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Zusammenfassung

Die Verordnungen der Statine haben auch 2015 weiter zugenommen. Dominierendes Präparat ist weiterhin Simvastatin. Den stärksten Zuwachs erzielte erneut Atorvastatin durch preisgünstige Generika. Andere Statine und Fibrate waren dagegen rückläufig. Ezetimibpräparate und Colestyramin wurden auf niedrigem Niveau wieder etwas mehr verordnet.

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References

  • Cannon CP, Blazing MA, Giugliano RP, McCagg A, White JA, Theroux P, Darius H, Lewis BS, Ophuis TO, Jukema JW, De Ferrari GM, Ruzyllo W, De Lucca P, Im K, Bohula EA, Reist C, Wiviott SD, Tershakovec AM, Musliner TA, Braunwald E, Califf RM; IMPROVE-IT Investigators (2015): Ezetimibe Added to Statin Therapy after Acute Coronary Syndromes. N Engl J Med 2015 Jun 3. [Epub ahead of print]

    Google Scholar 

  • Cholesterol Treatment Trialists’ (CTT) Collaborators (2005): Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90 056 participants in 14 randomised trials of statins. Lancet 366: 1267–1278

    Article  Google Scholar 

  • Cholesterol Treatment Trialists’ Collaboration, (2015): Efficacy and safety of LDL-lowering therapy among men and women: meta-analysis of individual data from 174,000 participants in 27 randomised trials. Lancet 385: 1397–1405

    Google Scholar 

  • De Lorgeril M, Salen P, Martin J-L, Monjaud I, Delaye J, Mamelle N (1999): Mediterranean diet, traditional risk factors, and the rate of cardiovascular complications after myocardial infarction. Circulation 99: 779–785

    Article  PubMed  Google Scholar 

  • De Souza RJ, Mente A, Maroleanu A, Cozma AI, Ha V, Kishibe T, Uleryk E, Budylowski P, Schünemann H, Beyene J, Anand SS (2015): Intake of saturated and trans unsaturated fatty acids and risk of all cause mortality, cardiovascular disease, and type 2 diabetes: systematic review and meta-analysis of observational studies. BMJ. 2015 Aug 11;351:h3978. doi:10.1136/bmj.h3978

    PubMed Central  Google Scholar 

  • Deutsche Gesellschaft für Kardiologie—Herz- und Kreislaufforschung (2011): ESC/EAS/DGK Pocket-Leitlinien: Diagnostik und Therapie der Dyslipidämien. Internet: http://leitlinien.dgk.org/images/pdf/leitlinien_pocket/2012_pll_25_dys.pdf

  • Estruch R, Ros E, Salas-Salvadó J, Covas MI, Corella D, Arós F, Gómez-Gracia E, Ruiz-Gutiérrez V, Fiol M, Lapetra J, Lamuela-Raventos RM, Serra-Majem L, Pintó X, Basora J, Muñoz MA, Sorlí JV, Martínez JA, Martínez-González MA; PREDIMED Study Investigators (2013): Primary prevention of cardiovascular disease with a Mediterranean diet. N Engl J Med 368: 1279–1290

    Article  CAS  PubMed  Google Scholar 

  • Heart Protection Study Collaborative Group (2011): C-reactive protein concentration and the vascular benefits of statin therapy: an analysis of 20,536 patients in the Heart Protection Study. Lancet 377: 469–476

    Article  PubMed Central  Google Scholar 

  • HPS2-Thrive Collaborative Group (2013): HPS2-THRIVE randomized placebo-controlled trial in 25 673 high-risk patients of ER niacin/laropiprant: trial design, pre-specified muscle and liver outcomes, and reasons for stopping study treatment. Eur Heart J 34: 1279–1291

    Article  PubMed Central  Google Scholar 

  • Jun M, Foote C, Lv L, Neal B, Patel A, Nicholls S, Grobbee DE, Cass A, Chalmers A, Perkovic V (2010): Effects of fibrates on cardiovascular outcomes: a systematic review and meta-analysis. Lancet 375: 1875–1884

    Article  CAS  PubMed  Google Scholar 

  • Kastelein JJ, Akdim F, Stroes ES, Zwinderman AH, Bots ML, Stalenhoef AF, Visseren FL, Sijbrands EJ, Trip MD, Stein EA, Gaudet D, Duivenvoorden R, Veltri EP, Marais AD, de Groot E; ENHANCE Investigators (2008): Simvastatin with or without ezetimibe in familial hypercholesterolemia. N Engl J Med 358: 1431–1443

    Article  CAS  PubMed  Google Scholar 

  • Klose G (2011): Möglichkeiten und Grenzen der modernen Lipidtherapie. Internist 52: 328–335

    Article  CAS  PubMed  Google Scholar 

  • Klose G, Beil FU, Dieplinger H, von Eckardstein A, Föger B, Gouni-Berthold I, Koenig W, Kostner GM, Landmesser U, Laufs U, Leistikow F, März W, Merkel M, Müller-Wieland D, Noll G, Parhofer KG, Paulweber B, Riesen W, Schaefer JR, Steinhagen-Thiessen E, Steinmetz A, Toplak H, Wanner C, Windler E (2014): Neue AHA- und ACC-Leitlinie zur Risikoreduktion von Herz-Kreislauf-Erkrankungen durch Cholesterinsenkung, Stellungnahme der D•A•CH-Gesellschaft Prävention von Herz-Kreislauf-Erkrankungen e. V., der Österreichischen Atherosklerose Gesellschaft und der Arbeitsgruppe Lipide und Atherosklerose (AGLA) der Schweizer Gesellschaft für Kardiologie. Internist 55: 601–606

    Article  CAS  PubMed  Google Scholar 

  • Libby P (2013): Mechanisms of acute coronary syndromes and their implications for therapy. N Engl J Med 368: 2004–2013

    Article  CAS  PubMed  Google Scholar 

  • Lipid Research Clinics Program (1984): Lipid Research Clinics Coronary Primary Prevention Trial Results. I. Reduction in incidence of coronary heart disease. II. Relationship of reduction in incidence of coronary heart disease to cholesterol lowering. JAMA 251: 351–364, 365–374

    Google Scholar 

  • Nicholls SJ for the ACCELERATE Investigators, The ACCELERATE Trial, Impact of the Cholesteryl Ester Transfer Protein Inhibitor Evacetrapib on Cardiovascular Outcome, ACC 2016 Presentation

    Google Scholar 

  • Nidorf SM, Eikelboom JW, Budgeon CA, Thompson PL (2013): Low-dose colchicine for secondary prevention of cardiovascular disease. J Am Coll Cardiol 61: 404–410

    Article  CAS  PubMed  Google Scholar 

  • Nissen SE, Tuzcu EM, Schoenhagen P, Crowe T, Sasiela WJ, Tsai J et al.; Reversal of Atherosclerosis with Aggressive Lipid Lowering (REVERSAL) Investigators (2005): Statin therapy, LDL cholesterol, C-reactive protein, and coronary artery disease. N Engl J Med 352: 29–38

    Google Scholar 

  • Raal FJ, Stein EA, Dufour R, Turner T, Civeira F, Burgess L, Langslet G, Scott R, Olsson AG, Sullivan D, Hovingh GK, Cariou B, Gouni-Berthold I, Somaratne R, Bridges I, Scott R, Wasserman SM, Gaudet D; RUTHERFORD-2 Investigators (2015a): PCSK9 inhibition with evolocumab (AMG 145) in heterozygous familial hypercholesterolaemia (RUTHERFORD-2): a randomised, double-blind, placebo-controlled trial. Lancet 385: 331–340

    Google Scholar 

  • Raal FJ, Honarpour N, Blom DJ, Hovingh GK, Xu F, Scott R, Wasserman SM, Stein EA; TESLA Investigators (2015b): Inhibition of PCSK9 with evolocumab in homozygous familial hypercholesterolaemia (TESLA Part B): a randomised, double-blind, placebo-controlled trial. Lancet 385: 341–350

    Google Scholar 

  • Ridker PM, Cannon CP, Morrow D, Rifai N, Rose LM, McCabe CH, Pfeffer MA, Braunwald E; Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis in Myocardial Infarction 22 (PROVE IT-TIMI 22) Investigators (2005): C-reactive protein levels and outcomes after statin therapy. N Engl J Med 352: 20–28

    Article  CAS  PubMed  Google Scholar 

  • Ridker PM (2014): LDL cholesterol: controversies and future therapeutic directions. Lancet 384: 607–617

    Article  CAS  PubMed  Google Scholar 

  • Robinson JG, Nedergaard BS, Rogers WJ, Fialkow J, Neutel JM, Ramstad D, Somaratne R, Legg JC, Nelson P, Scott R, Wasserman SM, Weiss R; LAPLACE-2 Investigators (2014): Effect of evolocumab or ezetimibe added to moderateor high-intensity statin therapy on LDL-C lowering in patients with hypercholesterolemia: the LAPLACE-2 randomized clinical trial. JAMA 311: 1870–1882

    Article  PubMed  Google Scholar 

  • Robinson JG, Farnier M, Krempf M, Bergeron J, Luc G, Averna M, Stroes ES, Langslet G, Raal FJ, El Shahawy M, Koren MJ, Lepor NE, Lorenzato C, Pordy R, Chaudhari U, Kastelein JJ; ODYSSEY LONG TERM Investigators (2015): Efficacy and safety of alirocumab in reducing lipids and cardiovascular events. N Engl J Med 372: 1489–1499

    Article  CAS  PubMed  Google Scholar 

  • Robinson JG, Stone NJ (2015): The 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular disease risk: a new paradigm supported by more evidence. Eur Heart J 2015 May 20. pii: ehv182. [Epub ahead of print]

    Google Scholar 

  • Rossebø AB, Pedersen TR, Boman K, Brudi P, Chambers JB, Egstrup K, Gerdts E, Gohlke-Bärwolf C, Holme I, Kesäniemi YA, Malbecq W, Nienaber CA, Ray S, Skjaerpe T, Wachtell K, Willenheimer R; SEAS Investigators (2008): N Engl J Med 359: 1343–1356

    Article  PubMed  Google Scholar 

  • Schönbeck U, Libby P (2004): Inflammation, immunity, and HMG-CoA reductase inhibitors: statins as antiinflammatory agents? Circulation 109 (Suppl II): II 18–26

    Google Scholar 

  • Schwartz GG, Olsson AG, Abt M, Ballantyne CM, Barter PJ, Brumm J, Chaitman BR, Holme IM, Kallend D, Leiter LA, Leitersdorf E, McMurray JJ, Mundl H, Nicholls SJ, Shah PK, Tardif JC, Wright RS; dal-OUTCOMES Investigators (2012): Effects of dalcetrapib in patients with a recent acute coronary syndrome. N Engl J Med 367: 2089–2099

    Article  CAS  PubMed  Google Scholar 

  • Shepherd J (2002): Resource management in prevention of coronary heart disease: optimising prescription of lipid-lowering drugs. Lancet 359: 2271–2273

    Article  PubMed  Google Scholar 

  • Stone NJ, Robinson J, Lichtenstein AH, Merz CN, Blum CB, Eckel RH, Goldberg AC, Gordon D, Levy D, Lloyd-Jones DM, McBride P, Schwartz JS, Shero ST, Smith SC Jr, Watson K, Wilson PW (2013): 2013 ACC/AHA Guideline on the Treatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Risk in Adults: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation. 2013 Nov 12. [Epub ahead of print]

    Google Scholar 

  • The ACCORD Study Group (2010): Effects of combination lipid therapy in type 2 diabetes mellitus. N Engl J Med 362: 1563–1574

    Article  PubMed Central  Google Scholar 

  • The AIM-HIGH Investigators (2011): Niacin in patients with low HDL cholesterol levels receiving intensive statin therapy. N Engl J Med 365: 2255–2267

    Article  Google Scholar 

  • The Bezafibrate Infaction prevention (BIP) Study Group (2000): Secondary prevention by raising HDL cholesterol and reducing triglycerides in patients with coronary artery disease: the Bezafibrate Infaction Prevention (BIP) study. Circulation 102: 21–27

    Article  Google Scholar 

  • The FIELD study Investigators (2005): Effects of long-term fenofibrate therapy on cardiovascular events in 9795 people with type 2 diabetes mellitus (the FIELD study): randomised controlled trial. Lancet 366: 1849–1861

    Article  Google Scholar 

  • The STABILITY Investigators (2014): Darapladib for Preventing Ischemic Events in Stable Coronary Heart Disease. N Engl J Med 370: 1702–1711

    Article  Google Scholar 

  • The Task FORCE for the management of dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS) (2011): ESC/EAS Guidelines for the management of dyslipidaemias. Eur Heart J 32: 1769–818

    Article  Google Scholar 

  • Wiesner G, Grimm J, Bittner E (1999): Zum Herzinfarktgeschehen in der Bundesrepublik Deutschland: Prävalenz, Inzidenz, Trend, Ost-West-Vergleich. Gesundheitswesen 61(Sonderheft 2): S72–S78

    PubMed  Google Scholar 

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Klose, G., Schwabe, U. (2016). Lipidsenkende Mittel. In: Schwabe, U., Paffrath, D. (eds) Arzneiverordnungs-Report 2016. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-50351-5_32

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  • DOI: https://doi.org/10.1007/978-3-662-50351-5_32

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