Abstract
Tissue engineering and advanced biomedical technologies have proved to be potential to improve the quality of human life. During the last four decades, the capability to engineer or repair new functional tissues has been a very effective approach to improve the quality of life of patients. Since its discovery by Hench and co-workers in the 1960s, bioglasses and glass ceramics have attracted considerable attention of many researchers because of their unique properties which can easily be tailored by manipulating its compositions and morphology. Over the years, many questions concerning its interactions with both hard and soft tissues have been answered with a multidisciplinary team of surgeons, scientists and engineers. Many clinical Bioglass® and other similar structures and compositions are being used for bone augmentation and restoration, in orthopaedic, dental and maxillofacial surgery and in general in the field of tissue engineering. They have proved to be efficient and effective, some with outperformance over other bioceramic and metal prostheses. It is our aim in this chapter to present the development of these important biomaterials focusing on the history, synthesis, properties, modern characterisation methods and the current development of nano- and biocomposite materials for clinical applications.
Dedicated to Prof Larry Hench who has given us the ‘Bioglass’ and beyond.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Ben-Nissan B, Ylänen HO (2006) Bioactive glasses and glass ceramics, Wiley encyclopedia of biomedical engineering. Wiley, Hoboken
McMillan PW (1964) Glass ceramics. Academic, London
Hench LL, Wilson J (1984) Surface active materials. Science 226:630–636
Hench LL (1988) Bioactive ceramics. In: Ducheyne P, Lemons JE (eds) Bioceramics: materials characteristics vs. in vivo behavior. New York Academy of Science, New York
Kokubo T (1991) Recent progress in glass-based materials for biomedical applications. J Ceram Soc Japan 99:965–973
Kokubo T (1990) Novel biomaterials derived from glasses. In: Soga W, Kato A (eds) Ceramics: towards the 21st century. J Ceram Soc Japan, pp. 500–518.
Hench LL, Splinter RJ, Allen WC et al (1972) Bonding mechanisms at the interface of ceramic prosthetic materials. J Biomed Mater Res Symp 2:117–141
Vrouwenvelder WCA, Groot CG, de Groot K (1993) Histological and biochemical evaluation of osteoblasts cultured on bioactive glass, hydroxylapatite, titanium alloy, and stainless steel. J Biomed Mater Res 27:465–475
Andersson OH, Kangasniemi I (1991) Calcium phosphate formation at the surface of bioactive glass in vitro. J Biomed Mat Res 25:1019–1030
Li P, Yang Q, Zhang F et al (1992) The effect of residual glassy phase in a bioactive glass-ceramic on the formation of its surface apatite layer in vitro. J Mater Sci: Mater Med 3:452–456
Kokubo T, Shigematsu M, Nagashima Y et al (1982) Apatite-wollastonite containing glass-ceramic for prosthetic application. Bull Inst Chem Res 60:260–268
Li R, Clark AE, Hench LL (1991) An investigation of bioactive glass powders by sol-gel processing. J Appl Biomat 2:231–239
Arriagada FJ, Osseo-Asare K (1999) Synthesis of nanosize silica in a nonionic water-in-oil microemulsion: effects of the water/surfactant molar ratio and ammonia concentration. J Colloid Interf Sci 211:210–220
Singh S, Bhardwaj P, Singh V et al (2008) Synthesis of nanocrystalline calcium phosphate in microemulsion-effect of nature of surfactants. J Colloid Interf Sci 319:322–329
Karagiozov C, Momchilova D (2005) Synthesis of nano-sized particles from metal carbonates by the method of reversed mycelles. Chem Eng Process 44:115–119
Sun Y, Guo G, Tao D et al (2007) Reverse microemulsion-directed synthesis of hydroxyapatite nanoparticles under hydrothermal conditions. J Phys Chem Solids 68:373–377
Boccaccini AR, Erol M, Stark WJ et al (2010) Polymer/bioactive glass nanocomposites for biomedical applications: A review. Compos Sci Technol 70:1764–1776
Lim GK, Wang J, Ng SC et al (1996) Processing of fine hydroxyapatite powders via an inverse microemulsion route. Mater Lett 28:431–436
Lim GK, Wang J, Ng SC et al (1999) Formation of nanocrystalline hydroxyapatite in nonionic surfactant emulsions. Langmuir 15:7472–7477
Quintero F, Mann AB, Pou J et al (2007) Rapid production of ultralong amorphous ceramic nanofibers by laser spinning. Appl Phys Lett 90:153109–3
Quintero F, Pou J, Lusquiños F et al (2007) Experimental analysis of the production of micro- and nanofibres by Laser Spinning. Appl Surf Sci 254:1042–1047
Quintero F, Dieste O, Pou J et al (2009) On the conditions to produce micro- and nanofibres by laser spinning. J Phys D: Appl Phys 42:1–10
Quintero F, Pou J, Comesaña R et al (2009) Laser spinning of bioactive glass nanofibers. Adv Funct Mater 19:3084–3090
Pratsinis SE (1998) Flame aerosol synthesis of ceramic powders. Prog Energ Combust Sci 24:197–219
Stark WJ, Madler L, Maciejewski M et al (2003) Flame synthesis of nanocrystalline ceria-zirconia: effect of carrier liquid. Chem Comm 5:588–589
Madler L, Stark WJ, Pratsinis SE (2002) Flame-made ceria nanoparticles. J Mater Res 17:1356–1362
Athanassiou EK, Grass RN, Stark WJ (2010) Chemical aerosol engineering as a novel tool for material science: from oxides to salt and metal nanoparticles. Aerosol Sci Tech 44:161–172
Vollenweider M, Brunner TJ, Knecht S et al (2007) Remineralization of human dentin using ultrafine bioactive glass particles. Acta Biomater 3:936–943
Mohn D, Zehnder M, Imfeld T et al (2010) Radio-opaque nanosized bioactive glass for potential root canal application: evaluation of radiopacity, bioactivity and alkaline capacity. Int Endod J 43:210–217
Ebelmen M (1846) On the synthesis of silica gels from alkoxides. Annales de chimie et de physique 16:129
Graham T (1864) On the properties of silicic acid and other analogous colloidal substances. J Chem Soc 17:318–327
Liesegang RE (1896) Ueber einige Eigenschaften von Gallerten. Naturwissenschaftliche Wochenschrift 11:353–362
Hench LL, West JK (1990) The sol-gel process. Chem Rev 90:33–72
Cacciotti I, Lombardi M, Bianco A et al (2012) Sol-gel derived 45S5 bioglass: synthesis, microstructural evolution and thermal behaviour. J Mater Sci Mater Med 23:1849–1866
Chen QZ, Thouas GA (2011) Fabrication and characterization of sol-gel derived 45S5 Bioglass (R)-ceramic scaffolds. Acta Biomat 7:3616–3626
Saboori A, Rabiee M, Mutarzadeh F et al (2009) Synthesis, characterization and in vitro bioactivity of sol-gel-derived SiO2-CaO-P2O5-MgO bioglass. Mat Sci Eng C-Bio S 29:335–340
Jie Q, Lin KL, Zhong JP et al (2004) Preparation of macroporous sol-gel bioglass using PVA particles as pore former. J Sol-Gel Sci Technol 30:49–61
Greenspan DC, Zhong JP, Chen XF et al (1997) The evaluation of degradability of melt and sol-gel derived Bioglass (R) in-vitro. Bioceramics 10:391–394
Sakka S (1985) Glasses and glass-ceramics from gels. J Non-Cryst Solids 73:651
Sepulveda P, Jones JR, Hench LL (2001) Characterization of melt-derived 45S5 and sol-gel-derived 58S bioactive glasses. J Biomed Mater Res 58:734–740
Pereira MM, Hench LL (1996) Mechanisms of hydroxyapatite formation on porous gel-silica substrates. J Sol-Gel Sci Technol 7:59–68
Andersson ÖH (1992) Glass transition temperature of glasses in the SiO2-Na2O-CaO-P2O5-Al2O3-B2O3 system. J Mat Sci Mat Med 3:326–328
Peitl Filho O, LaTorre GP, Hench LL (1996) Effect of crystallization on apatite-layer formation of bioactive glass 45S5. J Biomed Mater Res 30:509–514
Brink M (1997) Bioactive glasses with a large working range. Dissertation, Åbo Akademi University
Hayakawa S, Tsuru K, Ohtsuki C (1999) Mechanism of apatite formation on a sodium silicate class in a simulated body fluid. J Am Ceram Soc 82:2155–2160
Arstila HE, Vedel L, Hupa L et al (2004) Measuring the devitrification of bioactive glasses. Key Eng Mater 254–256:67–70
Ylänen HO, Helminen T, Helminen A et al (1999) Porous bioactive glass matrix in reconstruction of articular osteochondral defects. Ann Chir Gyn 83:237–245
Fröberg L, Hupa L, Hupa M (2004) Porous bioactive glasses with controlled mechanical strength. Key Eng Mater 254–256:973–976
Oonishi H, Hench LL, Wilson J et al (2000) Quantitative comparison of bone growth behaviour in granules in bioglass®, A-W glass-ceramic, and hydroxyapatite. J Biomed Mater Res 51:37–46
Hench LL (1997) Glass and genes: a forecast to future. Glastech Ber Glass Sci Technol 70:439–452
Hench LL (1998) Bioceramics. J Am Ceram Soc 81:1705–1727
Strnad Z (1992) Role of the glass phase in bioactive glass-ceramic. Biomaterials 13:317–321
Karlsson KH, Ylänen HO (1998) Porous bone implants. In: Vincenzini P (ed) Materials in clinical applications, advances in science and technology 28. 9th Cimtec-World Forum on New Materials, Florence
Serra J, González P, Liste S et al (2002) Influence of the non-bridging oxygen groups on the bioactivity of silicate glasses. J Mater Sci Mater Med 13:1221–1225
Serra J, González P, Liste S et al (2003) FTIR and XPS studies of bioactive silica based glasses. J Noncryst Solids 332:20–27
Ducheyne P, Brown S, Blumenthal N et al (1988) Bioactive glasses, aluminum oxide, and titanium. Ion transport phenomena and surface analysis. Ann NY Acad Sci 523:257–261
Andersson ÖH, Karlsson KH, Kangasniemi K (1990) Calcium-phosphate formation at the surface of bioactive glass in vivo. J. Non-Cryst Solids 119:290–296
Niki M, Ito G, Matsuda T et al (1991) Comparative push-out data of bioactive and non-bioactive materials of similar rugosity. In: Davies JE (ed) Bone-material interface. University of Toronto Press, Toronto
Fujiu T, Ogino M (1984) Difference of bone bonding behavior among surface active glasses and sintered apatite. J Biomed Mater Res 18:845–859
Wilson J, Pigott GH, Schoen FJ et al (1981) Toxicology and biocompatibility of bioglasses. J Biomed Mater Res 15:805–817
LeGeros RZ, LeGeros JP (1993) Dense hydroxyapatite. In: Hench LL, Wilson J (eds) An introduction to bioceramics, vol 1. World Scientific, Singapore
Lai W, Ducheyne P, Garino J (1998) Removal pathway of silicon released from bioactive glass granules in vivo. In: LeGeros RZ, LeGeros JP (eds) Bioceramics, vol 11. World Scientific, New York
Hench LL, West JK (1996) Biological applications of bioactive glasses. Life Chem Rep 13:187–241
Hench LL, Paschall HA (1973) Direct chemical bond of bioactive glass-ceramic materials to bone and muscle. J Biomed Mater Res 7:25–42
Hench LL (1991) Bioceramics: from concept to clinic. J Am Ceram Soc 74:1487–1510
Merwin GE (1990) Review of bioactive materials for otologic and maxillofacial applications. In: Yamamuro T, Hench LL, Wilson J (eds) Handbook of bioactive ceramics, vol 1. CRC Press, Florida
Cai YR, Zhou L (2005) Effect of thermal treatment on the microstructure and mechanical properties of gel-derived bioglasses. Mater Chem Phys 94:283–287
Hench LL (2006) The story of bioglass. J Mater Sci Mater Med 14:967–978
Hench LL, Andersson ÖH (1993) Bioactive glasses. In: Hench LL, Wilson J (eds) An introduction to bioceramics, vol 1. World Scientific, Singapore
Gross U, Kinne R, Schmitz HJ et al (1988) The response of bone to surface active glass/glass-ceramics. CRC Crit Rev Biocomput 4:2–15
Hench LL, Polak JM, Xynos ID et al (2000) Bioactive materials to control cell cycle. Mater Res Innov 3:313–323
Ylänen HO, Karlsson KH, Itälä A et al (2000) Effect of immersion in SBF on porous bioactive bodies made by sintering bioactive glass microspheres. J Noncryst Solids 275:107–115
Cao WP, Hench LL (1996) Bioactive materials. Ceram Int 22:493–507
Hench LL (1998) Bioactive materials: the potential for tissue regeneration. J Biomed Mater Res 41:511–518
Hench LL (1998) Bioceramics, a clinical success. Am Ceram Soc Bull 77:67–74
Loty C, Sautier J, Loty S et al (1998) Bioglass(R) promoted differentiation of cultured rat osteoblasts and created a template for bone formation. In: LeGeros RZ, LeGeros JP (eds) Bioceramics, vol 11. World Scientific, New York
Xynos ID, Hukkanen MVJ, Batten JJ et al (2000) Bioglass (R) 45S5 stimulates osteoblast turnover and enhances bone formation in vitro: Implications and applications for bone tissue engineering. Calcified Tissue Int 67:321–329
Hench LL, Hench JW, Greenspan DC (2004) Bioglass: a short history and bibliography. J Aust Ceram Soc 40:1–42
Andersson Ö (1990) The bioactivity of silicate glass. Dissertation. Åbo Akademi University
Niemelä T (2010) Self-reinforced bioceramic and polylactide based composites. Dissertation. Tampere University of Technology
Brink M (1997) The influence of alkali and alkaline earths on the working range for bioactive glasses. J Biomed Mater Res 36:109–117
Moritz N, Vedel E, Ylänen H et al (2003) Creation of bioactive glass coating on titanium by local laser irradiation, Part I: Optimisation of the processing parameters. Key Eng Mater 240–242:221–224
Vedel E, Moritz N, Ylänen H et al (2003) Creation of bioactive glass coating on titanium by local laser irradiation, Part II: Effect of the irradiation on the bioactivity of the glass. Key Eng Mater 240–242:225–228
Kokubo T, Ito S, Sakka S et al (1986) Formation of high-strength bioactive glass-ceramic in the system MgO-CaO-SiO2-P2O5. J Mater Sci 21:536–540
Nakamura T, Yamamuro T (1993) Development of a bioactive ceramic, A/W glass-ceramic. In: Ducheyne P, Christiansen D (eds) Bioceramics, vol 6. Butterworth-Heinemann, Oxford
Kokubo T (1992) Bioactivity of glasses and glass-ceramics. In: Ducheyne P, Kokubo T, Van Blitterswijk CA (eds) Bone- bonding. Reed Healthcare Communications, Leiderdorp
Blencké BA, Brömer H, Deutscher KK (1978) Compatibility and long-term stability of glass-ceramic implants. J Biomed Mater Res 12:307–316
Vogel W, Höland W (1990) Development, structure, properties and application of glass-ceramics for medicine. J Non-Cryst Solids 123:349–353
Berger G, Sauer R, Steinborn G et al (1989) Clinical application of surface reactive apatite/wollastonite containing glass-ceramics. In: Mazurin OV (ed) Proceedings of XV international congress on glass. Leningrad, Nauka.
Pavek V, Novak Z, Strnad Z et al (1994) Clinical application of bioactive glass-ceramic BAS-O for filling cyst cavities in stomatology. Biomaterials 15:353–358
Kokubo T (1990) Surface chemistry of bioactive glass-ceramics. J Non-Cryst Solids 120:138–151
Kokubo T (1991) Bioactive glass-ceramics: properties and applications. Biomaterials 12:155–163
Strunz V, Bunte M, Gross UM et al (1978) Coating of metal implants with the bioactive glass-ceramics. Ceravital Dtsch Zahnarztl Z 33:862–865
Fuchs GA, Deutscher K (1981) Glass-ceramic coated implants. A simple model for a loaded hip prosthesis with a bioactive interface. Arch Orthop Trauma Surg 98:121–126
Takatsuka K, Yamamuro T, Kitsugi T et al (1993) A new bioactive glass-ceramic as a coating material on titanium alloy. J Appl Biomater 4:317–329
Ido K, Matsuda Y, Yamamuro T et al (1993) Cementless total hip replacement. Bioactive glass ceramic coating studied in dogs. Acta Orthop Scand 64:607–612
Li ZL, Kitsugi T, Yamamuro T et al (1995) Bone-bonding behavior under load-bearing conditions of an alumina ceramic implant incorporating beads coated with glass-ceramic containing apatite and wollastonite. J Biomed Mater Res 29:1081–1088
Kitsugi T, Nakamura T, Oka M et al (1996) Bone-bonding behavior of plasma-sprayed coatings of Bioglass®, AW-glass ceramic, and tricalcium phosphate on titanium alloy. J Biomed Mater Res 30:261–269
Schwarz K (1973) A bound form of silicon in glycosaminoglycans and polyuronides. Proc Natl Acad Sci USA 70:1608–1612
Carlisle EM (1970) Silicon: a possible factor in bone calcification. Science 167:279–280
Chen QZ, Boccaccini AR (2006) Poly(D, L-lactic acid) coated 45S5 Bioglass-based scaffolds: processing and characterization. J Biomed Mater Res A 77:445–457
Kim HW, Song JH, Kim HE (2006) Bioactive glass nanofiber-collagen nanocomposite as a novel bone regeneration matrix. J Biomed Mater Res A 79:698–705
Hong Z, Reis RL, Mano JF (2009) Preparation and in vitro characterization of novel bioactive glass ceramic nanoparticles. J Biomed Mater Res A 88:304–313
Hajiali H, Karbasi S, Hosseinalipour M et al (2010) Preparation of a novel biodegradable nanocomposite scaffold based on poly (3-hydroxybutyrate)/bioglass nanoparticles for bone tissue engineering. J Mater Sci Mater Med 21:2125–2132
Valenzuela F, Covarrubias C, Martinez C et al (2012) Preparation and bioactive properties of novel bone-repair bionanocomposites based on hydroxyapatite and bioactive glass nanoparticles. J Biomed Mater Res B Appl Biomater 100:1672–1682
Mehdikhani-Nahrkhalaji M, Fathi MH, Mortazavi V et al (2012) Novel nanocomposite coating for dental implant applications in vitro and in vivo evaluation. J Mater Sci Mater Med 23:485–495
Arcos D, Ragel CV, Vallet-Regi M (2001) Bioactivity in glass/PMMA composites used as drug delivery system. Biomaterials 22:701–708
Soundrapandian C, Datta S, Kundu B et al (2010) Porous bioactive glass scaffolds for local drug delivery in osteomyelitis: development and in vitro characterization. Aaps Pharmscitech 11:1675–1683
Zhu M, Wang H, Liu J et al (2011) A mesoporous silica nanoparticulate/beta-TCP/BG composite drug delivery system for osteoarticular tuberculosis therapy. Biomaterials 32:1986–1995
Kim HW, Lee HH, Chun GS (2008) Bioactivity and osteoblast responses of novel biomedical nanocomposites of bioactive glass nanofiber filled poly(lactic acid). J Biomed Mater Res A 85:651–663
Lee HH, Yu HS, Jang JH et al (2008) Bioactivity improvement of poly(epsilon-caprolactone) membrane with the addition of nanofibrous bioactive glass. Acta Biomater 4:622–629
Niemelä T, Niiranen H, Kellomäki M et al (2005) Self-reinforced composites of bioabsorbable polymer and bioactive glass with different bioactive glass contents. Part I: Initial mechanical properties and bioactivity. Acta Biomat 1:235–242
Wilson J, Yli-Urpo A, Happonen RP (1993) Bioactive glasses: clinical applications. In: Hench LL, Wilson J (eds) An introduction to bioceramics, vol 1. World Scientific, Singapore
Stanley HR, Hall MB, Clark AE et al (1997) Using 45S5 bioglass cones as endosseous ridge maintenance implants to prevent alveolar ridge resorption: a 5-year evaluation. Int J Oral Maxollofac Implants 12:95–105
Suominen E, Kinnunen J (1996) Bioactive glass granules and plates in the reconstruction of defects of the facial bones. Scand J Plast Reconstr Surg Hand Surg 30:281–289
Aitasalo K, Suonpää J, Kinnunen I et al (1999) Reconstruction of orbital floor fractures with bioactive glass (S53P4). In: Ohgushi H, Hastings GW, Yoshikawa T (eds) Bioceramics, vol 12. World Scientific, Singapore
Suonpää J, Sipilä J, Aitasalo K et al (1997) Operative treatment of frontal sinusitis. Acta Otolaryngol Suppl (Stockh) 529:181–183
Peltola M, Suonpää J, Aitasalo K et al (1998) Obliteration of the frontal sinus cavity with bioactive glass. Head Neck 20:315–318
Peltola M, Aitasalo K, Suonpää J et al (2006) Bioactive glass S53P4 in frontal sinus obliteration: A long-term clinical experience. Head Neck-J Sci Spec 28:834–841
Stoor P, Söderling E, Salonen JI (1998) Antibacterial effects of a bioactive glass paste on oral microorganisms. Acta Odontol Scand 56:161–165
Stoor P, Söderling E, Grenman R (1999) Interactions between the bioactive glass S53P4 and the atrophic rhinitis-associated microorganism Klebsiella ozaenae. J Biomed Mater Res 48:869–874
Stoor P, Pulkkinen J, Grenman R (2010) Bioactive glass s53p4 in the filling of cavities in the mastoid cell area in surgery for chronic otitis media. Ann Oto Rhinol Laryn 119:377–382
Ylänen HO (2000) Bone ingrowth into porous bodies made by sintering bioactive glass microspheres. Dissertation, Åbo Akademi University
Hench LL, Greenspan D (2013) Interactions between bioactive glass and collagen: a review and new perspectives. J Aust Ceram Soc 49:1–40
Heikkilä JT, Aho AJ, Yli-Urpo A et al (1993) Bioactive glass versus hydroxyapatite in reconstruction of osteochondral defects in the rabbit. Acta Orthop Scand 64:678–682
Suominen E, Aho AJ, Vedel E et al (1996) Subchondral bone and cartilage repair with bioactive glasses, hydroxyapatite, and hydroxyapatite-glass composite. J Biomed Mater Res 32:543–551
Aho AJ, Tirri T, Kukkonen J et al (2004) Injectable bioactive glass/biodegradable polymer composite for bone and cartilage reconstruction: Concept and experimental outcome with thermoplastic composites of poly(epsilon-caprolactone-CO-D, L-lactide) and bioactive glass S53P4. J Mater Sci Mater Med 15:1165–1173
Lee YK, Song J, Moon HJ et al (2004) In Vitro and in vivo evaluation of non-crystalline calcium phosphate glass as a bone substitute. Key Engineer Mater 254–256:185–188
Lim HC, Sohn JY, Park JC et al (2010) Osteoconductive effects of calcium phosphate glass cement grafts in rabbit calvarial defects. J Biomed Mater Res B 95B:47–52
Schepers E, De Clercq M, Ducheyne P et al (1991) Bioactive glass granulate material as a filler for bone lesions. J Oral Rehabil 18:439–452
Gatti AM, Zaffe D (1991) Long-term behavior of active glasses in sheep mandibular bone. Biomaterials 12:345–350
Garcia AJ, Ducheyne P (1994) Numerical analysis of extra- cellular fluid flow and chemical species transport around and within porous bioactive glass. J Biomed Mater Res 28:947–960
Gatti AM, Valdre G, Tombesi A (1996) Importance of micro-analysis in understanding mechanism of transformation in active glassy biomaterials. J Biomed Mater Res 31:475–480
Heikkilä JT, Aho HJ, Yli-Urpo A et al (1995) Bone formation in rabbit cancellous bone defects filled with bioactive glass granules. Acta Orthop Scand 66:463–467
Oonishi H, Hench LL, Wilson J et al (1999) Comparative bone growth behavior in granules of bioceramic materials of various sizes. J Biomed Mater Res 44:31–43
Virolainen P, Heikkilä J, Yli-Urpo A et al (1997) Histomorphometric and molecular biologic comparison of bioactive glass granules and autogenous bone grafts in augmentation of bone defect healing. J Biomed Mater Res 35:9–17
Kawashita M, Shineha R, Kim HM et al (2003) Preparation of ceramic microspheres for in situ radiotherapy of deep-seated cancer. Biomaterials 24:2955–2963
Kawashita M (2002) Ceramic microspheres for in situ radiotherapy of cancer. Mat Sci Eng C-Bio S 22:3–8
Kawashita M, Kokubo T, Inoue Y (1999) Preparation of Y2O3 microspheres for In Situ radiotherapy of cancer. In: Ohgushi H, Hastings GW, Yoshikawa T (eds) Bioceramics, vol 12. World Scientific, Singapore
Kawashita M, Tanaka M, Kokubo T et al (2002) Preparation of magnetite microspheres for hyperthermia of cancer. In: Brown S, Clarke I, Williams P (eds) Bioceramics, vol 14. Trans Tech Pub, Switzerland
Kawashita M, Tanaka M, Kokubo T et al (2005) Preparation of ferrimagnetic magnetite microspheres for in situ hyperthermic treatment of cancer. Biomaterials 26:2231–2238
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2017 Springer-Verlag GmbH Germany
About this chapter
Cite this chapter
Ben-Nissan, B., Choi, A.H., Macha, I. (2017). Advances in Bioglass and Glass Ceramics for Biomedical Applications. In: Li, Q., Mai, YW. (eds) Biomaterials for Implants and Scaffolds. Springer Series in Biomaterials Science and Engineering, vol 8. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-53574-5_5
Download citation
DOI: https://doi.org/10.1007/978-3-662-53574-5_5
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-662-53572-1
Online ISBN: 978-3-662-53574-5
eBook Packages: Chemistry and Materials ScienceChemistry and Material Science (R0)