Zusammenfassung
Die Evidenz für die verschiedenen chirurgischen Behandlungsverfahren beim perforierten Magen- und Duodenalulkus ist trotz der Häufigkeit der Pathologie begrenzt. Viele der in den Leitlinien, Metaanalysen und klinischen Studien analysierten Daten sind mehr als 10 Jahre alt und stammen zum Teil sogar aus den 1990er-Jahren. Patienten mit dem Verdacht auf eine Perforation des Magens oder Duodenums müssen chirurgisch vorgestellt werden. Eine Peritonitis oder septischer Schock müssen dann zur unverzüglichen operativen Versorgung führen. Bei Patienten ohne Peritonitis und Schockzeichen kann ein konservatives Vorgehen ausreichend sein. Bei klinischer Verschlechterung unter konservativer Therapie ist die Operation indiziert. Zur Behandlung des benignen Ulkus wird die einfache Übernähung empfohlen, resezierende Verfahren sollten möglichst vermieden werden. In erfahrenen Händen ist die Laparoskopie der Laparotomie zur Fokussanierung und im kurz- und langfristigen Outcome nicht unterlegen. Wenn möglich, soll eine intraoperative Schnellschnittuntersuchung erfolgen, gerade bei Patienten über 70 Jahren ist in mehr als 10 % ein Karzinom Ursache der Perforation. Die Resektion und Rekonstruktion soll auch bei Zeichen einer Peritonitis erfolgen. Bei Schock und hämodynamischer Instabilität sowie schwerer Peritonitis ist ein zweizeitiges Vorgehen dem einzeitigen in Bezug auf das onkologische Outcome nicht unterlegen. Perforationen nach ERCP und Duodenoskopie können häufig im Rahmen der eigentlichen Intervention oder konservativ behandelt werden.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsLiteratur
Adachi Y, Mori M, Maehara Y, Matsumata T, Okudaira Y, Sugimachi K (1997) Surgical results of perforated gastric carcinoma: an analysis of 155 Japanese patients. Am J Gastroenterol 92:516–518
Agresta F, Ansaloni L, Baiocchi GL, Bergamini C, Campanile FC, Carlucci M, Cocorullo G, Corradi A, Franzato B, Lupo M et al (2012) Laparoscopic approach to acute abdomen from the Consensus Development Conference of the Società Italiana di Chirurgia Endoscopica e nuove tecnologie (SICE), Associazione Chirurghi Ospedalieri Italiani (ACOI), Società Italiana di Chirurgia (SIC), Società Italiana di Chirurgia d'Urgenza e del Trauma (SICUT), Società Italiana di Chirurgia nell'Ospedalità Privata (SICOP), and the European Association for Endoscopic Surgery (EAES). Surg Endosc 26:2134–2164
Baron TH, Gostout CJ, Herman L (2000) Hemoclip repair of a sphincterotomy-induced duodenal perforation. Gastrointest Endosc 52:566–568
Bertleff MJ, Halm JA, Bemelman WA, van der Ham AC, van der Harst E, Oei HI, Smulders JF et al (2009) Randomized clinical trial of laparoscopic versus open repair of the perforated peptic ulcer: the LAMA trial. World J Surg 33:1368–1373
Bertleff MJ, Lange JF (2010) Laparoscopic correction of perforated peptic ulcer: first choice? a review of literature. Surg Endosc 24:1231–1239
Boey J, Lee NW, Koo J, Lam PH, Wong J, Ong GB (1982) Immediate definitive surgery for perforated duodenal ulcers: a prospective controlled trial. Ann Surg 196:338–344
Bucher P, Oulhaci W, Morel P, Ris F, Huber O (2007) Results of conservative treatment for perforated gastroduodenal ulcers in patients not eligible for surgical repair. Swiss Med Wkly 137:337–340
Cheng M, Li WH, Cheung MT (2012) Early outcome after emergency gastrectomy for complicated peptic ulcer disease. Hong Kong Med J 18:291–298
Christensen M, Matzen P, Schulze S, Rosenberg J (2004) Complications of ERCP: a prospective study. Gastrointest Endosc 60:721–731
Christiansen J, Andersen OB, Bonnesen T, Baekgaard N (1987) Perforated duodenal ulcer managed by simple closure versus closure and proximal gastric vagotomy. Br J Surg 74:286–287
Cohen SA, Siegel JH, Kasmin FE (1996) Complications of diagnostic and therapeutic ERCP. Abdom Imaging 21:385–394
Crofts TJ, Park KG, Steele RJ, Chung SS, Li AK (1989) A randomized trial of nonoperative treatment for perforated peptic ulcer. N Engl J Med 320:970–973
Enns R, Eloubeidi MA, Mergener K, Jowell PS, Branch MS, Pappas TM, Baillie J (2002) ERCP-related perforations: risk factors and management. Endoscopy 34:293–298
Fatima J, Baron TH, Topazian MD, Houghton SG, Iqbal CW, Ott BJ, Farley DR, Farnell MB, Sarr MG (2007) Pancreaticobiliary and duodenal perforations after periampullary endoscopic procedures: diagnosis and management. Arch Surg 142:448–454
Ford AC, Gurusamy KS, Delaney B, Forman D, Moayyedi P (2016) Eradication therapy for peptic ulcer disease in Helicobacter pylori-positive people. Cochrane Database Syst Rev; 4:CD003840. doi: https://doi.org/10.1002/14651858.CD003840. pub5.
Genzlinger JL, McPhee MS, Fisher JK, Jacob KM, Helzberg JH (1999) Significance of retroperitoneal air after endoscopic retrograde cholangiopancreatography with sphincterotomy. Am J Gastroenterol 94:1267–1270
Gertsch P, Choe LWC, Yuen ST, Chau KY, Lauder IJ (1996) Long term survival after gastrectomy for advanced bleeding or perforated gastric carcinoma. Eur J Surg 162:723–727
Gurusamy K, Pallari E (2016) Medical versus surgical treatment for refractory or recurrent peptic ulcer. Cochrane Database of Systematic Reviews; 3:CD011523. doi: https://doi.org/10.1002/14651858.CD011523.pub2.
Hay JM, Lacaine F, Kohlmann G, Fingerhut A (1988) Immediate definitive surgery for perforated duodenal ulcer does not increase operative mortality: a prospective controlled trial. World J Surg 12:705–709
Jang JS, Lee S, Lee HS, Yeon MH, Han JH, Yoon SM, Chae HB, Youn SJ, Park SM (2015) Efficacy and safety of endoscopic papillary balloon dilation using cap-fitted forward-viewing endoscope in patients who underwent Billroth II gastrectomy. Clin Endosc 48:421–427
Jwo S, Chien R, Chao T, Chen HY, Lin CY (2005) Clinicopathalogical features, surgical management, and disease outcome of perforated gastric cancer. J Surg Oncol 91:219–225
Kirschner M (1926) Die Behandlung der akuten eitrigen freien Bauchfellentzündung. Arch Klin Chir 142:253–311
Kuwabara K, Matsuda S, Fushimi K, Ishikawa KB, Horiguchi H, Fujimori K (2011) Reappraising the surgical approach on the perforated gastroduodenal ulcer: should gastric resection be abandoned? J Clin Med Res 3:213–222
Lau H (2004) Laparoscopic repair of perforated peptic ulcer: a meta-analysis. Surg Endosc 18:1013–1021
Lau WY, Leung KL, Kwong KH, Davey IC, Robertson C, Dawson JJ, Chung SC, Li AK (1996) A randomized study comparing laparoscopic versus open repair of perforated peptic ulcer using suture or sutureless technique. Ann Surg 224:131–138
Lehnert T, Buhl K, Dueck M, Hinz U, Herfarth C (2000) Two-stage radical gastrectomy for perforated gastric cancer. Eur J Surg Oncol 26:780–784
Lo HC, Wu SC, Huang HC, Yeh CC, Huang JC, Hsieh CH (2011) Laparoscopic simple closure alone is adequate for low risk patients with perforated peptic ulcer. World J Surg 35:1873–1878
Millat B, Fingerhut A, Borie F (2000) Surgical treatment of complicated duodenal ulcers: controlled trials. World J Surg 24:299–306
Mutignani M, Iacopini F, Dokas S, Larghi A, Familiari P, Tringali A, Costamagna G (2006) Successful endoscopic closure of a lateral duodenal wall perforation at ERCP with fibrin glue. Gastrointest Endosc 63:725–727
Ozmen MM, Zulfikaroglu B, Kece C, Aslar AK, Ozalp N, Koc M (2002) Factors influencing mortality in spontaneous gastric tumour perforations. J Int Med Res 30:180–184
Park SM (2016) Recent Advanced Endoscopic Management of Endoscopic Retrograde Cholangiopancreatography Related Duodenal Perforations. Clin Endosc 49:376–382
Paspatis GA, Dumonceau JM, Barthet M, Meisner S, Repici A, Saunders BP, Vezakis A, Gonzalez JM, Turino SY, Tsiamoulos ZP et al (2014) Diagnosis and management of iatrogenic endoscopic perforations: European Society of Gastrointestinal Endoscopy (ESGE) Position Statement. Endoscopy 46:693–711
Pungpapong S, Kongkam P, Rerknimitr R, Kullavanijaya P (2005) Experience on endoscopic retrograde cholangiopancreatography at tertiary referral center in Thailand: risks and complications. J Med Assoc Thai 88:238–246
Roviello F, Simone R, Marrelli D, De Manzoni G, Pedrazzani C, Morgagni P, Corso G, Pinto E (2006) Perforated gastric carcinoma: a report of 10 cases and review of the literature. World J Surg Oncol 4:19–24.
Sanabria A, Villegas MI, Morales Uribe CH (2013). Laparoscopic repair for perforated peptic ulcer disease. Cochrane Database Syst Rev: CD004778. doi: https://doi.org/10.1002/14651858.CD004778.pub3.
Sarath S, Kumar S (2009) Definitive or conservative surgery for perforated gastric ulcer? An unresolved problem. Int J Surg 7:136–139
Sartelli M, Viale P, Catena F, Ansaloni L, Moore E, Malangoni M, Moore FA, Velmahos G, Coimbra R, Ivatury R et al (2013) 2013 WSES guidelines for management of intra-abdominal infections. World Journal of Emergency Surgery 8:3
Satoh K, Yoshino J, Akamatsu T, Itoh T, Kato M, Kamada T, Takagi A, Chiba T, Nomura S, Mizokami Y et al. (2016) Evidence-based clinical practice guidelines for peptic ulcer disease 2015. J Gastroenterol 51:177–194
Siegel JH, Rodriquez R, Cohen SA, Kasmin FE, Cooperman AM (1994) Endoscopic management of cholangitis: critical review of an alternative technique and report of a large series. Am J Gastroenterol 89(8):1142–1146
Singh V, Singh G, Verma GR, Yadav TD, Gupta V (2013) Pseudobowel perforation following endoscopic retrograde cholangiopancreatography. Dig Dis Sci 58:1781–1783
Siu WT, Leong HT, Law BK, Chau CH, Li AC, Fung KH, Tai YP, Li MK (2002) Laparoscopic repair for perforated peptic ulcer: a randomized controlled trial. Ann Surg 235:313–319
So JBY, Yam A, Cheah WK, Kum CK, Goh PM (2000) Risk factors related to operative mortality and morbidity in patients undergoing emergency gastrectomy. Br J Surg 87:1702–1707
Sogne B, Jean F, Foulatier O, Khalil H, Scotté M (2004) Non operative treatment for perforated peptic ulcer: results of a prospective study. Ann Chir 129: 578–582
Stapfer M, Selby RR, Stain SC, Katkhouda N, Parekh D, Jabbour N, Garry D (2000) Management of duodenal perforation after endoscopic retrograde cholangiopancreatography and sphincterotomy. Ann Surg 232:191–198
Svanes C, Lie RT, Svanes K, Lie SA, Soreide O (1994) Adverse effects of delayed treatment for perforated peptic ulcer. Ann Surg 220:168–175
Tan S, Wu G, Zhuang Q, Xi Q, Meng Q, Jiang Y, Han Y, Yu C, Yu Z, Li N (2016) Laparoscopic versus open repair for perforated peptic ulcer: A meta analysis of randomized controlled trials. Int J Surg; 33 Pt A:124–132
Tanphiphat C, Tanprayoon T, Nathalong A (1985) Surgical treatment of perforated duodenal ulcer: a prospective trial between simple closure and definitive surgery. Br J Surg 72:370
Tsugawa K, Koyanagi N, Hashizume M, Tomikawa M, Akahoshi K, Ayukawa K, Wada H, Tanoue K, Sugimachi K (2001) The therapeutic strategies in performing emergency surgery for gastroduodenal ulcer perforation in 130 patients over 70 years of age. Hepatogastroenterology 48:156–162
Turner WW Jr, Thompson WM Jr, Thal ER (1988) Perforated gastric ulcers. A plea for management by simple closures. Arch Surg 123:960–964
Wysocki A, Biesiada Z, Beben P, Budzynski A (2000) Perforated gastric ulcer. Dig Surg 17:132–137
Zimmermann M, Wellnitz T, Laubert T, Hoffmann M, Begum N, Bürk C, Bruch H-P, Schlöricke E (2014) Gastric and duodenal perforations: what is the role of laparoscopic surgery? Zentralbl Chir 139:72–78
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2017 Springer-Verlag GmbH Deutschland
About this chapter
Cite this chapter
Hoffmann, M. (2017). Magen- und Duodenalulkus. In: Germer, CT., Keck, T., Grundmann, R. (eds) Evidenzbasierte Viszeralchirurgie benigner Erkrankungen. Evidenzbasierte Chirurgie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-53553-0_7
Download citation
DOI: https://doi.org/10.1007/978-3-662-53553-0_7
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-662-53552-3
Online ISBN: 978-3-662-53553-0
eBook Packages: Medicine (German Language)