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Pathogenesis and Treatment of Disorders of Sexual Development

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Endocrine Surgery in Children

Abstract

This chapter reviews the pathogenesis and treatment of Disorders of Sex Development (DSD). “Disorders of Sex Development” is a more comprehensive term than the older terms “Ambiguous Genitalia” or “Intersex” and covers a broad clinical spectrum of hormonal, metabolic, and chromosomal abnormalities resulting in abnormal genital development. Patients with DSD are best evaluated and treated by a multidisciplinary team of medical and surgical specialists. In this era of shared decision-making, the diagnosis and treatment plan must be thoroughly discussed with parents, with the goal of giving the child the most satisfactory quality of life possible. It is essential that surgeons taking care of these complex patients feel comfortable with all the available techniques, so they can achieve satisfactory anatomical and functional repairs that support either the male of female gender.

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Authors and Affiliations

  1. Department of Pediatric Surgery, MassGeneral Hospital for Children, 55 Fruit Street, Boston, MA, 02114, USA

    Rafael V. Pieretti

  2. Pediatric Surgical Research Laboratories, Massachusetts General Hospital, Boston, MA, 02414, USA

    Patricia K. Donahoe

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  1. Rafael V. Pieretti
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  2. Patricia K. Donahoe
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Correspondence to Rafael V. Pieretti .

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Editors and Affiliations

  1. Seattle Children’s Hospital, Seattle, Washington, USA

    Daniel J. Ledbetter

  2. Academic Pediatric Surgery Unit, Nuffield Department of Surgical Sciences, John Radcliffe Hospital, Oxford, United Kingdom

    Paul R.V. Johnson

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Pieretti, R.V., Donahoe, P.K. (2018). Pathogenesis and Treatment of Disorders of Sexual Development. In: Ledbetter, D., Johnson, P. (eds) Endocrine Surgery in Children. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-54256-9_18

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