Abstract
POCT systems are able to measure the different phases of hemostasis (primary hemostasis, thrombin/fibrin formation, clotting and fibrinolysis). The measurements record complex biological processes. These analytical systems mostly demand a high level of training, interpretative competence and quality assurance. Devices for patient-near global coagulation tests (INR, PTT, ACT) are frequently used for this. The self-management of vitamin K antagonists by patients measuring their own INR has produced very good clinical results.
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References
Avidan MS, Alcock El, Da Fonseca JH et al. (2004) Comparison of structured use of routine laboratory tests or near-patient assessment with clinical judgement in the management of bleeding after cardiac surgery. Br J Anaesth 92: 178–86
Bosch YP, Ganushchak YM, de Jong DS (2006) Comparison of ACT point-of-care measurements: repeatability and agreement. Perfusion 1: 27–31
Calatzis A, Heesen M, Spannagl M (2003) Patientennahe Sofortdiagnostik von Hämostaseveränderungen in der Anästhesie und Intensivmedizin. Anaesthesist 52: 229–37
Ferring M, Reber G, de Moerloose P, Merlani P, Diby M, Ricou B (2001) Point of care and central laboratory determinations of the aPTT are not interchangeable in surgical intensive care patients. Can J Anaesth 48: 1155–60
Gibbs NM (2009) Point-of-care assessment of antiplatelet agents in the perioperative period: a review. Anaesth Intensive Care 37:354–69
Hartert H (1948) Blutgerinnungsstudien mit der Thrombelastographie, einem neuen Untersuchungsverfahren. Klin Wschr 26: 577–83
Haubelt H, Anders C, Vogt A, Hoerdt P, Seyfert UT, Hellstern P (2005) Variables influencing Platelet Function Analyzer-100 closure times in healthy individuals. Br J Haematol 130: 759–67
Hayward CP, Harrison P, Cattaneo M, Ortel TL, Rao AK (2006) Platelet function analyzer (PFA)-100 closure time in the evaluation of platelet disorders and platelet function. J Thromb Haemost 4: 312–9
Karger R, Donner-Banzhoff N, Müller HH et al. (2007) Diagnostic performance of the platelet function analyzer (PFA-100) for the detection of disorders of primary haemostasis in patients with a bleeding history-a systematic review and meta-analysis. Platelets 18: 249–60
Koscielny J, Ziemer S, Radtke H et al. (2004) A practical concept for preoperative identification of patients with impaired primary hemostasis. Clin Appl Thromb Hemost 10: 195–204
Kratzer MA, Born GV (1985) Simulation of primary haemostasis in vitro. Haemostasis 15:357–62
Leyvi G, Shore-Lesserson L, Harrington D, Vela-Cantos F, Hossain S (2001) An investigation of a new activated clotting time “MAX-ACT” in patients undergoing extracorporeal circulation. Anesth Analg 92: 578–83
Luddington RJ (2005) Thrombelastography/thromboelastometry. Clin Lab Haematol 27(2): 81–90
Murray DJ, Brosnahan WJ, Pennell B, Kapalanski D, Weiler JM, Olson J (1997) Heparin detection by the activated coagulation time: a comparison of the sensitivity of coagulation tests and heparin assays. J Cardiothorac Vasc Anesth 11:24–8
Niederdöckl J, Dempfle CE, Schönherr HR, Bartsch A, Miles G, Laggner A, Pathil A (2016) Point-of-care PT and aPTT in patients with suspected deficiencies of coagulation factors. Int J Lab Hematol 38:426–34
Nitu-Whalley IC, Lee CA, Brown SA, Riddell A, Hermans C (2003) The role of the platelet function analyser (PFA-100) in the characterization of patients with von Willebrand’s disease and its relationships with von Willebrand factor and the ABO blood group. Haemophilia 9: 298–302
Paniccia R, Priora R, Liotta AA, Abbate R (2015) Platelet function tests: a comparative review. Vasc Health Risk Manag 11:133–48
Price MJ, Berger PB, Teirstein PS, Tanguay JF, Angiolillo DJ, Spriggs D, Puri S, Robbins M, Garratt KN, Bertrand OF, Stillabower ME, Aragon JR, Kandzari DE, Stinis CT, Lee MS, Manoukian SV, Cannon CP, Schork NJ, Topol EJ; GRAVITAS Investigators (2011) Standard- vs. high-dose clopidogrel based on platelet function testing after percutaneous coronary intervention: the GRAVITAS randomized trial. JAMA 305:1097–105
Sibbing D, Braun S, Morath T, Mehilli J, Vogt W, Schömig A, Kastrati A, von Beckerath N (2009) Platelet reactivity after clopidogrel treatment assessed with point-of-care analysis and early drug-eluting stent thrombosis. J Am Coll Cardiol 53:849–56
Smith JW, Steinhubl SR, Lincoff AM et al. (1999) Rapid platelet-function assay: an automated and quantitative cartridge-based method. Circulation 99:620–5
Spannagl M, Dick A, Junker R (2010) Qualitätssicherung bei POCT-Methoden in der Hämostaseologie. Hämostaseologie 30;2: 82–90
Spannagl M, Dick A, Junker R (2010) POCT in coagulation. Hämostaseologie 30:82–90
Toth O, Calatzis A, Penz S, Losonczy H, Siess W (2006) Multiplate electrode aggregometry: a new device to measure platelet aggregation in whole blood. Thromb Haemost 96:781–8
Zucker ML (2007) The National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines for Point of Care Coagulation Testing. Point of Care 6: 223–6
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Spannagl, M., Peetz, D. (2018). Laboratory coagulation tests. In: Luppa, P.B., Junker, R. (eds) Point-of-Care Testing. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-54497-6_6
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DOI: https://doi.org/10.1007/978-3-662-54497-6_6
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