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Strategien in der Respiratorentwöhnung

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Weaning

Zusammenfassung

Nicht selten resultieren aus einer komplexen, intensivmedizinischen Behandlung mit Beatmung immer älter werdender Patienten eine Langzeitabhängigkeit von Beatmungsmedizin. Nur etwa die Hälfte langzeitbeatmeter Patienten (>14 Tage) ist vor Entlassung aus dem Krankenhaus vom Respirator entwöhnt. Und nur etwa 41 % der Patienten nach Langzeitbeatmung leben noch ein Jahr nach Entlassung aus dem Krankenhaus. Die Ursachen für eine Langzeitbeatmung und ein Scheitern der Respiratorentwöhnung sind vielfältig und reichen von iatrogenen Verursachungen, wie z. B. Übersedierung, Fehlen eines protokollbasierten Managements zur Erfassung des Weaningpotentials, einer unzureichenden Adaption der Beatmungsunterstützung an die klinische Situation des Patienten, über Folgezustände einer protrahierten Intensivtherapie mit Entwicklung z. B. eines Delirs oder Ausbildung eines schwerwiegenden neuromuskulären Organversagens, bis hin zu Problemen, die durch die respiratorische Grunderkrankung begründet sind.

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Literatur

  1. Damuth E, Mitchell JA, Bartock JL, Roberts BW, Trzeciak S (2015) Long-term survival of critically ill patients treated with prolonged mechanical ventilation: a systematic review and meta-analysis. Lancet Respir Med 3(7):544–553

    Article  PubMed  Google Scholar 

  2. Fried TR, Bradley EH, Towle VR, Allore H (2002) Understanding the treatment preferences of seriously ill patients. N Engl J Med 346(14):1061–1066

    Article  PubMed  Google Scholar 

  3. Geiseler J, Kelbel C (2016) Weaning from mechanical ventilation: weaning categories and weaning concepts. Med Klin Intensivmed Notfmed 111(3):208–214

    Article  CAS  PubMed  Google Scholar 

  4. Boles JM, Bion J, Connors A, Herridge M, Marsh B, Melot C et al (2007) Weaning from mechanical ventilation. Eur Respir J 29(5):1033–1056

    Article  PubMed  Google Scholar 

  5. Funk GC, Anders S, Breyer MK, Burghuber OC, Edelmann G, Heindl W et al (2010) Incidence and outcome of weaning from mechanical ventilation according to new categories. Eur Respir J 35(1):88–94

    Article  PubMed  Google Scholar 

  6. Béduneau G, Pham T, Schortgen F, Piquilloud L, Zogheib E, Jonas M et al (2017) Epidemiology of weaning outcome according to a new definition. The WIND study. Am J Respir Crit Care Med 195(6):772–783

    Article  PubMed  Google Scholar 

  7. American Psychiatric Association (1980) Diagnostic and statistical manual of mental disorders

    Google Scholar 

  8. Brummel NE, Jackson JC, Pandharipande PP, Thompson JL, Shintani AK, Dittus RS et al (2014) Delirium in the ICU and subsequent long-term disability among survivors of mechanical ventilation. Crit Care Med 42(2):369–377

    Article  PubMed  PubMed Central  Google Scholar 

  9. Luetz A, Heymann A, Radtke FM, Chenitir C, Neuhaus U, Nachtigall I et al (2010) Different assessment tools for intensive care unit delirium: which score to use? Crit Care Med 38(2):409–418

    Article  PubMed  Google Scholar 

  10. Veiga D, Luis C, Parente D, Fernandes V, Botelho M, Santos P, Abelha F (2012) Postoperative delirium in intensive care patients: risk factors and outcome. Rev Bras Anestesiol 62(4):469–483

    Article  PubMed  Google Scholar 

  11. Ely EW, Shintani A, Truman B, Speroff T, Gordon SM, Harrell FE et al (2004) Delirium as a predictor of mortality in mechanically ventilated patients in the intensive care unit. JAMA 291(14):1753–1762

    Article  CAS  PubMed  Google Scholar 

  12. Ely EW, Gautam S, Margolin R, Francis J, May L, Speroff T et al (2001) The impact of delirium in the intensive care unit on hospital length of stay. Intensive Care Med 27(12):1892–1900

    Article  CAS  PubMed  Google Scholar 

  13. Zhang Z, Pan L, Ni H (2013) Impact of delirium on clinical outcome in critically ill patients: a meta-analysis. Gen Hosp Psychiatry 35(2):105–111

    Article  CAS  PubMed  Google Scholar 

  14. Lat I, McMillian W, Taylor S, Janzen JM, Papadopoulos S, Korth L et al (2009) The impact of delirium on clinical outcomes in mechanically ventilated surgical and trauma patients. Crit Care Med 37(6):1898–1905

    Article  PubMed  Google Scholar 

  15. Pandharipande PP, Girard TD, Jackson JC, Morandi A, Thompson JL, Pun BT et al (2013) Long-term cognitive impairment after critical illness. N Engl J Med 369(14):1306–1316

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Jeon K, Jeong BH, Ko MG, Nam J, Yoo H, Chung CR, Suh GY (2016) Impact of delirium on weaning from mechanical ventilation in medical patients. Respirology 21(2):313–320

    Article  PubMed  Google Scholar 

  17. Jackson DL, Proudfoot CW, Cann KF, Tim Walsh T (2010) A systematic review of the impact of sedation practice in the ICU on resource use, costs and patient safety. Crit Care 14:R59

    Google Scholar 

  18. DAS-Taskforce 2015; Baron R, Binder A, Biniek R, Braune S, Buerkle H, Dall P, Demirakca S, Eckardt R, Eggers V, Eichler I, Fietze I, Freys S, Fründ A, Garten L, Gohrbandt B, Harth I, Hartl W, Heppner HJ, Horter J, Huth R, Janssens U, Jungk C, Kaeuper KM, Kessler P, Kleinschmidt S, Kochanek M, Kumpf M, Meiser A, Mueller A, Orth M, Putensen C, Roth B, Schaefer M, Schaefers R, Schellongowski P, Schindler M, Schmitt R, Scholz J, Schroeder S, Schwarzmann G, Spies C, Stingele R, Tonner P, Trieschmann U, Tryba M, Wappler F, Waydhas C, Weiss B, Weisshaar G (2015) Evidence and consensus based guideline for the management of delirium, analgesia, and sedation in intensive care medicine. Revision 2015 (DAS-Guideline 2015) – short version. Ger Med Sci 13:Doc19

    Google Scholar 

  19. Windisch W (2008) Pathophysiology of respiratory muscle weakness. Pneumologie 62(Suppl 1):S18–S22

    Article  PubMed  Google Scholar 

  20. Jaber S, Petrof BJ, Jung B, Chanques G, Berthet JP, Rabuel C et al (2011) Rapidly progressive diaphragmatic weakness and injury during mechanical ventilation in humans. Am J Respir Crit Care Med 183(3):364–371

    Article  CAS  PubMed  Google Scholar 

  21. Jaber S, Jung B, Matecki S, Petrof BJ (2011) Clinical review: ventilator-induced diaphragmatic dysfunction––human studies confirm animal model findings! Crit Care 15(2):206

    Article  PubMed  PubMed Central  Google Scholar 

  22. Levine S, Nguyen T, Taylor N, Friscia ME, Budak MT, Rothenberg P et al (2008) Rapid disuse atrophy of diaphragm fibers in mechanically ventilated humans. N Engl J Med 358(13):1327–1335

    Article  CAS  PubMed  Google Scholar 

  23. Wollersheim T, Woehlecke J, Krebs M, Hamati J, Lodka D, Luther-Schroeder A et al (2014) Dynamics of myosin degradation in intensive care unit-acquired weakness during severe critical illness. Intensive Care Med 40(4):528–538

    Article  CAS  PubMed  Google Scholar 

  24. Hooijman PE, Beishuizen A, Witt CC, de Waard MC, Girbes AR, Spoelstra-de Man AM et al (2015) Diaphragm muscle fiber weakness and ubiquitin-proteasome activation in critically ill patients. Am J Respir Crit Care Med 91(10):1126–1138

    Article  CAS  Google Scholar 

  25. Powers SK, Kavazis AN, Levine S (2009) Prolonged mechanical ventilation alters diaphragmatic structure and function. Crit Care Med 37(10):S347

    Article  PubMed  PubMed Central  Google Scholar 

  26. Pickerodt PA, Francis RC, Weber-Carstens S (2013) Monitoring of the respiratory muscle function during weaning from mechanical ventilation. Anasthesiol Intensivmed Notfallmed Schmerzther 48(10):634–639

    Article  PubMed  Google Scholar 

  27. Orozco-Levi M, Lloreta J, Minguella J, Serrano S, Broquetas JM, Gea J (2001) Injury of the human diaphragm associated with exertion and chronic obstructive pulmonary disease. Am J Respir Crit Care Med 164(9):1734–1739

    Article  CAS  PubMed  Google Scholar 

  28. Laghi F, Topeli A, Tobin MJ (1998) Does resistive loading decrease diaphragmatic contractility before task failure? J Appl Physiol (1985) 85(3):1103–1112

    Article  Google Scholar 

  29. Laghi F, D'Alfonso N, Tobin MJ (1995) Pattern of recovery from diaphragmatic fatigue over 24 hours. J Appl Physiol (1985) 79(2):539–546

    Article  CAS  PubMed  Google Scholar 

  30. Kollef MH, Shapiro SD, Silver P, St John RE, Prentice D, Sauer S et al (1997) A randomized, controlled trial of protocol-directed versus physician-directed weaning from mechanical ventilation. Crit Care Med 25(4):567–574

    Article  CAS  PubMed  Google Scholar 

  31. Ely EW, Bennett PA, Bowton DL, Murphy SM, Florance AM, Haponik EF (1999) Large scale implementation of a respiratory therapist-driven protocol for ventilator weaning. Am J Respir Crit Care Med 159:439–446

    Article  CAS  PubMed  Google Scholar 

  32. Blackwood B, Burns KE, Cardwell CR, O'Halloran P (2014) Protocolized versus non-protocolized weaning for reducing the duration of mechanical ventilation in critically ill adult patients. Cochrane Database Syst Rev 6(11):CD006904

    Google Scholar 

  33. Girard TD, Kress JP, Fuchs BD, Thomason JW, Schweickert WD, Pun BT et al (2008) Efficacy and safety of a paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care (awakening and breathing controlled trial): a randomised controlled trial. Lancet 371(9607):126–134

    Article  PubMed  Google Scholar 

  34. Schweickert WD, Pohlman MC, Pohlman AS, Nigos C, Pawlik AJ, Esbrook CL et al (2009) Early physical and occupational therapy in mechanically ventilated, critically ill patients: a randomised controlled trial. Lancet 373(9678):1874–1882

    Article  PubMed  Google Scholar 

  35. Morandi A, Brummel NE, Ely EW (2011) Sedation, delirium and mechanical ventilation: the 'ABCDE' approach. Curr Opin Crit Care 17(1):43–49

    Article  PubMed  Google Scholar 

  36. Burry L, Rose L, McCullagh IJ, Fergusson DA, Ferguson ND, Mehta S (2014) Daily sedation interruption versus no daily sedation interruption for critically ill adult patients requiring invasive mechanical ventilation. Cochrane Database Syst Rev 7:CD009176

    Google Scholar 

  37. Vincent JL, Shehabi Y, Walsh TS, Pandharipande PP, Ball JA, Spronk P et al (2016) Comfort and patient-centred care without excessive sedation: the ecash concept. Intensive Care Med 42(6):962–971

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  38. Balas MC, Devlin JW, Verceles AC, Morris P, Ely EW (2016) Adapting the ABCDEF bundle to meet the needs of patients requiring prolonged mechanical ventilation in the long-term acute care hospital setting: historical perspectives and practical implications. Semin Respir Crit Care Med 37(1):119–135

    Article  PubMed  Google Scholar 

  39. Schönhofer B, Dellweg D, Geiseler J, Moerer O, Weber-Carstens S, Sitter H (2014) S2k-Leitlinie Prolongiertes Weaning. Peumologie 68:19–75

    Google Scholar 

  40. Schönhofer B, Euteneuer S, Nava S, Suchi S, Köhler D (2002) Survival of mechanically ventilated patients admitted to a specialised weaning centre. Intensive Care Med 28(7):908–916

    Article  PubMed  Google Scholar 

  41. Yang KL, Tobin MJ (1991) A prospective study of indexes predicting the outcome of trials of weaning from mechanical ventilation. N Engl J Med 324(21):1445–1450

    Article  CAS  PubMed  Google Scholar 

  42. MacIntyre NR, Cook DJ, Ely, W. E, Jr., Epstein SK et al (2001) Evidence-based guidelines for weaning and discontinuing ventilatory support: a collective task force facilitated by the american college of chest physicians; the american association for respiratory care; and the american college of critical care medicine. Chest 120(6 Suppl):375S–95S

    Google Scholar 

  43. Savi A, Teixeira C, Silva JM, Borges LG, Pereira PA, Pinto KB et al (2012) Weaning predictors do not predict extubation failure in simple-to-wean patients. J Crit Care 27(2):221.e1–e8

    Article  PubMed  Google Scholar 

  44. Tanios MA, Nevins ML, Hendra KP, Cardinal P, Allan JE, Naumova EN, Epstein SK (2006) A randomized, controlled trial of the role of weaning predictors in clinical decision making. Crit Care Med 34(10):2530–2535

    Article  PubMed  Google Scholar 

  45. Sahn SA, Lakshminarayan S (1973) Bedside criteria for discontinuation of mechanical ventilation. Chest 63(6):1002–1005

    Article  CAS  PubMed  Google Scholar 

  46. Jubran A, Grant BJ, Duffner LA, Collins EG, Lanuza DM, Hoffman LA, Tobin MJ (2013) Effect of pressure support vs unassisted breathing through a tracheostomy collar on weaning duration in patients requiring prolonged mechanical ventilation: a randomized trial. JAMA 309(7):671–677

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  47. Brochard L, Rauss A, Benito S, Conti G, Mancebo J, Rekik N et al (1994) Comparison of three methods of gradual withdrawal from ventilatory support during weaning from mechanical ventilation. Am J Respir Crit Care Med 150(4):896–903

    Article  CAS  PubMed  Google Scholar 

  48. Moerer O (2012) Effort-adapted modes of assisted breathing. Curr Opin Crit Care 18(1):61–69

    PubMed  Google Scholar 

  49. Bein T (2014) Current concepts of augmented spontaneous breathing: new modes of effort-adapted weaning. Anaesthesist 63(4):279–286

    Article  CAS  PubMed  Google Scholar 

  50. Di Mussi R, Spadaro S, Mirabella L, Volta CA, Serio G, Staffieri F et al (2016) Impact of prolonged assisted ventilation on diaphragmatic efficiency: NAVA versus PSV. Crit Care 20:1

    Article  PubMed  PubMed Central  Google Scholar 

  51. Schönhofer B, Kuhlen R (2004) Beatmung als Therapie der akuten respiratorischen Insuffizienz. Dtsch med Wschr 129:517–522

    Google Scholar 

  52. Westhoff M, Schönhofer B, Neumann P, Bickenbach J, Barchfeld T, Becker H et al (2015) Noninvasive mechanical ventilation in acute respiratory failure. Pneumologie 69(12):719–756

    Article  CAS  PubMed  Google Scholar 

  53. Burns KE, Meade MO, Premji A, Adhikari NK (2014) Noninvasive ventilation as a weaning strategy for mechanical ventilation in adults with respiratory failure: a cochrane systematic review. CMAJ 186(3):E112–E122

    Article  PubMed  PubMed Central  Google Scholar 

  54. Burns KE, Lellouche F, Lessard MR, Friedrich JO (2014) Automated weaning and spontaneous breathing trial systems versus non-automated weaning strategies for discontinuation time in invasively ventilated postoperative adults. Cochrane Database Syst Rev 2:CD008639

    Google Scholar 

  55. Brower RG (2009) Consequences of bed rest. Crit Care Med 37(10):S422

    Article  PubMed  Google Scholar 

  56. TEAM Study Investigators (2015) Early mobilization and recovery in mechanically ventilated patients in the ICU: a bi-national, multi-centre, prospective cohort study. Crit Care 19(1):81

    Article  Google Scholar 

  57. Nydahl P, Ewers A, Brodda D (2014) Complications related to early mobilization of mechanically ventilated patients on intensive care units. Nurs Crit Care. https://doi.org/10.1111/nicc.12134

  58. Nydahl P, Ruhl AP, Bartoszek G, Dubb R, Filipovic S, Flohr HJ et al (2014) Early mobilization of mechanically ventilated patients: a 1-day point-prevalence study in Germany. Crit Care Med 42(5):1178–1186

    Article  PubMed  Google Scholar 

  59. Schaller SJ, Anstey M, Blobner M, Edrich T, Grabitz SD, Gradwohl-Matis I et al (2016) Early, goal-directed mobilisation in the surgical intensive care unit: a randomised controlled trial. Lancet 388(10052):1377–1388

    Article  PubMed  Google Scholar 

  60. Kim WY, Suh HJ, Hong SB, Koh Y, Lim CM (2011) Diaphragm dysfunction assessed by ultrasonography: influence on weaning from mechanical ventilation. Crit Care Med 39(12):2627–2630

    Article  PubMed  Google Scholar 

  61. Kabitz HJ, Windisch W, Schönhofer B (2013) Understanding ventilator-induced diaphragmatic dysfunction (VIDD): progress and advances. Pneumologie 67(8):435–441

    Article  PubMed  Google Scholar 

  62. Grosu HB, Lee YI, Lee J, Eden E, Eikermann M, Rose KM (2012) Diaphragm muscle thinning in patients who are mechanically ventilated. Chest 142(6):1455–1460

    Article  PubMed  Google Scholar 

  63. DiNino E, Gartman EJ, Sethi JM, McCool FD (2014) Diaphragm ultrasound as a predictor of successful extubation from mechanical ventilation. Thorax 69(5):423–427

    Article  PubMed  Google Scholar 

  64. Goligher EC, Fan E, Herridge MS, Murray A, Vorona S, Brace D et al (2015) Evolution of diaphragm thickness during mechanical ventilation. Impact of inspiratory effort. Am J Respir Crit Care Med 192(9):1080–1088

    Article  PubMed  Google Scholar 

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Schönhofer, B., Weber-Carstens, S. (2018). Strategien in der Respiratorentwöhnung. In: Bickenbach, J., Marx, G., Dreher, M., Schönhofer, B. (eds) Weaning. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-49795-1_3

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