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Serum, Synovial, and Salivary Biomarkers for Orofacial Pain Conditions

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Orofacial Pain Biomarkers

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Abstract

Orofacial conditions such as temporomandibular disorders are often associated with extended bouts of debilitating chronic pain. Unfortunately, these and other similar pathologies are characterized by their inherent complexity and poorly understood etiologies making diagnoses and subsequent treatments exceedingly difficult. With a significant proportion of the population suffering from painful orofacial conditions, the development of new and accurate diagnostic procedures is essential to improve the current standard of care. Here, we overview the potential of serum, saliva, and synovial fluids as reservoirs of biochemical information capable of discerning specific disorders, including those correlated with orofacial pain. Determining the worth of these biofluids in the assessment of health status could expedite diagnoses and enhance pain management strategies while also enhancing our understanding of disease pathophysiology.

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Authors and Affiliations

  1. University of California Los Angeles, School of Dentistry, 10833 Le Conte Ave., 73-041 CHS, Los Angeles, CA, 90095, USA

    Stergios Katsiougiannis PhD, Varun R. Mallela BDS, DDS & Christopher A. Schafer BS, MBA, PhD

  2. Department of Dentistry, UCLA, 10833 Le Conte Ave., 73-038 CH, Los Angeles, CA, 90095, USA

    David T. W. Wong MD, DMD, DMSc

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  1. Stergios Katsiougiannis PhD
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  2. Varun R. Mallela BDS, DDS
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  3. Christopher A. Schafer BS, MBA, PhD
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  4. David T. W. Wong MD, DMD, DMSc
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Correspondence to David T. W. Wong MD, DMD, DMSc .

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  1. Faculté de médecine dentaire, Université Laval, Québec, Canada

    Jean-Paul Goulet

  2. Faculty of Dentistry, McGill University, Department of Dentistry of Jewish General Hospital, Montréal, Québec, Canada

    Ana Miriam Velly

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Katsiougiannis, S., Mallela, V.R., Schafer, C.A., Wong, D.T.W. (2017). Serum, Synovial, and Salivary Biomarkers for Orofacial Pain Conditions. In: Goulet, JP., Velly, A. (eds) Orofacial Pain Biomarkers. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-53994-1_9

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