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Grundlagen der Therapie von Aneurysmen

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Zerebrale Aneurysmen und Gefäßmalformationen

Zusammenfassung

Das Wissen über Hirnarterienaneurysmen und ihr Blutungsrisiko hat seit den 1990er-Jahren stetig zugenommen. Die Daten- und Faktenlage hat sich aufgrund multizentrischer Studien und großer veröffentlichter Fallserien geändert, und mit den endovaskulären Interventionsmöglichkeiten sind mannigfaltige neue Behandlungsoptionen hinzugekommen. Im Verlauf führte dies zu einer gravierenden Änderung der Behandlungsempfehlungen. Bei der Entscheidung, welche Läsion behandelt wird und welche nicht, ist eine stringente Risiko-Nutzen-Abwägung notwendig. Auch für die Entscheidung über die Art der Behandlung ist eine individuelle Abwägung vieler Einflussgrößen erforderlich. Aufgrund der mittlerweile bekannten vielen Einflussfaktoren auf das Blutungs-, aber auch das Behandlungsrisiko sind die Therapieempfehlungen deswegen mittlerweile äußerst komplex geworden. In diesem Kapitel werden in kondensierter Form die Grundlagen für die Entscheidungsfindung und für Empfehlungen in einer Beratungssituation dargestellt.

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Literatur

  • AHA/ASA (2015) AHA/ASA Guideline for the management of patients with unruptured intracranial aneurysms. http://doi.org/10.1161/STR.0000000000000070, p 1–36

  • Backes D, Vergouwen MDI, Tiel Groenestege AT, Bor ASE, Velthuis BK, Greving JP, et al (2015) PHASES score for prediction of intracranial aneurysm growth. Stroke 46 (5): 1221–1226. http://doi.org/10.1161/STROKEAHA.114.008198

  • Bijlenga P, Ebeling C, Jaegersberg M, Summers P, Rogers A, Waterworth A, et al (2013) Risk of rupture of small anterior communicating artery aneurysms is similar to posterior circulation aneurysms. Stroke 44 (11): 3018–3026. http://doi.org/10.1161/STROKEAHA.113.001667

  • Bijlenga P, Stapf C (2015) Watch your neighbor's garden, or Delphi's oracle for unruptured intracranial aneurysm treatment. Neurology [epub ahead of print]. http://doi.org/10.1212/WNL.0000000000001899

  • Bonares MJ, de Oliveira Manoel AL, Macdonald RL, Schweizer TA (2014) Behavioral profile of unruptured intracranial aneurysms: a systematic review. Annals Clin Translat Neurol 1 (3): 220–232. http://doi.org/10.1002/acn3.41

  • Brinjikji W, Rabinstein AA, Nasr DM, Lanzino G, Kallmes DF, Cloft HJ (2011) Better outcomes with treatment by coiling relative to clipping of unruptured intracranial aneurysms in the United States, 2001–2008. Am J Neuroradiol 32 (6): 1071–1075. http://doi.org/10.3174/ajnr.A2453

  • Can A, Du R (2015) Association of hemodynamic factors with intracranial aneurysm formation and rupture: systematic review and meta-analysis. Neurosurg [epub ahead of print]. http://doi.org/10.1227/NEU.0000000000001083

  • Chen M, Ouyang B, Goldstein-Smith L, Feldman L (2011) Oral contraceptive and hormone replacement therapy in women with cerebral aneurysms. J Neurointerv Surg 3 (2): 163–166. http://doi.org/10.1136/jnis.2010.003855

  • Chung J, Hong C-K, Shim YS, Joo J Y, Lim Y C, Shin YS, Kim YB (2015) Microsurgical clipping of unruptured middle cerebral artery bifurcation aneurysms: incidence of and risk factors for procedure-related complications. World Neurosurg 83 (5): 666–672. http://doi.org/10.1016/j.wneu.2015.01.023

  • Elsharkawy A, Lehecka M, Niemelä M, Kivelev J, Billon-Grand R, Lehto H, et al (2013) Anatomic risk factors for middle cerebral artery aneurysm rupture: computed tomography angiography study of 1009 consecutive patients. Neurosurg 73 (5): 825–37, discussion 836–7. http://doi.org/10.1227/NEU.0000000000000116

  • Etminan N, Macdonald RL (2015) Computational fluid dynamics and intracranial aneurysms: higher mathematics meets complex biology. World Neurosurg 83 (6): 1017–1019. http://doi.org/10.1016/j.wneu.2015.02.015

  • Etminan N, Beseoglu K, Barrow D L, Bederson J, Brown RD, Connolly ES, Derdeyn CP, Hänggi D, Hasan D, Juvela S, Kasuya H, Kirkpatrick PJ, Knuckey N, Koivisto T, Lanzino G, Lawton MT, LeRoux P, McDougall CG, Mee E, Mocco J, Molyneux A, Morgan MK, Mori K, Morita A, Murayama Y, Nagahiro S, Pasqualin A, Raabe A, Raymond J, Rinkel GJE, Rüfenacht D, Seifert V, Spears J, Steiger H-J, Steinmetz H, Torner JC, Vajkoczy P, Wanke I, Wong GKC, Wong JH, Macdonald RL (2014) Multidisciplinary consensus on assessment of unruptured intracranial aneurysms: proposal of an international research group. Stroke 45 (5): 1523–1530. http://doi.org/10.1161/STROKEAHA.114.004519

  • Etminan N, Brown RD, Beseoglu K, Juvela S, Raymond J, Morita A, et al (2015) The unruptured intracranial aneurysm treatment score: A multidisciplinary consensus. Neurology [epub ahead of print]. http://doi.org/10.1212/WNL.0000000000001891

  • Frösen J (2012) The pathobiology of saccular cerebral artery aneurysm rupture and repair. Dissertation, Medical Faculty, University of Helsinki

    Google Scholar 

  • Frösen J, Piippo A, Paetau A, Kangasniemi M, Niemelä M, Hernesniemi J, Jääskeläinen J (2004) Remodeling of saccular cerebral artery aneurysm wall is associated with rupture: histological analysis of 24 unruptured and 42 ruptured cases. Stroke 35 (10): 2287–2293. http://doi.org/10.1161/01.STR.0000140636.30204.da

  • Germans MR, Coert BA, Vandertop WP, Verbaan D (2014) Time intervals from subarachnoid hemorrhage to rebleed. J Neurol 261 (7): 1425–1431. http://doi.org/10.1007/s00415-014-7365-0

  • Gounis MJ, van der Marel K, Marosfoi M, Mazzanti ML, Clarençon F, Chueh J-Y, et al (2015) Imaging inflammation in cerebrovascular disease. Stroke 46 (10): 2991–2997. http://doi.org/10.1161/STROKEAHA.115.008229

  • Greving JP, Wermer MJH, Brown RD, Morita A, Juvela S, Yonekura M, et al (2014) Development of the PHASES score for prediction of risk of rupture of intracranial aneurysms: a pooled analysis of six prospective cohort studies. Lancet Neurol 13 (1): 59–66. http://doi.org/10.1016/S1474-4422 (13)70263-1

  • Hasegawa T, Horiuchi T, Hongo K (2015) Histological analysis of aneurysm wall occluded with clip blades. A case report. World Neurosurg 84 (2): 592.e1–592.e2. http://doi.org/10.1016/j.wneu.2015.03.023

  • Hashimoto N, Kim C, Kikuchi H, Kojima M, Kang Y, Hazama F (1987) Experimental induction of cerebral aneurysms in monkeys. J Neurosurg 67 (6): 903–905. http://doi.org/10.3171/jns.1987.67.6.0903

  • Hazama F, Kataoka H, Yamada E, Kayembe K, Hashimoto N, Kojima M, Kim C (1986) Early changes of experimentally induced cerebral aneurysms in rats. Light-microscopic study. Am J Pathol 124 (3): 399–404

    CAS  PubMed  Google Scholar 

  • Hussain S, Barbarite E, Chaudhry NS, Gupta K, Dellarole A, Peterson EC, Elhammady MS (2015) Search for biomarkers of intracranial aneurysms: a systematic review. World Neurosurg 84 (5): 1473–1483. http://doi.org/10.1016/j.wneu.2015.06.034

  • Inoue T, Shimizu H, Fujimura M, Saito A, Tominaga T (2012) Annual rupture risk of growing unruptured cerebral aneurysms detected by magnetic resonance angiography. J Neurosurg 117 (1): 20–25. http://doi.org/10.3171/2012.4.JNS112225

  • Johnston SC, Dowd CF, Higashida RT, Lawton MT, Duckwiler GR, Gress DR, CARAT Investigators (2008) Predictors of rehemorrhage after treatment of ruptured intracranial aneurysms: the Cerebral Aneurysm Rerupture After Treatment (CARAT) study. Stroke 39 (1): 120–125. http://doi.org/10.1161/STROKEAHA.107.495747

  • Juvela S, Porras M, Poussa K (2000) Natural history of unruptured intracranial aneurysms: probability of and risk factors for aneurysm rupture. J Neurosurg 93 (3): 379–387. http://doi.org/10.3171/jns.2000.93.3.0379

  • Juvela S, Poussa K (2001) Factors affecting formation and growth of intracranial aneurysms: a long-term follow-up study. Stroke 32 (2): 485–491

    Article  CAS  Google Scholar 

  • Kataoka K, Taneda M, Asai T, Kinoshita A, Ito M, Kuroda R (1999) Structural fragility and inflammatory response of ruptured cerebral aneurysms. A comparative study between ruptured and unruptured cerebral aneurysms. Stroke 30 (7): 1396–1401

    CAS  PubMed  Google Scholar 

  • Koivisto T, Vanninen R, Hurskainen H, Saari T, Hernesniemi J, Vapalahti M (2000) Outcomes of early endovascular versus surgical treatment of ruptured cerebral aneurysms. A prospective randomized study. Stroke 31 (10): 2369–2377

    CAS  PubMed  Google Scholar 

  • Kojima M, Handa H, Hashimoto N, Kim C, Hazama F (1986) Early changes of experimentally induced cerebral aneurysms in rats: scanning electron microscopic study. Stroke 17 (5): 835–841

    Article  CAS  Google Scholar 

  • Li Z-Q, Wang Q-H, Chen G, Quan Z (2012) Outcomes of endovascular coiling versus surgical clipping in the treatment of ruptured intracranial aneurysms. J Int Med Res 40 (6): 2145–2151

    Article  Google Scholar 

  • Macdonald RL (2015) Editorial: Clip or coil? Six years of follow-up in BRAT. J Neurosurg 123 (3): 605–608. http://doi.org/10.3171/2014.11.JNS142261

  • Matsushige T, Akiyama Y, Okazaki T, Shinagawa K, Ichinose N, Awai K, Kurisu K (2015) Vascular wall imaging of unruptured cerebral aneurysms with a hybrid of Opposite-Contrast MR Angiography. Am J Neuroradiol 36 (8): 1507–1511. http://doi.org/10.3174/ajnr.A4318

  • McDougall CG, Johnston SC, Gholkar A, Barnwell SL, Vazquez Suarez JC, Massó Romero J, et al (2014) Bioactive versus bare platinum coils in the treatment of intracranial aneurysms: the MAPS (Matrix and Platinum Science) trial. Am J Neuroradiol 35 (5): 935–942. http://doi.org/10.3174/ajnr.A3857

  • Molyneux A (2002) International Subarachnoid Aneurysm Trial (ISAT) of neurosurgical clipping versus endovascular coiling in 2143 patients with ruptured intracranial aneurysms: a randomised trial. Lancet 360 (9342): 1267–1274. http://doi.org/10.1016/S0140-6736 (02)11314-6

  • Molyneux AJ, Birks J, Kerr RSC (2015) ISAT: end of the debate on coiling versus clipping? Authors' reply. Lancet 385 (9984): 2252. http://doi.org/10.1016/S0140-6736 (15)61061–3

  • Molyneux AJ, Clarke A, Sneade M, Mehta Z, Coley S, Roy D, et al (2012) Cerecyte coil trial: angiographic outcomes of a prospective randomized trial comparing endovascular coiling of cerebral aneurysms with either cerecyte or bare platinum coils. Stroke 43 (10): 2544–2550. http://doi.org/10.1161/STROKEAHA.112.657254

  • Molyneux AJ, Kerr, RSC, Birks J, Ramzi N, Yarnold J, Sneade M, et al (2009) Risk of recurrent subarachnoid haemorrhage, death, or dependence and standardised mortality ratios after clipping or coiling of an intracranial aneurysm in the International Subarachnoid Aneurysm Trial (ISAT): long-term follow-up. Lancet Neurol 8 (5): 427–433. http://doi.org/10.1016/S1474-4422 (09)70080-8

  • Naggara ON, White PM, Guilbert F, Roy D, Weill A, Raymond J (2010) Endovascular treatment of intracranial unruptured aneurysms: systematic review and meta-analysis of the literature on safety and efficacy. Radiology 256 (3): 887–897. http://doi.org/10.1148/radiol.10091982

  • Ohkuma H (2002) Dissecting aneurysms of intracranial carotid circulation. Stroke 33 (4): 941–947. http://doi.org/10.1161/01.STR.0000013564.73522.05

  • Ohkuma H, Tsurutani H, Suzuki S (2001) Incidence and significance of early aneurysmal rebleeding before neurosurgical or neurological management. Stroke 32 (5): 1176–1180

    Article  CAS  Google Scholar 

  • Penn DL, Witte SR, Komotar RJ, Sander Connolly E (2014) The role of vascular remodeling and inflammation in the pathogenesis of intracranial aneurysms. J Clin Neurosci 21 (1): 28–32. http://doi.org/10.1016/j.jocn.2013.07.004

  • Penn DL, Witte SR, Komotar RJ, Sander Connolly E (2015) Pathological mechanisms underlying aneurysmal subarachnoid haemorrhage and vasospasm. J Clin Neurosci 22 (1): 1–5. http://doi.org/10.1016/j.jocn.2014.05.025

  • Pyysalo MJ, Pyysalo LM, Pessi T, Karhunen PJ, Lehtimäki T, Oksala N, Öhman JE (2016) Bacterial DNA findings in ruptured and unruptured intracranial aneurysms. Acta Odontol Scand 1–6. http://doi.org/10.3109/00016357.2015.1130854

  • Rinkel G (2005) Intracranial aneurysm screening: indications and advice for practice. Lancet Neurol 4 (2): 122–128. http://doi.org/10.1016/S1474-4422 (05)00993-2

  • Rinkel GJ, Djibuti M, Algra A, van Gijn J (1998) Prevalence and risk of rupture of intracranial aneurysms: a systematic review. Stroke 29 (1): 251–256

    Article  Google Scholar 

  • Ruigrok YM, Buskens E, Rinkel GJ (2001) Attributable risk of common and rare determinants of subarachnoid hemorrhage. Stroke 32 (5): 1173–1175

    Article  Google Scholar 

  • Russin JJ, Kramer DR, Thomas D, Hasson D, Liu CY, Amar AP, et al (2015) The importance of preoperative diagnosis of blister aneurysms. J Clin Neurosci 22 (9): 1408–1412. http://doi.org/10.1016/j.jocn.2015.03.010

  • Sadatomo T, Yuki K, Migita K, Taniguchi E, Kodama Y, Kurisu K (2008) Morphological differences between ruptured and unruptured cases in middle cerebral artery aneurysms. Neurosurg 62 (3): 602–9, discussion 602–9. http://doi.org/10.1227/01.NEU.0000311347.35583.0C

  • Sasaki O, Ogawa H, Koike T, Koizumi T, Tanaka R (1991) A clinicopathological study of dissecting aneurysms of the intracranial vertebral artery. J Neurosurg 75 (6): 874–882. http://doi.org/10.3171/jns.1991.75.6.0874

  • Seifert V, Gerlach R, Raabe A, Güresir E, Beck J, Szelényi A, et al (2008) The interdisciplinary treatment of unruptured intracranial aneurysms. Deutsches Ärzteblatt International 105 (25): 449–456. http://doi.org/10.3238/arztebl.2008.0449

  • Sonobe M, Yamazaki T, Yonekura M, Kikuchi H (2010) Small unruptured intracranial aneurysm verification study: SUAVe study, Japan. Stroke 41 (9): 1969–1977. http://doi.org/10.1161/STROKEAHA.110.585059

  • Spetzler RF, McDougall CG, Albuquerque FC, Zabramski JM, Hills NK, Partovi S, et al (2013) The Barrow Ruptured Aneurysm Trial: 3-year results. J Neurosurg 119 (1): 146–157. http://doi.org/10.3171/2013.3.JNS12683

  • Spetzler RF, McDougall CG, Zabramski JM, Albuquerque FC, Hills NK, Russin JJ, et al (2015) The Barrow Ruptured Aneurysm Trial: 6-year results. J Neurosurg 123 (3): 609–617. http://doi.org/10.3171/2014.9.JNS141749

  • Tulamo R, Frösen J, Junnikkala S, Paetau A, Kangasniemi M, Peláez J, et al (2010a) Complement system becomes activated by the classical pathway in intracranial aneurysm walls. Laboratory Investigation 90 (2): 168–179. http://doi.org/10.1038/labinvest.2009.133

  • Tulamo R, Frösen J, Junnikkala S, Paetau A, Pitkäniemi J, Kangasniemi M, et al (2006) Complement activation associates with saccular cerebral artery aneurysm wall degeneration and rupture. Neurosurg 59 (5): 1069–76, discussion 1076–7. http://doi.org/10.1227/01.NEU.0000245598.84698.26

  • Tulamo R, Frösen J, Paetau A, Seitsonen S, Hernesniemi J, Niemelä M, et al (2010b) Lack of complement inhibitors in the outer intracranial artery aneurysm wall associates with complement terminal pathway activation. Am J Pathol 177 (6): 3224–3232. http://doi.org/10.2353/ajpath.2010.091172

  • UCAS Japan Investigators, Morita A, Kirino T, Hashi K, Aoki N, Fukuhara S, et al (2012) The natural course of unruptured cerebral aneurysms in a Japanese cohort. N Engl J Med 366 (26), 2474–2482. http://doi.org/10.1056/NEJMoa1113260

  • Vlak MHM, Rinkel GJE, Greebe P, van der Bom JG, Algra A (2012) Trigger factors for rupture of intracranial aneurysms in relation to patient and aneurysm characteristics. J Neurol 259 (7): 1298–1302. http://doi.org/10.1007/s00415-011-6341-1

  • Vlak MHM, Rinkel GJE, Greebe P, Algra A (2013) Independent risk factors for intracranial aneurysms and their joint effect: a case-control study. Stroke 44 (4): 984–987. http://doi.org/10.1161/STROKEAHA.111.000329

  • Welling LC, Welling MS, Teixeira MJ, Figueiredo EG (2015) Vessel wall Magnetic Resonance Imaging, inflammatory cascade, aspirin, and aneurysm rupture: future paradigms? World Neurosurg 84 (2): 206–207. http://doi.org/10.1016/j.wneu.2015.06.037

  • White PM, Lewis SC, Gholkar A, Sellar RJ, Nahser H, Cognard C, et al (2011) Hydrogel-coated coils versus bare platinum coils for the endovascular treatment of intracranial aneurysms (HELPS): a randomised controlled trial. Lancet 377 (9778): 1655–1662. http://doi.org/10.1016/S0140-6736 (11)60408-X

  • Wiebers D (2003) Unruptured intracranial aneurysms: natural history, clinical outcome, and risks of surgical and endovascular treatment. Lancet 362 (9378): 103–110. http://doi.org/10.1016/S0140-6736 (03)13860-3

  • Wiebers D, et al. (1998) Unruptured intracranial aneurysms – risk of rupture and risks of surgical intervention. International Study of Unruptured Intracranial Aneurysms Investigators. N Engl J Med 339 (24): 1725–1733. http://doi.org/10.1056/NEJM199812103392401

  • Yamaura A, Ono J, Hirai S (2000) Clinical picture of intracranial non-traumatic dissecting aneurysm. Neuropathol 20 (1): 85–90

    Article  CAS  Google Scholar 

  • Yonas H, Agamanolis D, Takaoka Y, White RJ (1977) Dissecting intracranial aneurysms. Surg Neurol 8 (6): 407–415

    CAS  PubMed  Google Scholar 

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Kretschmer, T., Schmidt, T. (2017). Grundlagen der Therapie von Aneurysmen. In: Kretschmer, T. (eds) Zerebrale Aneurysmen und Gefäßmalformationen. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-50478-9_4

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