Skip to main content
SpringerLink
Log in

Nebennierenrinde

  • Chapter
  • First Online:
Funktionsdiagnostik in Endokrinologie, Diabetologie und Stoffwechsel

  • 3889 Accesses

Zusammenfassung

Erläutert werden alle relevanten Funktionstests mit ausführlicher Darstellung von Indikationen, Kontraindikationen, Nebenwirkungen, Testvorbereitung, Rahmenbedingungen, konkreten Handlungsanleitung der eigentlichen Testdurchführung sowie der Interpretation der Testergebnisse. Es werden immer konkrete Normbereiche und Cut-off-Werte angegeben, auch für besondere Situationen (Geschlecht, Alter, BMI, Pubertätsphasen, Zyklusphasen, akute Erkrankungen, Medikamente etc.). Ein besonderes Merkmal ist die Betonung der Testvorbereitung, -durchführung und -interpretation sowie des interdisziplinären Charakters. Gegliedert nach Zona reticularis, Zona fasciculata und Zona glomerulosa werden Nebennierenrinden-Erkrankungen im Hinblick auf die funktionelle Testdiagnostik abgehandelt. Dieses Kapitel ist von eminenter Bedeutung für die endokrinologische Diagnostik per se und ist charakterisiert durch sehr viele verschiedene, teils sehr anspruchsvolle Testverfahren bis hin zum Nebennierenvenen-Katheter. Medikamenteninteraktionen und Interpretation der Testdiagnostik spielen eine praxisrelevante Rolle, ebenso wie die Unterscheidung zwischen Screening-, Bestätigungs- und Lokalisationstests.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 89.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Literatur

  1. Findling JW, Raff H, Aron DC (2004) The low-dose dexamethasone suppression test: a reevaluation in patients with Cushing’s syndrome. J Clin Endocrinol Metab 89:1222–1226

    Article  CAS  PubMed  Google Scholar 

  2. Pecori Giraldi F, Ambrogio AG, De Martin M, Fatti LM, Scacchi M, Cavagnini F (2007) Specificity of first-line tests for the diagnosis of Cushing’s syndrome: assessment in a large series. J Clin Endocrinol Metab 92:4123–4129

    Article  PubMed  Google Scholar 

  3. Isidori AM, Kaltsas GA, Mohammed S, Morris DG, Jenkins P, Chew SL, Monson JP, Besser GM, Grossman AB (2003) Discriminatory value of the low-dose dexamethasone suppression test in establishing the diagnosis and differential diagnosis of Cushing’s syndrome. J Clin Endocrinol Metab 88:5299–5306

    Article  CAS  PubMed  Google Scholar 

  4. Reimondo G, Paccotti P, Minetto M, Termine A, Stura G, Bergui M, Angeli A, Terzolo M (2003) The corticotrophin-releasing hormone test is the most reliable noninvasive method to differentiate pituitary from ectopic ACTH secretion in Cushing’s syndrome. Clin Endocrinol (Oxf) 58:718–724

    Article  CAS  Google Scholar 

  5. Reimondo G, Allasino B, Bovio S, Paccotti P, Angeli A, Terzolo M (2005) Evaluation of the effectiveness of midnight serum cortisol in the diagnostic procedures for Cushing’s syndrome. Eur J Endocrinol 153:803–809

    Article  CAS  PubMed  Google Scholar 

  6. Papanicolaou DA, Mullen N, Kyrou I, Nieman LK (2002) Nighttime salivary cortisol: a useful test for the diagnosis of Cushing’s syndrome. J Clin Endocrinol Metab 87:4515–4521

    Article  CAS  PubMed  Google Scholar 

  7. Funder JW, Carey RM, Fardella C, Gomez-Sanchez CE, Mantero F, Stowasser M, Young WF Jr, Montori VM (2008) Case detection, diagnosis, and treatment of patients with primary aldosteronism: an endocrine society clinical practice guideline. J Clin Endocrinol Metab 93:3266–3281

    Article  CAS  PubMed  Google Scholar 

  8. Diederich S, Bidlingmaier M, Quinkler M, Reincke M (2007) Diagnosis of primary hyperaldosteronism. Med Klin (Munich) 102:16–21

    Article  CAS  Google Scholar 

  9. Phillips JL, Walther MM, Pezzullo JC, Rayford W, Choyke PL, Berman AA, Linehan WM, Doppman JL, Gill JR Jr (2000) Predictive value of preoperative tests in discriminating bilateral adrenal hyperplasia from an aldosterone-producing adrenal adenoma. J Clin Endocrinol Metab 85:4526–4533

    Article  CAS  PubMed  Google Scholar 

  10. Espiner EA, Ross DG, Yandle TG, Richards AM, Hunt PJ (2003) Predicting surgically remedial primary aldosteronism: role of adrenal scanning, posture testing, and adrenal vein sampling. J Clin Endocrinol Metab 88:3637–3644

    Article  CAS  PubMed  Google Scholar 

  11. Holland OB, Brown H, Kuhnert L, Fairchild C, Risk M, Gomez-Sanchez CE (1984) Further evaluation of saline infusion for the diagnosis of primary aldosteronism. Hypertension 6:717–723

    Article  CAS  PubMed  Google Scholar 

  12. Mulatero P, Milan A, Fallo F, Regolisti G, Pizzolo F, Fardella C, Mosso L, Marafetti L, Veglio F, Maccario M (2006) Comparison of confirmatory tests for the diagnosis of primary aldosteronism. J Clin Endocrinol Metab 91:2618–2623

    Article  CAS  PubMed  Google Scholar 

  13. Schirpenbach C, Seiler L, Maser-Gluth C, Rudiger F, Nickel C, Beuschlein F, Reincke M (2006) Confirmatory testing in normokalaemic primary aldosteronism: the value of the saline infusion test and urinary aldosterone metabolites. Eur J Endocrinol 154:865–873

    Article  CAS  PubMed  Google Scholar 

  14. Kem DC, Weinberger MH, Mayes DM, Nugent CA (1971) Saline suppression of plasma aldosterone in hypertension. Arch Intern Med 128:380–386

    Article  CAS  PubMed  Google Scholar 

  15. Young WF (2007) Primary aldosteronism: renaissance of a syndrome. Clin Endocrinol (Oxf) 66:607–618

    Article  CAS  Google Scholar 

  16. Stowasser M, Gordon RD (2004) Primary aldosteronism: careful investigation is essential and rewarding. Mol Cell Endocrinol 217:33–39

    Article  CAS  PubMed  Google Scholar 

  17. Lim PO, Farquharson CA, Shiels P, Jung RT, Struthers AD, MacDonald TM (2001) Adverse cardiac effects of salt with fludrocortisone in hypertension. Hypertension 37:856–861

    Article  CAS  PubMed  Google Scholar 

  18. Giacchetti G, Mulatero P, Mantero F, Veglio F, Boscaro M, Fallo F (2008) Primary aldosteronism, a major form of low renin hypertension: from screening to diagnosis. Trends Endocrinol Metab 19:104–108

    Article  CAS  PubMed  Google Scholar 

  19. Lyons DF, Kem DC, Brown RD, Hanson CS, Carollo ML (1983) Single dose captopril as a diagnostic test for primary aldosteronism. J Clin Endocrinol Metab 57:892–896

    Article  CAS  PubMed  Google Scholar 

  20. Castro OL, Yu X, Kem DC (2002) Diagnostic value of the post-captopril test in primary aldosteronism. Hypertension 39:935–938

    Article  CAS  PubMed  Google Scholar 

  21. Rossi GP, Belfiore A, Bernini G, Desideri G, Fabris B, Ferri C, Giacchetti G, Letizia C, Maccario M, Mallamaci F, Mannelli M, Palumbo G, Rizzoni D, Rossi E, Agabiti-Rosei E, Pessina AC, Mantero F (2007) Comparison of the captopril and the saline infusion test for excluding aldosterone-producing adenoma. Hypertension 50:424–431

    Article  CAS  PubMed  Google Scholar 

  22. Agharazii M, Douville P, Grose JH, Lebel M (2001) Captopril suppression versus salt loading in confirming primary aldosteronism. Hypertension 37:1440–1443

    Article  CAS  PubMed  Google Scholar 

  23. Mulatero P, Bertello C, Garrone C, Rossato D, Mengozzi G, Verhovez A, Fallo F, Veglio F (2007) Captopril test can give misleading results in patients with suspect primary aldosteronism. Hypertension 50:e26–e27

    Article  CAS  PubMed  Google Scholar 

  24. Rossi GP, Seccia TM, Pessina AC (2008) Primary aldosteronism: part II: subtype differentiation and treatment. J Nephrol 21:455–462

    CAS  PubMed  Google Scholar 

  25. Rossi GP, Ganzaroli C, Miotto D, De Toni R, Palumbo G, Feltrin GP, Mantero F, Pessina AC (2006) Dynamic testing with high-dose adrenocorticotrophic hormone does not improve lateralization of aldosterone oversecretion in primary aldosteronism patients. J Hypertens 24:371–379

    Article  CAS  PubMed  Google Scholar 

  26. Gordon RD (1995) Primary aldosteronism. J Endocrinol Invest 18:495–511

    Article  CAS  PubMed  Google Scholar 

  27. Zarnegar R, Young WF Jr, Lee J, Sweet MP, Kebebew E, Farley DR, Thompson GB, Grant CS, Clark OH, Duh QY (2008) The aldosteronoma resolution score: predicting complete resolution of hypertension after adrenalectomy for aldosteronoma. Ann Surg 247:511–518

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Klinik und Poliklinik für Innere Medizin III, Universitätsklinikum Gießen und Marburg (UKGM), Standort Giessen, Giessen, Deutschland

    Andreas Schäffler & Thomas Karrasch

  2. Lehrstuhl für Geriatrie, Universitätsklinikum Aachen, Universität Aachen, Aachen, Deutschland

    Cornelius Bollheimer

  3. Abteilung für Innere Medizin, Caritas Krankenhaus St. Josef, Regensburg, Regensburg, Deutschland

    Roland Büttner

  4. Klinik für Allgemeine Innere Medizin und Geriatrie, Krankenhaus der Barmherzigen Brüder, Regensburg, Deutschland

    Christiane Girlich

  5. Institut für Klinische Chemie und Laboratoriumsmedizin, Klinikum der Universität Regensburg, Regensburg, Deutschland

    Charalampos Aslanidis

  6. Institut für Pathologie, Klinikum der Universität Regensburg, Regensburg, Deutschland

    Wolfgang Dietmaier

  7. Medizinische Klinik und Poliklinik I, Universitätsklinikum Würzburg, Würzburg, Deutschland

    Margarita Bala

  8. Abteilung für Innere Medizin, Klinikum Bogen, Bogen, Deutschland

    Viktoria Guralnik

  9. Klinik und Poliklinik für Innere Medizin I, Klinikum der Universität Regensburg, Regensburg, Deutschland

    Sylvia Schneider

Authors
  1. Andreas Schäffler
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Cornelius Bollheimer
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Roland Büttner
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Christiane Girlich
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Charalampos Aslanidis
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Wolfgang Dietmaier
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Margarita Bala
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Viktoria Guralnik
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Thomas Karrasch
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Sylvia Schneider
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Andreas Schäffler .

Editor information

Editors and Affiliations

  1. Medizinische Klinik und Poliklinik III, Universitätsklinikum Gießen und Marburg (UKGM), Standort Gießen, Gießen, Germany

    Andreas Schäffler

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer-Verlag GmbH Deutschland

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Schäffler, A. et al. (2018). Nebennierenrinde. In: Schäffler, A. (eds) Funktionsdiagnostik in Endokrinologie, Diabetologie und Stoffwechsel. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-55914-7_9

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-55914-7_9

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-55913-0

  • Online ISBN: 978-3-662-55914-7

  • eBook Packages: Medicine (German Language)

Publish with us

Policies and ethics

Search

Navigation