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Pediatric Kidney Disease pp 277–302Cite as

Disorders of Kidney Formation

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Abstract

In this chapter, disorders of kidney formation, so-called congenital anomalies of the kidney and urinary tract (CAKUT) are defined including their epidemiology and long-term outcome. A detailed review of the molecular signaling pathways that lead to normal kidney and urinary tract formation is included with a focus on those genes and proteins that have been shown to be pertinent in animal models of CAKUT and in humans. Clinical management of unilateral renal agenesis, renal hypo/dysplasia, multicystic renal dysplasia, renal ectopia, and renal fusion anomalies is also discussed.

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Notes

  1. 1.

    http://www.ncbi.nlm.nih.gov/

  2. 2.

    http://www.medicine.uiowa.edu/pendredandbor/

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Acknowledgement

The authors would like to thank Dr. Remi Salomon for his contributions to the previous version of this chapter in the first edition of this volume.

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Authors and Affiliations

  1. Division of Nephrology, Department of Pediatrics, Hospital for Sick Children, University of Toronto, 686 Bay St, Rm 16-9-706, Toronto, ON, M5G 0A4, Canada

    Norman D. Rosenblum

  2. Division of Nephrology, Department of Pediatrics, Montreal Children’s Hospital, McGill University, 2300 Tupper Street, Montreal, Quebec, H3H 1P3, Canada

    Indra R. Gupta

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Correspondence to Norman D. Rosenblum .

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  1. Division of Nephrology, The Hospital for Sick Children, Toronto, Ontario, Canada

    Denis F. Geary

  2. Division of Pediatric Nephrology, University of Heidelberg, Heidelberg, Germany

    Franz Schaefer

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Rosenblum, N.D., Gupta, I.R. (2016). Disorders of Kidney Formation. In: Geary, D., Schaefer, F. (eds) Pediatric Kidney Disease. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-52972-0_10

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