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Neurologische Komplikationen entzündlicher Darmerkrankungen

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Zusammenfassung

Mit einigen entzündlichen Darmerkrankungen sind neurologische Symptome assoziiert, die zum Teil das Krankheitsbild wesentlich mit charakterisieren und die Diagnosestellung erleichtern oder überhaupt erst ermöglichen. In anderen Fällen ist die Verknüpfung schwer zu belegen und läuft somit Gefahr, übersehen zu werden – insbesondere, wenn neurologische Symptome den intestinalen vorausgehen oder umgekehrt bzw. andere mögliche Ursachen bestehen. Neurologische Komplikationen sind sowohl bei den chronisch entzündlichen Darmerkrankungen im engeren Sinne als auch bei der Zöliakie und auch beim durch grampositive Bakterien verursachten Morbus Whipple beschrieben. Dieses Kapitel fasst die Literatur zu neurologischen Komplikationen der genannten entzündlichen Darmerkrankungen hinsichtlich ihrer Charakteristika, Diagnostik, Abgrenzung anderer Ursachen und therapeutischer Strategien zusammen.

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Literatur

  • Addolorato G, Di Giuda D, De Rossi G, Valenza V, Domenicali M, Caputo F et al (2004) Regional cerebral hypoperfusion in patients with celiac disease. Am J Med 116(5):312–317

    Article  PubMed  Google Scholar 

  • Akbayir N, Calis AB, Alkim C, Sokmen HM, Erdem L, Ozbal A et al (2005) Sensorineural hearing loss in patients with inflammatory bowel disease: a subclinical extraintestinal manifestation. Dig Dis Sci 50(10):1938–1945

    Article  PubMed  Google Scholar 

  • Anderson M (2000) Neurology of Whipple’s disease. J Neurol Neurosurg Psychiatry 68(1):2–5

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • van Assche G, Van Ranst M, Sciot R, Dubois B, Vermeire S, Noman M et al (2005) Progressive multifocal leukoencephalopathy after natalizumab therapy for Crohn‘s disease. New Engl J Med 353(4):362–368

    Article  PubMed  Google Scholar 

  • Bachmann O, Langer F, Rademacher J (2010) Pulmonary manifestations of inflammatory bowel disease. Der Internist 51(Suppl 1):264–268

    Article  PubMed  Google Scholar 

  • Barbado FJ, Vazquez JJ, Gil A, Ortiz Vazquez J (1980) Vasculitis and ulcerative colitis. Gastroenterol 79(2):417–418

    CAS  Google Scholar 

  • Baron BW, Jeon HR, Glunz C, Peterson A, Cohen R, Hanauer S et al (2002) First two patients with ulcerative colitis who developed classical thrombotic thrombocytopenic purpura successfully treated with medical therapy and plasma exchange. J Clin Apheresis 17(4):204–206

    Article  PubMed  Google Scholar 

  • Baumgart DC, Sandborn WJ (2007) Inflammatory bowel disease: clinical aspects and established and evolving therapies. Lancet 369(9573):1641–1657

    Article  CAS  PubMed  Google Scholar 

  • Berden JH, Hoitsma AJ, Merx JL, Keyser A (1985) Severe central-nervous-system toxicity associated with cyclosporin. Lancet 1(8422):219–220

    Article  CAS  PubMed  Google Scholar 

  • Bernstein CN, Wajda A, Blanchard JF (2005) The clustering of other chronic inflammatory diseases in inflammatory bowel disease: a population-based study. Gastroenterol 129(3):827–836

    Article  Google Scholar 

  • Boulos A, Rolain JM, Raoult D (2004) Antibiotic susceptibility of Tropheryma whipplei in MRC5 cells. Antimicrob Agents Chemother 48(3):747–752

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Burk K, Bosch S, Muller CA, Melms A, Zuhlke C, Stern M et al (2001a) Sporadic cerebellar ataxia associated with gluten sensitivity. Brain: J Neurol 124(5):1013–1019

    Article  CAS  Google Scholar 

  • Burk K, Melms A, Schulz JB, Dichgans J (2001b) Effectiveness of intravenous immunoglobin therapy in cerebellar ataxia associated with gluten sensitivity. Ann Neurol 50(6):827–828

    Article  CAS  PubMed  Google Scholar 

  • Carmona MA, Jaume Anselmi F, Ramirez Rivera J (2000) Cerebral thrombosis and vasculitis: an uncommon complication of ulcerative colitis. Bol Asoc Med P R 92(1–3):9–11

    PubMed  CAS  Google Scholar 

  • Colombel JF, Loftus EV Jr, Tremaine WJ, Egan LJ, Harmsen WS, Schleck CD et al (2004) The safety profile of infliximab in patients with Crohn’s disease: the Mayo clinic experience in 500 patients. Gastroenterol 126(1):19–31

    Article  CAS  Google Scholar 

  • Cortese I, Chaudhry V, So YT, Cantor F, Cornblath DR, Rae-Grant A (2011) Evidence-based guideline update: plasmapheresis in neurologic disorders: report of the therapeutics and technology assessment subcommittee of the American academy of Neurology. Neurol 76(3):294–300

    Article  CAS  Google Scholar 

  • Dimitrova AK, Ungaro RC, Lebwohl B, Lewis SK, Tennyson CA, Green MW et al (2013) Prevalence of migraine in patients with celiac disease and inflammatory bowel disease. Headache 53(2):344–355

    Article  PubMed  Google Scholar 

  • Druschky A, Heckmann J, Engelhardt A, Neundorfer (1996) Myositis – a rare complication of Crohn disease. Fortschr Neurol Psychiatr 64(10):422–424

    Article  CAS  PubMed  Google Scholar 

  • Duffy LF, Daum F, Fisher SE, Selman J, Vishnubhakat SM, Aiges HW et al (1985) Peripheral neuropathy in Crohn’s disease patients treated with metronidazole. Gastroenterol 88(3):681–684

    Article  CAS  Google Scholar 

  • Elsehety A, Bertorini TE (1997) Neurologic and neuropsychiatric complications of Crohn‘s disease. S Med J 90(6):606–610

    Article  CAS  Google Scholar 

  • Felber J, Aust D, Baas S, Bischoff S, Blaker H, Daum S et al (2014) Results of a S2k-Consensus Conference of the German Society of Gastroenterolgy, Digestive- and Metabolic Diseases (DGVS) in conjunction with the German Coeliac Society (DZG) regarding coeliac disease, wheat allergy and wheat sensitivity. Z Gastroenterol 52(7):711–743

    Article  CAS  PubMed  Google Scholar 

  • Ferrante M, de Hertogh G, Hlavaty T, D‘Haens G, Penninckx F, D‘Hoore A et al (2006) The value of myenteric plexitis to predict early postoperative Crohn’s disease recurrence. Gastroenterol 130(6):1595–1606

    Article  Google Scholar 

  • Ferro JM, Oliveira S (2014) Neurologic manifestations of gastrointestinal and liver diseases. Curr Neurol Neurosci Rep 14(10):487

    Article  CAS  PubMed  Google Scholar 

  • Feurle GE, Moos V, Schneider T, Fenollar F, Raoult D (2012) The combination of chloroquine and minocycline, a therapeutic option in cerebrospinal infection of Whipple‘s disease refractory to treatment with ceftriaxone, meropenem and co-trimoxazole. J Antimicrob Chemother 67(5):1295–1296

    Article  CAS  PubMed  Google Scholar 

  • Figueroa JJ, Loftus EV Jr, Harmsen WS, Dyck PJ, Klein CJ (2013) Peripheral neuropathy incidence in inflammatory bowel disease: a population-based study. Neurol 80(18):1693–1697

    Article  Google Scholar 

  • Final report on the safety assessment of Ricinus (2007) Communis (Castor) Seed Oil, Hydrogenated Castor Oil, Glyceryl Ricinoleate, Glyceryl Ricinoleate SE, Ricinoleic Acid, Potassium Ricinoleate, Sodium Ricinoleate, Zinc Ricinoleate, Cetyl Ricinoleate, Ethyl Ricinoleate, Glycol Ricinoleate, Isopropyl Ricinoleate, Methyl Ricinoleate, and Octyldodecyl Ricinoleate. Int J Toxicol 26(Suppl 3):31–77

    Google Scholar 

  • Finnie IA, Shields R, Sutton R, Donnelly R, Morris AI (1994) Crohn‘s disease and myasthenia gravis: a possible role for thymectomy. Gut 35(2):278–279

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Freeman HJ (2008) Neurological disorders in adult celiac disease. Can J Gastroenterol = J Can gastroenterol 22(11):909–911

    Article  Google Scholar 

  • Galldiks N, Burghaus L, Vollmar S, Cizek J, Impekoven P, Thomas A et al (2004) Novel neuroimaging findings in a patient with cerebral Whipple‘s disease: a magnetic resonance imaging and positron emission tomography study. J Neuroimaging 4(4):372–376

    Article  Google Scholar 

  • Gelfenbeyn M, Goodkin R, Kliot M (2006) Sterile recurrent spinal epidural abscess in a patient with Crohn’s disease: a case report. Surg Neurol 65(2):178–184

    Article  PubMed  Google Scholar 

  • Gerard A, Sarrot-Reynauld F, Liozon E, Cathebras P, Besson G, Robin C et al (2002) Neurologic presentation of Whipple disease: report of 12 cases and review of the literature. Med 81(6):443–457

    Article  Google Scholar 

  • Gobbele R, Reith W, Block F (2000) Cerebral vasculitis as a concomitant neurological illness in Crohn’s disease. Der Nervenarzt 71(4):299–304

    Article  CAS  PubMed  Google Scholar 

  • Gobbi G, Bouquet F, Greco L, Lambertini A, Tassinari CA, Ventura A et al (1992) Coeliac disease, epilepsy, and cerebral calcifications. The Italian Working Group on Coeliac Disease and Epilepsy. Lancet 340(8817):439–443

    Article  CAS  PubMed  Google Scholar 

  • Gondim FA, Brannagan TH 3rd, Sander HW, Chin RL, Latov N (2005) Peripheral neuropathy in patients with inflammatory bowel disease. Brain: J Neurol 128(4):867–879

    Article  CAS  Google Scholar 

  • Gower-Rousseau C, Reumaux D, Bellard M, Delecourt L, Ribet M, Colombel JF (1993) Remission of myasthenia gravis after proctocolectomy in a patient with ulcerative colitis. Am J Gastroenterol 88(7):1136–1138

    PubMed  CAS  Google Scholar 

  • Gupta G, Gelfand JM, Lewis JD (2005) Increased risk for demyelinating diseases in patients with inflammatory bowel disease. Gastroenterol 129(3):819–826

    Article  Google Scholar 

  • Hadjivassiliou M, Aeschlimann P, Sanders DS, Maki M, Kaukinen K, Grunewald RA et al (2013) Transglutaminase 6 antibodies in the diagnosis of gluten ataxia. Neurol 80(19):1740–1745

    Article  CAS  Google Scholar 

  • Hadjivassiliou M, Boscolo S, Davies-Jones GA, Grunewald RA, Not T, Sanders DS et al (2002) The humoral response in the pathogenesis of gluten ataxia. Neurol 58(8):1221–1226

    Article  CAS  Google Scholar 

  • Hadjivassiliou M, Davies-Jones GA, Sanders DS, Grunewald RA (2003) Dietary treatment of gluten ataxia. J Neurol Neurosurg Psychiatry 74(9):1221–1224

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hadjivassiliou M, Duker AP, Sanders DS (2014) Gluten-related neurologic dysfunction. Handb Clin Neurol 120:607–619

    Article  PubMed  Google Scholar 

  • Hadjivassiliou M, Sanders DD, Aeschlimann DP (2015) Gluten-related disorders: gluten ataxia. Dig Dis 33(2):264–268

    Article  PubMed  Google Scholar 

  • Hadjivassiliou M, Sanders DS, Grunewald RA, Woodroofe N, Boscolo S, Aeschlimann D (2010) Gluten sensitivity: from gut to brain. Lancet Neurol 9(3):318–330

    Article  CAS  PubMed  Google Scholar 

  • Hadjivassiliou M, Sanders DS, Woodroofe N, Williamson C, Grunewald RA (2008) Gluten ataxia. Cerebellum 7(3):494–498

    Article  CAS  PubMed  Google Scholar 

  • Hagel S, Epple HJ, Feurle GE, Kern WV, Lynen Jansen P, Malfertheiner P et al (2015) S2k-guideline gastrointestinal infectious diseases and Whipple’s disease. Z Gastroenterol 53(5):418–459

    Article  CAS  PubMed  Google Scholar 

  • von Herbay A, Ditton HJ, Schuhmacher F, Maiwald M (1997) Whipple‘s disease: staging and monitoring by cytology and polymerase chain reaction analysis of cerebrospinal fluid. Gastroenterol 113(2):434–441

    Article  Google Scholar 

  • Heuer DK, Gager WE, Reeser FH (1982) Ischemic optic neuropathy associated with Crohn‘s disease. J Clin Neuroophthalmol 2(3):175–181

    PubMed  CAS  Google Scholar 

  • Humbert P, Monnier G, Billerey C, Birgen C, Dupond JL (1989) Polyneuropathy: an unusual extraintestinal manifestation of Crohn’s disease. Acta Neurol Scand 80(4):301–306

    Article  CAS  PubMed  Google Scholar 

  • Hunt KA, Zhernakova A, Turner G, Heap GA, Franke L, Bruinenberg M et al (2008) Newly identified genetic risk variants for celiac disease related to the immune response. Nat Genet 40(4):395–402

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Johns DR (1991) Cerebrovascular complications of inflammatory bowel disease. Am J Gastroenterol 86(3):367–370

    PubMed  CAS  Google Scholar 

  • Karajeh MA, Hadjivassiliou M, Hurlstone P, Grundman MJ (2004) Neurological sequelae of Crohn’s disease: opportunity to study common etiological pathways. J Gastroenterol Hepatol 19(9):1093–1094

    Article  PubMed  Google Scholar 

  • Lagier JC, Fenollar F, Lepidi H, Giorgi R, Million M, Raoult D (2014) Treatment of classic Whipple‘s disease: from in vitro results to clinical outcome. J Antimicrob Chemother 69(1):219–227

    Article  CAS  PubMed  Google Scholar 

  • Lagier JC, Fenollar F, Lepidi H, Raoult D (2010) Failure and relapse after treatment with trimethoprim/sulfamethoxazole in classic Whipple‘s disease. J Antimicrob Chemother 65(9):2005–2012

    Article  CAS  PubMed  Google Scholar 

  • Lam MC, Bressler B (2014) Vedolizumab for ulcerative colitis and Crohn‘s disease: results and implications of GEMINI studies. Immunother 6(9):963–971

    Article  CAS  Google Scholar 

  • Le Blay P, Rakotonirainy H, Lagier JC, Raoult D, Puechal X, Pers YM (2014) A severe Whipple disease with an immune reconstitution inflammatory syndrome: an additional case of thalidomide efficiency. Jt Bone spine: Rev Rhum 81(3):260–262

    Article  Google Scholar 

  • Levenstein S, Prantera C, Varvo V, Scribano ML, Andreoli A, Luzi C et al (2000) Stress and exacerbation in ulcerative colitis: a prospective study of patients enrolled in remission. Am J Gastroenterol 95(5):1213–1220

    Article  CAS  PubMed  Google Scholar 

  • Lossos A, River Y, Eliakim A, Steiner I (1995) Neurologic aspects of inflammatory bowel disease. Neurol 45(3 Pt 1):416–421

    Article  CAS  Google Scholar 

  • Louis ED (2003) Whipple disease. Curr Neurol Neurosci Rep 3(6):470–475

    Article  PubMed  Google Scholar 

  • Louis ED, Lynch T, Kaufmann P, Fahn S, Odel J (1996) Diagnostic guidelines in central nervous system Whipple‘s disease. Ann Neurol 40(4):561–568

    Article  CAS  PubMed  Google Scholar 

  • Luostarinen L, Himanen SL, Luostarinen M, Collin P, Pirttila T (2003) Neuromuscular and sensory disturbances in patients with well treated coeliac disease. J Neurol Neurosurg Psychiatry 74(4):490–494

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Mahnel R, Marth T (2004) Progress, problems, and perspectives in diagnosis and treatment of Whipple’s disease. Clin Exp Med 4(1):39–43

    Article  CAS  PubMed  Google Scholar 

  • Manzel K, Tranel D, Cooper G (2000) Cognitive and behavioral abnormalities in a case of central nervous system Whipple disease. Arch Neurol 57(3):399–403

    Article  CAS  PubMed  Google Scholar 

  • Masuda H, Ishii U, Aoki N, Nakayama H, Sato F, Karube H et al (2002) Ulcerative colitis associated with Takayasu’s disease in two patients who received proctocolectomy. J Gastroenterol 37(4):297–302

    Article  PubMed  Google Scholar 

  • Menard DB, Haddad H, Blain JG, Beaudry R, Devroede G, Masse S (1976) Granulomatous myositis and myopathy associated with crohn’s colitis. N Engl J Med 295(15):818–819

    Article  CAS  PubMed  Google Scholar 

  • Miehsler W, Reinisch W, Valic E, Osterode W, Tillinger W, Feichtenschlager T et al (2004) Is inflammatory bowel disease an independent and disease specific risk factor for thromboembolism? Gut 53(4):542–548

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Moos V, Feurle GE, Schinnerling K, Geelhaar A, Friebel J, Allers K et al (2013) Immunopathology of immune reconstitution inflammatory syndrome in Whipple’s disease. J Immunol 190(5):2354–2361

    Article  CAS  PubMed  Google Scholar 

  • Murai H, Tokunaga H, Kubo I, Kawajiri M, Iwaki T, Taniwaki T et al (2006) Myeloradiculitis caused by Cryptococcus neoformans infection in a patient with ulcerative colitis: a neuropathological study. J Neurol Sci 247(2):236–238

    Article  PubMed  Google Scholar 

  • Nelson J, Barron MM, Riggs JE, Gutmann L, Schochet SS Jr (1986) Cerebral vasculitis and ulcerative colitis. Neurol 36(5):719–721

    Article  CAS  Google Scholar 

  • Oldenburg B, Van Tuyl BA, van der Griend R, Fijnheer R, van Berge Henegouwen GP (2005) Risk factors for thromboembolic complications in inflammatory bowel disease: the role of hyperhomocysteinaemia. Dig Dis Sci 50(2):235–240

    Article  CAS  PubMed  Google Scholar 

  • Panani AD, Grigoriadou M, Magira E, Roussos C, Raptis SA (2006) Perinuclear antineutrophil cytoplasmic antibody myeloperoxidase-positive vasculitis in association with ulcerative colitis. Clin Rheumatol 25(1):35–37

    Article  PubMed  Google Scholar 

  • Purrmann J, Arendt G, Cleveland S, Borchard F, Furst W, Gemsa R et al (1992) Association of Crohn’s disease and multiple sclerosis. Is there a common background? J Clin Gastroenterol 14(1):43–46

    Article  CAS  PubMed  Google Scholar 

  • Qureshi JA, Staugaitis SM, Calabrese LH (2002) Neutrophilic myositis: an extra-intestinal manifestation of ulcerative colitis. J Clin Rheumatol 8(2):85–88

    Article  PubMed  Google Scholar 

  • Rashtak S, Ettore MW, Homburger HA, Murray JA (2008) Comparative usefulness of deamidated gliadin antibodies in the diagnosis of celiac disease. Clin Gastroenterol Hepatol 6(4):426–432; quiz 370

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Reinshagen M, Folsch UR (2004) Extraintestinal manifestations in ulcerative colitis. Z Gastroenterol 42(9):1024–1028

    PubMed  CAS  Google Scholar 

  • Richard S, Fairise A, Lacour JC, Ducrocq X (2010) Cerebral venous thrombosis in inflammatory bowel diseases. Inflamm Bowel Dis 16(3):366–367

    Article  PubMed  Google Scholar 

  • Romero Aroca P, Salvat Serra M, Perena Soriano F, Martinez Salcedo I (2001) Anterior optic neuritis do to ulcerative colitis. Arch Soc Esp Oftalmologia 76(3):189–191

    CAS  Google Scholar 

  • Scheid R, Teich N (2007) Neurologic manifestations of ulcerative colitis. Eur J Neurol 14(5):483–493

    Article  CAS  PubMed  Google Scholar 

  • van de Scheur MR, van der Waal RI, van Bodegraven AA, Volker-Dieben HJ, Starink TM, van der Waal I (2002) Cheilitis granulomatosa and optic neuropathy as rare extraintestinal manifestations of Crohn’s disease. J Clin Gastroenterol 34(5):557–559

    Article  PubMed  Google Scholar 

  • Schnider PJ, Reisinger EC, Gerschlager W, Muller C, Berger T, Krejs GJ et al (1996) Long-term follow-up in cerebral Whipple’s disease. Eur J Gastroenterol Hepatol 8(9):899–903

    PubMed  CAS  Google Scholar 

  • Shen TC, Lebwohl B, Verma H, Kumta N, Tennyson C, Lewis S et al (2012) Peripheral neuropathic symptoms in celiac disease and inflammatory bowel disease. J Clin Neuromuscul Dis 13(3):137–145

    Article  PubMed  Google Scholar 

  • Tarabar D, Hirsch A, Rubin DT (2016) Vedolizumab in the treatment of Crohn’s disease. Expert Rev Gastroenterol Hepatol 10(3):283–290

    Article  CAS  PubMed  Google Scholar 

  • Thomas CW Jr, Weinshenker BG, Sandborn WJ (2004) Demyelination during anti-tumor necrosis factor alpha therapy with infliximab for Crohn’s disease. Inflamm Bowel Dis 10(1):28–31

    Article  PubMed  Google Scholar 

  • Watkinson G (1986) Sulphasalazine: a review of 40 years’ experience. Drugs 32(Suppl 1):1–11

    Article  PubMed  Google Scholar 

  • Weber P, Husemann S, Vielhaber H, Zimmer KP, Nowak-Gottl U (1999) Coagulation and fibrinolysis in children, adolescents, and young adults with inflammatory bowel disease. J Pediatr Gastroenterol Nutr 28(4):418–422

    Article  CAS  PubMed  Google Scholar 

  • West J, Logan RF, Hill PG, Lloyd A, Lewis S, Hubbard R et al (2003) Seroprevalence, correlates, and characteristics of undetected coeliac disease in England. Gut 52(7):960–965

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Whipple G (1907) A hitherto undescribed disease characterized anatomically by deposits of fat and fatty acid in the intestinal and mesenteric lymphatic tissues. Bull Johns Hopkins Hosp 18:382–393

    CAS  Google Scholar 

  • WJ SRaS (Hrsg) (2004) Inflammatory bowel diseases: saunders

    Google Scholar 

  • Yesilova Z, Naharci I, Uygun A, Ulas HU, Dagalp K (2006) Motor axonal polyneuropathy in the course of ulcerative colitis: a case report. Turk J Gastroenterol 17(1):58–61

    PubMed  Google Scholar 

  • Zois CD, Katsanos KH, Kosmidou M, Tsianos EV (2010) Neurologic manifestations in inflammatory bowel diseases: current knowledge and novel insights. J Crohn’s Colitis 4(2):115–124

    Article  Google Scholar 

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Bachmann, O., Wehnert, N. (2018). Neurologische Komplikationen entzündlicher Darmerkrankungen. In: Stangel, M., Mäurer, M. (eds) Autoimmunerkrankungen in der Neurologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-55530-9_10

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