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Experimental Lung Tumors

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Pathology of Lung Disease

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Abstract

Mice, rats, and hamsters have been used as models for human lung cancer since several decades [1, 2]. In the past, mainly inhalation of tobacco smoke and other carcinogenic substances has been applied to these rodent species [3–6]. In most instances, lung carcinomas resembling the human counterpart could not be simulated with the exception of urethane-induced murine models. Moreover, rodents easily and spontaneously develop adenomas but not invasive carcinomas [7]. A cystic squamous lesion was induced in some experiments, which has been labeled as squamous cell carcinoma; however, this represents in essence bronchiectasis with squamous metaplasia and dysplasia, but never progressed into invasive squamous cell carcinoma [8, 9]. In recent time, genetically engineered lung carcinomas in mice became a tool to study carcinogenesis in adenocarcinomas and small-cell carcinomas. In this chapter, we will discuss progress as well as drawback by these different approaches in understanding human pulmonary carcinogenesis.

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  1. Institute of Pathology, Medical University Graz, Graz, Austria

    Helmut Popper

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Popper, H. (2017). Experimental Lung Tumors. In: Pathology of Lung Disease. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-50491-8_22

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