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Corneoxenometry: A Bioassay Exploring Skin Barrier Breaching

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Percutaneous Penetration Enhancers Drug Penetration Into/Through the Skin

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Abstract

Some specific chemical compounds called penetration enhancers breach the skin barrier function after topical applications. It is important to predict the severity of alteration of the skin permeability barrier function. Corneoxenometry was designed as an ex vivo bioassay predicting on human stratum corneum the efficacy and the potential noxious effects of xenobiotics. The test substrate is a cyanoacrylate skin surface stripping harvested from normal or altered skin. Dose-response effects are conveniently tested while avoiding any skin hazards.

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Authors and Affiliations

  1. Laboratory of Skin Bioengineering and Imaging, Liège University Hospital, CHU Sart Tilman, BE-4000, Liège, Belgium

    Claudine Piérard-Franchimont, Trinh Hermanns-Lê & Gérald E. Piérard MD, PhD

Authors
  1. Claudine Piérard-Franchimont
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  2. Trinh Hermanns-Lê
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  3. Gérald E. Piérard MD, PhD
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Corresponding author

Correspondence to Gérald E. Piérard MD, PhD .

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Editors and Affiliations

  1. Apoteka “Beograd”, Belgrade, Serbia

    Nina Dragicevic

  2. San Francisco, California, USA

    Howard I. Maibach

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Piérard-Franchimont, C., Hermanns-Lê, T., Piérard, G.E. (2017). Corneoxenometry: A Bioassay Exploring Skin Barrier Breaching. In: Dragicevic, N., I. Maibach, H. (eds) Percutaneous Penetration Enhancers Drug Penetration Into/Through the Skin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-53270-6_17

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  • DOI: https://doi.org/10.1007/978-3-662-53270-6_17

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-53268-3

  • Online ISBN: 978-3-662-53270-6

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