Abstract
Transplanted organs are harvested from three major sources: cadaveric “brain-dead” donors, cadaveric “cardiac death” donors (donation after cardiac death), and living (related and unrelated) donors. Cadaveric, brain-dead donors account for approximately 54 % of all donors, and the most common causes of death in this group are cerebrovascular accident (CVA)/stroke, head trauma, and anoxia. Traumatic brain injury (TBI), once the most common cause of brain death, has been surpassed by CVA and this has important implications. As such, organs from younger and healthier trauma patients have been replaced by older, sicker stroke patients. Both TBI and CVA will continue to contribute a significant number of organs as nearly 50,000 US residents die from TBI and nearly 142,000 citizens die from CVA per year.
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Braverman JM (2002) Increasing the quantity of lungs for transplantation using high-frequency chest wall oscillation: a proposal. Prog Transplant 12:266–274
Callahan DS, Kim D, Bricker S et al (2014) Trends in organ donor management: 2002 to 2012. J Am Coll Surg 219:752–756
Cooper DK, Novitzky D, Wicomb WN (1989) The pathophysiological effects of brain death on potential donor organs, with particular reference to the heart. Ann R Coll Surg Engl 71:261–266
Department of Health and Human Resources (2007) Centers for disease control and prevention. http://www.cdc.gov/nchs/injury.htm. Accessed 26 July 2007
Franz HG, DeJong W, Wolfe SM et al (1997) Explaining brain death: a critical feature of the donation process. J Transpl Coord 7:14–21
Hadjizacharia P, Salim A, Brown C et al (2010) Does the use of pulmonary artery catheters increase the number of organs available for transplantation? Clin Transplant 24:62–66
Jenkins DH, Reilly PM, Schwab CW (1999) Improving the approach to organ donation: a review. World J Surg 23:644–649
Manno EM (2006) The declaration of death and the withdrawal of care in the neurologic patient. Neurol Clin 24:159–169
Novitzky D, Cooper DK, Reichart B (1986) Value of triiodothyronine (T3) therapy to brain-dead potential organ donors. J Heart Transplant 5:486–487
Prodhan P, Casavant D, Medlock MD, Yager P, Kim J, Noviski N (2004) Inhaled nitric oxide in neurogenic cardiopulmonary dysfunction: implications for organ donation. Transplant Proc 36:2570–2572
Rosendale JD, Chabalewski FL, McBride MA et al (2002) Increased transplanted organs from the use of a standardized donor management protocol. Am J Transplant 2:761–768
Salim A, Brown C, Inaba K et al (2007) Improving consent rates for organ donation: the effect of an inhouse coordinator program. J Trauma 62:1411–1414
Salim A, Martin M, Brown C, Rhee P, Demetriades D, Belzberg H (2006) The effect of a protocol of aggressive donor management: implications for the national organ donor shortage. J Trauma 61:429–433; discussion 433–435
Salim A, Vassiliu P, Velmahos GC et al (2001) The role of thyroid hormone administration in potential organ donors. Arch Surg 136:1377–1380
Salim A, Velmahos GC, Brown C, Belzberg H, Demetriades D (2005) Aggressive organ donor management significantly increases the number of organs available for transplantation. J Trauma 58:991–994
Salter DR, Dyke CM, Wechsler AS (1992) Triiodothyronine (T3) and cardiovascular therapeutics: a review. J Card Surg 7:363–374
Shafer TJ, Davis KD, Holtzman SM, Van Buren CT, Crafts NJ, Durand R (2003) Location of in-house organ procurement organization staff in level I trauma centers increases conversion of potential donors to actual donors. Transplantation 75:1330–1335
Shafer TJ, Ehrle RN, Davis KD et al (2004) Increasing organ recovery from level I trauma centers: the in-house coordinator intervention. Prog Transplant 14:250–263
Siminoff LA, Mercer MB (2001) Public policy, public opinion, and consent for organ donation. Camb Q Healthc Ethics 10:377–386
Straznicka M, Follette DM, Eisner MD, Roberts PF, Menza RL, Babcock WD (2002) Aggressive management of lung donors classified as unacceptable: excellent recipient survival one year after transplantation. J Thorac Cardiovasc Surg 124:250–258
U.S. Department of Health and Human Services (2007) Organ donation breakthrough collaborative: from best practice to common practice. http://www.organdonationnow.org/. Accessed 26 July 2007
Wheeldon DR, Potter CD, Dunning J et al (1992) Haemodynamic correction in multiorgan donation. Lancet 339:1175
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Ley, E.J., Salim, A. (2017). Organ Donation. In: Velmahos, G., Degiannis, E., Doll, D. (eds) Penetrating Trauma. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-49859-0_84
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DOI: https://doi.org/10.1007/978-3-662-49859-0_84
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