Zusammenfassung
Seit 1995 sind die Verordnungen der Antitussiva und der Expektorantien stark zurückgegangen. Hauptgrund des rückläufigen Trends ist die zweifelhafte Wirksamkeit dieser Substanzen. Auch der Ausschluss rezeptfreier Arzneimittel aus der Erstattung hat die Abnahme des Verordnungsvolumens seit 2004 weiter beschleunigt. Im Jahre 2015 ist – wenn auch auf niedrigem Niveau – erstaunlicherweise eine Zunahme der Verordnungen festzustellen.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
American Academy of Pediatrics Committee on Drugs (1997): Use of codeine- and extromethorphan-containing cough remedies in children. Pediatrics 99: 918–920
Bundesgesundheitsamt (1981): Monographieentwürfe für anthroposophische und phytotherapeutische Arzneimittel. Dtsch Apoth Ztg 52: 2910–2913
Cegla UH (1988): Langzeittherapie über 2 Jahre mit Ambroxol (Mucosolvan) Retardkapseln bei Patienten mit chronischer Bronchitis. Ergebnisse einer Doppelblindstudie an 180 Patienten. Prax Klin Pneumol 42: 715–721
Celli BR, Decramer M, Wedzicha JA, Wilson KC, Augusti A, et al. (2015). An official Ameriocan Thoracis Society/European Respiratory Society statement: reseach questions in COPD. Eur Respir J 45:879–905
Cwientzek U, Ottillinger B, Arenberger P (2011): Acute bronchitis therapy with ivy leaves extracts in a two-arm study. A double-blind, randomised study vs. an other ivy leaves extract. Phytomedicine 18: 1105–1109
Dicpinigaitis PV, Morice AH, Birrung SS, McGarvey L, Smith JA, Canning BJ, Page CP (2014): Antitussive drugs—past, present, and future. Pharmacol Rev 66: 468–512
European Medicines Agency (2011): Community herbal monograph on Hedera helix L., folium. Final assessment report on Hedera helix L., folium. Internet: http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/herbal/medicines/herbal_med_000115.jsp&mid=WC0b01ac058001fa1d
European Medicines Agency (2012): Opinion of the HMPC on a community herbal monograph on Hedera helix L., folium. Internet: http://www.ema-europa.eu/docs/en_GB/document_library/Herbal_-_HMPC_opinion_on_Community_herbal_monograph/2012/01/WC500120649.pdf
European Medicines Agency (2015): Ambroxol and bromhexine expectorants: safety information to be updated. Press Release 25. February EMA/130676/2015 Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2010: Global Strategy for the Diagnosis, Management and Prevention of COPD. Available from: http://www.goldcopd.org
Guyatt GH, Townsend M, Kazim F, Newhouse MT (1987): A controlled trial of ambroxol in chronic bronchitis. Chest 92: 618–620
Jones AP, Wallis C (2010): Dornase alfa for cystic fibrosis. Cochrane Database Syst Rev 2010 Mar 17; (3):CD001127
Kayser O, Kolodziej H (1997): Antibacterial activity of extracts and constituents of Pelargonium sidoides and Pelargonium reniforme. Planta Med 63: 508–510
Kurz H (1986): Expektorantien und Antitussiva. Dtsch Apoth Ztg 126: 1024–1029
Lazaryan M, Shasha-Zigelman C, Dagan Z, Berkovitch M (2015): Codeine should not be prescribed for breastfeeding mothers or children under the age of 12. Act Paediatr 104:555–556
Malerba M, Ponticiello A, Radaeli A, Bensi G, Grassi V (2004): Effect of twelve-months therapy with oral ambroxol in preventing exacerbations in patients with COPD. Double-blind, randomised, mulicenter, placebo-controlled study (the AMETHIST Trial). Pulm Pharmacol Therpeut 17: 27–34
Mutschler E, Geisslinger G, Kroemer HK, Menzel S, Ruth P (2013): Arzneimittelwirkungen, 10. Aufl., Wissenschaftliche Verlagsgesellschaft Stuttgart, S. 581–582
Müller S, Jaffan L, Kloiber E, Läer S (2014): Dextrometorphan-Missbrauch bei Jugendlichen: Wie kann sich der Apotheker verhalten? Med Mo Pharm 37: 95–100
Oduwole O, Meremikwu MM, Oyo-Ita A, Udoh E.E. (2014): Honey for acute cough in children. Cochrane Database Syst Rev Dec 13;12:CD 007094
Olivieri D, Zavattini G, Tomasini G (1987): Ambroxol for the prevention of chronic bronchitis exacerbations: longterm multicenter trial. Respiration 51: Suppl 1, 42–51
Olsson B, Johansson M, Gabrielsson J, Bolme P (1988): Pharmacokinetics and bioavailability of reduced and oxidized N-acetylcysteine. Eur J Clin Pharmacol 34: 77–82
Øymar K, Skjerven HO, Mikalsen IB (2014): Acute bronchiolitis in infants, a review. Scand J Trauma Resusc Emerg Med 22: 23
Poole P, Black PN, Cates CJ. (2012): Mucolytic agents for chronic bronchitis or chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 15: 8: CD001287
Schmidt M, Thomsen M, Schmidt U (2012): Suitability of ivy extract for the treatment of paediatric cough. Phytother Res 26: 1942–1947
Sharfstein JM, North M, Serwint JR (2007): Over the counter but no longer under the radar—pediatric cough and cold medications. N Engl J Med 357: 2321–2324
Smith SM, Schroeder K, Fahey T (2014): Over-the-counter (OTC) medications for acute cough in children and adults in communitty settings. Cochrane Database Syst Rev Nov 24,11:CD0011831
Stauss-Grabo M, Atiye S, Warnke A, Wedemeyer RS, Donath F, Blume HH. (2010): Observational study on the tolerability and safety of film-coated tablets containing ivy extract (Prospan® Cough Tablets) in the treatment of colds accompanied by coughing. Phytomedicine. 15: 433–436
Timmer A, Günther J, Motschall E, Rücker G, Antes G, Kern WV (2013): Pelargonium sidoides extract for treating acute respiratory tract infections. Cochrane Database Syst Rev. 2013 Oct 22;10:CD006323
Tse HN, Raiteri L, Wong KY, Yee KS, Wai KY, Loo CK, Houng CM. (2013): High-Dose N-acetylcysteine in stable chronic obstructive pulmonary disease: the 1-year, double-blind, randomized, placebo-controlled HIACE study. Chest 144: 106–118
Virchow JC, Backer V, de Blay F, Kuna P, Ljørring C, Prieto JL, Villesen HH (2015): Defining moderate asthma exacerbations in clinical trials based on ATS/ERS joint statement. Resp Med 109: 547–556
Wark P, McDonald VM (2009): Nebulised hypertonic saline for cystic fibrosis. Cochrane Database Syst Rev. 2009 Apr 15; (2): CD001506
Zhang L, Mendoza-Sassi RA, Wainwright C, Klassen TP (2013): Nebulised hypertonic saline solution for acute bronchiolitis in infants. Cochrane Database Syst Rev. 2013 Jul 31; 7: CD006458
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2016 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Lemmer, B. (2016). Antitussiva und Expektorantien. In: Schwabe, U., Paffrath, D. (eds) Arzneiverordnungs-Report 2016. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-50351-5_20
Download citation
DOI: https://doi.org/10.1007/978-3-662-50351-5_20
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-662-50350-8
Online ISBN: 978-3-662-50351-5
eBook Packages: Medicine (German Language)