Skip to main content
SpringerLink
Log in
Book cover

Die Anästhesiologie pp 403–416Cite as

Lokalanästhetika

  • Chapter
  • First Online:

  • 1743 Accesses

Part of the book series: Springer Reference Medizin ((SRM))

Zusammenfassung

Die Physiologie der Nervenleitung, die chemische Struktur der gebräuchlichen Lokalanästhetika, ihre Pharmakodynamik und Pharmakokinetik werden ebenso erläutert, wie die sich daraus ableitenden Wirkungsunterschiede und Nebenwirkungen. Schwerpunkte bilden die Wirkungen auf das Zentralnervensystem und Herz-Kreislauf-System bei systemischer Resorption oder akzidenteller intravaskulärer Injektion und das Konzept der Wiederbelebung mittels Lipid Rescue bei lokalanästhetikainduziertem Herz-Kreislauf-Stillstand. Zusätzlich zu den Lokalanästhetika selbst werden häufig verwendete Adjuvanzien und ihre klinische Bedeutung abgehandelt und Empfehlungen für die klinische Anwendung bei den verschiedenen Formen der Regional- und Lokalanästhesie gegeben.

Die Nummerierung des Literaturverzeichnisses und die entsprechenden Textzitate wurden korrigiert.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   389.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Literatur

  1. Ahrens J, Leffler A (2014) Update on the pharmacology and effects of local anesthetics. Anaesthesist 63(5):376–386

    Article  CAS  Google Scholar 

  2. Butterworth JF 4th (2010) Models and mechanisms of local anesthetic cardiac toxicity: a review. Reg Anesth Pain Med 35:167–176

    Article  Google Scholar 

  3. Catterall WA (1984) The molecular basis of neuronal excitability. Science 223:653

    Article  CAS  Google Scholar 

  4. Catterall WA, Goldin AL, Waxman SG (2005) International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels. Pharmacol Rev 57:397–409

    Article  CAS  Google Scholar 

  5. Clarkson CW, Hondeghem LM (1985) Mechanism for bupivacaine depression for cardiac conduction: fast block of sodium channels during action potential with slow recovery from block during diastole. Anesthesiology 62:396–405

    Article  CAS  Google Scholar 

  6. Dony P, Dewinde V, Vanderick B et al (2000) The comparative toxicity of ropivacaine and bupivacaine at equipotent doses in rats. Anesth Analg 91:1489–1492

    Article  CAS  Google Scholar 

  7. Erlanger J, Gasser HS (1927) The role played by sizes of the constituent fibers of a nerve trunk in determining the role of its action potential wave. Am J Physiol 81:522–547

    Google Scholar 

  8. Ganapathy S, Sandhu H, Stockall C, Hurley D (2000) Transient neurologic symptom (TNS) following intrathecal ropivacaine. Anesthesiology 93:1537–1538

    Article  CAS  Google Scholar 

  9. Goerig M, Bacon, D, van Zundert A (2012) Carl Koller, cocaine and local anaesthesia: some less known and forgotten facts. Reg Anesth Pain Med 37(3):318–324. https://doi.org/10.1097/AAP.0b013e31825051f3

  10. Groban L, Deal DD, Vernon JC, James RL, Butterworth J (2001) Cardiac resuscitation after incremental overdosage with lidocaine, bupivacaine, levobupivacaine and ropivacaine in anesthetized dogs. Anesth Analg 92:37–43

    Article  CAS  Google Scholar 

  11. Lambert LA, Lambert DH, Strichartz GR (1994) Irreversible conduction block in isolated nerve by high concentration of local anesthetics. Anesthesiology 80:1082–9103

    Article  CAS  Google Scholar 

  12. Long WB, Rosenblum S, Grady IP (1989) Successfull resuscitation of bupivacaine-induced cardiac arrest using cardiopulmonary bypass. Anesth Analg 6:403–406

    Google Scholar 

  13. McDonald SB, Liu SS, Kopacz DJ, Stephenson RN (1999) Hyperbaric spinal ropivacaine: a comparison to bupivacaine in volunteers. Anesthesiology 90:971–977

    Article  CAS  Google Scholar 

  14. Moore DC, Batra MS (1981) The components of an effective test dose prior to epidural block. Anesthesiology 55:693

    Article  CAS  Google Scholar 

  15. Nau C, Wang GK (2004) Interactions of local anesthetics with voltage-gated Na+ channels. J Membr Biol 201:1–8

    Article  CAS  Google Scholar 

  16. Ostaad A, Kageyama N, Moy RL (1996) Tumescent anesthesia with a lidocaine dose of 55 mg/kg is safe for liposuction. Dermatol Surg 22:921–927

    Google Scholar 

  17. Ott K (2010) Lipid emulsion therapy for local anaesthetic toxicity (LipidRescue). Anaesthesist 59(6):575–583

    Article  CAS  Google Scholar 

  18. Pollock JE (2003) Neurotoxicity of intrathecal local anaesthetics and transient neurological symptoms. Best Pract Res Clin Anaesthesiol 17:471–484

    Article  CAS  Google Scholar 

  19. Rosenberg PH, Veering BT, Urmey WF (2004) Maximum recommended doses of local anesthetics: a multiofactorial concept. Reg Anesth Pain Med 29:564–751

    CAS  PubMed  Google Scholar 

  20. Roth SH, Miller KW (1986) Molecular and cellular mechanisms of anesthetics. Plenum, New York

    Book  Google Scholar 

  21. Schiebler TH, Schmidt W (1987) Lehrbuch der gesamten Anatomie des Menschen, 4. Aufl. Springer, Heidelberg/Berlin

    Book  Google Scholar 

  22. Schneider MC, Birnbach DJ (2001) Lidocaine neurotoxicity in the obstetric patient: is the water safe? Anesth Analg 92:287–290

    Article  CAS  Google Scholar 

  23. Scott DB (1986) Toxic effects of local anesthetic agents on the central nervous system. Br J Anaesth 58:732–735

    Article  CAS  Google Scholar 

  24. Scurlock JE (1977) The mechanism of action of local anesthetics. Reg Anesth 2:5

    Google Scholar 

  25. Sigworth FJ (1977) Sodium channels in nerve apparently have two conductance states. Nature 270:265

    Article  CAS  Google Scholar 

  26. Strichartz G (1977) Molecular mechanism of nerve block by local anesthetics. Anesthesiology 45:421

    Article  Google Scholar 

  27. Sztark F, Malgat M, Dabadie P et al (1998) Comparison of the effects of bupivacaine and ropivacaine on heart cell mitochondrial bioenergetics. Anesthesiology 88:1340–1349

    Article  CAS  Google Scholar 

  28. Tucker GT, Mather LE (1988) Properties, absorbtion and disposition of local anesthetic agents. In: Cousin MJ, Bridenbaugh PO (Hrsg) Neural blockade in clinical anesthesia and management of pain. Lippincott, Philadelphia

    Google Scholar 

  29. Weinberg G (2006) Lipid infusion resuscitation for local anesthetic toxicity: proof of clinical efficacy. Anesthesiology 105:7–8

    Article  Google Scholar 

  30. Weinberg GL et al (1998) Pretreatment or resuscitation with a lipid infusion shifts the dose response to bupivacaine-induced asystole in rats. Anesthesiology 88:1071–1075

    Article  CAS  Google Scholar 

  31. Werdehausen R, Braun S, Fazeli S et al (2012) Lipophilicity but not stereospecificity is a major determinant of local anaesthetic-induced cytotoxicity in human T-lymphoma cells. Eur J Anaesthesiol 29:35–41

    Article  CAS  Google Scholar 

  32. Zink W, Graf BM (2003) Toxicology of local anesthetics. Clinical, therapeutic and pathological mechanisms. Anaesthesist 52:1102–1123

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Medizinische Hochschule Hannover, Klinik für Anästhesiologie und Intensivmedizin, Hannover, Deutschland

    Andreas Leffler

  2. BLZ GmbH, Beratungszentrum für Hygiene, Freiburg, Deutschland

    Sebastian Schulz-Stübner

Authors
  1. Andreas Leffler
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Sebastian Schulz-Stübner
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Andreas Leffler .

Editor information

Editors and Affiliations

  1. Klinik für Anästhesiologie, Universitätsklinikum Aachen RWTH Aachen, Aachen, Germany

    Rolf Rossaint

  2. Klinik für Anästhesiologie, Universitätsklinikum Mainz, Mainz, Germany

    Christian Werner

  3. Klinik für Anästhesiologie und Intensivmedizin, Universitätsklinikum München Klinikum Großhadern, München, Germany

    Bernhard Zwißler

Section Editor information

  1. Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Klinik für Anästhesiologie, Mainz, Deutschland

    Christian Werner

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer-Verlag GmbH Deutschland, ein Teil von Springer Nature

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Leffler, A., Schulz-Stübner, S. (2019). Lokalanästhetika. In: Rossaint, R., Werner, C., Zwißler, B. (eds) Die Anästhesiologie. Springer Reference Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-54507-2_162

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-54507-2_162

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-54505-8

  • Online ISBN: 978-3-662-54507-2

  • eBook Packages: Medicine (German Language)

Publish with us

Policies and ethics

Search

Navigation