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Transdermal Delivery of Peptides and Proteins by Physical Methods

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Percutaneous Penetration Enhancers Physical Methods in Penetration Enhancement

Abstract

Delivery of peptides and proteins is critical for their clinical applications. Oral administration of these molecules is not feasible due to degradation in the gastrointestinal tract. Peptides and proteins are, hence, conventionally administered by the parenteral route. Transdermal route offers a good alternative for parenteral delivery of proteins resulting in improved patient compliance. However, due to their size and hydrophilicity, peptides and proteins are unable to permeate through the skin. To overcome the skin barrier, various physical enhancement techniques such as microporation, iontophoresis, sonophoresis, electroporation, and jet injectors have been investigated. These techniques enabling transdermal delivery of peptides and proteins will be discussed in this book chapter.

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Authors and Affiliations

  1. Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Mercer University, 3001 Mercer University Drive, Atlanta, GA, 30341, USA

    Yingcong Zhou, Vijay Kumar, Anushree Herwadkar & Ajay K. Banga

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  1. Yingcong Zhou
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  2. Vijay Kumar
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  3. Anushree Herwadkar
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  4. Ajay K. Banga
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Correspondence to Ajay K. Banga .

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  1. Apoteka “Beograd”, Belgrade, Serbia

    Nina Dragicevic

  2. San Francisco, California, USA

    Howard I. Maibach

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Zhou, Y., Kumar, V., Herwadkar, A., Banga, A.K. (2017). Transdermal Delivery of Peptides and Proteins by Physical Methods. In: Dragicevic, N., I. Maibach, H. (eds) Percutaneous Penetration Enhancers Physical Methods in Penetration Enhancement. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-53273-7_27

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