Zusammenfassung
Muskelrelaxanzien verhindern die neuromuskuläre Übertragung und werden routinemäßig in der Anästhesie eingesetzt, um die Skelettmuskulatur vorübergehend schlaff zu lähmen. Sie stellen neben Hypnotika und Analgetika eine der drei elementaren Säulen der balancierten Anästhesie dar. Indem sie unwillkürliche Bewegungen und motorische Reflexe verhindern, erleichtern sie die endotracheale Intubation, vermindern das Risiko von Stimmbandschäden, verringern den Gebrauch an Narkotika und ermöglichen gute chirurgische Operationsbedingungen.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Literatur
Bernard C (1864) Etudes physiologiques sur quelques poisons americains. Rev Deux Mondes 53:164–190
Bernard C (1851) Lecon sur les effets de substances toxiques et medicamenteuses. Bailliere, Paris
Hinder F, Ludemann P, Hinder S, Ringelstein EB, Van Aken H (1997) [Prolonged muscle weakness in intensive care patients with special attention to the so-called intensive care polyneuromyopathy]. Anaesthesist 46:211–219
Fon EA, Edwards RH (2001) Molecular mechanisms of neurotransmitter release. Muscle Nerve 24:581–601
Rowland LP (2002) Stroke, spasticity, and botulinum toxin. N Engl J Med 347:382–383
Van der Kloot W (1991) The regulation of quantal size. Prog Neurobiol 36:93–130
Fagerlund MJ, Eriksson LI (2009) Current concepts in neuromuscular transmission. Br J Anaesth 103:108–114
Jonsson Fagerlund M, Dabrowski M, Eriksson LI (2009) Pharmacological characteristics of the inhibition of nondepolarizing neuromuscular blocking agents at human adult muscle nicotinic acetylcholine receptor. Anesthesiology 110:1244–1252
Paton WD, Waud DR (1967) The margin of safety of neuromuscular transmission. J Physiol (Lond) 191:59–90
Fink H, Helming M, Unterbuchner C et al (2008) Systemic inflammatory response syndrome increases immobility-induced neuromuscular weakness. Crit Care Med 36:910–916
Gu Y, Hall ZW (1988) Immunological evidence for a change in subunits of the acetylcholine receptor in developing and denervated rat muscle. Neuron 1:117–125
Martyn JA, Richtsfeld M (2006) Succinylcholine-induced hyperkalemia in acquired pathologic states: etiologic factors and molecular mechanisms. Anesthesiology 104:158–169
Martyn JA, White DA, Gronert GA, Jaffe RS, Ward JM (1992) Up-and-down regulation of skeletal muscle acetylcholine receptors. Effects on neuromuscular blockers. Anesthesiology 76:822–843
Waud DR, Waud BE (1975) In vitro measurement of margin of safety of neuromuscular transmission. Am J Physiol 229:1632–1634
Jonsson M, Dabrowski M, Gurley DA et al (2006) Activation and inhibition of human muscular and neuronal nicotinic acetylcholine receptors by succinylcholine. Anesthesiology 104:724–733
Zaimis E (1976) The neuromuscular junction: area of uncertainty. In: Zaimis E (Hrsg) Neuromuscular junction. Springer, Berlin/Heidelberg
Elenes S, Ni Y, Cymes GD, Grosman C (2006) Desensitization contributes to the synaptic response of gain-of-function mutants of the muscle nicotinic receptor. J Gen Physiol 128:615–627
Yakel JL (1996) Gating of nicotinic ACh receptors: latest insights into ligand binding and function. J Physiol 588:597–602
Adams PR, Sakmann B (1978) Decamethonium both opens and blocks endplate channels. Proc Natl Acad Sci U S A 75:2994–2998
Marshall CG, Ogden DC, Colquhoun D (1990) The actions of suxamethonium (succinyldicholine) as an agonist and channel blocker at the nicotinic receptor of frog muscle. J Physiol 428:155–174
Griffith HR, Johnson GE (1942) The use of curare in general anesthesia. Anesthesiology 3:418–420
Hunt R, Taveau RdM (1906) On physiological action of certain choline derivates and new methods for decting choline. Br Med II:1788
Foldes FF, McNall PG, Borrego-Hinojosa JM (1952) Succinylcholine: a new approach to muscular relaxation in anesthesiology. N Engl J Med 247:596–600
Thesleff S (1951) Farmakologiska och kliniska forsok med L.T.I. (O, O-succinylcholine jodid). Nord Med 46:1045
Bovet D (1951) Some aspects of the relationship between chemical structure and curare-like activity. Ann NY Acad Sci 54:407–410
Baird WL, Reid AM (1967) The neuromuscular blocking properties of a new steroid compound, pancuronium bromide. A pilot study in man. Br J Anaesth 39:775–780
Kopman AF, Klewicka MM, Kopman DJ, Neuman GG (1999) Molar potency is predictive of the speed of onset of neuromuscular block for agents of intermediate, short, and ultrashort duration. Anesthesiology 90:425–431
Kopman AF (2003) The influence of the duration of anesthesia on neuromuscular potency. Anesthesiology 98:1300–1301
Melnikov AL, Malakhov KY, Helgesen KG, Lathrop DA (1999) Cardiac effects of non-depolarizing neuromuscular blocking agents pancuronium, vecuronium, and rocuronium in isolated rat atria. Gen Pharmacol 33:313–317
Beemer GH, Dawson PJ, Bjorksten AR, Edwards NE (1989) Early postoperative seizures in neurosurgical patients administered atracurium and isoflurane. Anaesth Intensive Care 17:504–509
Mesry S, Baradaran J (1974) Accidental intrathecal injection of gallamine triethiodide. Anaesthesia 29:301–304
Szenohradszky J, Trevor AJ, Bickler P et al (1993) Central nervous system effects of intrathecal muscle relaxants in rats. Anesth Analg 76:1304–1309
Chiodini F, Charpantier E, Muller D et al (2001) Blockade and activation of the human neuronal nicotinic acetylcholine receptors by atracurium and laudanosine. Anesthesiology 94:643–651
Fodale V, Santamaria LB (2002) Laudanosine, an atracurium and cisatracurium metabolite. Eur J Anaesthesiol 19:466–473
Lowman MA, Rees PH, Benyon RC, Church MK (1988) Human mast cell heterogeneity: histamine release from mast cells dispersed from skin, lung, adenoids, tonsils, and colon in response to IgE-dependent and nonimmunologic stimuli. J Allergy Clin Immunol 81:590–597
Hepner DL, Castells MC (2003) Anaphylaxis during the perioperative period. Anesth Analg 97:1381–1395
Lien CA, Belmont MR, Abalos A et al (1995) The cardiovascular effects and histamine-releasing properties of 51W89 in patients receiving nitrous oxide/opioid/barbiturate anesthesia. Anesthesiology 82:1131–1138
Savarese JJ, Ali HA, Basta SJ et al (1989) The cardiovascular effects of mivacurium chloride (BW B1090U) in patients receiving nitrous oxide – opiate – barbiturate anesthesia. Anesthesiology 70:386–394
Scott RP, Savarese JJ, Basta SJ et al (1985) Atracurium: clinical strategies for preventing histamine release and attenuating the haemodynamic response. Br J Anaesth 57:550–553
Mertes PM, Aimone-Gastin I, Gueant-Rodriguez RM et al (2008) Hypersensitivity reactions to neuromuscular blocking agents. Curr Pharm Des 14:2809–2825
Mertes PM, Laxenaire MC (2002) Allergic reactions occurring during anaesthesia. Eur J Anaesthesiol 19:240–262
Moneret-Vautrin DA, Kanny G (2002) Anaphylaxis to muscle relaxants: rational for skin tests. Allerg Immunol (Paris) 34:233–240
Dhonneur G, Combes X, Chassard D, Merle JC (2004) Skin sensitivity to rocuronium and vecuronium: a randomized controlled prick-testing study in healthy volunteers. Anesth Analg 98:986–989
Baldo BA, Fisher MM (1983) Anaphylaxis to muscle relaxant drugs: cross-reactivity and molecular basis of binding of IgE antibodies detected by radioimmunoassay. Mol Immunol 20:1393–1400
Mertes PM, Moneret-Vautrin DA, Leynadier F, Laxenaire MC (2007) Skin reactions to intradermal neuromuscular blocking agent injections: a randomized multicenter trial in healthy volunteers. Anesthesiology 107:245–252
Laxenaire MC (1999) [Epidemiology of anesthetic anaphylactoid reactions. Fourth multicenter survey (July 1994–December 1996)]. Ann Fr Anesth Reanim 18:796–809
Eriksson LI (1997) Recovery from neuromuscular block and vital function testing. Acta Anaesthesiol Belg 48:45–48
Berry FA Jr (1996) Intramuscular rocuronium in infants and children – is there a need? Anesthesiology 85:229–230
Atherton DP, Hunter JM (1999) Clinical pharmacokinetics of the newer neuromuscular blocking drugs. Clin Pharmacokinet 36:169–189
Savarese JJ, Ali HH, Basta SJ et al (1988) The clinical neuromuscular pharmacology of mivacurium chloride (BW B1090U): a short-acting nondepolarizing ester neuromuscular blocking drug. Anesthesiology 68:723–732
Kalow W, Genest K (1957) A method for the detection of atypical forms of human serum cholinesterase. Determination of dibucaine numbers. Can J Biochem Physiol 35:339–346
Harris H, Whittaker M (1961) Differential inhibition of human serum cholinesterase with fluoride: recognition of two new phenotypes. Nature 191:496–498
McAlpine PJ, Dixon M, Allderdice PW, Lockridge O, La Du BN (1991) The butyrylcholinesterase gene (BCHE) at 3q26.2 shows two RFLPs. Nucleic Acids Res 19:5088
Zeidler EM, Goetz AE, Zöllner C (2013) Pharmakogenetik. Klinische Bedeutung in der Anästhesiologie. Anaesthesist 62:874–886
Pantuck EJ (1993) Plasma cholinesterase: gene and variations. Anesth Analg 77:380–386
Motamed C, Kirov K, Lieutaud T, Duvaldestin P (2000) The mechanism of pancuronium potentiation of mivacurium block: use of the isolated-arm technique. Anesth Analg 91:732–735
Stovner J, Oftedal N, Holmboe J (1975) The inhibition of cholinesterases by pancuronium. Br J Anaesth 47:949–954
Fisher DM, Caldwell JE, Sharma M, Wiren JE (1988) The influence of bambuterol (carbamylated terbutaline) on the duration of action of succinylcholine-induced paralysis in humans. Anesthesiology 69:757–759
Kao YJ, Turner DR (1989) Prolongation of succinylcholine block by metoclopramide. Anesthesiology 70:905–908
Pantuck EJ (1966) Ecothiopate iodide eye drops and prolonged response to suxamethonium. Br J Anaesth 38:406–407
Weindlmayr-Goettel M, Gilly H, Kress HG (2002) Does ester hydrolysis change the in vitro degradation rate of cisatracurium and atracurium? Br J Anaesth 88:555–562
Waser PG, Wiederkehr H, Sin-Ren AC, Kaiser-Schonenberger E (1987) Distribution and kinetics of 14C-vecuronium in rats and mice. Br J Anaesth 59:1044–1051
Kremer JM, Wilting J, Janssen LH (1988) Drug binding to human alpha-1-acid glycoprotein in health and disease. Pharmacol Rev 40:1–47
Fink H, Luppa P, Mayer B et al (2003) Systemic inflammation leads to resistance to atracurium without increasing membrane expression of acetylcholine receptors. Anesthesiology 98:82–88
Iwasaki H, Igarashi M, Yamauchi M, Namiki A (1995) The effect of cardiac output on the onset of neuromuscular block by vecuronium. Anaesthesia 50:361–362
Donati F, Meistelman C, Plaud B (1990) Vecuronium neuromuscular blockade at the diaphragm, the orbicularis oculi, and adductor pollicis muscles. Anesthesiology 73:870–875
Meistelman C, Plaud B, Donati F (1992) Rocuronium (ORG 9426) neuromuscular blockade at the adductor muscles of the larynx and adductor pollicis in humans. Can J Anaesth 39:665–669
Varin F, Ducharme J, Besner JG, Theoret Y (1990) Determination of atracurium and laudanosine in human plasma by high- performance liquid chromatography. J Chromatogr 529:319–327
Fisher DM, Miller RD (1983) Neuromuscular effects of vecuronium (ORG NC45) in infants and children during N2O, halothane anesthesia. Anesthesiology 58:519–523
Markakis DA, Hart PS, Lau M, Brown R, Fisher DM (1996) Does age or pseudocholinesterase activity predict mivacurium infusion rate in children? Anesth Analg 82:39–43
Meistelman C, Agoston S, Kersten UW et al (1986) Pharmacokinetics and pharmacodynamics of vecuronium and pancuronium in anesthetized children. Anesth Analg 65:1319–1323
Smeulers NJ, Wierda JM, van den Broek L, Gallandat Huet RC, Hennis PJ (1995) Hypothermic cardiopulmonary bypass influences the concentration-response relationship and the biodisposition of rocuronium. Eur J Anaesthesiol Suppl 11:91–94
Leslie K, Sessler DI, Bjorksten AR, Moayeri A (1995) Mild hypothermia alters propofol pharmacokinetics and increases the duration of action of atracurium. Anesth Analg 80:1007–1014
Buzello W, Noeldge G, Krieg N, Brobmann GF (1986) Vecuronium for muscle relaxation in patients with myasthenia gravis. Anesthesiology 64:507–509
Rump AF, Schierholz J, Biederbick W et al (1999) Pseudocholinesterase-activity reduction during cardiopulmonary bypass: the role of dilutional processes and pharmacological agents. Gen Pharmacol 32:65–69
Foldes FF, Rendell-Baker L, Birch J (1956) Causes and prevention of prolonged apnea with succinylcholine. Anesth Analg 25:609
Mayrhofer O (1951) Kurz wirkende Muskelerschlaffungsmittel. Selbstversuche und klinische Erprobung am narkotisierten Menschen. Wien Klin Wochenschr 63:885–889
Fink H, Geldner G, Fuchs-Buder T et al (2006) [Muscle relaxants in Germany 2005: a comparison of application customs in hospitals and private practices]. Anaesthesist 55:668–678
Naguib M, Samarkandi A, Riad W, Alharby SW (2003) Optimal dose of succinylcholine revisited. Anesthesiology 99:1045–1049
Perry JJ, Lee JS, Sillberg VA, Wells GA (2008) Rocuronium versus succinylcholine for rapid sequence induction intubation. Cochrane Database Syst Rev CD002788
Vinik HR (1999) Intraocular pressure changes during rapid sequence induction and intubation: a comparison of rocuronium, atracurium, and succinylcholine. J Clin Anesth 11:95–100
Vachon CA, Warner DO, Bacon DR (2003) Succinylcholine and the open globe. Tracing the teaching. Anesthesiology 99:220–223
Gronert GA, Theye RA (1975) Pathophysiology of hyperkalemia induced by succinylcholine. Anesthesiology 43:89–99
Mayrhofer O (1959) Die Wirksamkeit von d-Tubocurarin zur Verhütung der Muskelschmerzen nach Succinylcholin. Anaesthesist 8:313–315
Schreiber JU, Lysakowski C, Fuchs-Buder T, Tramer MR (2005) Prevention of succinylcholine-induced fasciculation and myalgia: a meta-analysis of randomized trials. Anesthesiology 103:877–884
Mencke T, Becker C, Schreiber J, Bolte M, Fuchs-Buder T (2002) [Precurarization of succinylcholine with cisatracurium: the influence of the precurarization interval]. Anaesthesist 51:721–725
Ishigaki S, Masui K, Kazama T (2016) Saline flush after rocuronium bolus reduces onset time and prolongs duration of effect: a randomized clinical trial. Anesth Analg 122:706–711
Grosse-Sundrup M, Henneman JP, Sandberg WS, Bateman BT, Uribe JV, Nguyen NT, Ehrenfeld JM, Martinez EA, Kurth T, Eikermann M (2012) Intermediate acting non-depolarizing neuromuscular blocking agents and risk of postoperative respiratory complications: prospective propensity score matched cohort study. BMJ 345:e6329
McLean DJ, Diaz-Gil D, Farhan HN, Ladha KS, Kurth T, Eikermann M (2015) Dose-dependent association between intermediate-acting neuromuscular-blocking agents and postoperative respiratory complications. Anesthesiology 122:1201–1213
Blobner M, Frick CG, Stäuble RB, Feussner H, Schaller SJ, Unterbuchner C, Lingg C, Geisler M, Fink H (2015) Neuromuscular blockade improves surgical conditions (NISCO). Surg Endosc 29:627–636
Baumüller E, Schaller SJ, Chiquito Lama Y, Frick CG, Bauhofer T, Eikermann M, Fink H, Blobner M (2015) Postoperative impairment of motor function at train-of-four ratio ≥0.9 cannot be improved by sugammadex (1 mg kg-1). Br J Anaesth 114:785–793
Cammu G, De Witte J, De Veylder J et al (2006) Postoperative residual paralysis in outpatients versus inpatients. Anesth Analg 102:426–429
Fortier LP, McKeen D, Turner K, de Médicis É, Warriner B, Jones PM, Chaput A, Pouliot JF, Galarneau A (2015) The RECITE study: a Canadian prospective, multicenter study of the incidence and severity of residual neuromuscular blockade. Anesth Analg 121:366–372
Maybauer DM, Geldner G, Blobner M et al (2007) Incidence and duration of residual paralysis at the end of surgery after multiple administrations of cisatracurium and rocuronium. Anaesthesia 62:12–17
Beemer GH (1993) Pharmacodynamics of atracurium in clinical practice: effect of plasma potassium, patient demographics, and concurrent medication. Anesth Analg 76:1288–1295
Cook DR, Freeman JA, Lai AA et al (1992) Pharmacokinetics of Mivacurium in normal patients and in those with hepatic or renal failure. Br J Anaesth 69:580–585
Mathiesen I, Rimer M, Ashtari O et al (1999) Regulation of the size and distribution of agrin-induced postsynaptic- like apparatus in adult skeletal muscle by electrical muscle activity. Mol Cell Neurosci 13:207–217
Naguib M, Flood P, McArdle JJ, Brenner HR (2002) Advances in neurobiology of the neuromuscular junction: implications for the anesthesiologist. Anesthesiology 96:202–231
Ibebunjo C, Martyn JA (1999) Fiber atrophy, but not changes in acetylcholine receptor expression, contributes to the muscle dysfunction after immobilization. Crit Care Med 27:275–285
Hogue CW Jr, Itani MS, Martyn JA (1990) Resistance to d-tubocurarine in lower motor neuron injury is related to increased acetylcholine receptors at the neuromuscular junction. Anesthesiology 73:703–709
Kim C, Fuke N, Martyn JA (1988) Burn injury to rat increases nicotinic acetylcholine receptors in the diaphragm. Anesthesiology 68:401–406
Shayevitz JR, Matteo RS (1985) Decreased sensitivity to metocurine in patients with upper motoneuron disease. Anesth Analg 64:767–772
Frick CG, Richtsfeld M, Sahani ND et al (2007) Long-term effects of botulinum toxin on neuromuscular function. Anesthesiology 106:1139–1146
Viby Mogensen J, Hanel HK, Hansen E, Graae J (1975) Serum cholinesterase activity in burned patients. II: anaesthesia, suxamethonium and hyperkalaemia. Acta Anaesthesiol Scand 19:169–179
Kohlschütter B, Baur H, Roth F (1976) Suxamethonium-induced hyperkalaemia in patients with severe intra-abdominal infections. Br J Anaesth 48:557–562
John DA, Tobey RE, Homer LD, Rice CL (1976) Onset of succinylcholine-induced hyperkalemia following denervation. Anesthesiology 45:294–299
Tobey RE (1970) Paraplegia, succinylcholine and cardiac arrest. Anesthesiology 32:359–364
Cooperman LH (1970) Succinylcholine-induced hyperkalemia in neuromuscular disease. JAMA 213:1867–1871
Walton JD, Farman JV (1973) Suxamethonium hyperkalaemia in uraemic neuropathy. Anaesthesia 28:666–668
Eldridge L, Liebhold M, Steinbach JH (1981) Alterations in cat skeletal neuromuscular junctions following prolonged inactivity. J Physiol 313:529–545
Ikezu T, Okamoto T, Yonezawa K, Tompkins RG, Martyn JA (1997) Analysis of thermal injury-induced insulin resistance in rodents. Implication of postreceptor mechanisms. J Biol Chem 272:25289–25295
Yanez P, Martyn JA (1996) Prolonged d-tubocurarine infusion and/or immobilization cause upregulation of acetylcholine receptors and hyperkalemia to succinylcholine in rats. Anesthesiology 84:384–391
Blobner M, Busley R, Mann R, Jelen-Esselborn S, Kochs E (1999) Die neuromuskuläre Erholung nach Mivacurium läßt sich auch bei Patienten mit schweren Begleiterkrankungen prognostizieren. Anasthesiol Intensivmed Notfallmed Schmerzther 34:638–641
Knüttgen D, Doehn M, Zeidler D (1997) Postoperative Resistenzentwicklung gegenüber Atracurium. Anaesthesist 46:974–978
Tomera JF, Martyn JJ (1989) Intraperitoneal endotoxin but not protein malnutrition shifts d-tubocurarine dose-response curves in mouse gastrocnemius muscle. J Pharmacol Exp Ther 250:216–220
Knüttgen D, Zeidler D, Lefering R, Muller-Gorges MR, Doehn M (1998) Verminderte Wirksamkeit von Atracurium bei Patienten mit intrathorakalem Eiterherd. Anaesthesist 47:936–939
Eisenkraft JB, Book WJ, Mann SM, Papatestas AE, Hubbard M (1988) Resistance to succinylcholine in myasthenia gravis: a dose-response study. Anesthesiology 69:760–763
Baraka A (1992) Suxamethonium block in the myasthenic patient. Correlation with plasma cholinesterase. Anaesthesia 47:217–219
Fuchs-Buder T, Sparr HJ, Ziegenfuss T (1998) Thiopental or etomidate for rapid sequence induction with rocuronium [see comments]. Br J Anaesth 80:504–506
Gill RS, Scott RP (1992) Etomidate shortens the onset time of neuromuscular block. Br J Anaesth 69:444–446
Latorre F, de Almeida MC, Stanek A, Weiler N, Kleemann PP (1996) [The effects of cimetidine on the pharmacodynamics of rocuronium]. Anaesthesist 45:900–902
Harrah MD, Way WL, Katzung BG (1970) The interaction of d-tubocurarine with antiarrhythmic drugs. Anesthesiology 33:406–410
Kim CS, Arnold FJ, Itani MS, Martyn JA (1992) Decreased sensitivity to metocurine during long-term phenytoin therapy may be attributable to protein binding and acetylcholine receptor changes. Anesthesiology 77:500–506
Fiekers JF (1999) Sites and mechanisms of antibiotic-induced neuromuscular block: a pharmacological analysis using quantal content, voltage clamped end-plate currents and single channel analysis. Acta Physiol Pharmacol Ther Latinoam 49:242–250
Fuchs-Buder T, Wilder Smith OH, Borgeat A, Tassonyi E (1995) Interaction of magnesium sulphate with vecuronium-induced neuromuscular block. Br J Anaesth 74:405–409
Ghoneim MM, Long JP (1970) The interaction between magnesium and other neuromuscular blocking agents. Anesthesiology 32:23–27
Scheller M, Bufler J, Schneck H, Kochs E, Franke C (1997) Isoflurane and sevoflurane interact with the nicotinic acetylcholine receptor channels in micromolar concentrations. Anesthesiology 86:118–127
Liu M, Kato M, Hashimoto Y (2001) Neuromuscular blocking effects of the aminoglycoside antibiotics arbekacin, astromicin, isepamicin and netilmicin on the diaphragm and limb muscles in the rabbit. Pharmacology 63:142–146
Sieb JP, Milone M, Engel AG (1996) Effects of the quinoline derivatives quinine, quinidine, and chloroquine on neuromuscular transmission. Brain Res 712:179–189
Fryer JD, Lukas RJ (1999) Antidepressants noncompetitively inhibit nicotinic acetylcholine receptor function. J Neurochem 72:1117–1124
Scheller M, Bufler J, Hertle I et al (1996) Ketamine blocks currents through mammalian nicotinic acetylcholine receptor channels by interaction with both the open and the closed state. Anesth Analg 83:830–836
Hertle I, Scheller M, Bufler J et al (1997) Interaction of midazolam with the nicotinic acetylcholine receptor of mouse myotubes. Anesth Analg 85:174–181
Krampfl K, Schlesinger F, Dengler R et al (2000) Pentobarbital has curare-like effects on adult-type nicotinic acetylcholine receptor channel currents. Anesth Analg 90:970–974
Driessen JJ, Wuis EW, Gielen MJ (1985) Prolonged vecuronium neuromuscular blockade in a patient receiving orally administered dantrolene. Anesthesiology 62:523–524
Fanelli V, Morita Y, Cappello P, Ghazarian M, Sugumar B, Delsedime L, Batt J, Ranieri VM, Zhang H, Slutsky AS (2016) Neuromuscular blocking agent cisatracurium attenuates lung injury by inhibition of nicotinic acetylcholine receptor-α1. Anesthesiology 124:132–140
Arroliga A, Frutos-Vivar F, Hall J, Esteban A, Apezteguía C, Soto L, Anzueto A, International Mechanical Ventilation Study Group (2005) Use of sedatives and neuromuscular blockers in a cohort of patients receiving mechanical ventilation. Chest 128:496–506
Needham CJ, Brindley PG (2012) Best evidence in critical care medicine: the role of neuromuscular blocking drugs in early severe acute respiratory distress syndrome. Can J Anaesth 59:105–108
Neto AS, Pereira VG, Espósito DC, Damasceno MC, Schultz MJ (2012) Neuromuscular blocking agents in patients with acute respiratory distress syndrome: a summary of the current evidence from three randomized controlled trials. Ann Intensive Care 2:33
Greenberg SB, Vender J (2013) The use of neuromuscular blocking agents in the ICU: where are we now? Crit Care Med 41:1332–1344
Eikermann M, Groeben H, Husing J, Peters J (2003) Accelerometry of adductor pollicis muscle predicts recovery of respiratory function from neuromuscular blockade. Anesthesiology 98:1333–1337
Eriksson LI, Sundman E, Olsson R et al (1997) Functional assessment of the pharynx at rest and during swallowing in partially paralyzed humans. Simultaneous videomanometry and mechanomyography of awake human volunteers. Anesthesiology 87:1035–1043
Berg H, Roed J, Viby-Mogensen J et al (1997) Residual neuromuscular block is a risk factor for postoperative pulmonary complications. A prospective, randomised, and blinded study of postoperative pulmonary complications after atracurium, vecuronium and pancuronium. Acta Anaesthesiol Scand 41:1095–1103
Heerdt PM, Sunaga H, Savarese JJ (2015) Novel neuromuscular blocking drugs and antagonists. Curr Opin Anaesthesiol 28:403–410
Sasaki N, Meyer MJ, Malviya SA, Stanislaus AB, MacDonald T, Doran ME, Igumenshcheva A, Hoang AH, Eikermann M (2014) Effects of neostigmine reversal of nondepolarizing neuromuscular blocking agents on postoperative respiratory outcomes: a prospective study. Anesthesiology 121:959–968
Miller RD, Roderick LL (1978) Acid-base balance and neostigmine antagonism of pancuronium neuromuscular blockade. Br J Anaesth 50:317–324
Miller RD, Van Nyhuis LS, Eger EI 2nd, Way WL (1975) The effect of acid-base balance on neostigmine antagonism of d-tubocurarine-induced neuromuscular blockade. Anesthesiology 42:377–383
Bom A, Van Egmond J, Hope F, van de Pol BS (2002) Rapid reversal of rocuronium-induced neuromuscular block by ORG 25969 is independent of renal perfusion. Anesthesiology 99:A1158
Gijsenbergh F, Ramael S, Houwing N, van Iersel T (2005) First human exposure of Org 25969, a novel agent to reverse the action of rocuronium bromide. Anesthesiology 103:695–703
Boer HD de, van Egmond J, van de Pol F, Bom A, Booij LH (2006) Sugammadex, a new reversal agent for neuromuscular block induced by rocuronium in the anaesthetized Rhesus monkey. Br J Anaesth 96:473–479
Blobner M, Eriksson LI, Scholz J et al (2010) Reversal of rocuronium-induced neuromuscular blockade with sugammadex compared with neostigmine during sevoflurane anaesthesia: results of a randomised, controlled trial. Eur J Anaesthesiol 27:874–881
Jones RK, Caldwell JE, Brull SJ, Soto RG (2008) Reversal of profound rocuronium-induced blockade with sugammadex: a randomized comparison with neostigmine. Anesthesiology 109:816–824
Lee C, Jahr JS, Candiotti KA et al (2009) Reversal of profound neuromuscular block by sugammadex administered three minutes after rocuronium: a comparison with spontaneous recovery from succinylcholine. Anesthesiology 110:1020–1025
de Souza CM, Tardelli MA, Tedesco H, Garcia NN, Caparros MP, Alvarez-Gomez JA, de Oliveira Junior IS (2015) Efficacy and safety of sugammadex in the reversal of deep neuromuscular blockade induced by rocuronium in patients with end-stage renal disease: a comparative prospective clinical trial. Eur J Anaesthesiol 32:681–686
Kaufhold N, Schaller SJ, Stäuble CG, Baumüller E, Ulm K, Blobner M, Fink H (2016) Sugammadex and neostigmine dose-finding study for reversal of residual neuromuscular block at a train-of-four ratio of 0.2 (SUNDRO20). Br J Anaesth 116:233–240
US Food and Drug Administration (2008) Sugammadex, NDA 22-225, Anesthetic and Life Support Drugs Advisory Committee March 11, 2008. http://www.fda.gov/ohrms/dockets/ac/08/slides/2008-4346s1-01-Schering-Plough-corebackup.pdf. Zugegriffen am 04.08.2017
Buonanno P, Laiola A, Palumbo C, Spinelli G, Servillo G, Di Minno RM, Cafiero T, Di Iorio C (2016) Dexamethasone does not inhibit sugammadex reversal after rocuronium-induced neuromuscular block. Anesth Analg 122:1826–1830
Amorim P, Lagarto F, Gomes B, Esteves S, Bismarck J, Rodrigues N, Nogueira M (2014) Neostigmine vs. sugammadex: observational cohort study comparing the quality of recovery using the Postoperative Quality Recovery Scale. Acta Anaesthesiol Scand 58:1101–1110
Carron M, Veronese S, Foletto M, Ori C (2013) Sugammadex allows fast-track bariatric surgery. Obes Surg 23:1558–1563
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Section Editor information
Rights and permissions
Copyright information
© 2019 Springer-Verlag GmbH Deutschland, ein Teil von Springer Nature
About this chapter
Cite this chapter
Blobner, M., Lewald, H., Busley, R. (2019). Muskelrelaxanzien und ihre Antagonisten. In: Rossaint, R., Werner, C., Zwißler, B. (eds) Die Anästhesiologie. Springer Reference Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-54507-2_23
Download citation
DOI: https://doi.org/10.1007/978-3-662-54507-2_23
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-662-54505-8
Online ISBN: 978-3-662-54507-2
eBook Packages: Medicine (German Language)