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3D-Printed Artificial Meniscus

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Bio-orthopaedics

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Abstract

The majority of meniscal injuries require removal of the torn meniscus [1]. Although meniscectomy decreases the pain temporarily, even partial meniscectomy leads to osteoarthritis (OA) due to its crucial role in protecting articular cartilage [2, 3]. Meniscus repair could be a better option; however, owing to its poor healing potential, the indications for meniscus repair are limited, and failure rates remain high [4, 5]. Although there are now increasing data to support the use of allograft meniscus replacement and artificial meniscal substitutes in advanced cases of meniscus loss, even with the appropriate indications, these options are impaired by a lack of universal efficacy and limited availability. For this reason, tissue-engineering approaches and biological augmentation of meniscus repair and replacement are important considerations. This article summarizes current data on meniscus scaffolds for replacement surgery. Furthermore, we place particular focus on three-dimensional (3D)-printed artificial meniscus scaffolds.

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Acknowledgment

The authors acknowledge Chang H Lee PhD, Hanying Bai PhD, from Tissue Engineering and Regenerative Medicine Laboratory, Columbia University Medical Center, New York, New York.

Author information

Authors and Affiliations

  1. Tissue Engineering, Repair, and Regeneration Program, Hospital for Special Surgery, 535 East 70th Street, New York, NY, 10021, USA

    Yusuke Nakagawa M.D., Ph.D. & Scott A. Rodeo M.D.

  2. Center for Stem Cell and Regenerative Medicine, Tokyo Medical and Dental University, Tokyo, Japan

    Yusuke Nakagawa M.D., Ph.D. & Ichiro Sekiya M.D., Ph.D.

  3. Department of Clinical Sciences, College of Veterinary Medicine Weill Cornell Medical College, New York, NY, USA

    Lisa A. Fortier D.V.M., Ph.D.

  4. Tissue Engineering and Regenerative Medicine Laboratory, Columbia University Medical Center, New York, NY, USA

    Jeremy J. Mao Ph.D.

Authors
  1. Yusuke Nakagawa M.D., Ph.D.
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  2. Lisa A. Fortier D.V.M., Ph.D.
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  3. Jeremy J. Mao Ph.D.
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  4. Ichiro Sekiya M.D., Ph.D.
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  5. Scott A. Rodeo M.D.
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Corresponding author

Correspondence to Scott A. Rodeo M.D. .

Editor information

Editors and Affiliations

  1. O.A.S.I. Bioresearch Foundation NPO, Milan, Italy

    Alberto Gobbi

  2. Clínica do Dragão, Espregueira-Mendes Sports Centre – FIFA Medical Centre of Excellence, Porto, Portugal

    João Espregueira-Mendes

  3. Musculoskeletal and Joint Research Foundation, San Diego, California, USA

    John G. Lane

  4. Department of Orthopedics, Acibadem University, Istanbul, Turkey

    Mustafa Karahan

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Nakagawa, Y., Fortier, L.A., Mao, J.J., Sekiya, I., Rodeo, S.A. (2017). 3D-Printed Artificial Meniscus. In: Gobbi, A., Espregueira-Mendes, J., Lane, J., Karahan, M. (eds) Bio-orthopaedics. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-54181-4_33

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  • DOI: https://doi.org/10.1007/978-3-662-54181-4_33

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