcif Tissue Int 100:133–149

    Article  CAS  Google Scholar 

  • Follack N, Klöting I, Merk H (2005) Influence of diabetic metabolic state on fracture healing in spontaneously diabetic rats. Diabetes Metab Res Rev. 21:228–296

    Google Scholar 

  • Hernandez RK, Di TP, Critchlow CW, Dent RE, Jick SS (2012) Patient related risk factors for fracture healing complications in the United Kingdom general parctice research database. Acta Orthop 83:653–660

    Article  Google Scholar 

  • Loder RT (1988) The influence of diabetes mellitus on the healing of closed fractures. Clin Orthop Rel Res 232:210–2016

    Google Scholar 

  • McCabe LR (2007) Unterstanding the pathology and mechanism of type 1 diabetic bone loss. J. Cell Biochem 102(1343):1357

    Google Scholar 

  • Molinuevo MS, Schurman L, McCarthy AD et al (2010) Effect of metformin on bone marrow progenitor call differentiation: in vivo and in vitro studies. J Bone Min Res 25:211–221

    Article  CAS  Google Scholar 

  • Picke AK, Alaguero G, Campbell GM, Glüer CC, Salbach-Hirsch J, Rauner M, Hofbauer LC, Hofbauer C (2016) Bone defect rgeneration and cortical bone parameters od type 2 diabetic rats are improved by insulin therapy. Bone 82:108–115

    Article  CAS  Google Scholar 

  • Santana RB, Xu L, Chase HB, Amar S, Graves DT, Trackman PC (2003) A role for advanced glycation end products in diminished bone healing in type 1 diabetes. Diabetes 52:1502–1510

    Article  CAS  Google Scholar 

  • Shockley KR, Lazarenko OP, Czernik PF et al (2009) PPAR2 nuclear receptor controls multiple regulatory pathways of osteoblast differentiation from marrow mesenchymal stem cells. J Cell Biochem 106:232–239

    Article  CAS  Google Scholar 

  • Simpson CM, Calori GM, Giannoudis PV (2012) Diabetes and fracture healing: the skeletal effects of diabetic drugs. Expert Opin Drug Saf 11:215–220

    Article  CAS  Google Scholar 

  • Terada M, Inaba M, Yano Y, Hasuma T, Nishizawa Y, Morii H, Otani S (1998) Growth inhibitory effects of a high glucose concentration on osteoblast-like cells. Bone 22:17–23

    Article  CAS  Google Scholar 

  • The diabetes control and complications trial (DCCT)/Epidemiology of diabetes interventions and complications (EDIC) Study research group (2016) Intensive diabetes treatment and cardiovascular outcomes in type 1 diabetes: the DCCT/EDIC study 30 year follow up. Diab Care 39:686–693

    Article  Google Scholar 

  • Wang LX, Jiang HL, Du SL (2015) Observed impacts of insulin therapy on callus cell transforming growth factor ß1 expression in diabetic rats. Genet Mol Res 14:5076–5084

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Abteilung Innere Medizin I, Medizinische Universitätsklinik, Heidelberg, Deutschland

    Chrisitan Kasperk

Authors
  1. Chrisitan Kasperk
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Chrisitan Kasperk .

Editor information

Editors and Affiliations

  1. Abteilung Innere Medizin I, Medizinische Universitätsklinik, Heidelberg, Germany

    Lars Kihm

  2. Abteilung Innere Medizin I, Medizinische Universitätsklinik, Heidelberg, Germany

    Stefan Kopf

  3. Zentrum für Innere Medizin I und klinische Chemie, Medizinische Universitätsklinik, Heidelberg, Germany

    Peter Nawroth

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer-Verlag GmbH Deutschland, ein Teil von Springer Nature

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Kasperk, C. (2018). Fall 11: Spätschäden – 50 Jahre, ♂, DM Typ 1, Frakturheilungsstörung. In: Kihm, L., Kopf, S., Nawroth, P. (eds) Diabetes-Therapie – informiert entscheiden. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-55972-7_11

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-55972-7_11

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-55971-0

  • Online ISBN: 978-3-662-55972-7

  • eBook Packages: Medicine (German Language)

Publish with us

Policies and ethics

Search

Navigation