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Hematuria and Proteinuria

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Pediatric Kidney Disease

Abstract

Hematuria or proteinuria may be just a normal transient finding in children, usually accompanying a non-specific viral infection, or it can be an indicator of a kidney or urinary tract disorder. In this chapter, the various causes and significance of discolored urine, hematuria and proteinuria in children are discussed. A pragmatic clinical approach to evaluate a child with isolated hematuria or isolated proteinuria is suggested to reduce unnecessary extensive workup in benign cases and yet not miss the cases with significant glomerular or urinary tract disease. Early detection and treatment of significant disorders would hopefully delay or prevent the onset of renal insufficiency in children.

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References

  1. Vehaskari VM, Rapola J, Koskimies O, Savilahti E, Vilska J, Hallman N. Microscopic hematuria in schoolchildren: epidemiology and clinicopathologic evaluation. J Pediatr. 1979;95:676–84.

    Article  CAS  PubMed  Google Scholar 

  2. Shaw Jr ST, Poon SY, Wong ET. Routine urinalysis: is the dipstick enough? JAMA. 1985;253:1596–600.

    Article  PubMed  Google Scholar 

  3. Dodge WF. Cost effectiveness of renal disease screening. Am J Dis Child. 1977;131:1274–80.

    CAS  PubMed  Google Scholar 

  4. Fairley KF, Birch DF. Microscopic urinalysis in glomerulonephritis. Kidney Int Suppl. 1993;42:S9–12.

    CAS  PubMed  Google Scholar 

  5. Pollock C, Pei-Ling L, Gÿory AZ, Grigg R, Gallery ED, Caterson R, Ibels L, Mahony J, Waugh D. Dysmorphism of urinary red blood cells – value in diagnosis. Kidney Int. 1989;36:1045–9.

    Article  CAS  PubMed  Google Scholar 

  6. Schramek P, Moritsch A, Haschkowitz H, Binder BR, Maier M. In vitro generation of dysmorphic erythrocytes. Kidney Int. 1989;36:72–7.

    Article  CAS  PubMed  Google Scholar 

  7. Shichiri M, Hosoda K, Nishio Y, Ogura M, Suenaga M, Saito H, Tomura S, Shiigai T. Red-cell-volume distribution curves in diagnosis of glomerular and non- glomerular hematuria. Lancet. 1988;1:908–11.

    Article  CAS  PubMed  Google Scholar 

  8. Ito CA, Pecoits-Filho R, Bail L, Wosiack MA, Afinovicz D, Hauser AB. Comparative analysis of two methodologies for the identification of urinary red blood cell casts. J Bras Nefrol. 2011;33(4):402–7.

    Article  PubMed  Google Scholar 

  9. Pham PT, Pham PC, Wilkinson AH, Lew SQ. Renal abnormalities in sickle cell anemia. Kidney Int. 2000;57:1–8.

    Article  CAS  PubMed  Google Scholar 

  10. Hohenfellner M, Steinbach F, Schultz-Lampel D, Lampel A, Steinbach F, Cramer BM, Thuroff JW. The nutcracker syndrome: new aspects of pathophysiology, diagnosis and treatment. J Urol. 1991;146:685–8.

    CAS  PubMed  Google Scholar 

  11. Mazzoni MB, Kottanatu L, Simonetti GD, Ragazzi M, Bianchetti MG, Fossali EF, Milani GP. Renal vein obstruction and orthostatic proteinuria: a review. Nephrol Dial Transplant. 2011;26(2):562–5.

    Article  PubMed  Google Scholar 

  12. Okada M, Tsuzuki K, Ito S. Diagnosis of the nutcracker phenomenon using two- dimensional ultrasonography. Clin Nephrol. 1998;49:35–40.

    CAS  PubMed  Google Scholar 

  13. Cho BS, Suh JS, Hahn WH, Kim SD, Lim JW. Multidetector computed tomography findings and correlations with proteinuria in nutcracker syndrome. Pediatr Nephrol. 2010;25(3):469–75.

    Article  PubMed  Google Scholar 

  14. Tanaka H, Waga S. Spontaneous remission of persistent severe hematuria in an adolescent with nutcracker syndrome: seven years’ observation. Clin Exp Nephrol. 2004;8:68–70.

    Article  PubMed  Google Scholar 

  15. Shin JL, Park JM, Lee SM, Shin YH, Kim JH, Lee JS, Kim MJ. Factors affecting spontaneous resolution of hematuria in childhood nutcracker syndrome. Pediatr Nephrol. 2005;20:609–13.

    Article  PubMed  Google Scholar 

  16. Venkatachalam S, Bumpus K, Kapadia SR, Gray B, Lyden S, Shishehbor MH. The nutcracker syndrome. Ann Vasc Surg. 2011;25(8):1154–64.

    Article  PubMed  Google Scholar 

  17. Athanasiou Y, Voskarides K, Gale DP, Damianou L, Patsias C, Zavros M, Maxwell PH, Cook HT, Demosthenous P, Hadjisavvas A, Kyriacou K, Zouvani I, Pierides A, Deltas C. Familial C3 glomerulopathy associated with CFHR5 mutations: clinical characteristics of 91 patients in 16 pedigrees. Clin J Am Soc Nephrol. 2011;6:1436–46.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Deltas C, Pierides A, Voskarides K. Molecular genetics of familial hematuric diseases. Nephrol Dial Transplant. 2013;28(12):2946–60.

    Article  CAS  PubMed  Google Scholar 

  19. Seri M, Pecci A, Di Bari F, Cusano R, Savino M, Panza E, Nigro N, Noris P, Gangarossa S, Rocca B, Gresele P, Bizzaro N, Malatesta P, Koivisto PA, Longo I, Musso R, Pecoraro C, Iolascon A, Magrini U, Soriano JR, Renieri A, Ghiggeri GM, Ravazzolo R, Balduini CL, Savoia A. MYH9-related disease. May-Hegglin anomaly, Sebastian syndrome, Fechtner syndrome, and Epstein syndrome are not distinct entities but represent a variable expression of a single illness. Medicine. 2003;82:203–15.

    PubMed  Google Scholar 

  20. Han KH, Lee HK, Kang HG, Moon KC, Lee JH, Park YS, Ha IS, Ahn HS, Choi Y, Cheong HI. Renal manifestations of patients with MYH9-related disorders. Pediatr Nephrol. 2011;26:549–55.

    Article  PubMed  Google Scholar 

  21. Plaisier E, Gribouval O, Alamowitch S, Mougenot B, Prost C, Verpont MCX, Marro B, Desmettre T, Cohen SY, Roullet E, Dracon M, Fardeau M, Van Agtmael T, Kerjaschki D, Antignac C, Ronco P. COL4A1 mutations and hereditary angiopathy, nephropathy, aneurysms, and muscle cramps. N Engl J Med. 2007;357:2687–95.

    Article  CAS  PubMed  Google Scholar 

  22. Mufson MA, Belshe RB, Horrigan TJ, Zollar LM. Causes of acute hemorrhagic cystitis in children. Am J Dis Child. 1973;126:605–9.

    CAS  PubMed  Google Scholar 

  23. Summer AP, Stauffer W, Maroushek SR, Nevins TE. Hematuria in children due to schistosomiasis in a nonendemic setting. Clin Pediatr (Phila). 2006;45:177–81.

    Article  Google Scholar 

  24. Altintepe L, Tonbul HZ, Ozbey I, Guney I, Odabas AR, Cetinkaya R, Piskin MM, Selcuk Y. Urinary tuberculosis: ten years’ experience. Ren Fail. 2005;27:657–61.

    Article  PubMed  Google Scholar 

  25. Polinsky MS, Kaiser BA, Baluarte HJ, Gruskin AB. Renal stones and hypercalciuria. Adv Pediatr. 1993;40:353–84.

    CAS  PubMed  Google Scholar 

  26. Stapleton FB, Roy SIII, Noe HN, Jerkins G. Hypercalciuria in children with hematuria. N Engl J Med. 1984;310:1345–8.

    Article  CAS  PubMed  Google Scholar 

  27. Shaw NJ, Wheeldon J, Brocklehurst JT. Indices of intact serum parathyroid hormone and renal excretion of calcium, phosphate and magnesium. Arch Dis Child. 1990;65:1208–12.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  28. Murakami M, Yamamoto H, Ueda Y, Murakami K, Yamauchi K. Urinary screening of elementary and junior high-school children over a 13-year period in Tokyo. Pediatr Nephrol. 1991;5:50–3.

    Article  CAS  PubMed  Google Scholar 

  29. Zainal D, Baba A, Mustaffa BE. Screening proteinuria and hematuria in Malaysian children. Southeast Asian J Trop Med Public Health. 1995;26:785–8.

    CAS  PubMed  Google Scholar 

  30. Yap HK, Quek CM, Shen Q, Joshi V, Chia KS. Role of urinary screening programmes in children in the prevention of chronic kidney disease. Ann Acad Med Singapore. 2005;34:3–7.

    CAS  PubMed  Google Scholar 

  31. Lin CY, Hsieh CC, Chen WP, Yang LY, Wang HH. The underlying diseases and follow-up in Taiwanese children screened by urinalysis. Pediatr Nephrol. 2001;16:232–7.

    Article  CAS  PubMed  Google Scholar 

  32. Cho BS, Kim SD, Choi YM, Kang HH. School urinalysis screening in Korea: prevalence of chronic renal disease. Pediatr Nephrol. 2001;16:1126–8.

    Article  CAS  PubMed  Google Scholar 

  33. Vivante A, Afek A, Frenkel-Nir Y, Tzur D, Farfel A, Golan E, Chaiter Y, Shohat T, Skorecki K, Calderon-Margalit R. Persistent asymptomatic isolated microscopic hematuria in Israeli adolescents and young adults and risk for end-stage renal disease. JAMA. 2011;306:729–36.

    Article  CAS  PubMed  Google Scholar 

  34. Diven SC, Travis LB. A practical primary care approach to hematuria in children. Pediatr Nephrol. 2000;14:65–72.

    Article  CAS  PubMed  Google Scholar 

  35. Buzza M, Wilson D, Savige J. Segregation of hematuria in thin basement membrane disease with haplotypes at the loci for Alport syndrome. Kidney Int. 2001;59:1670–6.

    Article  CAS  PubMed  Google Scholar 

  36. Carasi C, Van’t Hoff WG, Rees L, Risdon RA, Trompeter RS, Dillon MJ. Childhood thin GBM disease: review of 22 children with family studies and long-term follow-up. Pediatr Nephrol. 2005;20:1098–105.

    Article  PubMed  Google Scholar 

  37. Strøm EH, Banfi G, Krapf R, Abt AB, Mazzucco G, Monga G, Gloor F, Neuweiler J, Riess R, Stosiek P, et al. Glomerulopathy associated with predominant fibronectin deposits: a newly recognized hereditary disease. Kidney Int. 1995;48:163–70.

    Article  PubMed  Google Scholar 

  38. Castelletti F, Donadelli R, Banterla F, Hildebrandt F, Zipfel PF, Bresin E, Otto E, Skerka C, Renieri A, Todeschini M, Caprioli J, Caruso RM, Artuso R, Remuzzi G, Noris M. Mutations in FN1 cause glomerulopathy with fibronectin deposits. Proc Natl Acad Sci U S A. 2008;105:2538–43.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  39. Köhler H, Wandel E, Brunck B. Acanthocyturia – a characteristic marker for glomerular bleeding. Kidney Int. 1991;40:115–20.

    Article  PubMed  Google Scholar 

  40. Yoshikawa N, Iijima K, Ito H. IgA nephropathy in children. Nephron. 1999;83:1–12.

    Article  CAS  PubMed  Google Scholar 

  41. Coppo R, Gianoglio B, Porcellini G, Maringhini S. Frequency of renal diseases and clinical indication for renal biopsy in children (Report of the Italian National Registry for Renal biopsies in children). Nephrol Dial Transplant. 1998;13:293–7.

    Article  CAS  PubMed  Google Scholar 

  42. Feld LG, Meyers KE, Kaplan BS, et al. Limited evaluation of microscopic hematuria in pediatrics. Pediatrics. 1998;102:E42.

    Article  CAS  PubMed  Google Scholar 

  43. Gale DP. How benign is hematuria? Using genetics to predict prognosis. Pediatr Nephrol. 2013;28:1183–93.

    Article  PubMed  Google Scholar 

  44. Ruggenenti P, Perna A, Mosconi L, Pisoni R, Remuzzi G. Urinary protein excretion rate is the best independent predictor of ESRF in non-diabetic proteinuric chronic nephropathies. Kidney Int. 1998;53:1209–16.

    Article  CAS  PubMed  Google Scholar 

  45. Remuzzi G, Ruggenenti P, Benigni A. Understanding the nature of renal disease progression. Kidney Int. 1997;51:2–15.

    Article  CAS  PubMed  Google Scholar 

  46. Wingen AM, Fabian-Bach C, Schaefer F, Mehls O. Randomised, multicenter study of a low-protein diet on the progression of renal failure in children. Lancet. 1997;349:1117–23.

    Article  CAS  PubMed  Google Scholar 

  47. Grimm RH, Svendsen KH, Kasiske B, Keane WF, Wahi MM. Proteinuria is a risk factor for mortality over 10 years of follow-up: MRFIT Research Group, Multiple Risk Factor Intervention Trial. Kidney Int Suppl. 1997;63:S10–4.

    PubMed  Google Scholar 

  48. Kannel WB, Stampfer MJ, Castelli WP, Verter J. The prognostic significance of proteinuria: the Framingham Study. Am Heart J. 1984;108:1347–52.

    Article  CAS  PubMed  Google Scholar 

  49. Portman RJ, Hawkins E, Verani R. Premature atherosclerosis in pediatric renal patients: report of the Southwest Pediatric Nephrology Study Group. Pediatr Res. 1991;29:349A.

    Google Scholar 

  50. Kumar S, Muchmore A. Tamm-Horsfall protein-uromodulin (1950–1990). Kidney Int. 1990;37:1395–401.

    Article  CAS  PubMed  Google Scholar 

  51. Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group. KDIGO 2012 clinical practice guideline for the evaluation and management of chronic kidney disease. Kidney Int Suppl. 2013;3:1–150.

    Article  Google Scholar 

  52. Rademacher ER, Sinaiko AR. Albuminuria in children. Curr Opin Nephrol Hypertens. 2009;18:246–51.

    Article  CAS  PubMed  Google Scholar 

  53. Jones CA, Francis ME, Eberhardt MS, Chavers B, Coresh J, Engelgau M, et al. Microalbuminuria in the US population: Third National Health and Nutrition Examination Survey. Am J Kidney Dis. 2002;39:445–59.

    Article  PubMed  Google Scholar 

  54. Bangstad HJ, Jorgensen KD, Kjaersgaard P, Mevold K, Hanssen KF. Urinary albumin excretion rate and puberty in non-diabetic children and adolescents. Acta Paediatr. 1993;82:857–62.

    Article  CAS  PubMed  Google Scholar 

  55. Houser MT, Jahn MF, Kobayashi A, Walburn J. Assessment of urinary protein excretion in the adolescent: effect of body position and exercise. J Pediatr. 1986;109:556–61.

    Article  CAS  PubMed  Google Scholar 

  56. Amin R, Turner C, van Aken S, Bahu TK, Watts A, Lindsell DR, et al. The relationship between microalbuminuria and glomerular filtration rate in young type 1 diabetic subjects: the Oxford Regional Prospective Study. Kidney Int. 2005;68:1740–9.

    Article  PubMed  Google Scholar 

  57. Nguyen S, McCulloch C, Brakeman P, Portale A, Hsu CY. Being overweight modifies the association between cardiovascular risk factors and microalbuminuria in adolescents. Pediatrics. 2008;121:37–45.

    Article  PubMed  PubMed Central  Google Scholar 

  58. Csernus K, Lanyi E, Erhardt E, Molnar D. Effect of childhood obesity and obesity-related cardiovascular risk factors on glomerular and tubular protein excretion. Eur J Pediatr. 2005;164:44–9.

    Article  CAS  PubMed  Google Scholar 

  59. Brem AS. Neonatal hematuria and proteinuria. Clin Perinatol. 1981;8:321–32.

    CAS  PubMed  Google Scholar 

  60. Hogg RJ, Portman RJ, Milliner D, Lemley KV, Eddy A, Ingelfinger J. Evaluation and management of proteinuria and nephrotic syndrome in children: recommendations from a pediatric nephrology panel established at the National Kidney Foundation Conference on Proteinuria, Albuminuria, Risk, Assessment, Detection, and Elimination (PARADE). Pediatrics. 2000;105:1242–9.

    Article  CAS  PubMed  Google Scholar 

  61. Rose BD. Pathophysiology of renal disease. 2nd ed. New York: McGraw-Hill; 1987. p. 11–6.

    Google Scholar 

  62. Elises JS, Griffiths PD, Hocking MD, Taylor CM, White RH. Simplified quantification of urinary protein excretion in children. Clin Nephrol. 1988;30:225–9.

    CAS  PubMed  Google Scholar 

  63. Ginsberg JM, Chang BS, Matarese RA, Garella S. Use of single voided urine samples to estimate quantitative proteinuria. N Engl J Med. 1983;309:1543–6.

    Article  CAS  PubMed  Google Scholar 

  64. Yoshimoto M, Tsukahara H, Saito M, Hayashi S, Haruki S, Fujisawa S, Sudo M. Evaluation of variability of proteinuria indices. Pediatr Nephrol. 1990;4:136–9.

    Article  CAS  PubMed  Google Scholar 

  65. Kaneko K, Someya T, Nishizaki N, Shimojima T, Ohtaki R, Kaneko KI. Simplified quantification of urinary protein excretion using a novel dipstick in children. Pediatr Nephrol. 2005;20:834–6.

    Article  PubMed  Google Scholar 

  66. Guy M, Newall R, Borzomato J, Kalra PA, Price C. Use of a first-line urine protein-to-creatinine ratio strip test on random urines to rule out proteinuria in patients with chronic kidney disease. Nephrol Dial Transplant. 2009;24(4):1189–93.

    Article  CAS  PubMed  Google Scholar 

  67. Sebestyen JF, Alon US. The teenager with asymptomatic proteinuria: think orthostatic first. Clin Pediatr. 2011;50(3):179–82.

    Article  Google Scholar 

  68. Vehaskari VM. Mechanism of orthostatic proteinuria. Pediatr Nephrol. 1990;4:328–30.

    Article  CAS  PubMed  Google Scholar 

  69. Berns JS, McDonald B, Gaudio KM, Siegel NJ. Progression of orthostatic proteinuria to focal and segmental glomerulosclerosis. Clin Pediatr. 1986;25:165–6.

    Article  CAS  Google Scholar 

  70. Springberg PD, Garrett Jr LE, Thompson Jr AL, Collins NF, Lordon RE, Robinson RR. Fixed and reproducible orthostatic proteinuria: results of a 20-year follow-up study. Ann Intern Med. 1982;97:516–9.

    Article  CAS  PubMed  Google Scholar 

  71. Rizvi SA, Naqvi SA, Jawad F, Ahmed E, Asghar A, Zafar MN, Akhtar F. Living kidney donor follow-up in a dedicated clinic. Transplantation. 2005;79:1247–51.

    Article  PubMed  Google Scholar 

  72. Chang RL, Deen WM, Robertson CR, Brenner BM. Permselectivity of the glomerular capillary wall: III. Restricted transport of polyanions. Kidney Int. 1975;8:212–8.

    Article  CAS  PubMed  Google Scholar 

  73. Takahashi S, Watanabe S, Wada N, Murakami H, Funaki S, Yan K, Kondo Y, Harada K, Nagata M. Charge selective function in childhood glomerular diseases. Pediatr Res. 2006;59:336–40.

    Article  PubMed  Google Scholar 

  74. Kriz W, Kretzler M, Provoost AP, Shirato I. Stability and leakiness: opposing challenges to the glomerulus. Kidney Int. 1996;49:1570–4.

    Article  CAS  PubMed  Google Scholar 

  75. Ruggenenti P, Remuzzi G. The role of protein traffic in the progression of renal diseases. Annu Rev Med. 2000;51:315–27.

    Article  CAS  PubMed  Google Scholar 

  76. Joachim GR, Cameron JS, Schwartz M, Becker EL. Selectivity of protein excretion in patients with the nephrotic syndrome. J Clin Invest. 1964;43:2332–46.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  77. Cameron JS, White RHR. Selectivity of proteinuria in children with the nephrotic syndrome. Lancet. 1965;1:463–8.

    Article  CAS  PubMed  Google Scholar 

  78. Bazzi C, Petrini C, Rizza V, Arrigo G, D’Amico G. A modern approach to selectivity of proteinuria and tubulointerstitial damage in nephrotic syndrome. Kidney Int. 2000;58:1732–41.

    Article  CAS  PubMed  Google Scholar 

  79. Bergon E, Granados R, Fernandez-Segoviano P, Miravalles E, Bergon M. Classification of renal proteinuria: a simple algorithm. Clin Chem Lab Med. 2002;40:1143–50.

    Article  CAS  PubMed  Google Scholar 

  80. Dodge WF, West EF, Smith EH, Bunce HIII. Proteinuria and hematuria in school-age children: epidemiology and early natural history. J Pediatr. 1976;88:327–47.

    Article  CAS  PubMed  Google Scholar 

  81. Vehaskari VM, Rapola J. Isolated proteinuria: analysis of a school-age population. J Pediatr. 1982;101:661–8.

    Article  CAS  PubMed  Google Scholar 

  82. Hisano S, Ueda K. Asymptomatic hematuria and proteinuria: renal pathology and clinical outcome in 54 children. Pediatr Nephrol. 1989;3:229–34.

    Article  CAS  PubMed  Google Scholar 

  83. Ruggenenti P, Schieppati A, Remuzzi G. Progression, remission, regression of chronic renal diseases. Lancet. 2001;357:1601–8.

    Article  CAS  PubMed  Google Scholar 

  84. Schwartz GJ, Munoz A, Schneider MF, Mak RH, Kaskel F, Warady BA, Furth SL. New equations to estimate GFR inchildren with CKD. J Am Soc Nephrol. 2009;20:629–37.

    Article  PubMed  PubMed Central  Google Scholar 

  85. Park SJ, Lim JW, Cho BS, Yoon TY, Oh JH. Nutcracker syndrome in children with orthostatic proteinuria: diagnosis on the basis of Doppler sonography. J Ultrasound Med. 2002;21:39–45.

    Article  PubMed  Google Scholar 

  86. Perna A, Remuzzi G. Abnormal permeability to proteins and glomerular lesions: a meta-analysis of experimental and human studies. Am J Kidney Dis. 1996;27:34–41.

    Article  CAS  PubMed  Google Scholar 

  87. Bergstein JM. A practical approach to proteinuria. Pediatr Nephrol. 1999;13:697–700.

    Article  CAS  PubMed  Google Scholar 

  88. Hama T, Nakanishi K, Shima Y, Mukaiyama H, Togawa H, Tanaka R, Hamahira K, Kaito H, Iijima K, Yoshikawa N. Renal biopsy criterion in children with asymptomatic constant isolated proteinuria. Nephrol Dial Transplant. 2012;27:3186–90.

    Article  CAS  PubMed  Google Scholar 

  89. Williams JD, Coles GA. Proteinuria – a direct cause of renal morbidity. Kidney Int. 1994;45:443–50.

    Article  CAS  PubMed  Google Scholar 

  90. Kasiske BL, Lakatua JD, Ma JZ, Louis TA. A meta-analysis of the effects of dietary protein restriction on the rate of decline in renal function. Am J Kidney Dis. 1998;31:954–61.

    Article  CAS  PubMed  Google Scholar 

  91. Jureidini KF, Hogg RJ, van Renen MJ, Southwood TR, Henning PH, Cobiac L, Daniels L, Harris S. Evaluation of long-term aggressive dietary management of chronic renal failure in children. Pediatr Nephrol. 1990;4:1–10.

    Article  CAS  PubMed  Google Scholar 

  92. Uauy RD, Hogg RJ, Brewer ED, Reisch JS, Cunningham C, Holliday MA. Dietary protein and growth in infants with chronic renal insufficiency: a report from the Southwest Pediatric Nephrology Study Group and the University of California San Francisco. Pediatr Nephrol. 1994;8:45–50.

    Article  CAS  PubMed  Google Scholar 

  93. Ellis D, Vats A, Moritz ML, Reitz S, Grosso MJ, Janosky JE. Long-term antiproteinuric and renoprotective efficacy and safety of losartan in children with proteinuria. J Pediatr. 2003;143:89–97.

    Article  CAS  PubMed  Google Scholar 

  94. The ESCAPE Trial Group. Strict blood-pressure control and progression of renal failure in children. N Engl J Med. 2009;361:1639–1650.95.

    Article  Google Scholar 

  95. Tabacova S. Mode of action: angiotensin-converting enzyme inhibition – developmental effects associated with exposure to ACE inhibitors. Crit Rev Toxicol. 2005;35:747–55.

    Article  CAS  PubMed  Google Scholar 

  96. Lee GJ, Cohen R, Chang AC, Cleary JP. Angiotensin converting enzyme inhibitor (ACEI)-induced acute renal failure in premature newborns with congenital heart disease. J Pediatr Pharmacol Ther. 2010;15(4):290–6.

    PubMed  PubMed Central  Google Scholar 

  97. Gantenbein MH, Bauersfeld U, Baenziger O, Frey B, Neuhaus T, Sennhauser F, Bernet V. Side effects of angiotensin converting enzyme inhibitor (captopril) in newborns and young infants. J Perinat Med. 2008;36(5):448–52.

    Article  CAS  PubMed  Google Scholar 

  98. Dionne JM, Abitbol CL, Flynn JT. Hypertension in infancy: diagnosis, management and outcome. Pediatr Nephrol. 2012;27:17–32.

    Article  PubMed  Google Scholar 

  99. Persson F, Rossing P, Reinhard H, Juhl T, Stehouwer CD, Schalkwijk C, Danser AH, Boomsma F, Frandsen E, Parving HH. Renal effects of aliskiren compared with and in combination with irbesartan in patients with type 2 diabetes, hypertension and albuminuria. Diabetes Care. 2009;32:1873–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  100. Kelland EE, McAuley LM, Filler G. Are we ready to use aliskiren in children? Pediatr Nephrol. 2011;26:473–7.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Pediatrics, National University of Singapore, 1E Kent Ridge Road, NUHS Tower Block Level 12, Singapore, 119228, Singapore

    Hui-Kim Yap

  2. Khoo Teck Puat-National University Children’s Medical Institute, National University Hospital, 1E Kent Ridge Road, NUHS Tower Block Level 12, Singapore, 119228, Singapore

    Perry Yew-Weng Lau

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Correspondence to Hui-Kim Yap .

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Editors and Affiliations

  1. Division of Nephrology, The Hospital for Sick Children, Toronto, Ontario, Canada

    Denis F. Geary

  2. Division of Pediatric Nephrology, University of Heidelberg, Heidelberg, Germany

    Franz Schaefer

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Yap, HK., Lau, P.YW. (2016). Hematuria and Proteinuria. In: Geary, D., Schaefer, F. (eds) Pediatric Kidney Disease. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-52972-0_14

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