Zusammenfassung
Calciumantagonisten hemmen am Herzen und an der glatten Muskulatur den Einstrom von Calciumionen aus dem Extrazellulärraum. Dies führt zu einer Vasodilatation (vorwiegend der arteriellen Gefäße) und am Herzen zu einer Abnahme von Kontraktionskraft und Herzfrequenz, die allerdings durch eine adrenerge Gegenregulation infolge der Vasodilatation kompensiert wird. Bei kurz- und schnellwirksamen Calciumantagonisten vom Nifedipintyp (Dihydropyridine) bewirkt dieser als ungünstig anzusehende Mechanismus nicht selten eine reflektorische Tachykardie und Flush-Symptomatik.
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Eschenhagen, T. (2017). Calciumantagonisten. In: Schwabe, U., Paffrath, D., Ludwig, WD., Klauber, J. (eds) Arzneiverordnungs-Report 2017. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-54630-7_23
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DOI: https://doi.org/10.1007/978-3-662-54630-7_23
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