Skip to main content

Bone and Soft Tissue

  • Chapter
  • First Online:
Pediatric Cytopathology
  • 937 Accesses

Abstract

A wide variety of bone and soft tissue lesions are seen in the pediatric population, including benign and malignant neoplasms, as well non-neoplastic processes. Fine needle aspiration and/or small biopsies are increasingly used for evaluating these lesions and in many cases, allow definitive diagnosis or a narrowed differential diagnosis on which to base treatment. This chapter describes the cytologic features of a number of common and uncommon neoplastic and non-neoplastic lesions of bone and soft tissue seen in the pediatric population, as well as key clinical and radiographic features of those entities and differential diagnostic considerations.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 159.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Kilpatrick SE, Ward WG, Chauvenet AR, Pettanati MJ. The role of fine-needle aspiration biopsy in the initial diagnosis of pediatric bone and soft tissue tumors: an institutional experience. Mod Pathol. 1998;11:923–8.

    CAS  PubMed  Google Scholar 

  2. Ward Sr WG, Kilpatrick S. Fine needle aspiration of primary bone tumors. Clin Orthop Relat Res. 2000;373:80–7.

    Article  Google Scholar 

  3. Kilpatrick SE, Cappellari JP, Bos GD, et al. Is fine-needle aspiration biopsy a practical alternative to open biopsy for the primary diagnosis of sarcoma? Experience with 140 patients. Am J Clin Pathol. 2001;115:59–68.

    Article  CAS  PubMed  Google Scholar 

  4. Sapi Z, Antal I, Papai Z, et al. Diagnosis of soft tissue tumors by fine-needle aspiration with combined cytopathology and ancillary techniques. Diagn Cytopathol. 2002;26:232–42.

    Article  PubMed  Google Scholar 

  5. Singh HK, Kilpatrck SE, Silverman JF. Fine needle aspiration biopsy of soft tissue sarcomas: utility and diagnostic challenges. Adv Anat Pathol. 2004;11:24–37.

    Article  PubMed  Google Scholar 

  6. Domanski HA. Fine-needle aspiration cytology of soft tissue lesions: diagnostic challenges. Diagn Cytopathol. 2007;35:768–73.

    Article  PubMed  Google Scholar 

  7. Walaas L, Kindblom LG. Light and electron microscopic examination of fine-needle aspirates in the preoperative diagnosis of osteogenic tumors: a study of 21 osteosarcomas and two osteoblastomas. Diagn Cytopathol. 1990;6:27–38.

    Article  CAS  PubMed  Google Scholar 

  8. Venugopal SB, Prasad S. Cytological diagnosis of osteoblastoma of cervical spine: a case report with review of literature. Diagn Cytopathol. 2015;43:218–21.

    Article  PubMed  Google Scholar 

  9. Dodd LG, Scully SP, Cothran RL, Harrelson JM. Utility of fine-needle aspiration in the diagnosis of primary osteosarcoma. Diagn Cytopathol. 2002;27:350–3.

    Article  PubMed  Google Scholar 

  10. Akerman M, Domanski HA, Jonsson K. Cytological features of bone tumours in FNA smears I: osteogenic tumours. Monogr Clin Cytol. 2010;19:18–30.

    PubMed  Google Scholar 

  11. Sathiyamoorthy S, Ali SZ. Osteoblastic osteosarcoma: cytomorphologic characteristic and differential diagnosis on fine-needle aspiration. Acta Cytol. 2012;56:481–6.

    Article  PubMed  Google Scholar 

  12. VandenBussche CJ, Sathiyamoorthy S, Wakely Jr PE, Ali SZ. Chondroblastic osteosarcoma: cytomorphologic characteristics and differential diagnosis on FNA. Cancer Cytopathol. 2016;124:493–500.

    Article  CAS  PubMed  Google Scholar 

  13. Akerman M, Domanski HA, Jonsson K. Cytological features of bone tumours in FNA smears II: cartilaginous tumours. Monogr Clin Cytol. 2010;19:31–44.

    PubMed  Google Scholar 

  14. Sreedharanunni S, Gupta N, Rajwanshi A, et al. Fine needle aspiration cytology in two cases of chondromyxoid fibroma of bone and review of literature. Diagn Cytopathol. 2013;41:904–8.

    PubMed  Google Scholar 

  15. Cozzolino I, Zeppa P, Zapatta A, et al. Benign chondroblastoma on fine-needle aspiration smears: a seven-case experience and review of the literature. Diang Cytopathol. 2015;43:734–8.

    Google Scholar 

  16. Krishnappa A, Shobha SN, Shankar SV, Aradhya S. Fine needle aspiration cytology of chondroblastoma: a report of two case with brief review of pitfalls. J Cytol. 2016;33:40–2.

    Article  PubMed  PubMed Central  Google Scholar 

  17. Creager AJ, Madden CR, Bergman S, Geisinger KR. Aneurysmal bone cyst: fine-needle aspiration findings in 23 patients with clinical and radiologic correlation. Am J Clin Pathol. 2007;128:740–5.

    Google Scholar 

  18. Klijanienko J, Couturier J, Bourdeaut F, et al. Fine-needle aspiration as a diagnostic technique in 50 cases of primary Ewing sarcoma/peripheral neuroectodermal tumor. Institut Curie’s experience. Diagn Cytopathol. 2012;40:19–25.

    Article  PubMed  Google Scholar 

  19. Frostad B, Tani E, Brosjo O, et al. Fine needle aspiration cytology in the diagnosis and management of children and adolescents with Ewing sarcoma and peripheral primitive neuroectodermal tumor. Med Pediatr Oncol. 2002;38:33–40.

    Article  CAS  PubMed  Google Scholar 

  20. Shabb N, Fanning CV, Carrasco CH, et al. Diagnosis of eosinophilic granuloma of bone by fine-needle aspiration with concurrent institution of therapy. A cytologic, histologic, clinical and radiologic study of 27 cases. Diagn Cytopathol. 1993;9:3–12.

    Article  CAS  PubMed  Google Scholar 

  21. Kilpatrick SE, Teot LA, Stanley MW, et al. Fine needle aspiration biopsy of synovial sarcoma: a cytomorphologic analysis of primary, recurrent, and metastatic tumors. Am J Clin Pathol. 1996;106:769–75.

    Article  CAS  PubMed  Google Scholar 

  22. Klijanienko J, Caillaud JM, Lagace R, Viehl P. Cytohistologic correlations in 56 synovial sarcomas in 36 patients: the Institut Curie experience. Diagn Cytopathol. 2002;27:96–102.

    Article  PubMed  Google Scholar 

  23. Wakely Jr PE, Ali SZ, Bishop JA. The cytopathology of malignant peripheral nerve sheath tumor. A report of 55 fine-needle aspiration cases. Cancer Cytopathol. 2012;120:334–41.

    Article  PubMed  Google Scholar 

General Resource

  • Fletcher CDM, Bridge JA, Hogendoorn PCW, Mertens F, editors. WHO classification of tumours of soft tissue and bone. Lyons: IARC Press; 2013.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Lisa A. Teot MD .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Teot, L.A. (2017). Bone and Soft Tissue. In: Monaco, S., Teot, L. (eds) Pediatric Cytopathology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-53441-0_5

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-53441-0_5

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-53439-7

  • Online ISBN: 978-3-662-53441-0

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics