Zusammenfassung
In-vitro-Untersuchungen an Zellkulturen und tierexperimentelle Daten zeigen, dass Temperaturerhöhung (Hyperthermie) einen zytotoxischen und sensibilisierenden Effekt hat. Die Definition einer thermischen Dosis ist möglich. Eine Sensibilisierung ist schon bei Temperaturen ab 39–40 °C bei Zytostatika (Cisplatin, Ifosfamid) und ab 40–41 °C bei Radiatio nachweisbar. Die regionale Hyperthermie wird mit phasengesteuerten Antennenarrays im Radiowellenbereich (70–300 MHz) durchgeführt. Es gibt Standardsysteme (BSD mit SIGMA-Applikatoren), mit denen erfolgreich Studien bei Zervixkarzinomen und Weichteilsarkomen durchgeführt wurden. In einem Hybridsystem wurde die MR-Thermometrie klinisch etabliert. Eine Weiterentwicklung zur MR-gesteuerten, online optimierten regionalen Hyperthermie wird angestrebt. Weitere Studien bei abdominellen Tumoren (Pankreaskarzinom) und pelvinen Tumoren (Blasenkarzinom, Prostatakarzinom, Analkarzinom) wurden initiiert.
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Beck M, Ghadjar P, Weihrauch M, Burock S, Budach V, Nadobny J, Sehouli J, Wust P (2015) Regional hyperthermia of the abdomen, a pilot study towards the treatment of peritoneal carcinomatosis. Radiat Oncol 10: 157
Datta NR, Rogers S, Gómez Ordóñez S, Puric E, Bodis S (2016a) Hyperthermia and radiotherapy in the management of head and neck cancers: A systematic review and meta-analysis. Int J Hyperthermia 32: 31–40
Datta NR, Puric E, Klingbiel D, Gomez S, Bodis S (2016b) Hyperthermia and radiation therapy in locoregional recurrent breast cancers: a systematic review and meta-analysis. Int J Radiat Oncol Biol Phys 94: 1073–1087
Dewhirst MW, Viglianti BL, Lora-Michiels M, Hanson M, Hoopes PJ (2003) Basic principles of thermal dosimetry and thermal thresholds for tissue damage from hyperthermia. Int J Hyperthermia 19: 267–294
Fotopoulou C, Cho CH, Kraetschell R, Gellermann J, Wust P, Lichtenegger W, Sehouli J (2010) Regional abdominal hyperthermia combined with systemic chemotherapy for the treatment of patients with ovarian cancer relapse: Results of a pilot study. Int J Hyperthermia 26: 118–126
Flameling B, Nordberg T, Ott O, Issels RD, Wust P, Crezee J, Lindner L, Stalpers L, Mella O, Keijser A, Fietkau R., et al (2016) An international multicenter phase III study of chemoradiotherapy versus chemoradiotherapy plus hyperthermia for locally advanced cervical cancer. J Clin Oncol 34 (Suppl e17023)
Franckena M, Lukas JA Stalpers, Peter CM Koper, Ruud GJ Wiggenraad, Wim J. Hoogenraad, Jan DP van Dijk, Carla C. Wárlám-Rodenhuis, Jan J. Jobsen, van Rhoon GC, van der Zee J (2008) Long-term improvement in treatment outcome after radiotherapy and hyperthermia in locoregionally advanced cervix cancer: an update of the Dutch Deep Hyperthermia Trial. Int J Radiat Oncol Biol Phys 70: 1176–1182
Gellermann J, Wlodarczyk W, Ganter H, Nadobny J, Fähling H, Seebass M, Felix R, Wust P (2005) A practical approach to thermography in a hyperthermia/magnetic resonance hybrid system: validation in a heterogeneous phantom. Int J Radiat Oncol Biol Phys 61: 267–277
Gellermann J, Hildebrandt B, Issels R, Ganter H, Wlodarczyk W, Budach V, Felix R, Tunn PU, Reichardt P, Wust P (2006) Noninvasive magnetic resonance thermography of soft tissue sarcomas during regional hyperthermia: correlation with response and direct thermometry. Cancer 107: 1373–1382
Harima Y, Nagata K, Harima K, Ostapenko VV, Tanaka Y, Sawada S (2001) A randomized clinical trial of radiation therapy versus thermoradiotherapy in stage IIIB cervical carcinoma. Int J Hyperthermia 17: 97–105
Huilgol N, Gupta S, Sridhar C (2010) Hyperthermia with radiation in the treatment of locally advanced head and neck cancer: A report of randomized trial. J Cancer Res Therap 6: 492
Issels RD, Lindner LH, Verweij J, Wust P, Reichardt P, Schem BC, Abdel-Rahman S, Daugaard S, Salat C, Wendtner CM, Vujaskovic Z, Wessalowski R, Jauch KW, Dürr HR, Ploner F, Baur-Melnyk A, Mansmann U, Hiddemann W, Blay JY, Hohenberger P (2010) European Organisation for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group (EORTC-STBSG); European Society for Hyperthermic Oncology (ESHO). Neo-adjuvant chemotherapy alone or with regional hyperthermia for localised high-risk soft-tissue sarcoma: a randomised phase 3 multicentre study. Lancet Oncol 11: 561–570
Jones EL, Oleson JR, Prosnitz LR, Samulski TV, Vujaskovic Z, Yu D, Sanders LL, Dewhirst MW (2005) Randomized trial of hyperthermia and radiation for superficial tumors. J Clin Oncol 23: 3079–3085
Kok HP, Wust P, Stauffer PR, Bardati F, van Rhoon GC, Crezee J (2015) Current state of the art regional hyperthermia treatment planning: a review. Radiat Oncol 10: 196
Oberacker E, Kuehne A, Waiczies H, Nadobny J, Zschaeck S, Ghadjar P, Wust p, Niendorf T, Winter L (2017) Radiofrequency applicator concepts for simultaneous MR imaging and hyperthermia treatment of glioblastoma multiforme: A 7.0 T (298 MHz) study. ISMRM, Honolulu, USA
Rau B, Wust P, Tilly W, Gellermann J, Harder C, Riess H, Budach V, Felix R, Schlag PM (2000) Preoperative radiochemotherapy in locally advanced or recurrent rectal cancer: regional radiofrequency hyperthermia correlates with clinical parameters. Int J Radiat Oncol Biol Phys 48: 381–391
Seebass M, Beck R, Gellermann J, Nadobny J, Wust P (2001) Electromagnetic phased arrays for regional hyperthermia: optimal frequency and antenna arrangement. Int J Hyperthermia 17: 321–336
Van der Zee J, Gonzalez Gonzalez D, van Rhoon GC, van Dijk JDP, van Putten WLJ, Hart AAM (2000) Comparison of radiotherapy alone with radiotherapy plus hyperthermia in locally advanced pelvic tumours: a prospective, randomised, multicentre trial. Lancet 355: 1119–1125
Weihrauch M, Wust P, Weiser M, Nadobny J, Eisenhardt S, Budach V, Gellermann J 2007) Adaptation of antenna profiles for control of MR guided hyperthermia (HT) in a hybrid MR-HT system. Med Phys 34: 4717–4725
Winter L, Özerdem C, Hoffmann W, Santoro D, Müller A, Waiczies H, Seemann R, Graessl A, Wust P, Niendorf T (2013) Design and evaluation of a hybrid radiofrequency applicator for magnetic resonance imaging and RF induced hyperthermia: electromagnetic field simulations up to 14.0 Tesla and proof-of-concept at 7.0 Tesla. PLoS One 8: e61661
Winter L, Oberacker E, Paul K, Ji Y, Oezerdem C, Ghadjar P, Thieme A, Budach V, Wust P, Niendorf T (2016) Magnetic Resonance Thermometry: Methodology, Pitfalls and Practical Solutions. Int J Hyperthermia 32: 63–75
Wust P (2016) Thermotherapy in Oncology. UNI-MED Science, Bremen, London, Boston
Wust P, Hildebrandt B, Sreenivasa G, Rau B, Gellermann J, Riess H, Felix R, Schlag PM (2002) Hyperthermia in combined treatment of cancer. Lancet Oncol 3: 487–497
Wust P, Cho CH, Hildebrandt B, Gellermann J (2006) Thermal monitoring: invasive, minimal-invasive and non-invasive approaches. Int J Hyperthermia 22: 255–262
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Wust, P., Ghadjar, P. (2018). Wirkungsmechanismus sowie experimentelle und klinische Daten zur regionalen Hyperthermie. In: Rau, B., Piso, P., Königsrainer, A. (eds) Peritoneale Tumoren und Metastasen. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-54500-3_15
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DOI: https://doi.org/10.1007/978-3-662-54500-3_15
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