Skip to main content

Schizophrenie

  • Chapter
MKT+

Part of the book series: Psychotherapie: Manuale ((PSMA))

  • 4140 Accesses

Zusammenfassung

Was genau bedeutet Schizophrenie und welche Symptome sind charakteristisch? Welche Erklärungsmodelle zur Entstehung gibt es für diese Störung und wie wird sie behandelt? Das Kapitel 2 bietet einen umfassenden und aktuellen Überblick zur Epidemiologie und Diagnostik der Schizophrenie. Im Abschnitt zu ätiologischen Modellen wird auch auf genetische und neurobiologische Veränderungen eingegangen, die bei Schizophrenie beobachtet wurden. Dem Wahn als eines der eindrücklichsten Symptome (und zudem ein Zielsymptom des Individualisierten Metakognitiven Therapieprogramms MKT+) wird ein eigener Abschnitt gewidmet. Im Abschnitt zur Behandlung der Schizophrenie werden neben aktuellen psychopharmakologischen Therapiemöglichkeiten evidenzbasierte psychotherapeutische Behandlungsstrategien vorgestellt. Das Kapitel schließt mit der aktuellen Studienlage zum MKT-Gruppentraining sowie zum MKT+.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Notes

  1. 1.

    Die Arbeitsgruppe um McKenna äußert sich recht kritisch und pessimistisch über die kognitive Verhaltenstherapie bei Psychosen. Eine Metaanalyse von Lynch und Kollegen (2010) wurde von Kingdon (2010) aufgrund methodischer Mängel in seiner Erwiderung zu Recht zurückgewiesen (»Lynching-Party«). Allerdings räumen auch Befürworter ein, dass die Wirksamkeit der kognitiven Verhaltenstherapie bei Psychosen geringer ist als z. B. bei Angststörungen.

Literatur

  • Achim, A. M., Maziade, M., Raymond, É., Olivier, D., Mérette, C., & Roy, M. A. (2011). How prevalent are anxiety disorders in schizophrenia? A meta-analysis and critical review on a significant association. Schizophrenia Bulletin 37, 811–821.

    Google Scholar 

  • Adriano, F., Caltagirone, C., & Spalletta, G. (2012). Hippocampal volume reduction in first-episode and chronic schizophrenia: A review and meta-analysis. The Neuroscientist 18, 180–200.

    Google Scholar 

  • Agid, O., Kapur, S., Arenovich, T., & Zipursky, R. B. (2003). Delayed-onset hypothesis of antipsychotic action: a hypothesis tested and rejected. Archives of General Psychiatry 60, 1228–1235.

    Google Scholar 

  • Aghotor, J., Pfueller, U., Moritz, S., Weisbrod, M., & Roesch-Ely, D. (2010). Metacognitive training for patients with schizophrenia (MCT): Feasibility and preliminary evidence for its efficacy. Journal of Behavior Therapy and Experimental Psychiatry 41, 207–211.

    Google Scholar 

  • American Psychiatric Association (APA). (2013). Diagnostic and statistical manual of mental disorders (5th ed.). Arlington, VA: American Psychiatric Publishing.

    Google Scholar 

  • American Psychiatric Association (APA). (2015). Schizophrenia spectrum and other psychotic disorders: DSM-5 selections. Arlington, VA: American Psychiatric Publishing.

    Google Scholar 

  • Andreasen, N. C., Flaum, M., Swayze, V. W., Tyrrell, G., & Arndt, S. (1990). Positive and negative symptoms in schizophrenia. A critical reappraisal. Archives of General Psychiatry 47, 615–621.

    Google Scholar 

  • Andreou, C., Moritz, S., Veith, K., Veckenstedt, R., & Naber, D. (2014). Dopaminergic modulation of probabilistic reasoning and overconfidence in errors: a double-blind study. Schizophrenia Bulletin 40, 558–565.

    Google Scholar 

  • Balzan, R. P., Delfabbro, P. H., Galletly, C. A., & Woodward, T. S. (2014). Metacognitive training for patients with schizophrenia: Preliminary evidence for a targeted, single-module programme. The Australian and New Zealand Journal of Psychiatry 48, 1126–1136.

    Google Scholar 

  • Bäuml, J., Pitschel-Walz, G., Volz, A., Engel, R. R., & Kessling, W. (2007). Psychoeducation in schizophrenia: 7-year follow-up concerning rehospitalization and days in hospital in the Munich Psychosis Information Project Study. Journal of Clinical Psychiatry 68, 854–861.

    Google Scholar 

  • Bechdolf, A., & Klingberg, S. (2014). Psychotherapie bei schizophrenen Störungen: Kein Evidenz-, sondern ein Implementierungsproblem. Psychiatrische Praxis 41, 8–10.

    Google Scholar 

  • Beck, A. T., Baruch, E., Balter, J. M., Steer, R. A., & Warman, D. M. (2004). A new instrument for measuring insight: The Beck Cognitive Insight Scale. Schizophrenia Research 68, 319–329.

    Google Scholar 

  • Bell, V., Halligan, P. W., & Ellis, H. D. (2008). Are anomalous perceptual experiences necessary for delusions? Journal of Nervous and Mental Disease 196, 3–8.

    Google Scholar 

  • Bender, S., & Dittmann-Balzar, A. (2008). Kognitives Training bei Schizophrenie. In T. Kircher & S. Gauggel (Hrsg.), Neuropsychologie der Schizophrenie. Symptome, Kognition, Gehirn (S. 589–598). Berlin Heidelberg: Springer.

    Google Scholar 

  • Birchwood, M., Smith, J., Drury, V., Healy, J., Macmillan, F., & Slade, M. (1994). A self-report Insight Scale for psychosis: reliability, validity and sensitivity to change. Acta Psychiatrica Scandinavica 89, 62–67.

    Google Scholar 

  • Brandl, E. J., Kennedy, J. L., & Müller, D. J. (2014). Pharmacogenetics of antipsychotics. Canadian Journal of Psychiatry 59, 76–88.

    Google Scholar 

  • Briki, M., Monnin, J., Haffen, E. et al. (2014). Metacognitive training for schizophrenia: a multicentre randomised controlled trial. Schizophrenia Research 157, 99–106.

    Google Scholar 

  • Brohan, E., Elgie, R., Sartorius, N., Thornicroft, G., & GAMIAN-Europe Study Group (2010). Self-stigma, empowerment and perceived discrimination among people with schizophrenia in 14 European countries: the GAMIAN-Europe study. Schizophrenia Research 122, 232–238.

    Google Scholar 

  • Buckley, P. F., & Hwang, M. Y. (2015). Comorbid psychiatric disorders in schizophrenia: more than just a chance co-occurrence. In L. De Haan, F. Schirmbeck, & M. Zink (Eds.), Obsessive-Compulsive Symptoms in Schizophrenia (pp. 3–10). Switzerland: Springer International Publishing.

    Google Scholar 

  • Buckley, P. F., Miller, B. J., Lehrer, D. S., & Castle, D. J. (2009). Psychiatric comorbidities and schizophrenia. Schizophrenia Bulletin 35, 383–402.

    Google Scholar 

  • Buonocore, M., Bosia, M., Riccaboni, R., et al. (2015). Combined neurocognitive and metacognitive rehabilitation in schizophrenia: effects on bias against disconfirmatory evidence. European Psychiatry 30, 615–621.

    Google Scholar 

  • Burns, A. M., Erickson, D. H., & Brenner, C. A. (2014). Cognitive-behavioral therapy for medication-resistant psychosis: a meta-analytic review. Psychiatric Services 65, 874–880.

    Google Scholar 

  • Byerly, M. J., Nakonezny, P. A., & Lescouflair, E. (2007). Antipsychotic medication adherence in schizophrenia. Psychiatric Clinics of North America 30, 437–452.

    Google Scholar 

  • Byrne, R., & Morrison, A. P. (2014). Service users’ priorities and preferences for treatment of psychosis: a user-led Delphi study. Psychiatric Services 65, 1167–1169.

    Google Scholar 

  • Carillo, S., & Klein, S. (2011). Schizophrener Wahn – Ein Spiegel unserer Zeit? Eine Untersuchung schizophrener Symptome und ihrer Behandlung zu drei Zeitpunkten (1970, 1990, 2010). Psychologische Diplomarbeit. Hamburg: Universität Hamburg.

    Google Scholar 

  • Carpenter, W. T. Jr., Strauss, J. S., & Muleh, S. (1973). Are there pathognomonic symptoms in schizophrenia? An empiric investigation of Schneider’s first-rank symptoms. Archives of General Psychiatry 28, 847–852.

    Google Scholar 

  • Cermolacce, M., Sass, L., & Parnas, J. (2010). What is bizarre in bizarre delusions? A critical review. Schizophrenia Bulletin. doi:10.1093/schbul/sbq001.

    Google Scholar 

  • Combs, D. R., Adams, S. D., Penn, D. L., Roberts, D., Tiegreen, J., & Stem, P. (2007). Social Cognition and Interaction Training (SCIT) for inpatients with schizophrenia spectrum disorders: preliminary findings. Schizophrenia Research 91, 112–116.

    Google Scholar 

  • Conrad, K. (1959). Die beginnende Schizophrenie – Versuch einer Gestaltsanalyse des Wahns. Stuttgart: Thieme.

    Google Scholar 

  • Craig, T. J., Bromet, E. J., Fennig, S., Tanenberg-Karant, M., Lavelle, J., & Galambos, N. (2000). Is there an association between duration of untreated psychosis and 24-month clinical outcome in a first-admission series? American Journal of Psychiatry 157, 60–66.

    Google Scholar 

  • Crow, T. J. (2008). The emperors of the schizophrenia polygene have no clothes. Psychological Medicine 38, 1681–1685.

    Google Scholar 

  • de Leede-Smith, S., & Barkus, E. (2013). A comprehensive review of auditory verbal hallucinations: lifetime prevalence, correlates and mechanisms in healthy and clinical individuals. Frontiers in Human Neuroscience 7, 367.

    Google Scholar 

  • Dilling, H., Mombour, W., & Schmidt, M. H.; World Health Organization (WHO). (Hrsg.) (2000). Internationale Klassifikation psychischer Störungen ICD-10 Kapitel V (F); klinisch-diagnostische Leitlinien (4. Aufl.). Bern: Hans Huber.

    Google Scholar 

  • Eichner, C., & Berna, F. (2016). Acceptance and efficacy of Metacognitive Training (MCT) on positive symptoms and delusions in patients with schizophrenia: a meta-analysis taking into account important moderators. Schizophrenia Bulletin 42, 952–962.

    Google Scholar 

  • Erawati, E., Keliat, B. A., Helena, N., & Hamid, A. (2014). The influence of metacognitive training on delusion severity and metacognitive ability in schizophrenia. Journal of Psychiatric and Mental Health Nursing 21, 841–847.

    Google Scholar 

  • Falkai, P., Wobrock, T., Schneider-Axmann, T., & Gruber, O. (2008). Die »Hirnstörung« Schizophrenie und ihre Entwicklung. Fortschritte der Neurologie & Psychiatrie 76 (Suppl. 1), 63–67.

    Google Scholar 

  • Favrod, J., Maire, A., Bardy, S., Pernier, S., & Bonsack, C. (2011). Improving insight into delusions: a pilot study of metacognitive training for patients with schizophrenia. Journal of Advanced Nursing 67, 401–407.

    Google Scholar 

  • Favrod, J., Rexhaj, S., Bardy, S., Ferrari, P., Hayoz, C., Moritz, S., Conus, P., & Bonsack, C. (2014). Sustained antipsychotic effect of metacognitive training in psychosis: A randomized-controlled study. European Psychiatry 29, 275–281.

    Google Scholar 

  • Fervaha, G., Zakzanis, K. K., Foussias, G., Graff-Guerrero, A., Agid, O., & Remington, G. (2014). Motivational deficits and cognitive test performance in schizophrenia. Journal of the American Medical Association Psychiatry 71: 1058–1065.

    Google Scholar 

  • Ferwerda, J., Boer, K., & van der Gaag, M. (2010). Metacognitieve training voor patiënten met een psychotische kwetsbaarheid. Directieve Therapie 30, 263–279.

    Google Scholar 

  • Finn, S. E., Bailey, J. M., Schultz, R. T., & Faber, R. (1990). Subjective utility ratings of neuroleptics in treating schizophrenia. Psychological Medicine 20, 843–848.

    Google Scholar 

  • Freeman, D. (2006). Delusions in the nonclinical population. Current Psychiatry Reports 8, 191–204.

    Google Scholar 

  • Freeman, D. (2007). Suspicious minds: the psychology of persecutory delusions. Clinical Psychology Review 27, 425–457.

    Google Scholar 

  • Fusar-Poli, P., Smieskova, R., Kempton, M. J., Ho, B. C., Andreasen, N. C., & Borgwardt, S. (2013). Progressive brain changes in schizophrenia related to antipsychotic treatment? A meta-analysis of longitudinal MRI studies. Neuroscience & Biobehavioral Reviews 37, 1680–1691.

    Google Scholar 

  • Gaebel, W., Falkai, P., Weinmann, S., & Wobrock, T.; Deutsche Gesellschaft für Psychiatrie, Psychotherapie und Nervenheilkunde (DGPPN). (Hrsg.). (2006). Band 1: Behandlungsleitlinie Schizophrenie. Darmstadt: Steinkopff.

    Google Scholar 

  • Gallinat, J., & Gudlowski, Y. (2008). Die Glutamathypothese der Schizophrenie. Nervenheilkunde 27, 317–325.

    Google Scholar 

  • Gallinat J, McMahon K, Kühn S, Schubert F, Schaefer M. (2016). Cross-sectional study of glutamate in the anterior cingulate and hippocampus in schizophrenia. Schizophrenia Bulletin 42, 425–433.

    Google Scholar 

  • Garety, P. A., Hemsley, D. R., & Wessely, S. (1991). Reasoning in deluded schizophrenic and paranoid patients. Biases in performance on a probabilistic inference task. Journal of Nervous and Mental Disease 179, 194–201.

    Google Scholar 

  • Garety, P. A., Fowler, D. G., Freeman, D., Bebbington, P., Dunn, G., & Kuipers, E. (2008). Cognitive-behavioural therapy and family intervention for relapse prevention and symptom reduction in psychosis: randomised controlled trial. British Journal of Psychiatry 192, 412–423.

    Google Scholar 

  • Gawęda, L., Krężołek, M., Olbryś, J., Turska, A., & Kokoszka, A. (2015). Decreasing self-reported cognitive biases and increasing clinical insight through meta-cognitive training in patients with chronic schizophrenia. Journal of Behavior Therapy and Experimental Psychiatry 48, 98–104.

    Google Scholar 

  • Gemeinsamer Bundesausschuss (2014). Tragende Gründe zum Beschluss Entwurf des Gemeinsamen Bundesausschusses über eine Änderung der Qualitätsmanagement-Richtlinie vertragsärztliche Versorgung: Umsetzung des § 137 Absatz 1d Satz 1 SGB V. https://www.g-ba.de/downloads/40-268-3574/2015-12-17_QM-RL_Erstfassung_TrG.pdf. Zugegriffen: 01. Mai 2016.

  • Gershon, E. S., & Alliey-Rodriguez, N. (2013). New ethical issues for genetic counseling in common mental disorders. American Journal of Psychiatry 170, 968–976.

    Google Scholar 

  • Glahn, D. C., Laird, A. R., Ellison-Wright, I., Thelen, S. M., Robinson, J. L., Lancaster, J. L., Bullmore, E., & Fox, P. T. (2008). Meta-analysis of gray matter anomalies in schizophrenia: application of anatomic likelihood estimation and network analysis. Biological Psychiatry 64, 774–781.

    Google Scholar 

  • Gleich, T., Deserno, L., Lorenz, R. C., Boehme, R., Pankow, A., Buchert, R., Kühn, S., Heinz, A., Schlagenhauf, F., & Gallinat, J. (2015). Prefrontal and striatal glutamate differently relate to striatal dopamine: potential regulatory mechanisms of striatal presynaptic dopamine function? Journal of Neuroscience 35, 9615–9621.

    Google Scholar 

  • Goff, D.C. (2014). Bitopertin: the good news and bad news. Journal of the American Medical Association Psychiatry 71, 621–622.

    Google Scholar 

  • Gottesman, I. I. (1991). Schizophrenia genesis: The origins of madness. New York: WH Freeman.

    Google Scholar 

  • Gouzoulis-Mayfrank, E. (2008). Kognitionen bei Modellpsychosen. In T. Kircher, & S. Gauggel (Hrsg.), Neuropsychologie der Schizophrenie. Symptome, Kognition, Gehirn (S. 82–95). Berlin Heidelberg: Springer.

    Google Scholar 

  • Gunduz-Bruce, H., McMeniman, M., Robinson, D. G., Woerner, M. G., Kane, J. M., Schooler, N. R., & Lieberman, J. A. (2005). Duration of untreated psychosis and time to treatment response for delusions and hallucinations. American Journal of Psychiatry 162, 1966–1969.

    Google Scholar 

  • Haddock, G., McCarron, J., Tarrier, N., & Faragher, E. B. (1999). Scales to measure dimensions of hallucinations and delusions: the psychotic symptom rating scales (PSYRATS). Psychological Medicine 29, 879–889.

    Google Scholar 

  • Hammen, C. L., & Krantz, S. E. (1976). Effects of success and failure on depressive cognitions. Journal of Abnormal Psychology 85, 577–586.

    Google Scholar 

  • Hanson, E., Healey, K., Wolf, D., & Kohler, C. (2010). Assessment of pharmacotherapy for negative symptoms of schizophrenia. Current Psychiatry Reports 12, 563–571.

    Google Scholar 

  • Hasan, A., Malchow, P., Falkai, A., & Schmitt, A. (2014). Die Glutamathypothese der Schizophrenie. Fortschritte in Neurologie und Psychiatrie 82, 447–456.

    Google Scholar 

  • Heinrichs, R. W., & Zakzanis, K. K. (1998). Neurocognitive deficit in schizophrenia: a quantitative review of the evidence. Neuropsychology 12, 426–445.

    Google Scholar 

  • Heres, S., Schmitz, F. S., Leucht, S., & Pajonk, F. G. (2007). The attitude of patients towards antipsychotic depot treatment. International Clinical Psychopharmacology 22, 275–282.

    Google Scholar 

  • Hill, M. K., & Sahhar, M. (2006). Genetic counselling for psychiatric disorders. Medical Journal of Australia 185, 507–510.

    Google Scholar 

  • Ho, B. C., Psych, M. R. C., Alicata, D., Moser, D. J., O’Leary, D. S., Arndt, S., & Andreasen, N. C. (2003). Untreated initial psychosis: relation to cognitive deficits and brain morphology in first-episode schizophrenia. American Journal of Psychiatry 160, 142–148.

    Google Scholar 

  • Ho, B. C., Andreasen, N. C., Ziebell, S., Pierson, R., & Magnotta, V. (2011). Long-term antipsychotic treatment and brain volumes: a longitudinal study of first-episode schizophrenia. Archives of General Psychiatry 68, 128–137.

    Google Scholar 

  • Hor, K., & Taylor, M. (2010). Review: Suicide and schizophrenia: a systematic review of rates and risk factors. Journal of Psychopharmacology 24 (Suppl. 4), 81–90.

    Google Scholar 

  • Howes, O. D., & Kapur, S. (2009). The dopamine hypothesis of schizophrenia: version III – the final common pathway. Schizophrenia Bulletin 35, 549–562.

    Google Scholar 

  • Howes, O., McCutcheon, R., & Stone, J. (2015). Glutamate and dopamine in schizophrenia: An update for the 21st century. Journal of Psychopharmacology 29, 97–115.

    Google Scholar 

  • Huschka, L. (2005). Subjektives Wahnerleben und Wahninhalte bei Patienten mit paranoid-halluzinatorischer Schizophrenie. Eine deskriptive Analyse. Unveröffentlichte Diplomarbeit. Hamburg: Universität Hamburg.

    Google Scholar 

  • Hutton, P., Morrison, A. P., Yung, A. R., Taylor, P. J., French, P., & Dunn, G. (2012). Effects of drop-out on efficacy estimates in five Cochrane reviews of popular antipsychotics for schizophrenia. Acta Psychiatrica Scandinavica 126, 1–11.

    Google Scholar 

  • Jaspers, K. (1913). Allgemeine Psychopathologie. Berlin, Heidelberg: Springer.

    Google Scholar 

  • Javitt, D.C., & Zukin, S.R. (1991). Recent advances in the phencyclidine model of schizophrenia. The American Journal of Psychiatry 148, 1301–1308.

    Google Scholar 

  • Kapur, S. (2003). Psychosis as a state of aberrant salience: a framework linking biology, phenomenology, and pharmacology in schizophrenia. American Journal of Psychiatry 160, 13–23.

    Google Scholar 

  • Kapur, S., Zipursky, R., Jones, C., Remington, G., & Houle, S. (2000). Relationship between dopamine D (2) occupancy, clinical response, and side effects: a double-blind PET study of first-episode schizophrenia. The American Journal of Psychiatry 157, 514–520.

    Google Scholar 

  • Kasanin, J. (1933). The acute schizoaffective psychoses. American Journal of Psychiatry 90, 97–126.

    Google Scholar 

  • Kay, S. R., Opler, L. A., & Lindenmayer, J. P. (1989). The Positive and Negative Syndrome Scale (PANSS): rationale and standardisation. The British Journal of Psychiatry 155 (Suppl. 7), 59–67.

    Google Scholar 

  • Keefe, R. S., & Fenton, W. S. (2007). How should DSM-V criteria for schizophrenia include cognitive impairment? Schizophrenia Bulletin 33, 912–920.

    Google Scholar 

  • Keefe, R. S., Bilder, R. M., Davis, S. M., et al. (2007). Neurocognitive effects of antipsychotic medications in patients with chronic schizophrenia in the CATIE Trial. Archives of General Psychiatry 64, 633–647.

    Google Scholar 

  • Kennedy, J. L., Altar, C. A., Taylor, D. L., Degtiar I., & Hornberger, J. C. (2014).The social and economic burden of treatment-resistant schizophrenia: a systematic literature review.International Clinical Psychopharmacology 29, 63–76.

    Google Scholar 

  • Kety, S. (1980). The syndrome of schizophrenia: unresolved questions and opportunities for research. The British Journal of Psychiatry 136, 421–436.

    Google Scholar 

  • Kingdon, D. (2010). Over-simplification and exclusion of non-conforming studies can demonstrate absence of effect: a lynching party? A commentary on »Cognitive behavioural therapy for major psychiatric disorder: does it really work? A meta-analytical review of well-controlled trials« by Lynch et al. (2009). Psychological Medicine 40, 25–27.

    Google Scholar 

  • Klingberg, S., Wittorf, A., & Buchkremer, G. (2008). Kognitive Verhaltenstherapie der schizophrenen Störungen – Einfluss auf Symptome und Kognition. In T. Kircher, & S. Gauggel (Hrsg.),Neuropsychologie der Schizophrenie. Symptome, Kognition, Gehirn (S. 577–588). Berlin Heidelberg: Springer.

    Google Scholar 

  • Klosterkötter, J. (1992). The meaning of basic symptoms for the genesis of the schizophrenic nuclear syndrome. Japanese Journal of Psychiatry & Neurology 46, 609–630.

    Google Scholar 

  • Köther, U., Vetorazzi, E., Veckenstedt, R., Hottenrott, B., Bohn, F., Scheu, F., Pfueller, U., Roesch-Ely, D., & Moritz, S. (2016). Bayesian analyses of the effect of metacognitive training on social cognition deficits and overconfidence in errors. Journal of Experimental Psychopathology.

    Google Scholar 

  • Koutsouleris, N., Davatzikos, C., Borgwardt, S., et al. (2013). Accelerated brain aging in schizophrenia and beyond: a neuroanatomical marker of psychiatric disorders. Schizophrenia Bulletin 40, 1140–1153.

    Google Scholar 

  • Krantz, S., & Hammen, C. L. (1979). Assessment of cognitive bias in depression. Journal of Abnormal Psychology 88, 611–619.

    Google Scholar 

  • Kuhnigk, O., Slawik, L., Meyer, J., Naber, D., & Reimer, J. (2012). Valuation and attainment of treatment goals in schizophrenia: perspectives of patients, relatives, physicians, and payers. Journal of Psychiatric Practice 18, 321–328.

    Google Scholar 

  • Kuipers, E., Garety, P., Fowler, D., Freeman, D., Dunn, G., & Bebbington, P. (2006). Cognitive, emotional, and social processes in psychosis: refining cognitive behavioral therapy for persistent positive symptoms. Schizophrenia Bulletin 32 (Suppl. 1), 24–31.

    Google Scholar 

  • Kumar, D., Zia Ul Haq, M., Dubey, I., Dotiwala, K., Siddiqui, S. V., & Abhishek, P. (2010). Effect of meta-cognitive training in the reduction of positive symptoms in schizophrenia. European Journal of Psycotherapy & Counselling 12, 149–158.

    Google Scholar 

  • Kuokkanen, R., Lappalainen, R., Repo-Tiihonen, E., & Tiihonen, J. (2014). Metacognitive group training for forensic and dangerous non-forensic patients with schizophrenia: A randomised controlled feasibility trial. Criminal Behaviour and Mental Health 24, 345–357.

    Google Scholar 

  • Kymalainen, J. A., & Weisman de Mamani, A. G. (2008). Expressed emotion, communication deviance, and culture in families of patients with schizophrenia: a review of the literature. Cultural Diversity and Ethnic Minority Psychology 14, 85–91.

    Google Scholar 

  • Lam, K. C., Ho, C. P., Wa, J. C., Chan, S. M., Yam, K. K., Yeung, O. S., Wong, W. C., & Balzan, R. P. (2014). Metacognitive training (MCT) for schizophrenia improves cognitive insight: a randomized controlled trial in a Chinese sample with schizophrenia spectrum disorders. Behaviour Research and Therapy 64, 38–42.

    Google Scholar 

  • Lambert, M., & Naber, D. (2009). Pharmakotherapie der Schizophrenie. Stuttgart: Thieme.

    Google Scholar 

  • Laruelle, M. (1998). Imaging dopamine transmission in schizophrenia. A review and meta-analysis. Quarterly Journal of Nuclear Medicine 42, 211–221.

    Google Scholar 

  • Lepping, P., Sambhi, R. S., Whittington, R., Lane, S., & Poole, R. (2011). Clinical relevance of findings in trials of antipsychotics: systematic review. The British Journal of Psychiatry 198, 341–345.

    Google Scholar 

  • Leube, D., & Pauly, K. (2008). Ich-Störungen – Psychologie. In T. Kircher, & S. Gauggel (Hrsg.), Neuropsychologie der SchizophrenieSymptome, Kognition, Gehirn (S. 484–495). Berlin, Heidelberg: Springer.

    Google Scholar 

  • Leucht, S., Arbter, D., Engel, R. R., Kissling, W., & Davis, J. M. (2009a). How effective are second-generation antipsychotic drugs? A meta-analysis of placebo-controlled trials. Molecular Psychiatry 14, 429–447.

    Google Scholar 

  • Leucht, S., Corves, C., Arbter, D., Engel, R. R., Li, C., & Davis, J. M. (2009b). Second-generation versus first-generation antipsychotic drugs for schizophrenia: a meta-analysis. The Lancet 373, 31–41.

    Google Scholar 

  • Leucht, S., Tardy, M., Komossa, Heres, S., Kissling, W., Salanti, G., Davis, J. M. (2012). Antipsychotic drugs versus placebo for relapse prevention in schizophrenia: a systematic review and meta-analysis. The Lancet 379, 2063–2071.

    Google Scholar 

  • Leucht, S., Cipriani, A., Spineli, L. et al. (2013). Comparative efficacy and tolerability of 15 antipsychotic drugs in schizophrenia: a multiple-treatments meta-analysis. The Lancet 382, 951–962.

    Google Scholar 

  • Lieberman, J. A., Stroup, T. S., McEvoy, J. P., et al. (2005). Effectiveness of antipsychotic drugs in patients with chronic schizophrenia. New England Journal of Medicine 353, 1209–1223.

    Google Scholar 

  • Liddle, P. F. (1987). The symptoms of chronic schizophrenia. A re-examination of the positive-negative dichotomy. British Journal of Psychiatry 151, 145–151.

    Google Scholar 

  • Lincoln, T. (2014). Kognitive Verhaltenstherapie der Schizophrenie: Ein individuenzentrierter Ansatz. Göttingen: Hogrefe.

    Google Scholar 

  • Lincoln, T. M., & Keller, E. (2008). Delusions and hallucinations in students compared to the general population. Psychology and Psychotherapy 81, 231–235.

    Google Scholar 

  • Lincoln, T. M., Wilhelm, K., & Nestoriuc, Y. (2007). Effectiveness of psychoeducation for relapse, symptoms, knowledge, adherence and functioning in psychotic disorders: a meta-analysis. Schizophrenia Research 96, 232–245.

    Google Scholar 

  • Lynch, D., Laws, K. R., & McKenna, P. J. (2010). Cognitive behavioural therapy for major psychiatric disorder: does it really work? A meta-analytical review of well-controlled trials. Psychological Medicine 40, 9–24.

    Google Scholar 

  • Maher, B. A. (1974). Delusional thinking and perceptual disorder Journal of Individual Psychology 30, 98–113.

    Google Scholar 

  • Marker, K. (2003). COGPACK Manual Version 5.9. Ladenburg: Marker Software.

    Google Scholar 

  • Mathalon, D. H., Pfefferbaum, A., Lim, K. O., Rosenbloom, M. J., & Sullivan, E. V. (2003). Compounded brain volume deficits in schizophrenia-alcoholism comorbidity. Archives of General Psychiatry 60, 245–252.

    Google Scholar 

  • McGrath, J., Saha, S., Chant, D., & Welham, J. (2008). Schizophrenia: a concise overview of incidence, prevalence, and mortality. Epidemiologic Reviews 30, 67–76.

    Google Scholar 

  • Mehl, S., & Lincoln, T. (2015). KVT bei Wahn und Halluzinationen. PiD-Psychotherapie im Dialog 16, 58–63.

    Google Scholar 

  • Mehl, S., Werner, D., & Lincoln, T. M. (2015). Does cognitive behavior therapy for psychosis (CBTp) show a sustainable effect on delusions? A meta-analysis. Frontiers in Psychology. doi: 10.3389/fpsyg.2015.01450.

    Google Scholar 

  • Mehler-Wex, C., & J. Renner, T. (2008). Genetische Befunde zu Schizophrenie. Zeitschrift für Kinder-und Jugendpsychiatrie und Psychotherapie 36, 17–26.

    Google Scholar 

  • Mizrahi, R., Kiang, M., Mamo, D. C., Arenovich, T., Bagby, R. M., Zipursky, R. B., & Kapur, S. (2006). The selective effect of antipsychotics on the different dimensions of the experience of psychosis in schizophrenia spectrum disorders. Schizophrenia Research 88, 111–118.

    Google Scholar 

  • Moritz, S., & Andresen, B. (2002). Analyse der Schizophreniespezifität schizotypischer Fragebogenskalen. Entwicklung eines Instrumentes zur Erfassung schizophrenienaher Schizotypiemerkmale. Zeitschrift für Psychologie 210, 141–150.

    Google Scholar 

  • Moritz, S., & Larøi, F. (2008). Differences and similarities in the sensory and cognitive signatures of voice-hearing, intrusions and thoughts. Schizophrenia Research 102, 96–107.

    Google Scholar 

  • Moritz, S., & Lincoln, T. M. (2008). Wahn – Psychologie. In T. Kircher, & S. Gauggel (Hrsg.), Neuropsychologie der Schizophrenie. Symptome, Kognition, Gehirn (S. 456–467). Berlin, Heidelberg: Springer.

    Google Scholar 

  • Moritz, S., & Woodward, T. S. (2007). Metacognitive training for schizophrenia patients (MCT): A pilot study on feasibility, treatment adherence, and subjective efficacy. German Journal of Psychiatry 10, 69–78.

    Google Scholar 

  • Moritz, S., Andresen, B., Jacobsen, D., Mersmann, K., Wilke, U., Lambert, M., Naber, D., & Krausz, M. (2001a). Neuropsychological correlates of schizophrenic syndromes in patients treated with atypical neuroleptics. European Psychiatry 16, 354–361.

    Google Scholar 

  • Moritz, S., Heeren, D., Andresen, B., & Krausz, M. (2001b). An analysis of the specificity and the syndromal correlates of verbal memory impairments in schizophrenia. Psychiatry Research 101, 23–31.

    Google Scholar 

  • Moritz, S., Andresen, B., Perro, C., Schickel, M., Krausz, M., & Naber, D. (2002a). Neurocognitive performance in first-episode and chronic schizophrenic patients. European Archives of Psychiatry and Clinical Neuroscience 252, 33–37.

    Google Scholar 

  • Moritz, S., Woodward, T. S., Krausz, M., & Naber, D. (2002b). Relationship between neuroleptic dosage and subjective cognitive dysfunction in schizophrenic patients treated with either conventional or atypical neuroleptic medication. International Clinical Psychopharmacology 17, 41–44.

    Google Scholar 

  • Moritz, S., Woodward, T. S., & Ruff, C. C. (2003). Source monitoring and memory confidence in schizophrenia. Psychological Medicine 33, 131–139.

    Google Scholar 

  • Moritz, S., Ferahli, S., & Naber, D. (2004). Memory and attention performance in psychiatric patients: lack of correspondence between clinician-rated and patient-rated functioning with neuropsychological test results. Journal of the International Neuropsychological Society 10, 623–633.

    Google Scholar 

  • Moritz, S., Woodward, T. S., & Burlon, M. (2005). Metakognitives Training für schizophrene Patienten (MKT). Manual. Hamburg: VanHam Campus.

    Google Scholar 

  • Moritz, S., Peters, M. J. V., Karow, A., Deljkovic, A., Tonn, P., & Naber, D. (2009a). Cure or curse? Ambivalent attitudes towards neuroleptic medication in schizophrenia and non-schizophrenia patients. Mental Illness 1, 4–9.

    Google Scholar 

  • Moritz, S., Veckenstedt, R., Hottenrott, B., Woodward, T. S., Randjbar, S., & Lincoln, T. M. (2010). Different sides of the same coin? Intercorrelations of cognitive biases in schizophrenia. Cognitive Neuropsychiatry 15, 406–421.

    Google Scholar 

  • Moritz, S., Kerstan, A., Veckenstedt, R., Randjbar, S., Vitzthum, F., Schmidt, C., Heise, M., & Woodward, T. S. (2011a). Further evidence for the efficacy of a metacognitive group training in schizophrenia. Behaviour Research and Therapy 49, 151–157.

    Google Scholar 

  • Moritz, S., Veckenstedt, R., Randjbar, S., Vitzthum, F., & Woodward, T. S. (2011b). Antipsychotic treatment beyond antipsychotics: metacognitive intervention for schizophrenia patients improves delusional symptoms. Psychological Medicine 41, 1823–1832.

    Google Scholar 

  • Moritz, S., Andreou, C., Klingberg, S., Thoering, T., & Peters, M. J. (2013a). Assessment of subjective cognitive and emotional effects of antipsychotic drugs. Effect by defect? Neuropharmacology 72, 179–186.

    Google Scholar 

  • Moritz, S., Veckenstedt, R., Bohn, F. et al. (2013b). Complementary group Metacognitive Training (MCT) reduces delusional ideation in schizophrenia. Schizophrenia Research 151, 61–69.

    Google Scholar 

  • Moritz, S., Favrod, J., Andreou, C., Morrison, A. P., Bohn, F., Veckenstedt, R., Tonn, P., & Karow, A. (2013c). Beyond the usual suspects: positive attitudes towards positive symptoms is associated with medication noncompliance in psychosis. Schizophrenia Bulletin 39, 917–922.

    Google Scholar 

  • Moritz, S., Claussen, M., Hauschildt, M., & Kellner, M. (2014a). Perceptual properties of obsessive thoughts are associated with low insight in obsessive-compulsive disorder. The Journal of Nervous and Mental Disease 202, 562–565.

    Google Scholar 

  • Moritz, S., Veckenstedt, R., Andreou, C. et al. (2014b). Delayed and »sleeper« effects of metacognitive group training (MCT) in schizophrenia. Journal of the American Medical Association Psychiatry 71, 1103–1111.

    Google Scholar 

  • Moritz, S., Hörmann, C. C., Schröder, J., Berger, T., Jacob, G. A., Meyer, B., Holmes, E. A., Späth, C., Hautzinger, M., Lutz, W., Rose, M., & Klein, J. P. (2014c). Beyond words: sensory properties of depressive thoughts. Cognition and Emotion 28, 1047–1056.

    Google Scholar 

  • Moritz, S., Thoering, T., Kühn, S., Willenborg, B., Westermann, S., & Nagel, M. (2015). Metacognition-augmented cognitive remediation training reduces jumping to conclusions and overconfidence but not neurocognitive deficits in psychosis. Frontiers in Psychology. doi: 10.3389/fpsyg.2015.01048.

    Google Scholar 

  • Moritz, S., Berna, F., Jaeger, S., Westermann, S., & Nagel, M. (2016a). The customer is always right? Subjective target symptoms and treatment preferences in patients with psychosis. European Archives of Psychiatry and Clinical Neuroscience. doi: 10.1007/s00406-016-0694-5.

    Google Scholar 

  • Moritz, S., Werner, D., Menon, M., Balzan, R. P., & Woodward, T. S. (2016b). Jumping to negative conclusions – a case of study-gathering bias? Psychological Medicine 46, 59–61.

    Google Scholar 

  • Moritz, S., Schröder, J., Klein, J. P., Lincoln, T. M., Andreou, C., Fischer, A., & Arlt, S. (2016c). Effects of online intervention for depression on mood and positive symptoms in schizophrenia. Schizophrenia Research. doi: 10.1016/j.schres.2016.04.033.

    Google Scholar 

  • Nelson, H. E. (2010). Kognitiv-behaviorale Therapie bei Wahn und Halluzinationen. Stuttgart: Schattauer.

    Google Scholar 

  • Ochoa, S., Usall, J., Cobo, J., Labad, X., & Kulkarni, J. (2012). Gender differences in schizophrenia and first-episode psychosis: a comprehensive literature review. Schizophrenia Research and Treatment. doi:10.1155/2012/916198.

    Google Scholar 

  • Overall, J.E., & Gorham, D.R. (1962). The brief psychiatric rating scale. Psychological Reports 10, 799–812.

    Google Scholar 

  • Penttilä, M., Jääskeläinen, E., Hirvonen, N., Isohanni, M., & Miettunen, J. (2014). Duration of untreated psychosis as predictor of long-term outcome in schizophrenia: systematic review and meta-analysis. The British Journal of Psychiatry 205, 88–94.

    Google Scholar 

  • Perkins, D. O., Gu, H., Boteva, K., & Lieberman, J. A. (2005). Relationship between duration of untreated psychosis and outcome in first-episode schizophrenia: a critical review and meta-analysis. American Journal of Psychiatry 162, 1785–1804.

    Google Scholar 

  • Pilling, S., Bebbington, P., Kuipers, E., Garety, P., Geddes, J., Orbach, G., & Morgan, C. (2002). Psychological treatments in schizophrenia: I. Meta-analysis of family intervention and cognitive behaviour therapy. Psychological Medicine 32, 763–782.

    Google Scholar 

  • Pilowsky, L. S., Bressan, R. A., Stone, J. M., Erlandsson, K., Mulligan, R. S., Krystal, J. H., & Ell, P. J. (2006). First in vivo evidence of an NMDA receptor deficit in medication-free schizophrenic patients. Molecular Psychiatry 11, 118–119.

    Google Scholar 

  • Raine, A. (1991). The SPQ: a scale for the assessment of schizotypal personality based on DSM-III-R criteria. Schizophrenia Bulletin 17, 555–564.

    Google Scholar 

  • Ripke, S., O’Dushlaine, C., Chambert, K., et al. (2013). Genome-wide association analysis identifies 13 new risk loci for schizophrenia. Nature Genetics 45, 1150–1159.

    Google Scholar 

  • Rocha, N. B., & Queirós, C. (2013). Metacognitive and social cognition training (MSCT) in schizophrenia: a preliminary efficacy study. Schizophrenia Research 150, 64–68.

    Google Scholar 

  • Roder, V., & Müller, D. R. (Hrsg.). (2013). INT-Integrierte neurokognitive Therapie bei schizophren Erkrankten. Berlin Heidelberg: Springer.

    Google Scholar 

  • Roder, V., Mueller, D. R., Mueser, K. T., & Brenner, H. D. (2006). Integrated psychological therapy (IPT) for schizophrenia: is it effective? Schizophrenia Bulletin 32 (Suppl. 1), 81–93.

    Google Scholar 

  • Rosenberg, M. (1965). Society and the adolescent self-image. Princeton, NJ: Princeton University Press.

    Google Scholar 

  • Rosenheck, R., Stroup, S., Keefe, R. S., McEvoy, J., Swartz, M., Perkins, D., Hsiao, J., Shumway, M., & Lieberman, J. (2005). Measuring outcome priorities and preferences in people with schizophrenia. The British Journal of Psychiatry 187, 529–536.

    Google Scholar 

  • Ross, K., Freeman, D., Dunn, G., & Garety, P. (2011). A randomized experimental investigation of reasoning training for people with delusions. Schizophrenia Bulletin 37, 324–333.

    Google Scholar 

  • Rund, B. R. (2013). Does active psychosis cause neurobiological pathology? A critical review of the neurotoxicity hypothesis. Psychological Medicine 44, 1–14.

    Google Scholar 

  • Sarin, F., Wallin, L., & Widerlöv, B. (2011). Cognitive behavior therapy for schizophrenia: a meta-analytical review of randomized controlled trials. Nordic Journal of Psychiatry 65, 162–174.

    Google Scholar 

  • Savla, G. N., Vella, L., Armstrong, C. C., Penn, D. L., & Twamley, E. W. (2013). Deficits in domains of social cognition in schizophrenia: a meta-analysis of the empirical evidence. Schizophrenia Bulletin 39, 979–992.

    Google Scholar 

  • Schaefer, J., Giangrande, E., Weinberger, D. R., & Dickinson, D. (2013). The global cognitive impairment in schizophrenia: consistent over decades and around the world. Schizophrenia Research 150, 42–50.

    Google Scholar 

  • Schizophrenia Working Group of the Psychiatric Genomics Consortium (SWGPGC). (2014). Biological insights from 108 schizophrenia-associated genetic loci. Nature 511, 421–427.

    Google Scholar 

  • Schneider, S. D., Jelinek, L., Lincoln, T. M., & Moritz, S. (2011). What happened to the voices? A fine-grained analysis of how hallucinations and delusions change under psychiatric treatment. Psychiatry Research 188, 13–17.

    Google Scholar 

  • Schwab, S. G., & Wildenauer, D. B. (2013). Genetics of psychiatric disorders in the GWAS era: an update on schizophrenia. European Archives of Psychiatry and Clinical Neuroscience 263, 147–154.

    Google Scholar 

  • Shepherd, A. M., Laurens, K. R., Matheson, S. L., Carr, V. J., & Green, M. J. (2012). Systematic meta-review and quality assessment of the structural brain alterations in schizophrenia. Neuroscience & Biobehavioral Reviews 36, 1342–1356.

    Google Scholar 

  • So, S. H. W., Chan, A., Chong, C., Wong, M., Lo, W., Chung, D., & Chan, S. (2015). Metacognitive Training for delusions (MCTd): Effectiveness on data-gathering and belief flexibility in a Chinese sample. Frontiers in Psychology. doi: 10.3389/fpsyg.2015.00730.

    Google Scholar 

  • Spitzer, M. (1989a). Was ist Wahn? Untersuchungen zum Wahnproblem. Berlin: Springer.

    Google Scholar 

  • Spitzer, M. (1989b). Ein Beitrag zum Wahnproblem. Nervenarzt 60, 95–101.

    Google Scholar 

  • Steen, R. G., Mull, C., McClure, R., Hamer, R. M., & Lieberman, J. A. (2006). Brain volume in first-episode schizophrenia: systematic review and meta-analysis of magnetic resonance imaging studies. British Journal of Psychiatry 188, 510–518.

    Google Scholar 

  • Steinebrunner, E., & Scharfetter, C. (1976). Wahn im Wandel der Geschichte. Eine historisch-vergleichende Studie. Archiv für Psychiatrie und Nervenkrankheiten 222, 47–60.

    Google Scholar 

  • Tateyama, M., Asai, M., Hashimoto, M., Bartels, M., & Kasper, S. (1998). Transcultural study of schizophrenic delusions. Tokyo versus Vienna and Tübingen (Germany). Psychopathology 31, 59–68.

    Google Scholar 

  • Tsuang, M. (2000). Schizophrenia: genes and environment. Biological Psychiatry 47, 210–220.

    Google Scholar 

  • Tuominen, H. J., Tiihonen, J., & Wahlbeck, K. (2005). Glutamatergic drugs for schizophrenia: a systematic review and meta-analysis. Schizophrenia Research 72, 225–234.

    Google Scholar 

  • Turner, D. T., van der Gaag, M., Karyotaki, E., & Cuijpers, P. (2014). Psychological interventions for psychosis: a meta-analysis of comparative outcome studies. The American Journal of Psychiatry 171, 523–538.

    Google Scholar 

  • Ussorio, D., Giusti, L., Wittekind, C. E., Bianchini, V., Malavolta, M., Pollice, R., Casacchia, M., & Roncone, R. (2015). Metacognitive training for young subjects (MCT young version) in the early stages of psychosis: Is the duration of untreated psychosis a limiting factor? Psychology and Psychotherapy: Theory, Research and Practice. doi: 10.1111/papt.12059.

    Google Scholar 

  • van der Gaag, M., Hoffman, T., Remijsen, M. et al. (2006). The five-factor model of the Positive and Negative Syndrome Scale II: a ten-fold cross-validation of a revised model. Schizophrenia Research 85, 280–287.

    Google Scholar 

  • van Oosterhout, B., Krabbendam, L., de Boer, K., Ferwerda, J., van der Helm, M., Stant, A. D., & van der Gaag, M. (2014). Metacognitive group training for schizophrenia spectrum patients with delusions: a randomized controlled trial. Psychological Medicine 44, 3025–3035.

    Google Scholar 

  • van Oosterhout, B., Smit, F., Krabbendam, L., Castelein, S., Staring, A. B. P., & van der Gaag, M. (2015). Metacognitive training for schizophrenia spectrum patients: a meta-analysis on outcome studies. Psychological Medicine. doi:10.1017/S0033291715001105.

    Google Scholar 

  • van Os, J., & Kapur, S. (2009). Schizophrenia. The Lancet 374, 635–645.

    Google Scholar 

  • Vauth, R., & Stieglitz, R. D. (2007). Chronisches Stimmenhören und perstierender Wahn. Göttingen: Hogrefe.

    Google Scholar 

  • Vinogradov, S., Fisher, M., Warm, H., Holland, C., Kirshner, M. A., & Pollock, B. G. (2009). The cognitive cost of anticholinergic burden: decreased response to cognitive training in schizophrenia. American Journal of Psychiatry 166, 1055–1062.

    Google Scholar 

  • Walker, C. (1991). Delusion: what did Jaspers really say? British Journal of Psychiatry 159 (Suppl. 14), 94–103.

    Google Scholar 

  • Waller, H., Freeman, D., Jolley, S., Dunn, G., & Garety, P. (2011). Targeting reasoning biases in delusions: a pilot study of the Maudsley Review Training Programme for individuals with persistent, high conviction delusions. Journal of Behavior Therapy and Experimental Psychiatry 42, 414–421.

    Google Scholar 

  • Walter, A., Studerus, E., Smieskova, R., Kuster, P., Aston, J., Lang, U. E., Radue, E. W., Riecher-Rössler, A., & Borgwardt, S. (2012). Hippocampal volume in subjects at high risk of psychosis: a longitudinal MRI study. Schizophrenia Research 142, 217–222.

    Google Scholar 

  • Woodward, T. S., Jung, K., Smith, G. N., Hwang, H., Barr, A. M., Procyshyn, R. M., Flynn, S. W., van der Gaag, M., & Honer, W. G. (2014). Symptom changes in five dimensions of the Positive and Negative Syndrome Scale in refractory psychosis. European Archives of Psychiatry and Clinical Neuroscience 264, 673–682.

    Google Scholar 

  • World Health Organization (WHO). (2003). Adherence to long-term therapies: Evidence for action. Geneva (Switzerland): World Health Organization.

    Google Scholar 

  • Wykes, T., Steel, C., Everitt, B., & Tarrier, N. (2008). Cognitive behavior therapy for schizophrenia: effect sizes, clinical models, and methodological rigor. Schizophrenia Bulletin 34, 523–537.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer-Verlag GmbH Deutschland

About this chapter

Cite this chapter

Moritz, S., Krieger, E., Bohn, F., Veckenstedt, R. (2017). Schizophrenie. In: MKT+. Psychotherapie: Manuale. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-52998-0_2

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-52998-0_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-52997-3

  • Online ISBN: 978-3-662-52998-0

  • eBook Packages: Medicine (German Language)

Publish with us

Policies and ethics