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Coloproctology pp 289–301Cite as

Colon Cancer

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Part of the book series: European Manual of Medicine ((EUROMANUAL))

Abstract

Bowel cancer is the second most common cancer in Europe. The great majority of colon cancers are sporadic, and only 5 % are associated with a recognized familial pattern of inheritance. Complete flexible colonoscopy is the gold standard in the early detection of colorectal neoplasia. Patients present with alteration in bowel habit, frank rectal bleeding, or anemia. Symptoms such as intermittent abdominal pain, nausea, and vomiting are often secondary to partial obstruction or peritoneal dissemination.

Primary treatment for colon cancer is surgical resection of the primary and lymph nodes. Open and laparoscopic approaches are equally safe. Chemotherapy improves outcome but the prerequisite for adjuvant therapy is complete removal of the primary tumor. Neoadjuvant treatment is debated.

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Suggested Reading

  1. Ahmed S, et al. Survival impact of surgical resection of primary tumour in patients with stage IV colorectal cancer. Cancer. 2014;120:683–91.

    Article  PubMed  Google Scholar 

  2. Amado RG, Wolf M, Peeters M, Van Cutsem E, Siena S, Freeman DJ, Juan T, Sikorski R, Suggs S, Radinsky R, Patterson SD, Chang DD. Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer. J Clin Oncol. 2008;26(10):1626–34.

    Article  CAS  PubMed  Google Scholar 

  3. Aretz S. The differential diagnosis and surveillance of hereditary gastrointestinal polyposis syndromes. Dtsch Arztebl Int. 2010;107(10):163–73.

    PubMed  PubMed Central  Google Scholar 

  4. Bertelsen CA, et al. Can the quality of colonic surgery be improved by standardization of surgical technique with complete mesocolic excision? Colorectal Dis. 2011;13(10):1123–9.

    Article  CAS  PubMed  Google Scholar 

  5. Brenner H, et al. Long-term risk of colorectal cancer after negative colonoscopy. J Clin Oncol. 2011;29(28):3761–7.

    Article  PubMed  Google Scholar 

  6. Bulow S. Clinical features in familial polyposis coli. Results of the Danish Polyposis Register. Dis Colon Rectum. 1986;29(2):102–7.

    Article  CAS  PubMed  Google Scholar 

  7. Cao C, et al. A systematic review and meta-analysis of cytoreductive surgery with perioperative intraperitoneal chemotherapy for peritoneal carcinomatosis of colorectal origin. Ann Surg Oncol. 2009;16(8):2152–65.

    Article  PubMed  Google Scholar 

  8. Chang GJ, et al. Lymph node evaluation and survival after curative resection of colon cancer: systematic review. J Natl Cancer Inst. 2007;99(6):433–41.

    Article  PubMed  Google Scholar 

  9. de Gramont A, C.B., Navarro M, Tabernero J, Hickish T, Topham C, Bonetti A, Clingan P, Lorenzato C, André T. Oxaliplatin/5FU/LV in adjuvant colon cancer: updated efficacy results of the MOSAIC trial, including survival, with a median follow-up of six years. J Clin Oncol 2007 ASCO Annual Meeting Proceedings (Post-Meeting Edition) Vol 25, No 18S (June 20 Supplement), 2007: 4007, (2007).

    Google Scholar 

  10. Falcone A, et al. Phase III trial of infusional fluorouracil, leucovorin, oxaliplatin, and irinotecan (FOLFOXIRI) compared with infusional fluorouracil, leucovorin, and irinotecan (FOLFIRI) as first-line treatment for metastatic colorectal cancer: the Gruppo Oncologico Nord Ovest. J Clin Oncol. 2007;25(13):1670–6.

    Article  CAS  PubMed  Google Scholar 

  11. Feliu J, et al. XELOX (capecitabine plus oxaliplatin) as first-line treatment for elderly patients over 70 years of age with advanced colorectal cancer. Br J Cancer. 2006;94(7):969–75.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Ferlay J, et al. Cancer incidence and mortality patterns in Europe: estimates for 40 countries in 2012. Eur J Cancer. 2013;49(6):1374–403.

    Article  CAS  PubMed  Google Scholar 

  13. Ferrand F, et al. Impact of primary tumour resection on survival of patients with colorectal cancer and synchronous metastases treated by chemotherapy: results from the multicenter, randomised trial Federation Francophone de Cancerologie Digestive 9601. Eur J Cancer. 2013;49:90–7.

    Article  CAS  PubMed  Google Scholar 

  14. Floriani I, et al. Performance of imaging modalities in diagnosis of liver metastases from colorectal cancer: a systematic review and meta-analysis. J Magn Reson Imaging. 2010;31(1):19–31.

    Article  PubMed  Google Scholar 

  15. Fong Y, Fortner J, Sun RL, Brennan MF, Blumgart LH. Clinical score for predicting recurrence after hepatic resection for metastatic colorectal cancer: analysis of 1001 consecutive cases. Ann Surg. 1999;230(3):309–18.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Guillem JG, et al. Colonoscopic screening for neoplasms in asymptomatic first-degree relatives of colon cancer patients. A controlled, prospective study. Dis Colon Rectum. 1992;35(6):523–9.

    Article  CAS  PubMed  Google Scholar 

  17. Hohenberger W, et al. Standardized surgery for colonic cancer: complete mesocolic excision and central ligation – technical notes and outcome. Colorectal Dis. 2009;11(4):354–64. discussion 364-5.

    Article  CAS  PubMed  Google Scholar 

  18. Imperiale TF, et al. Results of screening colonoscopy among persons 40 to 49 years of age. N Engl J Med. 2002;346(23):1781–5.

    Article  PubMed  Google Scholar 

  19. Jasperson KW, et al. Hereditary and familial colon cancer. Gastroenterology. 2010;138(6):2044–58.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Jeffery M, Hickey BE, Hider PN. Follow-up strategies for patients treated for non-metastatic colorectal cancer. Cochrane Database Syst Rev. 2007; (1):CD002200.

    Google Scholar 

  21. Jones N, et al. Increased colorectal cancer incidence in obligate carriers of heterozygous mutations in MUTYH. Gastroenterology. 2009;137(2):489–94. 494 e1.

    Article  PubMed  Google Scholar 

  22. Killeeen S, Mannion M, Devaney A, Winter DC. Complete mesocolic resection and extended lymphadenectomy for colon cancer: a systematic review. Colorectal Dis. 2014;16(8):577–94.

    Article  Google Scholar 

  23. Kim KH, et al. Comparative analysis of radiofrequency ablation and surgical resection for colorectal liver metastases. J Korean Surg Soc. 2011;81(1):25–34.

    Article  PubMed  PubMed Central  Google Scholar 

  24. Kuhry E, et al. Long-term results of laparoscopic colorectal cancer resection. Cochrane Database Syst Rev. 2008(2): CD003432.

    Google Scholar 

  25. Lee WS, et al. Pulmonary resection for metastases from colorectal cancer: prognostic factors and survival. Int J Colorectal Dis. 2007;22(6):699–704.

    Article  PubMed  Google Scholar 

  26. Levin B, et al. Screening and surveillance for the early detection of colorectal cancer and adenomatous polyps, 2008: a joint guideline from the American Cancer Society, the US Multi-Society Task Force on Colorectal Cancer, and the American College of Radiology. Gastroenterology. 2008;134(5):1570–95.

    Article  CAS  PubMed  Google Scholar 

  27. Levy M, et al. Tumor markers in staging and prognosis of colorectal carcinoma. Neoplasma. 2008;55(2):138–42.

    CAS  PubMed  Google Scholar 

  28. Liang Y, et al. Laparoscopic versus open colorectal resection for cancer: a meta-analysis of results of randomized controlled trials on recurrence. Eur J Surg Oncol. 2008;34(11):1217–24.

    Article  CAS  PubMed  Google Scholar 

  29. Maindrault-Goebel F., G.L., B. Mineur CL, Andre T, Bennamoun M, Mabro M, Artru P, Louvet C, de Gramont A. Final results of OPTIMOX2, a large randomized phase II study of maintenance therapy or chemotherapy-free intervals (CFI) after FOLFOX in patients with metastatic colorectal cancer (MRC): a GERCOR study. J Clin Oncol, 2007 ASCO Annual Meeting Proceedings Part I. Vol 25, No. 18S (June 20 Supplement), 2007: 4013, 2007.

    Google Scholar 

  30. Miller PE, et al. Dietary patterns and colorectal adenoma and cancer risk: a review of the epidemiological evidence. Nutr Cancer. 2010;62(4):413–24.

    Article  PubMed  Google Scholar 

  31. Morreau H, Riddel R, Aretz S. MUTYH-associated polyposis. In: Bosman FT et al., editors. WHO classification of tumours of the digestive system. Lyon: IARC/ WHO Press; 2010. p. 156–9.

    Google Scholar 

  32. Niekel MC, Bipat S, Stoker J. Diagnostic imaging of colorectal liver metastases with CT, MR imaging, FDG PET, and/or FDG PET/CT: a meta-analysis of prospective studies including patients who have not previously undergone treatment. Radiology. 2010;257(3):674–84.

    Article  PubMed  Google Scholar 

  33. Nordlinger B, et al. Surgical resection of colorectal carcinoma metastases to the liver. A prognostic scoring system to improve case selection, based on 1568 patients. Association Francaise de Chirurgie. Cancer. 1996;77(7):1254–62.

    Article  CAS  PubMed  Google Scholar 

  34. Nordlinger B, et al. Perioperative chemotherapy with FOLFOX4 and surgery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC Intergroup trial 40983): a randomised controlled trial. Lancet. 2008;371(9617):1007–16.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  35. Portier G, et al. Multicenter randomized trial of adjuvant fluorouracil and folinic acid compared with surgery alone after resection of colorectal liver metastases: FFCD ACHBTH AURC 9002 trial. J Clin Oncol. 2006;24(31):4976–82.

    Article  CAS  PubMed  Google Scholar 

  36. Sargent DJ, et al. A pooled analysis of adjuvant chemotherapy for resected colon cancer in elderly patients. N Engl J Med. 2001;345(15):1091–7.

    Article  CAS  PubMed  Google Scholar 

  37. Schmiegel WH, A.R.-S., Freier W, Dietrich G, Arnold D, Kanzler S, Geissler M, Graeven U, Hegewisch-Becker S, Schmoll H. Comparable safety and response rate with bevacizumab in combination with capecitabine/oxaliplatin (CapOx/Bev) versus capecitabine/irinotecan (CapIri/Bev) in advanced CRC (mCRC): a randomized phase II study of the AIO GI tumor study group. J Clin Oncol, 2007 ASCO Annual Meeting Proceedings Part I. Vol 25, No. 18S (June 20 Supplement), 2007: 4034, 2007.

    Google Scholar 

  38. Schmoll HJ, et al. Phase III trial of capecitabine plus oxaliplatin as adjuvant therapy for stage III colon cancer: a planned safety analysis in 1,864 patients. J Clin Oncol. 2007;25(1):102–9.

    Article  CAS  PubMed  Google Scholar 

  39. Stillwell AP, Buettner PG, Ho YH. Meta-analysis of survival of patients with stage IV colorectal cancer managed with surgical resection versus chemotherapy alone. World J Surg. 2010;34(4):797–807.

    Article  CAS  PubMed  Google Scholar 

  40. Terry MB, et al. Risk factors for advanced colorectal adenomas: a pooled analysis. Cancer Epidemiol Biomarkers Prev. 2002;11(7):622–9.

    PubMed  Google Scholar 

  41. Van Cutsem E, R.L., Hossfeld D, Bodoky G, Roth A, Aranda E, Nordlinger B, Assadourian S, Wang K, Cunningham D. PETACC 3, randomized phase III trial comparing infused irinotecan/5-fluorouracil (5-FU)/folinic acid (IF) versus 5-FU/FA (F) in stage III colon cancer patients (pts). (PETACC 3). J Clin Oncol, 2005 ASCO Annual Meeting Proceedings., 2005. 23(16S, Part I of II (June 1 Supplement)).

    Google Scholar 

  42. Van Damme J-P. Vascular anatomy in abdominal surgery. Stuttgart: Thieme; 1990.

    Google Scholar 

  43. van Rossum LG, et al. Random comparison of guaiac and immunochemical fecal occult blood tests for colorectal cancer in a screening population. Gastroenterology. 2008;135(1):82–90.

    Article  PubMed  Google Scholar 

  44. Vasen HF, et al. The International Collaborative Group on Hereditary Non-Polyposis Colorectal Cancer (ICG-HNPCC). Dis Colon Rectum. 1991;34(5):424–5.

    Article  CAS  PubMed  Google Scholar 

  45. Verwaal VJ, et al. 8-year follow-up of randomized trial: cytoreduction and hyperthermic intraperitoneal chemotherapy versus systemic chemotherapy in patients with peritoneal carcinomatosis of colorectal cancer. Ann Surg Oncol. 2008;15(9):2426–32.

    Article  PubMed  Google Scholar 

  46. West NP, et al. Complete mesocolic excision with central vascular ligation produces an oncologically superior specimen compared with standard surgery for carcinoma of the colon. J Clin Oncol. 2010;28(2):272–8.

    Article  PubMed  Google Scholar 

  47. Winawer SJ, et al. Colorectal cancer screening: clinical guidelines and rationale. Gastroenterology. 1997;112(2):594–642.

    Article  CAS  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of General and Visceral Surgery, Clinic Ludwigsburg, Ludwigsburg, Germany

    Thomas H. K. Schiedeck MD

  2. Department of Surgery, Friedrich-Alexander University, Erlangen, Germany

    Klaus E. Matzel MD, PhD

Authors
  1. Thomas H. K. Schiedeck MD
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  2. Klaus E. Matzel MD, PhD
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Corresponding author

Correspondence to Thomas H. K. Schiedeck MD .

Editor information

Editors and Affiliations

  1. End- und Dickdarm-Zentrum Mannheim, Mannheim, Germany

    Alexander Herold

  2. Clinique de chirurgie digestive et endocrinienne, Institut des maladies de l’appareil digestif, Hotel Dieu, Nantes, France

    Paul-Antoine Lehur

  3. Chirurgische Klinik mit Poliklinik, Universitaet Erlangen, Erlangen, Germany

    Klaus E. Matzel

  4. UCD School of Medicine, St Vincent’s University Hospital, Dublin, Ireland

    P. Ronan O'Connell

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Schiedeck, T.H.K., Matzel, K.E. (2017). Colon Cancer. In: Herold, A., Lehur, PA., Matzel, K., O'Connell, P. (eds) Coloproctology. European Manual of Medicine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-53210-2_25

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  • DOI: https://doi.org/10.1007/978-3-662-53210-2_25

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  • Online ISBN: 978-3-662-53210-2

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