Abstract
Transdermal delivery of systemic therapeutics is an attractive alternative to conventional needle-based methods. Several physical and chemical strategies for skin permeabilization have been proposed to facilitate the transport of drug molecules across the skin barrier. Validation of a particular method and demonstration of its efficacy require the selection of a representative skin model as well as an appropriate system to measure drug transport. This review summarizes different skin models used to study drug transport across the skin as well as measurement techniques used to quantify the amount of transport. A careful consideration of both choices in development of transdermal delivery systems is critical to success.
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Cropek, D.M., Karande, P. (2017). Models, Methods, and Measurements in Transdermal Drug Delivery. In: Dragicevic, N., I. Maibach, H. (eds) Percutaneous Penetration Enhancers Drug Penetration Into/Through the Skin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-53270-6_9
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