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Kopfsc hmerz bei Medikamenten übergebrauch

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Schmerzpsychotherapie

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Zusammenfassung

Vermehrte Kopfschmerzen können zu vermehrter Schmerzmitteleinnahme, die vermehrte Einnahme wiederum kann zu Veränderungen im Nervensystem führen. So können sich Strukturen, die für die Aufnahme und Verarbeitung von Schmerz verantwortlich sind, verändern. Dies kann zu einem Ungleichgewicht zwischen schmerzverarbeitenden und schmerzhemmenden System führen, sodass Schmerzreize nicht mehr gut genug unterdrückt werden und die Häufigkeit der Kopfschmerzen zunimmt. Dies wiederum kann zu einem weiteren Anstieg der Medikamenteneinnahme führen, wodurch dann das schmerzverarbeitende System noch empfindlicher wird. Und so kann sich dieser Regelkreis wie eine Spirale in die Höhe schrauben. Die Medikamente helfen dann zwar noch, aber ihre Wirkung wird zunehmend schwächer. Vor allem aber sorgen sie dafür, dass die Kopfschmerzen noch häufiger auftreten.

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Literatur

  • Aurora S, Dodick D, Turkel C, Degryse R, Silberstein S, Lipton R, Diener HC, Brin MF; PREEMPT 1 Chronic Migraine Study Group (2010) Onabotulinumtoxina for treatment of chronic migraine: results from the double-blind, randomized, placebo-controlled phase of the PREEMPT 1 trial. Cephalalgia 30: 793–803

    Google Scholar 

  • Ayzenberg I, Katsarava Z (2012) Lifting the burden. The prevalence of primary headache disorders in Russia: a countrywide survey. Cephalalgia; 32: 373–381

    Google Scholar 

  • Bahra A, Walsh M, Menon S, Goadsby PJ (2003) Does chronic daily headache arise de novo in association with regular use of analgesics? Headache 43: 179–190

    Google Scholar 

  • Bigal ME, Lipton RB (2008) Excessive acute migraine medication use and migraine progression. Neurology 71: 1821–1828

    Google Scholar 

  • Boe MG, Mygland A, Salvesen R (2007) Prednisolone does not reduce withdrawal headache: a randomized, double-blind study. Neurology 69: 26–31

    Google Scholar 

  • DGN – Deutsche Gesellschaft für Neurologie (2012) Kopfschmerz bei Übergebrauch von Schmerz- und Migränemitteln. http://www.dgn.org/images/red_leitlinien/030-131l_S1_Kopfschmerz_Medikamentenuebergebrauch_2012_verlaengert.pdf. Zugegriffen: 12. Februar 2016

  • Diener HC (2012) Detoxification for medication overuse headache is not necessary. Cephalalgia 32: 423–427

    Google Scholar 

  • Diener HC, Dahlöf C (2000) Headache associated with chronic use of substances. In: Olesen J, Tfelt-Hansen P, Welch KMA (eds) The Headaches, 2nd ed. Lippincott, Williams & Wilkins, Philadelphia, pp 871–878

    Google Scholar 

  • Diener HC, Limmroth V (2004) Medication-overuse headache: a worldwide problem. Lancet Neurology 3: 475–483

    Google Scholar 

  • Diener HC, Slomke MA, Limmroth V (2007a) Headache and migraine. Nervenarzt 78 (Suppl 1): 7–13

    Google Scholar 

  • Diener H, Bussone G, Van Oene J, Lahaye M, Schwalen S, Goadsby P; TOPMAT-MIG-201(TOP-CHROME) Study Group (2007b) Topiramate reduces headache days in chronic migraine: a randomized, double-blind, placebo-controlled study. Cephalalgia 27: 814–823

    Google Scholar 

  • Diener H, Dodick D, Goadsby P, Bigal M, Bussone G, Silberstein S, Mathew N, Ascher S, Morein J, Hulihan JF, Biondi DM, Greenberg SJ (2009) Utility of topiramate for the treatment of patients with chronic migraine in the presence or absence of acute medication overuse. Cephalalgia 29: 1021–1027

    Google Scholar 

  • Diener H, Dodick D, Aurora S, Turkel C, Degryse R, Lipton R, Silberstein SD, Brin MF; PREEMPT 2 Chronic Migraine Study Group (2010) Onabotulinumtoxina for treatment of chronic migraine: results from the double-blind, randomized, placebo-controlled phase of the PREEMPT 2 trial. Cephalalgia 30: 804–814

    Google Scholar 

  • Dodick D, Turkel C, Degryse R, Aurora S, Silberstein S, Lipton R, Diener HC, Brin MF; PREEMPT Chronic Migraine Study Group (2010) Onabotulinumtoxina for treatment of chronic migraine: pooled results from the double-blind, randomized, placebo-controlled phases of the PREEMPT Clinical Program. Headache 50: 921–936

    Google Scholar 

  • Evers S, Marziniak M (2010) Clinical features, pathophysiology, and treatment of medication-overuse headache. Lancet Neurol 9: 391–401

    Google Scholar 

  • Fritsche G (2013) Spezielle Aspekte der psychologischen Exploration von Kopfschmerzpatienten. In: Fritsche G, Gaul C (Hrsg) Multimodale Therapie bei chronischen Kopfschmerzen. Thieme, Stuttgart, S 31–32

    Google Scholar 

  • Fritsche G, Diener HC (2002) Medication overuse headaches – what is new? Expert Opin Drug Saf 1: 331–338

    Google Scholar 

  • Fritsche G, Nitsch C, Pietrowsky R, Diener HC (2000) Psychologische Deskriptoren des Schmerzmittelabusus und des medikamenteninduzierten Kopfschmerzes. Schmerz 14: 217–255

    Google Scholar 

  • Fritsche G, Eberl A, Katsarava Z, Limmroth V, Diener HC (2001) Drug-induced headache: long-term follow-up of withdrawal therapy and persistence of drug misuse. Eur Neurol 45: 229–235

    Google Scholar 

  • Fritsche G, Frettlöh J, Hüppe M, Dlugaj M, Matatko N, Gaul C, Diener HC; Study Group (2010) Prevention of medication overuse in patients with migraine. Pain 151: 404–413

    Google Scholar 

  • Gaist D, Hallas J, Sindrup SH, Gram LF (1996) Is overuse of sumatriptan a problem? A population-based study. Eur J Clin Pharmacol 3: 161–165

    Google Scholar 

  • Gaul C, Liesering-Latta E, Schäfer B, Fritsche G, Holle D (2015) Integrated multidisciplinary care of headache disorders: A narrative review. Cephalalgia. doi: 10.1177/ 0333102415617413

    Google Scholar 

  • Grande R, Aaseth K, Benth J, Lundqvist C, Russell M (2011) Reduction in Medication-overuse headache after short information. The Akershus Study of Chronic Headache. Eur J Neurol 18: 129–137

    Google Scholar 

  • Haag G, Fritsche G, Gaul C (2013) Klinik und Pathogenese des Kopfschmerzes bei Medikamentenübergebrauch. In: Fritsche G, Gaul C (Hrsg) Multimodale Therapie bei chronischen Kopfschmerzen. Thieme, Stuttgart, S 50–53

    Google Scholar 

  • Hagen K, Albretsen C, Vilming ST, Salvesen R, Grønning M, Helde G, Gravdahl G, Zwart JA, Stovner LJ (2009) Management of medication overuse headache: 1-year randomized multicentre open-label trial. Cephalalgia 29: 221–232

    Google Scholar 

  • Hagen K, Linde M, Steiner TJ, Stovner LJ, Zwart JA (2012) Risk factors for medication-overuse headache: an 11-year follow-up study. The Nord-Trøndelag Health Studies. Pain 153: 56–61

    Google Scholar 

  • IHS – Headache Classification Committee of the International Headache Society (2004) The International Classification of Headache Disorders, 2nd ed. ICHD-II. Cephalalgia 24 (Suppl 1): 1–160

    Google Scholar 

  • IHS – Headache Classification Committee of the International Headache Society (2013) The International Classification of Headache Disorders, 3rd edition (beta version). Cephalalgia 33: 629–808

    Google Scholar 

  • Jage J, Willweber-Strumpf A, Maier C (2005) Risk factors for substance abuse and dependence in opioid therapy for chronic noncancer-related pain. Schmerz 19: 434–440

    Google Scholar 

  • Katsarava Z, Diener HC (2003) Medikamenteninduzierte Kopfschmerzen. In: Diener HC (Hrsg) Kopfschmerzen – Referenzreihe Neurologie. Thieme, Stuttgart, S 213–228

    Google Scholar 

  • Katsarava Z, Jensen R (2007) Medication-overuse headache: where are we now? Curr Opin Neurol 20: 326–330

    Google Scholar 

  • Katsarava Z, Obermann M (2013) Medication-overuse headache. Curr Opin Neurol 26: 276–281

    Google Scholar 

  • Katsarava Z, Fritsche G, Muessig M, Diener HC, Limmroth V (2001) Clinical features of withdrawal headache following overuse of triptans and other headache drugs. Neurology 57: 1694–1698

    Google Scholar 

  • Katsarava Z, Limmroth V, Finke M, Diener HC, Fritsche G (2003) Rates and predictors for relapse in medication overuse headache: a 1-year prospective study. Neurology 60: 1682–1683

    Google Scholar 

  • Katsarava Z, Schneeweiss S, Kurth T, Kroener U, Fritsche G, Eikermann A, Diener HC, Limmroth V (2004) Incidence and predictors for chronicity of headache in patients with episodic migraine. Neurology 62: 788–790

    Google Scholar 

  • Katsarava Z, Holle D, Diener HC (2009) Medication over- use headache. Curr Neurol Neurosci Rep 9: 115–119

    Google Scholar 

  • Krymchantowski AV, Moreira PF (2003) Out-patient detoxification in chronic migraine: comparison of strategies. Cephalalgia 23: 982–993

    Google Scholar 

  • Limmroth V, Katsarava Z, Fritsche G, Przywara S, Diener HC (2002) Features of medication overuse headache following overuse of different acute headache drugs. Neurology 59: 1011–1014

    Google Scholar 

  • Linde M, Gustavsson A, Stovner LJ, Steiner TJ, Barré J, Katsarava Z, Lainez JM, Lampl C, Lantéri-Minet M, Rastenyte D, Ruiz de la Torre E, Tassorelli C, Andrée C (2012) The cost of headache disorders in Europe: The Eurolight project. Eur J Neurol 19: 703–711

    Google Scholar 

  • Lundqvist C, Grande RB, Aaseth K, Russell MB (2012) Dependence scores predict prognosis of medication overuse headache: a prospective cohort from the Akershus study of chronic headache. Pain 153: 682–686

    Google Scholar 

  • Munksgaard SB, Jensen RH (2014) Medication overuse headache. Headache 54: 1251–1257

    Google Scholar 

  • Munksgaard S, Bendtsen L, Jensen R (2012) Detoxification of medication-overuse headache by a multidisciplinary treatment programme is highly effective: a comparison of two consecutive treatment methods in an open-label design. Cephalalgia 32: 834–844

    Google Scholar 

  • Pageler L, Katsarava Z, Diener HC, Limmroth V (2008) Prednisone vs. placebo in withdrawal therapy following medication overuse headache. Cephalalgia 28: 152–156

    Google Scholar 

  • Queiroz LP, Peres MF, Kowacs F, Piovesan EJ, Ciciarelli MC, Souza JA, Zukerman E (2008) Chronic daily headache in Brazil: a nationwide population-based study. Cephalalgia 28:1264–1269

    Google Scholar 

  • Rabe K, Pageler L, Gaul C, Lampl C, Kraya T, Foerderreuther S, Diener HC, Katsarava Z (2013) Prednisone for the treatment of withdrawal headache in patients with medication overuse headache: a randomized, double-blind, placebo-controlled study. Cephalalgia 33: 202–207

    Google Scholar 

  • Rossi P, Di Lorenzo C, Faroni J, Cesarino F, Nappi G (2006) Advice alone vs. structured detoxification programmes for medication overuse headache: a prospective, randomized, open-label trial in transformed migraine patients with low medical needs. Cephalalgia 26: 1097–1105

    Google Scholar 

  • Rossi P, Faroni JV, Nappi G (2011) Short-term effectiveness of simple advice as a withdrawal strategy in simple and complicated medication overuse headache. Eur J Neurol 18: 396–401

    Google Scholar 

  • Sandrini G, Perrotta A, Tassorelli C, Torelli P, Brighina F, Sances G, Nappi G (2011) Botulinum toxin type-A in the prophylactic treatment of medication overuse headache: a multicenter, double-blind, randomized, placebo-controlled, parallel group study. J Headache Pain 12: 427–433

    Google Scholar 

  • Scher AI, Stewart WF, Ricci JA, Lipton RB (2003) Factors associated with the onset and remission of chronic daily headache in a population-based study. Pain 106: 81–89

    Google Scholar 

  • Silverman K, Evans SM, Strain EC, Griffiths RR (1992) Withdrawal syndrome after the double-blind cessation of caffeine consumption. N Engl J Med 327: 1109–1114

    Google Scholar 

  • Steiner TJ, Paemeleire K, Jensen R, Valade D, Savi L, Lainez MJ, Diener HC, Martelletti P, Couturier EG, European Headache Federation, Lifting The Burden, The Global Campaign to Reduce the Burden of Headache Worldwide, World Health Organization (2007) European principles of management of common headache disorders in primary care. J Headache Pain 8 (Suppl 1): S3–S47

    Google Scholar 

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Authors and Affiliations

  1. Universitätsklinikum Essen (AöR) Neurologische Klinik, Hufelandstraße 55, 45122, Essen

    Dr. rer. medic. Dipl.-Psych. G. Fritsche

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  1. Dr. rer. medic. Dipl.-Psych. G. Fritsche
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Editors and Affiliations

  1. Universität Göttingen, Göttingen, Germany

    Birgit Kröner-Herwig

  2. Universitätsklinikum Bergmannsheil Bochum, Bochum, Germany

    Jule Frettlöh

  3. Universitätsklinikum Hamburg-Eppendorf (UKE), Hamburg, Germany

    Regine Klinger

  4. Johannes-Gutenberg-Universität Mainz, Mainz, Germany

    Paul Nilges

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Fritsche, G. (2017). Kopfsc hmerz bei Medikamenten übergebrauch. In: Kröner-Herwig, B., Frettlöh, J., Klinger, R., Nilges, P. (eds) Schmerzpsychotherapie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-50512-0_26

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  • DOI: https://doi.org/10.1007/978-3-662-50512-0_26

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-50511-3

  • Online ISBN: 978-3-662-50512-0

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