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ATR-FTIR Spectroscopy and the Skin Barrier: Evaluation of Penetration-Enhancement Effects

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Abstract

Among other biophysical techniques, attenuated total reflection–Fourier transform infrared (ATR-FTIR) spectroscopy has widely been employed to characterise the skin barrier. Major advantages are its non-destructive and time-saving nature. Spectra of the stratum corneum depict characteristic bands such as the CH2-stretching and CH2-scissoring as well as the amide 1 and 2 vibrations. While the latter describe the secondary structure of the stratum corneum proteins and may reflect upon the water absorption, the CH2-stretching and scissoring bands give information about the lateral packing of the skin lipids. This chapter provides an introduction on the characterisation of the stratum corneum by ATR-FTIR spectroscopy and an overview of the influence of selected permeation enhancers and drug delivery systems on the skin barrier as investigated by this technique.

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Authors and Affiliations

  1. University of Vienna, Research Platform ‘Characterisation of Drug Delivery Systems on Skin and Investigation of Involved Mechanisms, Althanstraße 14, 1090, Vienna, Austria

    Julia Covi-Schwarz, Victoria Klang & Claudia Valenta

  2. University of Vienna, Department of Pharmaceutical Technology and Biopharmaceutics, Althanstraße 14, 1090, Vienna, Austria

    Victoria Klang & Claudia Valenta

Authors
  1. Julia Covi-Schwarz
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  2. Victoria Klang
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  3. Claudia Valenta
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Corresponding author

Correspondence to Claudia Valenta .

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Editors and Affiliations

  1. Apoteka “Beograd”, Belgrade, Serbia

    Nina Dragicevic

  2. San Francisco, California, USA

    Howard I. Maibach

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Covi-Schwarz, J., Klang, V., Valenta, C. (2017). ATR-FTIR Spectroscopy and the Skin Barrier: Evaluation of Penetration-Enhancement Effects. In: Dragicevic, N., I. Maibach, H. (eds) Percutaneous Penetration Enhancers Drug Penetration Into/Through the Skin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-53270-6_14

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  • DOI: https://doi.org/10.1007/978-3-662-53270-6_14

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  • Print ISBN: 978-3-662-53268-3

  • Online ISBN: 978-3-662-53270-6

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