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Wissenschaftliche Grundlagen, Stand und Perspektiven der Plasmamedizin

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Zusammenfassung

Durch Zufuhr von elektrischer Energie kommt es zur Ionisation von Atomen oder Molekülen eines selbst nicht unmittelbar wirksamen Gases: Physikalisches Plasma entsteht. Medizinisch eingesetzte Plasmen werden unter atmosphärischen Bedingungen generiert. Biologische und medizinisch nutzbare Plasmaeffekte werden überwiegend über Veränderungen der flüssigen Zellumgebung vermittelt und basieren auf der Wirkung von redoxaktiven reaktiven Sauerstoff- und Stickstoffspezies. Aufgrund des physiologischen Vorkommens der redoxaktiven Spezies gibt es körpereigene Systeme zur Aufrechterhaltung der zellulären Redoxhomöostase. Geringe Behandlungsintensitäten/Einwirkungszeiten führen zur Stimulation von Zellen, was eine wesentliche Grundlage für die plasmaunterstützte Wundheilung darstellt. Höhere Behandlungsintensitäten/Einwirkungszeiten führen zur Inaktivierung/Abtötung von Zellen. Hieraus eröffnen sich Anwendungsperspektiven in der Krebstherapie.

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Authors and Affiliations

  1. Leibniz-Institut für Plasmaforschung und Technologie e.V. (INP), Felix-Hausdorff-Straße 2, 17489, Greifswald, Deutschland

    Thomas von Woedtke

  2. Leibniz-Institut für Plasmaforschung und Technologie e.V. (INP), Felix-Hausdorff-Straße 2, 17489, Greifswald, Deutschland

    Anke Schmidt

  3. Leibniz-Institut für Plasmaforschung und Technologie e.V. (INP) ZIK plasmatis, Felix-Hausdorff-Straße 2, 17489, Greifswald, Deutschland

    Sander Bekeschus

  4. Leibniz-Institut für Plasmaforschung und Technologie e.V. (INP), Felix-Hausdorff-Straße 2, 17489, Greifswald, Deutschland

    Kristian Wende

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  1. Thomas von Woedtke
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Editors and Affiliations

  1. Universitätsmedizin Greifswald, Mund-Kiefer-Gesichtschirurgie/Plastische Operation , Greifswald, Germany

    Hans-Robert Metelmann

  2. Technologie e.V., Leibniz-Institut für Plasmaforschung und Technologie e.V., Greifswald, Germany

    Thomas von Woedtke

  3. Leibniz-Institut für Plasmaforschung und Technologie e.V., Leibniz-Institut für Plasmaforschung und Technologie e.V., Greifswald, Germany

    Klaus-Dieter Weltmann

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von Woedtke, T., Schmidt, A., Bekeschus, S., Wende, K. (2016). Wissenschaftliche Grundlagen, Stand und Perspektiven der Plasmamedizin. In: Metelmann, HR., von Woedtke, T., Weltmann, KD. (eds) Plasmamedizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-52645-3_2

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