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Tumoren des Skeletts

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Zusammenfassung

Skeletttumoren werden in allen Haustierspezies beschrieben. Häufig sind sie jedoch nur beim Hund, und sie werden bei der Katze regelmäßig beobachtet. Osteosarkome sind mit 90 % die wichtigsten Tumoren des knöchernen Skeletts. Chondrosarkome, Fibrosarkome und Hämangiosarkome machen die restlichen 10 % der Skeletttumoren aus.

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Weiterführende Literatur

  • Alexander K, Joly H, Blond L, D’Anjou MA, Nadeau ME, Olive J, Beauchamp G (2012) A comparison of computed tomography, computed radiography, and film-screen radiography for the detection of canine pulmonary nodules. Vet Radiol Ultrasound 53:258–265

    PubMed  Google Scholar 

  • Amsellem PM, Selmic LE, Wypij JM, Bacon NJ, Culp WT, Ehrhart NP, Powers BE, Stryhn H, Farese JP (2014) Appendicular osteosarcoma in small-breed dogs: 51 cases (1986–2011). J Am Vet Med Assoc 245:203–210

    Article  PubMed  Google Scholar 

  • Armbrust LJ, Biller DS, Bamford A, Chun R, Garrett LD, Sanderson MW (2012) Comparison of three-view thoracic radiography and computed tomography for detection of pulmonary nodules in dogs with neoplasia. J Am Vet Med Assoc 240:1088–1094

    Article  PubMed  Google Scholar 

  • Ballegeer EA, Adams WM, Dubielzig RR, Paoloni MC, Klauer JM, Keuler NS (2010) Computed tomography characteristics of canine tracheobronchial lymph node metastasis. Vet Radiol Ultrasound 51:397–403

    Article  PubMed  Google Scholar 

  • Barrett LE, Pollard RE, Zwingenberger A, Zierenberg-Ripoll A, Skorupski KA (2014) Radiographic characterization of primary lung tumors in 74 dogs. Vet Radiol Ultrasound 55:480–487

    Article  PubMed  Google Scholar 

  • Bettini G, Marconato L, Morini M, Ferrari F (2009) Thyroid transcription factor-1 immunohistochemistry: diagnostic tool and malignancy marker in canine malignant lung tumours. Vet Comp Oncol 7:28–37

    Article  CAS  PubMed  Google Scholar 

  • Bitetto WV, Patnaik AK, Schrader SC, Mooney SC (1987) Osteosarcoma in cats: 22 cases (1974–1984). J Am Vet Med Assoc 190:91–93

    CAS  PubMed  Google Scholar 

  • Bongiovanni L, Mazzocchetti F, Malatesta D, Romanucci M, Ciccarelli A, Buracco P, De Maria R, Palmieri C, Martano M, Morello E, Maniscalco L, Della Salda L (2012) Immunohistochemical investigation of cell cycle and apoptosis regulators (survivin, beta-catenin, p53, caspase 3) in canine appendicular osteosarcoma. BMC Vet Res 8(78):1–4

    Google Scholar 

  • Bray JP, Worley DR, Henderson RA, Boston SE, Mathews KG, Romanelli G, Bacon NJ, Liptak JM, Scase TJ (2014) Hemipelvectomy: outcome in 84 dogs and 16 cats, A veterinary society of surgical oncology retrospective study. Vet Surg 43:27–37

    Article  PubMed  Google Scholar 

  • Brodey RS, Misdorp W, Riser WH, Van Der Heul RO (1974) Canine skeletal chondrosarcoma: a clinicopathologic study of 35 cases. J Am Vet Med Assoc 165:68–78

    CAS  PubMed  Google Scholar 

  • Culp WT, Olea-Popelka F, Sefton J, Aldridge CF, Withrow SJ, Lafferty MH, Rebhun RB, Kent MS, Ehrhart N (2014) Evaluation of outcome and prognostic factors for dogs living greater than one year after diagnosis of osteosarcoma: 90 cases (1997–2008). J Am Vet Med Assoc 245:1141–1146

    Article  PubMed  PubMed Central  Google Scholar 

  • D’Costa S, Yoon BI, Kim DY, Motsinger-Reif AA, Williams M, Kim Y (2012) Morphologic and molecular analysis of 39 spontaneous feline pulmonary carcinomas. Vet Pathol 49:971–978

    Article  PubMed  Google Scholar 

  • Dimopoulou M, Kirpensteijn J, Moens H, Kik M (2008) Histologic prognosticators in feline osteosarcoma: a comparison with phenotypically similar canine osteosarcoma. Vet Surg 37:466–471

    Article  PubMed  Google Scholar 

  • Eberle N, Fork M, Von Babo V, Nolte I, Simon D (2011) Comparison of examination of thoracic radiographs and thoracic computed tomography in dogs with appendicular osteosarcoma. Vet Comp Oncol 9:131–140

    Article  CAS  PubMed  Google Scholar 

  • Enneking WF, Spanier SS, Goodman MA (1980) A system for the surgical staging of musculoskeletal sarcoma. Clin Orthop Relat Res 153:106–120

    Google Scholar 

  • Evans HL, Ayala AG, Romsdahl MM (1977) Prognostic factors in chondrosarcoma of bone: a clinicopathologic analysis with emphasis on histologic grading. Cancer 40:818–831

    Article  CAS  PubMed  Google Scholar 

  • Farese JP, Kirpensteijn J, Kik M, Bacon NJ, Waltman SS, Seguin B, Kent M, Liptak J, Straw R, Chang MN, Jiang Y, Withrow SJ (2009) Biologic behavior and clinical outcome of 25 dogs with canine appendicular chondrosarcoma treated by amputation: a Veterinary Society of Surgical Oncology retrospective study. Vet Surg 38:914–919

    Article  PubMed  Google Scholar 

  • Goldfinch N, Argyle DJ (2012) Feline lung-digit syndrome: unusual metastatic patterns of primary lung tumours in cats. J Feline Med Surg 14:202–208

    Article  PubMed  Google Scholar 

  • Gottfried SD, Popovitch CA, Goldschmidt MH, Schelling C (2000) Metastatic digital carcinoma in the cat: a retrospective study of 36 cats (1992–1998). J Am Anim Hosp Assoc 36:501–509

    Article  CAS  PubMed  Google Scholar 

  • Hahn KA, McEntee MF (1997) Primary lung tumors in cats: 86 cases (1979–1994). J Am Vet Med Assoc 211:1257–1260

    CAS  PubMed  Google Scholar 

  • Hahn KA, McGavin MD, Adams WH (1997) Bilateral renal metastases of nasal chondrosarcoma in a dog. Vet athol 34:352–355.

    Article  CAS  Google Scholar 

  • Hahn KA, McEntee MF (1998) Prognosis factors for survival in cats after removal of a primary lung tumor: 21 cases (1979–1994). Vet Surg 27:307–311

    Article  CAS  PubMed  Google Scholar 

  • Heldmann E, Anderson MA, Wagner-Mann C (2000) Feline osteosarcoma: 145 cases (1990–1995). J Am Anim Hosp Assoc 36:518–521

    Article  CAS  PubMed  Google Scholar 

  • Helm J, Morris J (2012) Musculoskeletal neoplasia: an important differential for lumps or lameness in the cat. J Feline Med Surg 14:43–54

    Article  PubMed  Google Scholar 

  • Hodge SC, Degner D, Walshaw R, Teunissen B (2011) Vascularized ulnar bone grafts for limb-sparing surgery for the treatment of distal radial osteosarcoma. J Am Anim Hosp Assoc 47:98–111

    Article  PubMed  Google Scholar 

  • Karlsson EK, Sigurdsson S, Ivansson E, Thomas R, Elvers I, Wright J, Howald C, Tonomura N, Perloski M, Swofford R, Biagi T, Fryc S, Anderson N, Courtay-Cahen C, Youell L, Ricketts SL, Mandlebaum S, Rivera P, Von Euler H, Kisseberth WC, London CA, Lander ES, Couto G, Comstock K, Starkey MP, Modiano JF, Breen M, Lindblad-Toh K (2013) Genome-wide analyses implicate 33 loci in heritable dog osteosarcoma, including regulatory variants near CDKN2A/B. Genome Biol 14:R132

    Article  PubMed  PubMed Central  Google Scholar 

  • Kim J, Kwon SY, Cena R, Park S, Oh J, Oui H, Cho KO, Min JJ, Choi J (2014) CT and PET-CT of a dog with multiple pulmonary adenocarcinoma. J Vet Med Sci 76:615–620

    Article  PubMed  Google Scholar 

  • Kirpensteijn J, Kik M, Rutteman GR, Teske E (2002) Prognostic significance of a new histologic grading system for canine osteosarcoma. Vet Pathol 39:240–246

    Article  CAS  PubMed  Google Scholar 

  • Kujawa A, Olias P, Bottcher A, Klopfleisch R (2014) Thyroid transcription factor-1 is a specific marker of benign but not malignant feline lung tumours. J Comp Pathol 151:19–24

    Article  CAS  PubMed  Google Scholar 

  • Lee JH, Lee JH, Yoon HY, Kim NH, Sur JH, Jeong SW (2012) Hypertrophic osteopathy associated with pulmonary adenosquamous carcinoma in a dog. J Vet Med Sci 74:667–672

    Article  PubMed  Google Scholar 

  • Liu SK, Dorfman HD, Patnaik AK (1974) Primary and secondary bone tumours in the cat. J Small Anim Pract 15:141–156

    Article  CAS  PubMed  Google Scholar 

  • MacEwen EG, Pastor J, Kutzke J, Tsan R, Kurzman ID, Thamm DH, Wilson M, Radinsky R (2004) IGF-1 receptor contributes to the malignant phenotype in human and canine osteosarcoma. J Cell Biochem 92:77–91.

    Article  CAS  PubMed  Google Scholar 

  • Maniscalco L, Iussich S, Morello E, Martano M, Gattino F, Miretti S, Biolatti B, Accornero P, Martignani E, Sanchez-Cespedes R, Buracco P, De Maria R (2014) Increased expression of insulin-like growth factor-1 receptor is correlated with worse survival in canine appendicular osteosarcoma. Vet J 205:272–280

    Article  PubMed  Google Scholar 

  • Maritato KC, Schertel ER, Kennedy SC, Dudley R, Lamm C, Barnhart M, Kass P (2014) Outcome and prognostic indicators in 20 cats with surgically treated primary lung tumors. J Feline Med Surg 16:979–984

    Article  PubMed  Google Scholar 

  • Mayhew PD, Hunt GB, Steffey MA, Culp WT, Mayhew KN, Fuller M, Johnson LR, Pascoe PJ (2013) Evaluation of short-term outcome after lung lobectomy for resection of primary lung tumors via video-assisted thoracoscopic surgery or open thoracotomy in medium- to large-breed dogs. J Am Vet Med Assoc 243:681–688

    Article  PubMed  Google Scholar 

  • McCleese JK, Bear MD, Kulp SK, Mazcko C, Khanna C, London CA (2013) Met interacts with EGFR and Ron in canine osteosarcoma. Vet Comp Oncol 11:124–139

    Article  CAS  PubMed  Google Scholar 

  • McEntee MC (1997) Radiation therapy in the management of bone tumors. Vet Clin North Am Small Anim Pract 27:131–138

    Article  CAS  PubMed  Google Scholar 

  • McNiel EA, Ogilvie GK, Powers BE, Hutchison JM, Salman MD, Withrow SJ (1997) Evaluation of prognostic factors for dogs with primary lung tumors: 67 cases (1985–1992). J Am Vet Med Assoc 211:1422–1427

    CAS  PubMed  Google Scholar 

  • Morello E, Vasconi E, Martano M, Peirone B, Buracco P (2003) Pasteurized tumoral autograft and adjuvant chemotherapy for the treatment of canine distal radial osteosarcoma: 13 cases. Vet Surg 32:539–544

    Article  PubMed  Google Scholar 

  • Neihaus SA, Locke JE, Barger AM, Borst LB, Goring RL (2011) A novel method of core aspirate cytology compared to fine-needle aspiration for diagnosing canine osteosarcoma.. J Am Anim Hosp Assoc 47:317–323

    Article  PubMed  Google Scholar 

  • Okada M, Kitagawa M, Nagasawa A, Itou T, Kanayama K, Sakai T (2009) Magnetic resonance imaging and computed tomography findings of vertebral osteosarcoma in a cat. J Vet Med Sci 71:513–517

    Article  PubMed  Google Scholar 

  • Polton GA, Brearley MJ, Powell SM, Burton CA (2008) Impact of primary tumour stage on survival in dogs with solitary lung tumours. J Small Anim Pract 49:66–71

    Article  CAS  PubMed  Google Scholar 

  • Popovitch CA, Weinstein MJ, Goldschmidt MH (1994) Chondrosarcoma: a retrospective study of 97 dogs (1987–1990). J Am Anim Hosp Assoc 30:81–85

    Google Scholar 

  • Portela RF, Fadl-Alla BA, Pondenis HC, Byrum ML, Garrett LD, Wycislo KL, Borst LB, Fan TM (2014) Pro-tumorigenic effects of transforming growth factor beta 1 in canine osteosarcoma. J Vet Intern Med 28:894–904

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Quigley PJ, Leedale AH (1983) Tumors involving bone in the domestic cat: a review of fifty-eight cases. Vet Pathol 20:670–686

    Article  CAS  PubMed  Google Scholar 

  • Rozeman LB, Cleton-Jansen AM, Hogendoorn PC (2006) Pathology of primary malignant bone and cartilage tumours. Int Orthop 30:437–444

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ryseff JK, Bohn AA (2012) Detection of alkaline phosphatase in canine cells previously stained with Wright-Giemsa and its utility in differentiating osteosarcoma from other mesenchymal tumors. Vet Clin Pathol 41:391–395

    Article  PubMed  Google Scholar 

  • Sabattini S, Mancini FR, Marconato L, Bacci B, Rossi F, Vignoli M, Bettini G (2014) EGFR overexpression in canine primary lung cancer: pathogenetic implications and impact on survival. Vet Comp Oncol 12:237–248

    Article  CAS  PubMed  Google Scholar 

  • Schmidt AF, Nielen M, Klungel OH, Hoes AW, De Boer A, Groenwold RH, Kirpensteijn J, Investigators VSSO (2013) Prognostic factors of early metastasis and mortality in dogs with appendicular osteosarcoma after receiving surgery: an individual patient data meta-analysis. PrevVet Med 112:414–422

    CAS  Google Scholar 

  • Sonnenschein B, Dickomeit MJ, Bali MS (2012) Late-onset fracture-associated osteosarcoma in a cat. Vet Comp Orthop Traumatol 25:418–420

    Article  CAS  PubMed  Google Scholar 

  • Sylvestre AM, Cockshutt JR (1992) A case series of 25 dogs with chondrosarcoma. Vet Comp Ortho Traumatol 1:17–21

    Google Scholar 

  • Szewczyk M, Lechowski R, Zabielska K (2015) What do we know about canine osteosarcoma treatment? Review. Vet Res Commun 39:61–67

    Article  CAS  PubMed  Google Scholar 

  • Theon AP, Madewell BR, Harb MF, Dungworth DL (1993) Megavoltage irradiation of neoplasms of the nasal and paranasal cavities in 77 dogs. J Am Vet Med Assoc 202:1469–1475

    CAS  PubMed  Google Scholar 

  • Vail DM, Powers BE, Getzy DM, Morrison WB, McEntee MC, O’Keefe DA, Norris AM, Withrow SJ (1994) Evaluation of prognostic factors for dogs with synovial sarcoma: 36 cases (1986-1991). J Am Vet Med Assoc 205:1300–1307

    CAS  PubMed  Google Scholar 

  • Venzin C, Grundmann S, Montavon P (2012) Endoprosthesis (EN) in frontlimb-sparing surgery for distal radial tumours in the dog: preliminary results. Schweiz Arch Tierheilkd 154:337–343

    Article  CAS  PubMed  Google Scholar 

  • Wood EF, O’Brien RT, Young KM (1998) Ultrasound-guided fine-needle aspiration of focal parenchymal lesions of the lung in dogs and cats. J Vet Intern Med 12:338–342

    Article  CAS  PubMed  Google Scholar 

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Klopfleisch, R. (2017). Tumoren des Skeletts. In: Klopfleisch, R. (eds) Veterinäronkologie kompakt. Springer Spektrum, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-54987-2_11

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  • DOI: https://doi.org/10.1007/978-3-662-54987-2_11

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