Skip to main content

Vaskuläre Anomalien

  • Chapter
  • 3757 Accesses

Zusammenfassung

Der Terminus »vaskuläre Anomalien« umschreibt ein großes Spektrum von Erkrankungen vom einfachen »Geburtsmal« bis hin zu einer lebensbedrohlichen Erkrankung. Anhand einer einheitlichen Einteilung, der ISVVA-Klassifikation unterscheidet man die vaskulären Anomalien prinzipiell in vaskuläre Tumoren und vaskuläre Anomalien. Die Unterscheidung erfolgte in Anlehnung an das Erscheinungsbild sowie der radiologischen und pathologischen Merkmale. Vaskuläre Tumoren wachsen infolge einer zellulären Hyperplasie. Sie können je nach Typ wachsen, persistieren oder regressieren. Der häufigste Vertreter dieser Gruppe, das infantile Hämangiom, ist also ein benigner vaskulärer Tumor. Vaskuläre Malformationen hingegen sind das Ergebnis lokalisierter Defekte in der vaskulären Morphogenese, vermutlich infolge fehlerhafter Pfade im Rahmen der Embryo- und Vaskulogenese. Vaskuläre Malformationen regressieren niemals, sie bleiben zeitlebens bestehen. Sie wachsen während des Wachstums meist proportional mit.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   229.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD   299.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Literatur

Zu Kap. 26.1 und 26.2.1

  • Hoeger PH, Jarper JI, Baselga D, Boon LM, Degli Atti MC, El Hachem M, Oranje AP, Rubin AT, Weibel L, Léauté-Labrèze C (2015) Treatment of infantile haemangiomas: recommendations of an European expert group. Eur J Pediatr 174(7):855–65

    Google Scholar 

  • Léauté-Labrèze C, Dumas de la Roque E, Hubiche T, Boralevi F, Thambo JB, Taïeb A (2008) Propranolol for severe hemangiomas of infancy. N Engl J Med 358(24):2649–2651

    Google Scholar 

  • Magnuiness SH, Frieden F (2010) Current Management of Infantile Hemangiomas. Semin Cutan Med Surg 29(2):106–14

    Google Scholar 

Zu Kap. 26.2.2

  • Croteau SE, Liang MG, Kozakewich HP, et al. (2013) Kaposiform hemangioendothelioma: atypical features and risks of Kasabach-Merritt phenomenon in 107 referrals. The Journal of pediatrics 162:142–147

    Google Scholar 

  • Drolet BA, Trenor CC, 3rd, Brandao LR, et al. (2013) Consensus-derived practice standards plan for complicated Kaposiform hemangioendothelioma. The Journal of pediatrics 163:285–291

    Google Scholar 

  • ISSVA Classification of Vascular Anomalies (2014) 20th International Workshop on Vascular Anomalies, Melbourne, Australia

    Google Scholar 

  • Jahnel J, Lackner H, Reiterer F, Urlesberger B, Urban C (2012) Kaposiform hemangioendothelioma with Kasabach-Merritt phenomenon: from vincristine to sirolimus. Klinische Pädiatrie 224:395–397

    Google Scholar 

  • Lyons LL, North PE, Mac-Moune Lai F, Stoler MH, Folpe AL, Weiss SW (2004) Kaposiform hemangioendothelioma: a study of 33 cases emphasizing its pathologic, immunophenotypic, and biologic uniqueness from juvenile hemangioma. The American journal of surgical pathology 28:559–568

    Google Scholar 

  • Schneider DT, Brecht IB, Olson Th A, Ferrari A (2010) Rare Tumors in Children and Adolescents. Springer, Berlin Heidelberg New York

    Google Scholar 

Zu Kap. 26.2.3

  • Bhaskar SN, Jacoway JR (1966) Pyogenic granuloma - clinical features, incidence, histology, and result of treatment: report of 242 cases. J Oral Surg 24(5): 391–8

    Google Scholar 

  • Hartzell MB (1904) Granuloma pyogenicum (botryomycosis of French authors). J Cutan Dis 22: 520–523

    Google Scholar 

  • Höger Peter H. Kinderdermatologie – Differentialdiagnostik und Therapie bei Kindern und Jugendlichen. Schattauer, Stuttgart

    Google Scholar 

  • Kirschner RE, Low DW (1999) Treatment of pyogenic granuloma by shave excision and laser photocoagulation. Plast Reconstr Surg. 104(5): 1346–9

    Google Scholar 

  • Lenczowski JM et al. (2003) Disseminated vascular papules in an immunodeficient patient being treated with granulocyte colony-stimulating factor. J Am Acad Dermatol 49(1): 105–8

    Google Scholar 

  • Maier T (2014) Zysten, Knoten und Tumoren. In: Reinhardt D, Nicolai T, Zimmer K-P (eds) Therapie der Krankheiten im Kindes- und Jugendalter. Springer, Berlin Heidelberg New York

    Google Scholar 

  • Pagliai KA, Cohen BA (2004) Pyogenic granuloma in children. Pediatr Dermatol 21(1): 10–3

    Google Scholar 

  • Patrice SJ et al. (1991) Pyogenic granuloma (lobular capillary hemangioma): a clinicopathologic study of 178 cases. Pediatr Dermatol. 8(4): 267–76

    Google Scholar 

  • Poncet A, Dor L (1897) Botryomycose humaine. Rev Chir Orthop 18: 996

    Google Scholar 

  • Requena L, Sangueza OP (1997) Cutaneous vascular proliferations, part II: hyperplasias and benign neoplasms. J Am Acad Dermatol 37(6): 887–919; quiz 920–2

    Google Scholar 

Zu Kap. 26.2.4

  • Chakraborty S, Gharami RC, Das NK, Datta PK (2009) Annular tufted angioma: a rare entity. International journal of dermatology 48:614–616

    Google Scholar 

  • Chiu CS, Yang LC, Hong HS, Kuan YZ (2007) Treatment of a tufted angioma with intense pulsed light. The Journal of dermatological treatment 18:109–111

    Google Scholar 

  • Ferrandiz-Pulido C, Mollet J, Sabado C et al. (2010) Tufted angioma associated with Kasabach-Merritt phenomenon: a therapeutic challenge. Acta dermato-venereologica 90:535–537

    Google Scholar 

Zu Kap. 26.3.1

  • Ch`ng S, Tan ST (2008) Facial port-wine-stains – clinical stratification and risks of neuro-ocular involvement. J Plast Reconstr Aesthet Surg 61(8): 889–93

    Google Scholar 

  • Dasgupta R, Fishman SJ (2014) ISSVA classification. Semin Pediatr Surg 23(4):158–61

    Google Scholar 

  • Eerola I, Boon LM, Mullikken JB, Burrows PE, Dompmartin A, Watanabe S, Vanwijck R, Vikkula M (2003) Capillary malformation-Arterivenous Malformation. A new clinical and genetic disorder caused by RASA1 Mutations. Am J Hum Genet 73:1240–49

    Google Scholar 

  • Shirley MD, Tang H, Gallione CJ et al. (2013) Sturge-Weber-Syndrome and port-wine stains caused by somatic mutation in GNAQ. N Engl J Med 368: 1971–9

    Google Scholar 

  • Theiler M, Walchli R, Weibel L (2013) Vascular anomalies – a practical approach. J Dtsch Dermatol Ges

    Google Scholar 

  • Pleimes M, Göttler S, Weibel L (2013) Characteristic Congenital Reticular Erythema: Cutis Marmorata Teleangiectatica Congenita. J Pediatr 163: 604

    Google Scholar 

  • Thomas AC, Zeng Z, Rivière JB, O’Shaughnessy R, Al-Olabi L, St-Onge J, Atherton DJ, Aubert H, Bagazgoitia L, Barbarot S, Bourrat E, Chiaverini C, Chong WK, Duffourd Y, Glover M, Groesser L, Hadj-Rabia S, Hamm H, Happle R, Mushtaq I, Lacour JP, Waelchli R, Wobser M, Vabres P, Patton EE, Kinsler VA (2016) Mosaic Activating Mutations in GNA11 and GNAQ Are Associated with Phakomatosis Pigmentovascularis and Extensive Dermal Melanocytosis. J Invest Dermatol. 2016 Apr; 136(4):770–8

    Google Scholar 

  • Walechi R, Aylett SE, Robinson K, Chong WK, Martinez AE, Kinsler VA (2014) New vascular classification of port-wine stains: improving prediction of Sturge-Weber risk. Br J Dermatol 171: 861–7

    Google Scholar 

Zu 26.3.2

  • Adams DM, Trenor CC 3rd, Hammill AM, Vinks AA, Patel MN, Chaudry G, Wentzel, MS, Mobberley-Schuman PS, Campbell LM, Brookbank C, Gupta A, Chute C, Eile J, McKenna, J, Merrow AC, Fei L, Hornung L, Seid M, Dasgupta AR, Dickie BH, Ellurur RG, Lucky AW, Weiss B, Azizkhan RG (2016) Efficacy and Safety of Sirolismus in the Treatment of Complicated Vascular Anomalies. Pediatrics 137(2)

    Google Scholar 

  • Chervenak FA, Isaacson G, Blakemore KJ, et al. (1983) Fetal cystic hygroma. Cause and natural history. N Engl J Med 309:822–825

    Google Scholar 

  • Foldi E (1998) The treatment of lymphedema. Cancer 83:2833–2834

    Google Scholar 

  • Grunewald TG, Damke L, Maschan M, et al. (2010) First report of effective and feasible treatment of multifocal lymphangiomatosis (Gorham-Stout) with bevacizumab in a child. Annals of oncology. official journal of the European Society for Medical Oncology/ESMO 21:1733–1734

    Google Scholar 

  • Heritier S, Le Merrer M, Jaubert F, et al. (2010) Retrospective French nationwide survey of childhood aggressive vascular anomalies of bone, 1988–2009. Orphanet J Rare Dis 5:3

    Google Scholar 

  • Hwang JH, Choi JY, Lee JY, et al. (2007) Lymphscintigraphy predicts response to complex physical therapy in patients with early stage extremity lymphedema. Lymphology 40:172–176

    Google Scholar 

  • Lala S, Mulliken JB, Alomari AI et al. (2013) Gorham-Stout disease and generalized lymphatic anomaly--clinical, radiologic, and histologic differentiation. Skeletal radiology 42:917–924

    Google Scholar 

  • Landthaler M, Hohenleutner U (2006) Laser therapy of vascular lesions. Photodermatology, photoimmunology & photomedicine 22:324–332

    Google Scholar 

  • Ogita S, Tsuto T, Nakamura K et al. (1996) OK-432 therapy for lymphangioma in children: why and how does it work? J Pediatr Surg 31:477–480

    Google Scholar 

  • Patel GA, Schwartz RA (2009) Cutaneous lymphangioma circumscriptum: frog spawn on the skin. International journal of dermatology 48:1290–1295

    Google Scholar 

  • Perkins JA, Manning SC, Tempero RM, et al.(2010) Lymphatic malformations: review of current treatment. Otolaryngology--head and neck surgery. official journal of American Academy of Otolaryngology-Head and Neck Surgery 142:795–803, 803 e791

    Google Scholar 

  • Scavelli C, Weber E, Agliano M, et al. (2004) Lymphatics at the crossroads of angiogenesis and lymphangiogenesis. J Anat 204:433–449

    Google Scholar 

  • Sun S, Liu X, Ma B et al. (2011) Zhou, Y., Sun, H. Could local deliver of bisphosphonates be a new therapeutic choice for Gorham-Stout syndrome? Medical hypotheses 76:237–238

    Google Scholar 

  • Tanriverdi HA, Hendrik HJ, Ertan AK, Axt R, Schmidt W (2001) Hygroma colli cysticum: prenatal diagnosis and prognosis. American journal of perinatology 18:415–420

    Google Scholar 

  • Vardy PA, Lebenthal E, Shwachman H (1975) Intestinal lymphagiectasia: a reappraisal. Pediatrics 55:842–851

    Google Scholar 

  • Wilting J, Buttler K, Rossle J et al. (2007) Embryonic development and malformation of lymphatic vessels. Novartis Found Symp 283:220–227

    Google Scholar 

Zu Kap. 26.3.3

  • Flors L et al. (2015) Glomuvenous malformation: magnetic resonance imaging findings. Pediatr Radiol 45: 286–290

    Google Scholar 

  • Mattassi R et al. (2009) Hemangiomas and Vascular Malformations. Springer, Berlin Heidelberg New York

    Google Scholar 

  • Mulliken JB et al. (2000) Vascular anomalies. Current Problems in Surgery 37: 517, 519–584

    Google Scholar 

  • Restrepo R (2013) Multimodality imaging of vascular anomalies. Pediatr Radiol 43 (Suppl 1):S141–S154

    Google Scholar 

Zu Kap. 26.3.4

  • Hoppe H (2014) Bildgebung vaskulärer Malformationen mit Magnetresonanztomographie, Gefäßchirurgie 4/2014, 294–301. Springer, Berlin Heidelberg New York

    Google Scholar 

  • Mattassi R et al. (2009) Hemangiomas and Vascular Malformations. Springer, Berlin Heidelberg New York

    Google Scholar 

  • Mulliken, JB et al. (2000) Vascular anomalies. Current Problems in Surgery 37:517, 519–584

    Google Scholar 

  • Whitehead, KJ et al. (2012) Arteriovenous Malformations and Other Vascular Malformation Syndromes, Cold Spring Harb Perspect Med 3:a006635

    Google Scholar 

Zu Kap. 26.3.5

  • Babu LV, Evans O, Sankar A et al. (2014) Epiphysiodesis for limb length discrepancy: a comparison of two methods. Strategies in trauma and limb reconstruction 9:1–3

    Google Scholar 

  • Child FJ, Werring DJ, Vivier AW (1998) Proteus syndrome: diagnosis in adulthood. The British journal of dermatology 139:132–136

    Google Scholar 

  • Iacobas I, Burrows PE, Adams DM et al. (2011) Oral rapamycin in the treatment of patients with hamartoma syndromes and PTEN mutation. Pediatr Blood Cancer 57:321–323

    Google Scholar 

  • Kim YH, Choi JY, Kim YW, et al. (2009) Characterization of congenital vascular malformation in the extremities using whole body blood pool scintigraphy and lymphscintigraphy. Lymphology 42:77–84

    Google Scholar 

  • Lindhurst MJ, Parker VE., Payne F, et al. (2012) Mosaic overgrowth with fibroadipose hyperplasia is caused by somatic activating mutations in PIK3CA. Nature Genetics 44:928–933

    Google Scholar 

  • Lindhurst MJ, Sapp JC, Teer JK, et al. (2011) A mosaic activating mutation in AKT1 associated with the Proteus syndrome. N Engl J Med 365:611–619

    Google Scholar 

  • Maari C, Frieden IJ (2004) Klippel-Trenaunay syndrome: the importance of »geographic stains« in identifying lymphatic disease and risk of complications. J Am Acad Dermatol 51:391–398

    Google Scholar 

  • Marsh DJ, Trahair TN, Martin JL, et al. (2008) Rapamycin treatment for a child with germline PTEN mutation. Nature clinical practice Oncology 5:357–361

    Google Scholar 

  • Sapp JC, Turner JT, van de Kamp JM et al. (2007) Newly delineated syndrome of congenital lipomatous overgrowth, vascular malformations, and epidermal nevi (CLOVE syndrome) in seven patients. American journal of medical genetics Part A 143A:2944–2958

    Google Scholar 

  • Shirley MD, Tang H, Gallione CJ, et al. (2013) Sturge-Weber syndrome and port-wine stains caused by somatic mutation in GNAQ. N Engl J Med 368:1971–1979

    Google Scholar 

  • Steven M, Kumaran N, Carachi R, Desai A, Bennet G (2007) Haemangiomas and vascular malformations of the limb in children. Pediatr Surg Int 23:565–569

    Google Scholar 

  • Ziyeh S, Spreer J, Rossler J, et al. (2004) Parkes Weber or Klippel-Trenaunay syndrome? Non-invasive diagnosis with MR projection angiography. European radiology 14: 2025–2029

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer-Verlag GmbH Deutschland

About this chapter

Cite this chapter

Neuhaus, K., Lenz, Y., Weibel, L., Rössler, J., Fattouh, M. (2017). Vaskuläre Anomalien. In: Schiestl, C., Stark, G., Lenz, Y., Neuhaus, K. (eds) Plastische Chirurgie bei Kindern und Jugendlichen. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-51391-0_26

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-51391-0_26

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-51390-3

  • Online ISBN: 978-3-662-51391-0

  • eBook Packages: Medicine (German Language)

Publish with us

Policies and ethics