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Palliative Plasmabehandlung von Kopf-Hals-Tumoren und kurative Konzepte

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Plasmamedizin

Zusammenfassung

Die Behandlung von Tumoren im Kopf-Hals-Bereich mit CAP („cold atmospheric pressure plasma“) hat für die Patienten einen palliativen Nutzen, wenn im fortgeschrittenen Krankheitsstadium eine Dekontamination der infizierten Tumorgeschwüre gelingt, verbunden mit Schmerzlinderung, Verminderung der Sepsisgefahr und Beseitigung des typischen üblen Geruchs von vereiterten Tumoren. Die Kopf-Hals-Karzinome eignen sich auch als Modelltumor zur Entwicklung von kurativen Konzepten der Plasmatumortherapie. Als Nebeneffekt der Dekontamination ist regelmäßig eine klinisch erkennbare, morphologische Veränderung der CAP-behandelten Tumoroberfläche zu beobachten, auf der es zur Tumorschrumpfung kommt, zum Stopp des Wachstums, zur verstärkten Durchblutung oder zum Biofilmverlust. Eine Klassifikation der morphologischen Tumorveränderungen unter Einwirkung von CAP unterstützt die strukturierte weitere Forschung auf dem Weg zu einer kurativen Plasmatumortherapie.

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Authors and Affiliations

  1. Universitätsmedizin Greifswald Klinik und Poliklinik für Mund-Kiefer-Gesichtschirurgie/Plastische Operationen, Ferdinand-Sauerbruch-Straße DZ 7, 17475, Greifswald, Deutschland

    Christian Seebauer

  2. Department of Electrical Engineering and Computer Science Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, 464-8603, Nagoya, Japan

    Hiromasa Tanaka

  3. Plasma Medical Science Global Innovation Center, Nagoya University, Furo-cho, Chikusa-ku, 464-8603, Nagoya, Japan

    Hiromasa Tanaka

  4. Department of Electrical Engineering and Computer Science Graduate School of Engineering, Nagoya University, Furo-choChikusa-ku, 464-8603, Nagoya, Japan

    Masaru Hori

  5. Plasma Medical Science Global Innovation Center, Nagoya University, Furo-choChikusa-ku, 464-8603, Nagoya, Japan

    Masaru Hori

  6. Universitätsmedizin Greifswald Klinik und Poliklinik für Mund-Kiefer-Gesichtschirurgie/Plastische Operationen, Ferdinand-Sauerbruch-Straße DZ 7, 17475, Greifswald, Deutschland

    Hans Robert Metelmann

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  1. Christian Seebauer
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Editors and Affiliations

  1. Universitätsmedizin Greifswald, Mund-Kiefer-Gesichtschirurgie/Plastische Operation , Greifswald, Germany

    Hans-Robert Metelmann

  2. Technologie e.V., Leibniz-Institut für Plasmaforschung und Technologie e.V., Greifswald, Germany

    Thomas von Woedtke

  3. Leibniz-Institut für Plasmaforschung und Technologie e.V., Leibniz-Institut für Plasmaforschung und Technologie e.V., Greifswald, Germany

    Klaus-Dieter Weltmann

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Seebauer, C., Tanaka, H., Hori, M., Metelmann, H.R. (2016). Palliative Plasmabehandlung von Kopf-Hals-Tumoren und kurative Konzepte. In: Metelmann, HR., von Woedtke, T., Weltmann, KD. (eds) Plasmamedizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-52645-3_8

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