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Physio logie von Nozizeption und Schmerz

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Schmerzpsychotherapie

Zusammenfassung

Das nozizeptive System ist ein Subsystem der Somatosensorik mit sog. Nozizeptoren, spezifischen Sensoren zur Entdeckung faktisch oder potenziell schädigender Einwirkungen auf das Körpergewebe. Die Eigenschaften und Polymodalität der Nozizeptoren werden funktionell und molekular beschrieben. Die Eigenschaften der Zielneurone, die Besonderheiten der synaptischen Umschaltung im Rückenmark sowie der zum Gehirn aufsteigenden Bahnen werden ebenso erörtert wie die supraspinale Organisation des nozizeptiven Systems und die Rolle von Thalamus, Amygdala und Kortex. Einen besonderen Stellenwert haben die mannigfachen Plastizitätsmechanismen des nozizeptiven Systems: periphere und zentrale Sensibilisierung sowie synaptische Langzeitpotenzierung. Dies leitet über zu einem Exkurs in die Pathophysiologie des nozizeptiven Systems bei peripheren oder zentralen Läsionen (neuropathischer Schmerz).

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Authors and Affiliations

  1. Medizinische Fakultät Mannheim Lehrstuhl für Neurophysiologie Zentrum für Biomedizin und Medizintechnik (CBTM), Rupprecht-Karls-Universität Heidelberg, Ludolf-Krehl-Straße 13–17, 68167, Mannheim

    W. Magerl (Prof. (apl.) & Prof. Dr. med. R.-D. Treede

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  1. W. Magerl
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Editors and Affiliations

  1. Universität Göttingen, Göttingen, Germany

    Birgit Kröner-Herwig

  2. Universitätsklinikum Bergmannsheil Bochum, Bochum, Germany

    Jule Frettlöh

  3. Universitätsklinikum Hamburg-Eppendorf (UKE), Hamburg, Germany

    Regine Klinger

  4. Johannes-Gutenberg-Universität Mainz, Mainz, Germany

    Paul Nilges

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Magerl, W., Treede, RD. (2017). Physio logie von Nozizeption und Schmerz. In: Kröner-Herwig, B., Frettlöh, J., Klinger, R., Nilges, P. (eds) Schmerzpsychotherapie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-50512-0_3

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  • DOI: https://doi.org/10.1007/978-3-662-50512-0_3

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