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Biomaterials for Tendon Regeneration

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Muscle and Tendon Injuries

Abstract

Tendon is a highly complex tissue that exhibits high mechanical strength, flexibility, and extensibility to perform movement and physical exercise. However, it is exposed at a high-risk of injury, namely, at the tendon–bone interface (TBi).

The tendon natural healing process occurs by reactive scar formation, giving origin to a tissue that does not have the same characteristics of native tendon. As a consequence the healing response is suboptimal causing scar tissue formation, which implies inferior mechanical properties.

Tissue engineering using biomaterials trying to regenerate tendon tissue and improve clinical outcomes when treating tendon pathology is the focus of intense investigation worldwide. The authors review tendon structure and healing process and summarize the current knowledge about biomaterials for tendon regeneration.

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Authors and Affiliations

  1. Life and Health Sciences Research Institute (ICVS), School of Medicne, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal

    Nuno Sevivas, Hélder Pereira, António Salgado & João Espregueira-Mendes

  2. ICVS/3B’s - PT Government Associate Laboratory, Braga/Guimarães, Portugal

    Nuno Sevivas, Hélder Pereira, António Salgado & João Espregueira-Mendes

  3. Orthopaedics Department, Hospital de Braga, Braga, Portugal

    Nuno Sevivas, Guilherme França & Nuno Oliveira

  4. Orthopaedics Department, Hospital Privado de Braga, Braga, Portugal

    Nuno Sevivas

  5. Clínica Espregueira-Mendes, FIFA Medical Centre of Excellence, Estádio do Dragão, Porto, Portugal

    Nuno Sevivas & João Espregueira-Mendes

  6. 3B’s Research Group, Biomaterials, Biodegradables and Biomimetics, Department of Polymer Engineering, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Zona Industrial da Gandra, S. Cláudio do Barco, 4806-909 Caldas das Taipas, Guimarães, Portugal

    Hélder Pereira & João Espregueira-Mendes

  7. Orthopaedics Department, Centro Hospitalar Póvoa de Varzim – Vila do Conde, Póvoa de Varzim, Portugal

    Hélder Pereira

  8. School of Materials Science and Engineering, Nanyang Technological University, Singapore, Singapore

    K. W. Ng

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  1. Nuno Sevivas
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  2. Guilherme França
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  3. Nuno Oliveira
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  4. Hélder Pereira
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  5. K. W. Ng
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  6. António Salgado
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  7. João Espregueira-Mendes
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Correspondence to Nuno Sevivas .

Editor information

Editors and Affiliations

  1. Koelliker Hospital, Centre of Sports Traumatology, Torino, Italy

    Gian Luigi Canata

  2. Dept. of Orthopaedic Surgery, Aspetar Hospital Aspire Zone, Doha, Qatar

    Pieter d'Hooghe

  3. Department of Orthopedics, University of Colorado Hospital, Aurora, Colorado, USA

    Kenneth J. Hunt

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Sevivas, N. et al. (2017). Biomaterials for Tendon Regeneration. In: Canata, G., d'Hooghe, P., Hunt, K. (eds) Muscle and Tendon Injuries. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-54184-5_13

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  • DOI: https://doi.org/10.1007/978-3-662-54184-5_13

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