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Zusammenfassung

Die Beurteilung des Gehirns erfolgt üblicherweise zwischen der 19+0 und 22+0 SSW. Leitlinien empfehlen die Darstellung des Zerebellums, der Cisterna magna, der Seitenventrikel, des Plexus choroideus, der Falx cerebri und des Cavum septi pellucidi, um die Detektionsrate kongenitaler Hirnanomalien zu verbessern. Die zwei sonographischen Standardeinstellungen durch das fetale Gehirn werden dargelegt. Nach Beschreibung der Anatomie und der physiologischen Hirnentwicklung werden Krankheitsbilder und Fehlentwicklungen vorgestellt. Neben deren Diagnostik werden mögliche Therapien und die Prognose diskutiert. Zudem werden alle wichtigen Fehlbildungen des Rückenmarks und der Wirbelsäule behandelt.

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Literatur

Literatur zu Abschn. 6.1

  • Adamsbaum C, Moutard ML, André C, Merzoug V, Ferey S, Quéré MP, Lewin F, Fallet-Bianco C (2005) MRI of the fetal posterior fossa. Pediatric Radiol 35: 124–140

    Google Scholar 

  • AIUM (2003) AIUM Practice Guideline for the performance of an antepartum obstetric ultrasound examination. J Ultrasound Med 22: 1116–1125

    Google Scholar 

  • Alonso I, Borenstein M, Grant G, Narbona I, Azumendi G (2010) Depth of brain fissures in normal fetuses by prenatal ultrasound between 19 and 30 weeks of gestation. Ultrasound Obstet Gynecol 36: 693–699

    Google Scholar 

  • Baenziger O, Martin E, Willi U, Fanconi S, Real F, Boltshauser E (1993) Prenatal brain atrophy due to a giant vein of Galen malformation. Neuroradiology 35: 105–106

    Google Scholar 

  • Barkovich AJ (2002) Magnetic resonance imaging: role in the understanding of cerebral malformations. Brain Dev 24: 2–12

    Google Scholar 

  • Barkovich AJ, Chuang SH (1990) Unilateral megalencephaly: correlation of MR imaging and pathologic characteristics. AJNR 11: 523–531

    Google Scholar 

  • Barkovich AJ, Kjos BO (1992) Schizencephaly: correlation of clinical findings with MR characteristics. AJNR 13: 85–94

    Google Scholar 

  • Barkovich AJ, Norman D (1988) Anomalies of the corpus callosum: correlation with further anomalies of the brain. AJR 151: 171–179

    Google Scholar 

  • Barr M Jr, Cohen MM Jr (1999) Holoprosencephaly survival and performance. Am J Med Genetics 89: 116–120

    Google Scholar 

  • Benoist G, Salomon LJ, Jacquemard F, Daffos F, Ville Y (2008) The prognostic value of ultrasound abnormalities and biological parameters in blood of fetuses infected with cytomegalovirus. BJOG 115: 823–829

    Google Scholar 

  • Bird CR, Gilles FH (1987) Type I schizencephaly: CT and neuropathologic findings. AJNR 8: 451–454

    Google Scholar 

  • Blaas HG, Eriksson AG, Salvesen KA, Isaksen CV, Christensen B, Møllerløkken G, Eik-Nes SH (2002) Brains and faces in holoprosencephaly: pre- and postnatal description of 30 cases. Ultrasound Obstet Gynecol 19: 24–38

    Google Scholar 

  • Brasseur-Daudruy M, Vivier PH, Ickowicz V, Eurin D, Verspyck E (2012) Walker-Warburg syndrome diagnosed by findings of typical ocular abnormalities on prenatal ultrasound. Pediatr Radiol 42:488–490

    Google Scholar 

  • Breeze AC, Dey PK, Lees CC, Hackett GA, Smith GC, Murdoch EM (2005) Obstetric and neonatal outcomes in apparently isolated mild fetal ventriculomegaly. J Prenatal Med 33: 236–240

    Google Scholar 

  • Brojer E, Husebekk A, Debska M, Uhrynowska M, Guz K, Orzińska A, Dębski R, Maślanka K (2016) Fetal/neonatal alloimmune thrombocytopenia: pathogenesis, diagnostics and prevention. Arch Immunol Ther Exp (Warsz) 64: 279–290

    Google Scholar 

  • Calabro F, Arcuri T, Jinkins JR (2000) Blake’s pouch cyst: an entity within the Dandy-Walker continuum. Neuroradiology 42: 290–295

    Google Scholar 

  • Carroll SG, Porter H, Abdel-Fattah S, Kyle PM, Soothill PW (2000) Correlation of prenatal ultrasound diagnosis and pathologic findings in fetal brain abnormalities. Ultrasound Obstet Gynecol 16: 149–53

    Google Scholar 

  • Chen CP (2007) Prenatal diagnosis of arachnoid cysts. Taiwanese J Obstet Gynecol 46: 187–198

    Google Scholar 

  • Chitayat D, Toi A, Babul R, Blaser S, Moola S, Yarkoni D, Sermer M, Johnson JA, Vasjar J, Teshima I (1997) Omphalocele in Miller-Dieker syndrome: expanding the phenotype. Am J Med Genetics 69: 293–298

    Google Scholar 

  • Clark GD (2002) Brain development and the genetics of brain development. Neurol Clin 20: 917–39

    Google Scholar 

  • Cohen-Sacher B, Lerman-Sagie T, Lev D, Malinger G (2006) Sonographic developmental milestones of the fetal cerebral cortex: a longitudinal study. Ultrasound Obstet Gynecol 27: 494–502

    Google Scholar 

  • Croen LA, Shaw GM, Lammer EJ (1996) Holoprosencephaly: epidemiologic and clinical characteristics of a California population. Am J Med Genetics 64: 465–472

    Google Scholar 

  • D’Addario V, Pinto V, Meo F, Resta M (1998) The specificity of ultrasound in the detection of fetal intracranial tumors. J Prenatal Med 26 (6): 480–485

    Google Scholar 

  • Dahlgren L, Wilson RD (2001) Prenatally diagnosed microcephaly: a review of etiologies. Fetal Diagn Ther 16: 323–326

    Google Scholar 

  • Dan U, Shalev E, Greif M, Weiner E (1992) Prenatal diagnosis of fetal brain arteriovenous malformation: the use of color Doppler imaging. JCU 20: 149–151

    Google Scholar 

  • D’Antonio F, Khalil A, Garel C, Pilu G, Rizzo G, Lerman-Sagie T, Bhide A, Thilaganathan B, Manzoli L, Papageorghiou AT (2016) Systematic review and meta-analysis of isolated posterior fossa malformations on prenatal ultrasound imaging (part 1): nomenclature, diagnostic accuracy and associated anomalies. Ultrasound Obstet Gynecol 47: 690–697

    Google Scholar 

  • David AL, Gowda V, Turnbull C, Chitty LS (2007) The risk of recurrence of holoprosencephaly in euploid fetuses. Obstet Gynecol 110: 658–662

    Google Scholar 

  • Demyer W, Zeman W, Palmer CG (1964) The face predicts the brain: diagnostic significance of median facial anomalies for holoprosencephaly (arhinencephaly). Pediatrics 34: 256–263

    Google Scholar 

  • Dobyns WB, Pagon RA, Armstrong D, Curry CJ, Greenberg F, Grix A, et al (1989) Diagnostic criteria for Walker-Warburg syndrome. Am J Med Genet 32: 195–210

    Google Scholar 

  • Dobyns WB, Curry CJ, Hoyme HE, Turlington L, Ledbetter DH (1991) Clinical and molecular diagnosis of Miller-Dieker syndrome. Am J Hum Genet 48: 584–594

    Google Scholar 

  • Dubourg C, Bendavid C, Pasquier L, Henry C, Odent S, David V (2007) Holoprosencephaly. Orphanet J Rare Diseases 2: 8

    Google Scholar 

  • Duckelmann AM, Kalache KD (2010) Three-dimensional ultrasound in evaluating the fetus. Prenat Diagn 30: 631–8

    Google Scholar 

  • Flores-Sarnat L (2008) Hemimegalencephaly syndrome. In: Vinken PJ, Bruyn GW (eds) Handbook of clinical neurology. 87: 153–76

    Google Scholar 

  • Fong KW, Ghai S, Toi A, Blaser S, Winsor EJ, Chitayat D (2004) Prenatal ultrasound findings of lissencephaly associated with Miller-Dieker syndrome and comparison with pre- and postnatal magnetic resonance imaging. Ultrasound Obstet Gynecol 24: 716–723

    Google Scholar 

  • Forzano F, Mansour S, Ierullo A, Homfray T, Thilaganathan B (2007) Posterior fossa malformation in fetuses: a report of 56 further cases and a review of the literature. Prenat Diagn 27: 495–501

    Google Scholar 

  • Gagel K, Heling KS, Kalache KD, Chaoui R (2003) Prenatal Diagn of an intracranial arteriovenous fistula in the posterior fossa on the basis of color and three-dimensional power Doppler ultrasonography. J Ultrasound Med 22: 1399–1403

    Google Scholar 

  • Gaglioti P, Danelon D, Bontempo S, Mombro M, Cardaropoli S, Todros T (2005) Fetal cerebral ventriculomegaly: outcome in 176 cases. Ultrasound Obstet Gynecol 25: 372–377

    Google Scholar 

  • Garel C, Fallet-Bianco C, Guibaud L (2011) The fetal cerebellum: development and common malformations. J Child Neurol 26: 1483–1492

    Google Scholar 

  • Ghi T, Simonazzi G, Perolo A, Savelli L, Sandri F, Bernardi B, Santini D, Bovicelli L, Pilu G (2003) Outcome of antenatally diagnosed intracranial hemorrhage: case series and review of the literature. Ultrasound Obstet Gynecol 22: 121–130

    Google Scholar 

  • Girard N, Raybaud C, Gambarelli D, Figarella-Branger D (2001) Fetal brain MR imaging. Magn Reson Imaging Clin N Am 9: 19–56

    Google Scholar 

  • Goldstein I, Copel JA, Makhoul IR (2005) Mild cerebral ventriculomegaly in fetuses: characteristics and outcome. Fetal Diagn Ther 20: 281–284

    Google Scholar 

  • Golja AM, Estroff JA, Robertson RL (2004) Fetal imaging of central nervous system abnormalities. Neuroim Clin North Am 14: 293–306

    Google Scholar 

  • Goncalves LF, Lee W, Espinoza J, Romero R (2005) Three- and 4-dimensional ultrasound in obstetric practice: does it help? J Ultrasound Med 24: 1599–1624

    Google Scholar 

  • Guibaud L (2004) Practical approach to prenatal posterior fossa abnormalities using MRI. Pediatric Radiol 34: 700–711

    Google Scholar 

  • Guibaud L (2009) Fetal cerebral ventricular measurement and ventriculomegaly: time for procedure standardization. Ultrasound Obstet Gynecol 34: 127–130

    Google Scholar 

  • Guibaud L, Lacalm A (2015) Etiological diagnostic tools to elucidate ‘isolated’ ventriculomegaly. Ultrasound Obstet Gynecol 46: 1–11

    Google Scholar 

  • Guibaud L, Attia-Sobol J, Buenerd A, Foray P, Jacquet C, Champion F, Arnould P, Pracros JP, Golfier F (2004) Focal sonographic periventricular pattern associated with mild ventriculomegaly in foetal cytomegalic infection revealing cytomegalic encephalitis in the third trimester of pregnancy. Prenat Diagn 24: 727–732

    Google Scholar 

  • Gupta JK, Lilford RJ (1995) Assessment and management of fetal agenesis of the corpus callosum. Prenat Diagn 15: 301–312

    Google Scholar 

  • Gupta AK, Varma DR (2004) Vein of Galen malformations: review. Neurology India 52: 43–53

    Google Scholar 

  • Hogge WA, Schnatterly P, Ferguson JE 2nd (1995) Early prenatal diagnosis of an infratentorial arachnoid cyst: association with an unbalanced translocation. Prenat Diagn 15: 186–188

    Google Scholar 

  • International Society of Ultrasound in Obstetrics & Gynecology Education Committee (2007) Sonographic examination of the fetal central nervous system: guidelines for performing the ›basic examination‹ and the ›fetal neurosonogram‹. Ultrasound Obstet Gynecol 29: 109–116

    Google Scholar 

  • Kalache KD, Eder K, Esser T, Proquitte H, Stoltenburg-Didinger G, Hartung JP, et al (2006) Three-dimensional ultrasonographic reslicing of the fetal brain to assist prenatal diagnosis of central nervous system anomalies. J Ultrasound Med 25: 509–514

    Google Scholar 

  • Kapur RP, Mahony BS, Finch L, Siebert JR (2009) Normal and abnormal anatomy of the cerebellar vermis in midgestational human fetuses. Birth Defects Res A Clin Mol Teratol 85: 700–709

    Google Scholar 

  • Kilic T, Akakin A (2008) Anatomy of cerebral veins and sinuses. Front Neurol Neurosci 23: 4–15

    Google Scholar 

  • Lacalm A, Garel C, Massoud M, Gelot A, Jouannic J, Guibaud L (2015) Prenatal diagnosis of multiple cortical and deep cerebral vein thromboses in the absence of dural venous malformation. Ultrasound Obstet Gynecol 45: 486–8

    Google Scholar 

  • Laurichesse Delmas H, Winer N, Gallot D, Lopes K, Perrotin F, Fluncker S, Geissler F, Beaufrere AM, Vendittelli F, Couture C, Lemery D (2008) Prenatal diagnosis of thrombosis of the dural sinuses: report of six cases, review of the literature and suggested management. Ultrasound Obstet Gynecol 32: 188–198

    Google Scholar 

  • Malinger G, Ginath S, Lerman-Sagie T, Watemberg N, Lev D, Glezerman M (2001) The fetal cerebellar vermis: normal development as shown by transvaginal ultrasound. Prenat Diagn 21: 687–692

    Google Scholar 

  • Malinger G, Lev D, Lerman-Sagie T (2003) Assessment of fetal intracranial pathologies first demonstrated late in pregnancy: cell proliferation disorders. Reprod Biol Endocrin 1: 110

    Google Scholar 

  • Malinger G, Lev D, Zahalka N, Ben Aroia Z, Watemberg N, Kidron D, Sira LB, Lerman-Sagie T (2003) Fetal cytomegalovirus infection of the brain: the spectrum of sonographic findings. AJNR 24: 28–32

    Google Scholar 

  • Malinger G, Lev D, Lerman-Sagie T (2006) Normal and abnormal fetal brain development during the third trimester as demonstrated by neurosonography. Eur J Radiol 57: 226–232

    Google Scholar 

  • Martin HP (1970) Microcephaly and mental retardation. Am J Dis Child 119: 128–131

    Google Scholar 

  • Massoud M, Cagneaux M, Garel C, Varene N, Moutard ML, Billette T, et al (2014) Prenatal unilateral cerebellar hypoplasia in a series of 26 cases: significance and implications for prenatal diagnosis. Ultrasound Obstet Gynecol 44: 447–454

    Google Scholar 

  • Matsushita H, Harada A, Sato T, Kurabayashi T (2014) Fetal intracranial injuries following motor vehicle accidents with airbag deployment. J Obstet Gynaecol Res 40: 599–602

    Google Scholar 

  • Melchiorre K, Bhide A, Gika AD, Pilu G, Papageorghiou AT (2009) Counseling in isolated mild fetal ventriculomegaly. Ultrasound Obstet Gynecol 34: 212–224

    Google Scholar 

  • Mirlesse V, Courtiol C, Althuser M, Duyme M (2010) Ultrasonography of the fetal brainstem: a biometric and anatomical, multioperator, cross-sectional study of 913 fetuses of 21–36 weeks of gestation. Prenat Diagn 30: 739–745

    Google Scholar 

  • Mittal P, Goncalves LF, Kusanovic JP, Espinoza J, Lee W, Nien JK, et al (2007) Objective evaluation of sylvian fissure development by multiplanar 3-dimensional ultrasonography. J Ultrasound Med 26: 347–353

    Google Scholar 

  • Monteagudo A, Timor-Tritsch IE (1997) Development of fetal gyri, sulci and fissures: a transvaginal sonographic study. Ultrasound Obstet Gynecol 9: 222–228

    Google Scholar 

  • Monteagudo A, Timor-Tritsch IE (2009) Normal sonographic development of the central nervous system from the second trimester onwards using 2D, 3D and transvaginal sonography. Prenat Diagn 29: 326–339

    Google Scholar 

  • Olsen CL, Hughes JP, Youngblood LG, Sharpe-Stimac M (1997) Epidemiology of holoprosencephaly and phenotypic characteristics of affected children: New York State, 1984–1989. Am J Med Genet 73: 217–226

    Google Scholar 

  • Piastra M, Pietrini D, Massimi L, Caldarelli M, De Luca D, Del Lungo LM, De Carolis MP, Di Rocco C, Conti G, Zecca E (2009) Severe subdural hemorrhage due to minimal prenatal trauma. J Neurosurg Pediatr 4: 543–546

    Google Scholar 

  • Pilu G, Ambrosetto P, Sandri F, Tani G, Perolo A, Grisolia G, Ancora G (1994) Intraventricular fused fornices: a specific sign of fetal lobar holoprosencephaly. Ultrasound Obstet Gynecol 4: 65–67

    Google Scholar 

  • Pilu G, Falco P, Perolo A, Sandri F, Cocchi G, Ancora G, Bovicelli L (1997) Differential diagnosis and outcome of fetal intracranial hypoechoic lesions: report of 21 cases. Ultrasound Obstet Gynecol 9: 229–236

    Google Scholar 

  • Pomeranz S, Constantini S, Lubetzki-Korn I, Amir N (1991) Familial intracranial arachnoid cysts. Childs Nerv Syst 7: 100–102

    Google Scholar 

  • Rafferty PG, Britton J, Penna L, Ville Y (1998) Prenatal diagnosis of a large fetal arachnoid cyst. Ultrasound Obstet Gynecol 12: 358–361

    Google Scholar 

  • Raybaud C, Levrier O, Brunel H, Girard N, Farnarier P (2003) MR imaging of fetal brain malformations. Childs Nerv Syst 19: 455–470

    Google Scholar 

  • Rayssiguier R, Dumont C, Flunker S, Couture A, Boulot P, Prodhomme O (2014) Thrombosis of torcular herophili: diagnosis, prenatal management, and outcome. Prenat Diagn 34: 1168–1175

    Google Scholar 

  • Robain O, Floquet C, Heldt N, Rozenberg F (1988) Hemimegalencephaly: a clinicopathological study of four cases. Neuropathol Appl Neurobiol 14: 125–135

    Google Scholar 

  • Robinson AJ, Goldstein R (2007) The cisterna magna septa: vestigial remnants of Blake’s pouch and a potential new marker for normal development of the rhombencephalon. J Ultrasound Med 26: 83–95

    Google Scholar 

  • Robinson AJ, Blaser S, Toi A, Chitayat D, Halliday W, Pantazi S, Gundogan M, Laughlin S, Ryan G (2007) The fetal cerebellar vermis: assessment for abnormal development by ultrasonography and magnetic resonance imaging. Ultrasound Quart 23: 211–223

    Google Scholar 

  • Rolo LC, Araujo Junior E, Nardozza LM, de Oliveira PS, Ajzen SA, Moron AF (2011) Development of fetal brain sulci and gyri: assessment through two and three-dimensional ultrasound and magnetic resonance imaging. Arch Gynecol Obstet 283: 149–158

    Google Scholar 

  • Rufener SL, Ibrahim M, Raybaud CA, Parmar HA (2010) Congenital spine and spinal cord malformations--pictorial review. AJR 194 (3 Suppl): S 26–37

    Google Scholar 

  • Sakuta R, Aikawa H, Takashima S, Ryo S (1991) Epidermal nevus syndrome with hemimegalencephaly: neuropathological study. Brain Dev 13: 260–265

    Google Scholar 

  • Sanapo L, Wien M, Whitehead MT, Blask A, Gallagher M, DeBiasi RL, Du Plessis A (2017) Fetal anemia, cerebellar hemorrhage and hypoplasia associated with congenital Parvovirus infection. J Matern Fetal Neonatal Med 30: 1887–1890

    Google Scholar 

  • Schlembach D, Bornemann A, Rupprecht T, Beinder E (1999) Fetal intracranial tumors detected by ultrasound: a report of two cases and review of the literature. Ultrasound Obstet Gynecol 14: 407–418

    Google Scholar 

  • Sheerin F (2009) The imaging of the cerebral venous sinuses. Semin Ultrasound CT MR 30: 525–558

    Google Scholar 

  • Sherer DM, Onyeije CI (1998) Prenatal ultrasonographic diagnosis of fetal intracranial tumors: a review. Am J Perinatol 15: 319–328

    Google Scholar 

  • Silva F, Morais S, Sevivas T, Veiga R, Salvado R, Taborda A (2011) Severe intracranial haemorrhage in neonatal alloimmune thrombocytopenia. BMJ Case Rep 9: 2011

    Google Scholar 

  • Simonazzi G, Guerra B, Bonasoni P, Pilu G, Lazzarotto T, Santini D, Rizzo N (2010) Fetal cerebral periventricular halo at midgestation: an ultrasound finding suggestive of fetal cytomegalovirus infection. Am J Obstet Gynecol 202: 599 e1–5

    Google Scholar 

  • Sonigo PC, Rypens FF, Carteret M, Delezoide AL, Brunelle FO (1998) MR imaging of fetal cerebral anomalies. Pediatr Radiol 28: 212–222

    Google Scholar 

  • Suzuki H, Takanashi J, Sugita K, Barkovich AJ, Kohno Y (2002) Retrocerebellar arachnoid cysts in siblings with mental retardation and undescended testis. Brain Dev 24: 310–313

    Google Scholar 

  • Toi A, Lister WS, Fong KW (2004) How early are fetal cerebral sulci visible at prenatal ultrasound and what is the normal pattern of early fetal sulcal development? Ultrasound Obstet Gynecol 24: 706–715

    Google Scholar 

  • Vajsar J, Schachter H (2006) Walker-Warburg syndrome. Orphanet J Rare Dis 1: 29

    Google Scholar 

  • Volpe P, Campobasso G, De Robertis V, Rembouskos G (2009) Disorders of prosencephalic development. Prenat Diagn 29: 340–354

    Google Scholar 

  • Volpe P, Contro E, De Musso F, Ghi T, Farina A, Tempesta A, Volpe G, Rizzo N, Pilu G (2012) Brainstem-vermis and brainstem-tentorium angles allow accurate categorization of fetal upward rotation of cerebellar vermis. Ultrasound Obstet Gynecol 39: 632–635

    Google Scholar 

  • Vouga M, Baud D (2016) Imaging of congenital Zika virus infection: the route to identification of prognostic factors. Prenat Diagn 36: 799–811

    Google Scholar 

  • Yuval Y, Lerner A, Lipitz S, Rotstein Z, Hegesh J, Achiron R (1997) Prenatal diagnosis of vein of Galen aneurysmal malformation: report of two cases with proposal for prognostic indices. Prenat Diagn 17: 972–977

    Google Scholar 

  • Zalel Y, Seidman DS, Brand N, Lipitz S, Achiron R (2002) The development of the fetal vermis: an in-utero sonographic evaluation. Ultrasound Obstet Gynecol 19: 136–139

    Google Scholar 

  • Zalel Y, Yagel S, Achiron R, Kivilevich Z, Gindes L (2009) Three-dimensional ultrasonography of the fetal vermis at 18 to 26 weeks’ gestation: time of appearance of the primary fissure. J Ultrasound Med 28: 1–8

    Google Scholar 

Literatur zu Abschn. 6.2

  • Adzick NS, Thom EA, Spong CY, Brock JW, 3rd, Burrows PK, Johnson MP, et al (2011) A randomized trial of prenatal versus postnatal repair of myelomeningocele. New Engl J Med 364: 993–1004

    Google Scholar 

  • Allen LM, Silverman RK (2000) Prenatal ultrasound evaluation of fetal diastematomyelia: two cases of type I split cord malformation. Ultrasound Obstet Gynecol 15: 78–82

    Google Scholar 

  • Bahlmann F, Reinhard I, Schramm T, Geipel A, Gembruch U, von Kaisenberg CS, et al (2015) Cranial and cerebral signs in the diagnosis of spina bifida between 18 and 22 weeks of gestation: a German multicentre study. Prenat Diagn 35: 228–235

    Google Scholar 

  • Chaoui R, Nicolaides KH (2011) Detecting open spina bifida at the 11–13-week scan by assessing intracranial translucency and the posterior brain region: mid-sagittal or axial plane? Ultrasound Obstet Gynecol 38: 609–612

    Google Scholar 

  • Chaoui R, Benoit B, Mitkowska-Wozniak H, Heling KS, Nicolaides KH (2009) Assessment of intracranial translucency (IT) in the detection of spina bifida at the 11-13-week scan. Ultrasound Obstet Gynecol 34: 249–252

    Google Scholar 

  • Chaoui R, Benoit B, Heling KS, Kagan KO, Pietzsch V, Sarut Lopez A, et al (2011) Prospective detection of open spina bifida at 11–13 weeks by assessing intracranial translucency and posterior brain. Ultrasound Obstet Gynecol 38: 722–726

    Google Scholar 

  • Clemmensen D, Thygesen M, Rasmussen MM, Fenger-Gron M, Petersen OB, Mosdal C (2011) Decreased incidence of myelomeningocele at birth: effect of folic acid recommendations or prenatal diagnostics? Childs Nerv Syst 27: 1951–1955

    Google Scholar 

  • Czeizel AE, Dudas I (1992) Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation. N Engl J Med 327: 1832–1835

    Google Scholar 

  • D’Addario V, Rossi AC, Pinto V, Pintucci A, Di Cagno L (2008) Comparison of six sonographic signs in the prenatal diagnosis of spina bifida. J Perinat Med 36: 330–334

    Google Scholar 

  • De Biasio P, Ginocchio G, Aicardi G, Ravera G, Venturini PL, Vignolo M (2003) Ossification timing of sacral vertebrae by ultrasound in the mid-second trimester of pregnancy. Prenat Diagn 23: 1056–1059

    Google Scholar 

  • Degenhardt J, Schurg R, Winarno A, Oehmke F, Khaleeva A, Kawecki A, et al (2014) Percutaneous minimal-access fetoscopic surgery for spina bifida aperta. Part II: maternal management and outcome. Ultrasound Obstet Gynecol 44: 525–531

    Google Scholar 

  • Duckelmann AM, Kalache KD (2010) Three-dimensional ultrasound in evaluating the fetus. Prenat Diagn 30: 631–638

    Google Scholar 

  • Duthie SJ (2011) Folate and cancer: how DNA damage, repair and methylation impact on colon carcinogenesis. J Inherited Metab Dis 34: 101–109

    Google Scholar 

  • Ebbing M, Bønaa KH, Nygård O, Arnesen E, Ueland PM, Nordrehaug JE, et al (2009) Cancer incidence and mortality after treatment with folic acid and vitamin B12. JAMA 302: 2119–2126

    Google Scholar 

  • Fong KW, Toi A, Okun N, Al-Shami E, Menezes RJ (2011) Retrospective review of diagnostic performance of intracranial translucency in detection of open spina bifida at the 11–13-week scan. Ultrasound Obstet Gynecol 38: 630–634

    Google Scholar 

  • Frey L, Hauser WA (2003) Epidemiology of neural tube defects. Epilepsia 44 Suppl 3: 4–13

    Google Scholar 

  • Goldstein I, Makhoul IR, Weissman A, Drugan A (2005) Hemivertebra: prenatal diagnosis, incidence and characteristics. Fetal Diagn Ther 20: 121–126

    Google Scholar 

  • Hoffman CH, Dietrich RB, Pais MJ, Demos DS, Pribram HF (1993) The split notochord syndrome with dorsal enteric fistula. AJNR 14: 622–627

    Google Scholar 

  • Honein MA, Paulozzi LJ, Mathews TJ, Erickson JD, Wong LY (2001) Impact of folic acid fortification of the US food supply on the occurrence of neural tube defects. JAMA 285: 2981–2986

    Google Scholar 

  • Husler MR, Danzer E, Johnson MP, Bebbington M, Sutton L, Adzick NS, et al (2009) Prenatal diagnosis and postnatal outcome of fetal spinal defects without Arnold-Chiari II malformation. Prenat Diagn 29: 1050–1057

    Google Scholar 

  • Kohl T (2014) Percutaneous minimally invasive fetoscopic surgery for spina bifida aperta. Part I: surgical technique and perioperative outcome. Ultrasound Obstet Gynecol 44: 515–524

    Google Scholar 

  • Lee W, Chaiworapongsa T, Romero R, Williams R, McNie B, Johnson A, Treadwell M, Comstock CH (2002) A diagnostic approach for the evaluation of spina bifida by three-dimensional ultrasonography. J Ultrasound Med 21: 619–626

    Google Scholar 

  • Maiuri F, Corriero G, Giampaglia F, Simonetti L (1986) Lateral thoracic meningocele. Surg Neurol 26: 409–412

    Google Scholar 

  • Mangione R, Lelong N, Fontanges M, Amat S, Rosenblatt J, Khoshnood B, Jouannic JM (2011) Visualization of intracranial translucency at the 11–13-week scan is improved after specific training. Ultrasound Obstet Gynecol 38: 635–639

    Google Scholar 

  • Mangione R, Dhombres F, Lelong N, Amat S, Atoub F, Friszer S, Khoshnood B, Jouannic JM (2013) Screening for fetal spina bifida at the 11–13-week scan using three anatomical features of the posterior brain. Ultrasound Obstet Gynecol 42: 416–420

    Google Scholar 

  • Nievelstein RA, Valk J, Smit LM, Vermeij-Keers C (1994) MR of the caudal regression syndrome: embryologic implications. AJNR 15 (6): 1021–1029

    Google Scholar 

  • Pertl B, Karpf E, Juch H, Koppin D, Stern C (2012) A case of a transient enlargement of the intracranial translucency. Prenat Diagn 32: 1324–1325

    Google Scholar 

  • Pierre-Kahn A, Zerah M, Renier D, Cinalli G, Sainte-Rose C, Lellouch-Tubiana A, et al (1997) Congenital lumbosacral lipomas. Childs Nerv Syst 13: 298–334

    Google Scholar 

  • Scheier M, Lachmann R, Petros M, Nicolaides KH (2011) Three-dimensional sonography of the posterior fossa in fetuses with open spina bifida at 11-13 weeks’ gestation. Ultrasound Obstet Gynecol 38: 625–629

    Google Scholar 

  • Simpson JL, Mills J, Rhoads GG, Cunningham GC, Conley MR, Hoffman HJ (1991) Genetic heterogeneity in neural tube defects. Ann Genet 34: 279–286

    Google Scholar 

  • Stoll C, Alembik Y, Dott B (2007) Associated malformations in cases with neural tube defects. Genet Couns 18: 209–215

    Google Scholar 

  • Tortori-Donati P, Rossi A, Cama A (2000) Spinal dysraphism: a review of neuroradiological features with embryological correlations and proposal for a new classification. Neuroradiology 42: 471–491

    Google Scholar 

  • Van den Hof MC, Nicolaides KH, Campbell J, Campbell S (1990) Evaluation of the lemon and banana signs in one hundred thirty fetuses with open spina bifida. Am J Obstet Gynecol 162: 322–327

    Google Scholar 

  • Wax JR, Watson WJ, Miller RC, Ingardia CJ, Pinette MG, Cartin A, Grimes CK, Blackstone J (2008) Prenatal sonographic diagnosis of hemivertebrae: associations and outcomes. J Ultrasound Med 27: 1023–1027

    Google Scholar 

  • Weisz B, Achiron R, Schindler A, Eisenberg VH, Lipitz S, Zalel Y (2004) Prenatal sonographic diagnosis of hemivertebra. J Ultrasound Med 23: 853–857

    Google Scholar 

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Kalache, K.D., Dückelmann, A. (2018). Gehirn und Wirbelsäule. In: Gembruch, U., Hecher, K., Steiner, H. (eds) Ultraschalldiagnostik in Geburtshilfe und Gynäkologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-53662-9_6

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